Ab119827

antibody from Aladdin Scientific

Targeting: TP53 LFS1, p53

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Validation data

Product number: Ab119827 - Provider product page
Provider: Aladdin Scientific
Product name: p53 Mouse mAb
Antibody type: Monoclonal
Description: Mouse anti Human p53 Antibody, Monoclonal (D1), could be used for WB and so on. Application WB: 0.01-2 µg/mL Protein Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Reactivity: Human, Rat
Host: Mouse
Conjugate: Unconjugated
Antigen sequence: AA 133-393
Antibody clone number: D1
Vial size: 100_l,10_l,1ml,20_l,50_l
Concentration: Lot by Lot
Storage: Store at 4_ short term (1-2 weeks). Store at -20_ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

TP53 protein structure - Ab119827 shown in red.