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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [80]
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- Validations
- Western blot [1]
- Immunocytochemistry [2]
- Flow cytometry [1]
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- Product number
- MA1-19551 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- p53 Monoclonal Antibody (BP53-12), FITC
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- This antibody recognizes a defined epitope (aa 16-25) on human p53.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- BP53-12
- Vial size
- 100 µg
- Concentration
- 1 mg/mL
- Storage
- 4° C, store in dark, DO NOT FREEZE!
Submitted references High concordance of molecular tumor alterations between pre-operative curettage and hysterectomy specimens in patients with endometrial carcinoma.
The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization.
BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: a study of 44 Turkish patients.
Müllerian precursor lesions in serous ovarian cancer patients: using the SEE-Fim and SEE-End protocol.
Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity.
Serrated pathway adenocarcinomas: molecular and immunohistochemical insights into their recognition.
Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential.
Vitiligo: is it grace or curse?
UNC5H4-induced apoptosis in non-small cell lung cancer is not dependent on p53 status only.
Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer.
Genetic alteration and immunohistochemical staining patterns of ovarian high-grade serous adenocarcinoma with special emphasis on p53 immnnostaining pattern.
Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme.
Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma.
Association of RASSF1A and p63 with poor recurrence-free survival in node-negative stage I-II non-small cell lung cancer.
Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians.
Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer.
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.
GABA-A channel subunit expression in human glioma correlates with tumor histology and clinical outcome.
Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.
Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/β-catenin and P53 pathway activation.
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation.
Assessment of p53 functional activity in tumor cells and histologically normal mucosa from patients with head and neck squamous cell carcinoma.
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.
Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation.
Dermoscopic, histological and immunohistochemical evaluation of cancerous features in acquired melanocytic nevi that have been repeatedly exposed to UVA or UVB.
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
Persistence and dynamics of DNA damage signal amplification determined by microcolony formation and live-cell imaging.
Persistence and dynamics of DNA damage signal amplification determined by microcolony formation and live-cell imaging.
Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy.
Exploring antibody recognition of sequence space through random-sequence peptide microarrays.
Efficacy and drawbacks of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the thoracic esophagus.
Efficacy and drawbacks of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the thoracic esophagus.
Part II. Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines.
A Unique case of primary squamous carcinoma of the salpinx associated with serous carcinoma of the omentum: a pathological and molecular study.
Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study.
Wild type but not mutant APP is involved in protective adaptive responses against oxidants.
Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells.
TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.
Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.
Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21(WAF1/CIP1).
Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells.
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
Progression and tumor heterogeneity analysis in early rectal cancer.
p53 status-dependent sensitization of human tumour cells to hyperthermia by plant flavonol.
Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells.
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature.
Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins.
Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study.
A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells.
Clinicopathological significance of maspin expression in breast cancer.
Clinicopathological significance of maspin expression in breast cancer.
Abnormal stability of wild-type p53 protein in a human lung carcinoma cell line.
p63-specific activation of the BPAG-1e promoter.
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.
Pulmonary large cell carcinoma with rhabdoid phenotype.
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing.
RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage.
Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation.
Do collision tumors of the gastroesophageal junction exist? A molecular analysis.
Do collision tumors of the gastroesophageal junction exist? A molecular analysis.
Proteomic analysis of selected prognostic factors of breast cancer.
Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity.
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.
Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions.
Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions.
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
Clear cell adenocarcinoma of the tunica vaginalis of the testis with an adjacent uterus-like tissue.
Gap junctional intercellular communication and cellular response to heat stress.
Derivation and characterization of a Wilms' tumour cell line, WiT 49.
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53.
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53.
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes.
Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia.
Impact of p53 and Ki-67 in predicting recurrence and progression of superficial (pTa and pT1) urothelial cell carcinomas of urinary bladder.
Impact of p53 and Ki-67 in predicting recurrence and progression of superficial (pTa and pT1) urothelial cell carcinomas of urinary bladder.
Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.
Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation.
Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation.
Stelloo E, Nout RA, Naves LC, Ter Haar NT, Creutzberg CL, Smit VT, Bosse T
Gynecologic oncology 2014 May;133(2):197-204
Gynecologic oncology 2014 May;133(2):197-204
The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization.
Cubillos-Rojas M, Amair-Pinedo F, Peiró-Jordán R, Bartrons R, Ventura F, Rosa JL
The Journal of biological chemistry 2014 May 23;289(21):14782-95
The Journal of biological chemistry 2014 May 23;289(21):14782-95
BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: a study of 44 Turkish patients.
Akay OM, Aras BD, Isiksoy S, Toprak C, Mutlu FS, Artan S, Oner U, Gulbas Z
Cancer genetics 2014 Mar;207(3):87-93
Cancer genetics 2014 Mar;207(3):87-93
Müllerian precursor lesions in serous ovarian cancer patients: using the SEE-Fim and SEE-End protocol.
Mingels MJ, van Ham MA, de Kievit IM, Snijders MP, van Tilborg AA, Bulten J, Massuger LF
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2014 Jul;27(7):1002-13
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2014 Jul;27(7):1002-13
Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity.
Baumgarten P, Harter PN, Tönjes M, Capper D, Blank AE, Sahm F, von Deimling A, Kolluru V, Schwamb B, Rabenhorst U, Starzetz T, Kögel D, Rieker RJ, Plate KH, Ohgaki H, Radlwimmer B, Zörnig M, Mittelbronn M
Neuropathology and applied neurobiology 2014 Feb;40(2):205-16
Neuropathology and applied neurobiology 2014 Feb;40(2):205-16
Serrated pathway adenocarcinomas: molecular and immunohistochemical insights into their recognition.
Gurzu S, Szentirmay Z, Toth E, Bara T, Bara T Jr, Jung I
PloS one 2013;8(3):e57699
PloS one 2013;8(3):e57699
Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential.
Mosoyan G, Nagi C, Marukian S, Teixeira A, Simonian A, Resnick-Silverman L, DiFeo A, Johnston D, Reynolds SR, Roses DF, Mosoian A
PloS one 2013;8(1):e55145
PloS one 2013;8(1):e55145
Vitiligo: is it grace or curse?
Bakry OA, Hammam MA, Abdel Wahed MM
Acta dermatovenerologica Croatica : ADC 2013;21(2):71-9
Acta dermatovenerologica Croatica : ADC 2013;21(2):71-9
UNC5H4-induced apoptosis in non-small cell lung cancer is not dependent on p53 status only.
Zhao ZH, Lin L, Liang A, Li HQ, Zhu Y
Oncology letters 2013 Nov;6(5):1363-1369
Oncology letters 2013 Nov;6(5):1363-1369
Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer.
Bosse T, ter Haar NT, Seeber LM, v Diest PJ, Hes FJ, Vasen HF, Nout RA, Creutzberg CL, Morreau H, Smit VT
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013 Nov;26(11):1525-35
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013 Nov;26(11):1525-35
Genetic alteration and immunohistochemical staining patterns of ovarian high-grade serous adenocarcinoma with special emphasis on p53 immnnostaining pattern.
Lee SH, Kim H, Kim WY, Han HS, Lim SD, Kim WS, Kim S, Hwang TS
Pathology international 2013 May;63(5):252-9
Pathology international 2013 May;63(5):252-9
Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme.
Rosati A, Poliani PL, Todeschini A, Cominelli M, Medicina D, Cenzato M, Simoncini EL, Magrini SM, Buglione M, Grisanti S, Padovani A
Neuro-oncology 2013 May;15(5):618-25
Neuro-oncology 2013 May;15(5):618-25
Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma.
Lee E, Lee BB, Ko E, Kim Y, Han J, Shim YM, Park J, Kim DH
Cancer 2013 May 1;119(9):1752-60
Cancer 2013 May 1;119(9):1752-60
Association of RASSF1A and p63 with poor recurrence-free survival in node-negative stage I-II non-small cell lung cancer.
Ko E, Lee BB, Kim Y, Lee EJ, Cho EY, Han J, Shim YM, Park J, Kim DH
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Mar 1;19(5):1204-12
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Mar 1;19(5):1204-12
Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians.
Malhotra P, Anwar M, Nanda N, Kochhar R, Wig JD, Vaiphei K, Mahmood S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Jun;34(3):1901-11
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Jun;34(3):1901-11
Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer.
Sarasqueta AF, Forte G, Corver WE, de Miranda NF, Ruano D, van Eijk R, Oosting J, Tollenaar RA, van Wezel T, Morreau H
BMC cancer 2013 Jun 5;13:277
BMC cancer 2013 Jun 5;13:277
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.
Zhang Y, Zhou L, Rouge L, Phillips AH, Lam C, Liu P, Sandoval W, Helgason E, Murray JM, Wertz IE, Corn JE
Nature chemical biology 2013 Jan;9(1):51-8
Nature chemical biology 2013 Jan;9(1):51-8
GABA-A channel subunit expression in human glioma correlates with tumor histology and clinical outcome.
Smits A, Jin Z, Elsir T, Pedder H, Nistér M, Alafuzoff I, Dimberg A, Edqvist PH, Pontén F, Aronica E, Birnir B
PloS one 2012;7(5):e37041
PloS one 2012;7(5):e37041
Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.
Buizza L, Cenini G, Lanni C, Ferrari-Toninelli G, Prandelli C, Govoni S, Buoso E, Racchi M, Barcikowska M, Styczynska M, Szybinska A, Butterfield DA, Memo M, Uberti D
PloS one 2012;7(1):e29789
PloS one 2012;7(1):e29789
Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/β-catenin and P53 pathway activation.
Nout RA, Bosse T, Creutzberg CL, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, van Eijk R, Ter Haar NT, Smit VT
Gynecologic oncology 2012 Sep;126(3):466-73
Gynecologic oncology 2012 Sep;126(3):466-73
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation.
Piccinin S, Tonin E, Sessa S, Demontis S, Rossi S, Pecciarini L, Zanatta L, Pivetta F, Grizzo A, Sonego M, Rosano C, Dei Tos AP, Doglioni C, Maestro R
Cancer cell 2012 Sep 11;22(3):404-15
Cancer cell 2012 Sep 11;22(3):404-15
Assessment of p53 functional activity in tumor cells and histologically normal mucosa from patients with head and neck squamous cell carcinoma.
Van der Vorst S, Dekairelle AF, Weynand B, Hamoir M, Gala JL
Head & neck 2012 Nov;34(11):1542-50
Head & neck 2012 Nov;34(11):1542-50
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.
Zimmermann M, Arachchige-Don AS, Donaldson MS, Dallapiazza RF, Cowan CE, Horne MC
The Journal of biological chemistry 2012 Jun 29;287(27):22838-53
The Journal of biological chemistry 2012 Jun 29;287(27):22838-53
Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation.
Suzuki M, Yamauchi M, Oka Y, Suzuki K, Yamashita S
International journal of radiation oncology, biology, physics 2012 Jun 1;83(2):e241-50
International journal of radiation oncology, biology, physics 2012 Jun 1;83(2):e241-50
Dermoscopic, histological and immunohistochemical evaluation of cancerous features in acquired melanocytic nevi that have been repeatedly exposed to UVA or UVB.
Manganoni AM, Rossi MT, Sala R, Venturini M, Sereni E, Ungari M, Marocolo D, Lonardi S, Calzavara-Pinton P
Experimental dermatology 2012 Feb;21(2):86-90
Experimental dermatology 2012 Feb;21(2):86-90
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH
Cancer research 2012 Aug 15;72(16):4119-29
Cancer research 2012 Aug 15;72(16):4119-29
Persistence and dynamics of DNA damage signal amplification determined by microcolony formation and live-cell imaging.
Oka Y, Yamauchi M, Suzuki M, Yamashita S, Suzuki K
Journal of radiation research 2011;52(6):766-74
Journal of radiation research 2011;52(6):766-74
Persistence and dynamics of DNA damage signal amplification determined by microcolony formation and live-cell imaging.
Oka Y, Yamauchi M, Suzuki M, Yamashita S, Suzuki K
Journal of radiation research 2011;52(6):766-74
Journal of radiation research 2011;52(6):766-74
Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy.
Aydin F, Levent Y, Nilgun S, Pancar YE, Yasar TA
Indian journal of dermatology 2011 Sep-Oct;56(5):501-4
Indian journal of dermatology 2011 Sep-Oct;56(5):501-4
Exploring antibody recognition of sequence space through random-sequence peptide microarrays.
Halperin RF, Stafford P, Johnston SA
Molecular & cellular proteomics : MCP 2011 Mar;10(3):M110.000786
Molecular & cellular proteomics : MCP 2011 Mar;10(3):M110.000786
Efficacy and drawbacks of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the thoracic esophagus.
Wolfárd A, Paszt A, Szentpáli K, Hideghéthy K, Uhercsák G, Németh I, Tiszlavicz L, Lázár G
Hepato-gastroenterology 2011 Jul-Aug;58(109):1214-9
Hepato-gastroenterology 2011 Jul-Aug;58(109):1214-9
Efficacy and drawbacks of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the thoracic esophagus.
Wolfárd A, Paszt A, Szentpáli K, Hideghéthy K, Uhercsák G, Németh I, Tiszlavicz L, Lázár G
Hepato-gastroenterology 2011 Jul-Aug;58(109):1214-9
Hepato-gastroenterology 2011 Jul-Aug;58(109):1214-9
Part II. Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines.
Tarjan G, Haines GK 3rd, Vesper BJ, Xue J, Altman MB, Yarmolyuk YR, Khurram H, Elseth KM, Roeske JC, Aydogan B, Radosevich JA
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2011 Feb;32(1):87-98
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2011 Feb;32(1):87-98
A Unique case of primary squamous carcinoma of the salpinx associated with serous carcinoma of the omentum: a pathological and molecular study.
Giordano G, D'Adda T, Brigati F, Lombardi M, Raboni S
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Nov;29(6):533-8
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Nov;29(6):533-8
Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study.
Safadi RA, Al Jaber SZ, Hammad HM, Hamasha AA
Archives of oral biology 2010 Jun;55(6):454-61
Archives of oral biology 2010 Jun;55(6):454-61
Wild type but not mutant APP is involved in protective adaptive responses against oxidants.
Cenini G, Maccarinelli G, Lanni C, Bonini SA, Ferrari-Toninelli G, Govoni S, Racchi M, Butterfield DA, Memo M, Uberti D
Amino acids 2010 Jun;39(1):271-83
Amino acids 2010 Jun;39(1):271-83
Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells.
Yang LH, Xu HT, Han Y, Li QC, Liu Y, Zhao Y, Yang ZQ, Dong QZ, Miao Y, Dai SD, Wang EH
Molecular cancer 2010 Feb 2;9:25
Molecular cancer 2010 Feb 2;9:25
TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.
Pfaff E, Remke M, Sturm D, Benner A, Witt H, Milde T, von Bueren AO, Wittmann A, Schöttler A, Jorch N, Graf N, Kulozik AE, Witt O, Scheurlen W, von Deimling A, Rutkowski S, Taylor MD, Tabori U, Lichter P, Korshunov A, Pfister SM
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Dec 10;28(35):5188-96
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Dec 10;28(35):5188-96
Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.
Nielsen M, de Miranda NF, van Puijenbroek M, Jordanova ES, Middeldorp A, van Wezel T, van Eijk R, Tops CM, Vasen HF, Hes FJ, Morreau H
BMC cancer 2009 Jun 15;9:184
BMC cancer 2009 Jun 15;9:184
Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21(WAF1/CIP1).
Huschtscha LI, Moore JD, Noble JR, Campbell HG, Royds JA, Braithwaite AW, Reddel RR
Journal of cell science 2009 Aug 15;122(Pt 16):2989-95
Journal of cell science 2009 Aug 15;122(Pt 16):2989-95
Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells.
Thant AA, Wu Y, Lee J, Mishra DK, Garcia H, Koeffler HP, Vadgama JV
Anticancer research 2008 Nov-Dec;28(6A):3579-92
Anticancer research 2008 Nov-Dec;28(6A):3579-92
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
Turner NC, Lord CJ, Iorns E, Brough R, Swift S, Elliott R, Rayter S, Tutt AN, Ashworth A
The EMBO journal 2008 May 7;27(9):1368-77
The EMBO journal 2008 May 7;27(9):1368-77
Progression and tumor heterogeneity analysis in early rectal cancer.
Lips EH, van Eijk R, de Graaf EJ, Doornebosch PG, de Miranda NF, Oosting J, Karsten T, Eilers PH, Tollenaar RA, van Wezel T, Morreau H
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Feb 1;14(3):772-81
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Feb 1;14(3):772-81
p53 status-dependent sensitization of human tumour cells to hyperthermia by plant flavonol.
Hamamoto T, Suzuki K, Yamauchi M, Kodama S, Sasaki H, Watanabe M
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2008 Aug;24(5):415-24
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2008 Aug;24(5):415-24
Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells.
Ray S, Chatterjee A
International journal of radiation biology 2007 May;83(5):347-54
International journal of radiation biology 2007 May;83(5):347-54
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature.
Giordano G, D'Adda T, Gnetti L, Merisio C, Raboni S
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007 Jul;26(3):298-304
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007 Jul;26(3):298-304
Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins.
Rossner P Jr, Binkova B, Milcova A, Solansky I, Zidzik J, Lyubomirova KD, Farmer PB, Sram RJ
Mutation research 2007 Jul 1;620(1-2):34-40
Mutation research 2007 Jul 1;620(1-2):34-40
Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study.
Giordano G, D'Adda T, Gnetti L, Merisio C, Gabrielli M, Melpignano M
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007 Apr;26(2):199-204
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007 Apr;26(2):199-204
A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells.
Schumacher G, Scheunert S, Rueggeberg A, Bachem MG, Nussler AK, Spinelli A, Mukhopadhyay T, Pratschke J, Neuhaus P
Journal of gastroenterology and hepatology 2006 Jul;21(7):1207-12
Journal of gastroenterology and hepatology 2006 Jul;21(7):1207-12
Clinicopathological significance of maspin expression in breast cancer.
Lee MJ, Suh CH, Li ZH
Journal of Korean medical science 2006 Apr;21(2):309-14
Journal of Korean medical science 2006 Apr;21(2):309-14
Clinicopathological significance of maspin expression in breast cancer.
Lee MJ, Suh CH, Li ZH
Journal of Korean medical science 2006 Apr;21(2):309-14
Journal of Korean medical science 2006 Apr;21(2):309-14
Abnormal stability of wild-type p53 protein in a human lung carcinoma cell line.
Yamauchi M, Suzuki K, Kodama S, Watanabe M
Biochemical and biophysical research communications 2005 May 6;330(2):483-8
Biochemical and biophysical research communications 2005 May 6;330(2):483-8
p63-specific activation of the BPAG-1e promoter.
Osada M, Nagakawa Y, Park HL, Yamashita K, Wu G, Kim MS, Fomenkov A, Trink B, Sidransky D
The Journal of investigative dermatology 2005 Jul;125(1):52-60
The Journal of investigative dermatology 2005 Jul;125(1):52-60
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.
Torkin R, Lavoie JF, Kaplan DR, Yeger H
Molecular cancer therapeutics 2005 Jan;4(1):1-11
Molecular cancer therapeutics 2005 Jan;4(1):1-11
Pulmonary large cell carcinoma with rhabdoid phenotype.
Yilmazbayhan D, Ates LE, Dilege S, Gulluoglu M, Tanju S, Kalayci G
Annals of diagnostic pathology 2005 Aug;9(4):223-6
Annals of diagnostic pathology 2005 Aug;9(4):223-6
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing.
Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun DI, Xiao Y, Hoque MO, Westra WH, Califano JA, Sidransky D
Cancer research 2004 Sep 1;64(17):5982-7
Cancer research 2004 Sep 1;64(17):5982-7
RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage.
Fomenkov A, Zangen R, Huang YP, Osada M, Guo Z, Fomenkov T, Trink B, Sidransky D, Ratovitski EA
Cell cycle (Georgetown, Tex.) 2004 Oct;3(10):1285-95
Cell cycle (Georgetown, Tex.) 2004 Oct;3(10):1285-95
Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation.
Yamauchi M, Suzuki K, Kodama S, Watanabe M
Biochemical and biophysical research communications 2004 Oct 22;323(3):906-11
Biochemical and biophysical research communications 2004 Oct 22;323(3):906-11
Do collision tumors of the gastroesophageal junction exist? A molecular analysis.
Milne AN, Carvalho R, van Rees BP, van Lanschot JJ, Offerhaus GJ, Weterman MA
The American journal of surgical pathology 2004 Nov;28(11):1492-8
The American journal of surgical pathology 2004 Nov;28(11):1492-8
Do collision tumors of the gastroesophageal junction exist? A molecular analysis.
Milne AN, Carvalho R, van Rees BP, van Lanschot JJ, Offerhaus GJ, Weterman MA
The American journal of surgical pathology 2004 Nov;28(11):1492-8
The American journal of surgical pathology 2004 Nov;28(11):1492-8
Proteomic analysis of selected prognostic factors of breast cancer.
Roberts K, Bhatia K, Stanton P, Lord R
Proteomics 2004 Mar;4(3):784-92
Proteomics 2004 Mar;4(3):784-92
Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity.
Tabs S, Avci O
European journal of dermatology : EJD 2004 Mar-Apr;14(2):96-102
European journal of dermatology : EJD 2004 Mar-Apr;14(2):96-102
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Jun 30;24(26):6021-7
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Jun 30;24(26):6021-7
Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions.
Deveci MS, Deveci G
The Tohoku journal of experimental medicine 2004 Jan;202(1):13-22
The Tohoku journal of experimental medicine 2004 Jan;202(1):13-22
Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions.
Deveci MS, Deveci G
The Tohoku journal of experimental medicine 2004 Jan;202(1):13-22
The Tohoku journal of experimental medicine 2004 Jan;202(1):13-22
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC
Cancer research 2004 Dec 15;64(24):9080-5
Cancer research 2004 Dec 15;64(24):9080-5
Clear cell adenocarcinoma of the tunica vaginalis of the testis with an adjacent uterus-like tissue.
Tulunay O, Gögüş C, Baltaci S, Bulut S
Pathology international 2004 Aug;54(8):641-7
Pathology international 2004 Aug;54(8):641-7
Gap junctional intercellular communication and cellular response to heat stress.
Hamada N, Kodama S, Suzuki K, Watanabe M
Carcinogenesis 2003 Nov;24(11):1723-8
Carcinogenesis 2003 Nov;24(11):1723-8
Derivation and characterization of a Wilms' tumour cell line, WiT 49.
Alami J, Williams BR, Yeger H
International journal of cancer 2003 Nov 10;107(3):365-74
International journal of cancer 2003 Nov 10;107(3):365-74
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53.
Mascaux C, Martin B, Verdebout JM, Meert AP, Ninane V, Sculier JP
The European respiratory journal 2003 May;21(5):753-8
The European respiratory journal 2003 May;21(5):753-8
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53.
Mascaux C, Martin B, Verdebout JM, Meert AP, Ninane V, Sculier JP
The European respiratory journal 2003 May;21(5):753-8
The European respiratory journal 2003 May;21(5):753-8
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes.
Campàs C, Lopez JM, Santidrián AF, Barragán M, Bellosillo B, Colomer D, Gil J
Blood 2003 May 1;101(9):3674-80
Blood 2003 May 1;101(9):3674-80
Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia.
Campàs C, Dalmau M, Montaner B, Barragán M, Bellosillo B, Colomer D, Pons G, Pérez-Tomás R, Gil J
Leukemia 2003 Apr;17(4):746-50
Leukemia 2003 Apr;17(4):746-50
Impact of p53 and Ki-67 in predicting recurrence and progression of superficial (pTa and pT1) urothelial cell carcinomas of urinary bladder.
Kilicli-Camur N, Kilicaslan I, Gulluoglu MG, Esen T, Uysal V
Pathology international 2002 Jul;52(7):463-9
Pathology international 2002 Jul;52(7):463-9
Impact of p53 and Ki-67 in predicting recurrence and progression of superficial (pTa and pT1) urothelial cell carcinomas of urinary bladder.
Kilicli-Camur N, Kilicaslan I, Gulluoglu MG, Esen T, Uysal V
Pathology international 2002 Jul;52(7):463-9
Pathology international 2002 Jul;52(7):463-9
Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.
DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M, Brown M
Cancer research 2002 Jan 1;62(1):89-98
Cancer research 2002 Jan 1;62(1):89-98
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.
Suzuki K, Kodama S, Watanabe M
The Journal of biological chemistry 1999 Sep 3;274(36):25571-5
The Journal of biological chemistry 1999 Sep 3;274(36):25571-5
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.
Suzuki K, Kodama S, Watanabe M
The Journal of biological chemistry 1999 Sep 3;274(36):25571-5
The Journal of biological chemistry 1999 Sep 3;274(36):25571-5
Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation.
Ghosh JC, Suzuki K, Kodama S, Watanabe M
Journal of radiation research 1999 Mar;40(1):23-37
Journal of radiation research 1999 Mar;40(1):23-37
Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation.
Ghosh JC, Suzuki K, Kodama S, Watanabe M
Journal of radiation research 1999 Mar;40(1):23-37
Journal of radiation research 1999 Mar;40(1):23-37
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot was performed using Anti-p53 Monoclonal Antibody (BP53-12), FITC (Product # MA1-19551) and a 53 kDa band corresponding to Cellular tumor antigen p53 was observed in T-47D, HT-29 and MDA-MB-231 which are reported to be positive and not in any other cell lines like HCT 116, SK-OV-3, Caco-2 and HL-60 which are reported to be negative. Modified whole cell extracts (1%SDS) (30 µg lysate) of T-47D (Lane 1), HT-29 (Lane 2), MDA-MB-231 (Lane 3), HCT 116 (Lane 4), SK-O-V3 (Lane 5), Caco-2 (Lane 6), and HL-60 (Lane 7) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0302BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000 dilution) and detected by fluorescence using the iBright FL 1000 (Product # A32752). Fluorescent detection was performed.
- Conjugate
- Green dye
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of p53 using a monoclonal antibody (Product # MA1-19551).
- Conjugate
- Green dye
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescence analysis of Cellular tumor antigen p53 was performed using 70% confluent log phase MDA-MB-231 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with p53 Monoclonal Antibody (BP53-12), FITC (Product # MA1-19551) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight (Panel a: Green). Nuclei (Panel b: Blue) were stained with ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). F-actin (Panel c: Red) was stained with Rhodamine Phalloidin (Product # R415, 1:300). Panel d represents the merged image showing Nuclear localization. Panel e represents SK-OV-3 cells having no expression of p53. Panel f represents control cells with Isotype control to assess background. The images were captured at 60X magnification.
- Conjugate
- Green dye
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Separation of Ramos cells stained using anti-p53 (BP53.12) FITC Monoclonal antibody (Product # MA1-19551), concentration in sample 9 µg/mL (red) from unstained Ramos cells (black) in flow cytometry analysis (intracellular staining).
- Conjugate
- Green dye
