Antibody data
- Antibody Data
- Antigen structure
- References [63]
- Comments [0]
- Validations
- Western blot [3]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
- Chromatin Immunoprecipitation [1]
- Other assay [3]
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Validation data
Reference
Comment
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- Product number
- MA5-15244 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- p53 Monoclonal Antibody (PAb 240)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- MA5-15244 targets p53 in FACS, IHC (P), IP, and WB applications and shows reactivity with Human samples.
- Antibody clone number
- PAb 240
- Concentration
- 0.2 mg/mL
Submitted references TP53 transcription factor for the NEDD9/HEF1/Cas-L gene: potential targets in Non-Small Cell Lung Cancer treatment.
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.
Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.
Zyxin is a novel target for β-amyloid peptide: characterization of its role in Alzheimer's pathogenesis.
Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression.
The gain of function of p53 mutant p53S in promoting tumorigenesis by cross-talking with H-RasV12.
Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.
UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis.
Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma.
Topical grape seed proanthocyandin extract reduces sunburn cells and mutant p53 positive epidermal cell formation, and prevents depletion of Langerhans cells in an acute sunburn model.
Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors.
Searching for predictive blood biomarkers: misfolded p53 in mild cognitive impairment.
Two mechanisms underlying the loss of p16(Ink4a) function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence.
Pu-erh tea inhibits tumor cell growth by down-regulating mutant p53.
Exploring antibody recognition of sequence space through random-sequence peptide microarrays.
CIS is a surrogate marker of genetic instability and field carcinogenesis in the urothelial mucosa.
Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease.
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.
Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633.
Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633.
Wild type but not mutant APP is involved in protective adaptive responses against oxidants.
Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells.
ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition.
The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine.
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.
Conformationally altered p53: a novel Alzheimer's disease marker?
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.
Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy.
53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy.
Growth stimulation of UV-induced DNA damage retaining epidermal basal cells gives rise to clusters of p53 overexpressing cells.
Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis.
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals.
The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter.
Quantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays.
Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell.
P53 expression between 13-27 weeks old human male fetus gonads.
Multiple initial culture conditions enhance the establishment of cell lines from primary ovarian cancer specimens.
Effects of extracellular matrix on the morphology and behaviour of rabbit auricular chondrocytes in culture.
Cell death induced by taxanes in breast cancer cells: cytochrome C is released in resistant but not in sensitive cells.
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers.
Mutations in Apc and p53 synergize to promote mammary neoplasia.
p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma.
Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation.
The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model.
The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model.
Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of phosphatidylinositol 3-kinase.
Immunohistochemical studies concerning the neuronal cell cycle of the cat using PCNA, Ki-67 and p53 markers.
p53 targets simian virus 40 large T antigen for acetylation by CBP.
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression.
Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers.
Changes in expression and immunolocalization of protein associated with toxic bile salts-induced apoptosis in rat hepatocytes.
Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers.
Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers.
Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2.
The predictive value of neuroendocrine markers and p53 for response to chemotherapy and survival in patients with advanced non-small cell lung cancer.
The predictive value of neuroendocrine markers and p53 for response to chemotherapy and survival in patients with advanced non-small cell lung cancer.
The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.
Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients.
Use of neuroendocrine markers, p53, and HER2 to predict response to chemotherapy in patients with stage III non-small cell lung cancer: a Cancer and Leukemia Group B study.
Rousseau B, Jacquot C, Le Palabe J, Malleter M, Tomasoni C, Boutard T, Sakanyan V, Roussakis C
Scientific reports 2015 May 26;5:10356
Scientific reports 2015 May 26;5:10356
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ
Nature cell biology 2015 Aug;17(8):971-983
Nature cell biology 2015 Aug;17(8):971-983
IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.
Hsieh WL, Huang YH, Wang TM, Ming YC, Tsai CN, Pang JH
Cell proliferation 2015 Apr;48(2):187-97
Cell proliferation 2015 Apr;48(2):187-97
Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.
Phesse TJ, Myant KB, Cole AM, Ridgway RA, Pearson H, Muncan V, van den Brink GR, Vousden KH, Sears R, Vassilev LT, Clarke AR, Sansom OJ
Cell death and differentiation 2014 Jun;21(6):956-66
Cell death and differentiation 2014 Jun;21(6):956-66
Zyxin is a novel target for β-amyloid peptide: characterization of its role in Alzheimer's pathogenesis.
Lanni C, Necchi D, Pinto A, Buoso E, Buizza L, Memo M, Uberti D, Govoni S, Racchi M
Journal of neurochemistry 2013 Jun;125(5):790-9
Journal of neurochemistry 2013 Jun;125(5):790-9
Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression.
Buizza L, Prandelli C, Bonini SA, Delbarba A, Cenini G, Lanni C, Buoso E, Racchi M, Govoni S, Memo M, Uberti D
Cell death & disease 2013 Feb 7;4(2):e484
Cell death & disease 2013 Feb 7;4(2):e484
The gain of function of p53 mutant p53S in promoting tumorigenesis by cross-talking with H-RasV12.
Jia S, Zhao L, Tang W, Luo Y
International journal of biological sciences 2012;8(5):596-605
International journal of biological sciences 2012;8(5):596-605
Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.
Buizza L, Cenini G, Lanni C, Ferrari-Toninelli G, Prandelli C, Govoni S, Buoso E, Racchi M, Barcikowska M, Styczynska M, Szybinska A, Butterfield DA, Memo M, Uberti D
PloS one 2012;7(1):e29789
PloS one 2012;7(1):e29789
UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis.
Rebel HG, Bodmann CA, van de Glind GC, de Gruijl FR
Carcinogenesis 2012 Mar;33(3):714-20
Carcinogenesis 2012 Mar;33(3):714-20
Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma.
Árvai K, Nagy K, Barti-Juhász H, Peták I, Krenács T, Micsik T, Végső G, Perner F, Szende B
Pathology oncology research : POR 2012 Jul;18(3):607-14
Pathology oncology research : POR 2012 Jul;18(3):607-14
Topical grape seed proanthocyandin extract reduces sunburn cells and mutant p53 positive epidermal cell formation, and prevents depletion of Langerhans cells in an acute sunburn model.
Yuan XY, Liu W, Hao JC, Gu WJ, Zhao YS
Photomedicine and laser surgery 2012 Jan;30(1):20-5
Photomedicine and laser surgery 2012 Jan;30(1):20-5
Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors.
Hewedi IH, Radwan NA, Shash LS
Diagnostic pathology 2012 Jan 5;7:1
Diagnostic pathology 2012 Jan 5;7:1
Searching for predictive blood biomarkers: misfolded p53 in mild cognitive impairment.
Stanga S, Lanni C, Sinforiani E, Mazzini G, Racchi M
Current Alzheimer research 2012 Dec;9(10):1191-7
Current Alzheimer research 2012 Dec;9(10):1191-7
Two mechanisms underlying the loss of p16(Ink4a) function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence.
Wu X, Jia S, Zhang X, Si X, Tang W, Luo Y
Mechanisms of ageing and development 2012 Aug;133(8):549-55
Mechanisms of ageing and development 2012 Aug;133(8):549-55
Pu-erh tea inhibits tumor cell growth by down-regulating mutant p53.
Zhao L, Jia S, Tang W, Sheng J, Luo Y
International journal of molecular sciences 2011;12(11):7581-93
International journal of molecular sciences 2011;12(11):7581-93
Exploring antibody recognition of sequence space through random-sequence peptide microarrays.
Halperin RF, Stafford P, Johnston SA
Molecular & cellular proteomics : MCP 2011 Mar;10(3):M110.000786
Molecular & cellular proteomics : MCP 2011 Mar;10(3):M110.000786
CIS is a surrogate marker of genetic instability and field carcinogenesis in the urothelial mucosa.
Palmeira C, Lameiras C, Amaro T, Lima L, Koch A, Lopes C, Oliveira PA, Santos L
Urologic oncology 2011 Mar-Apr;29(2):205-11
Urologic oncology 2011 Mar-Apr;29(2):205-11
Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease.
Lanni C, Racchi M, Stanga S, Mazzini G, Ranzenigo A, Polotti R, Memo M, Govoni S, Uberti D
Journal of Alzheimer's disease : JAD 2010;20(1):97-104
Journal of Alzheimer's disease : JAD 2010;20(1):97-104
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.
Mir SE, De Witt Hamer PC, Krawczyk PM, Balaj L, Claes A, Niers JM, Van Tilborg AA, Zwinderman AH, Geerts D, Kaspers GJ, Peter Vandertop W, Cloos J, Tannous BA, Wesseling P, Aten JA, Noske DP, Van Noorden CJ, Würdinger T
Cancer cell 2010 Sep 14;18(3):244-57
Cancer cell 2010 Sep 14;18(3):244-57
Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633.
Graziano SL, Gu L, Wang X, Tatum AH, Vollmer RT, Strauss GM, Kratzke R, Dudek AZ, Vokes EE, Green MR, Cancer and Leukemia Group B, North Central Cancer Treatment Group, Radiation Therapy Oncology Group
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010 Jun;5(6):810-7
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010 Jun;5(6):810-7
Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633.
Graziano SL, Gu L, Wang X, Tatum AH, Vollmer RT, Strauss GM, Kratzke R, Dudek AZ, Vokes EE, Green MR, Cancer and Leukemia Group B., North Central Cancer Treatment Group., Radiation Therapy Oncology Group.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010 Jun;5(6):810-7
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010 Jun;5(6):810-7
Wild type but not mutant APP is involved in protective adaptive responses against oxidants.
Cenini G, Maccarinelli G, Lanni C, Bonini SA, Ferrari-Toninelli G, Govoni S, Racchi M, Butterfield DA, Memo M, Uberti D
Amino acids 2010 Jun;39(1):271-83
Amino acids 2010 Jun;39(1):271-83
Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells.
Wang Z, Qi Y, Chen Q, Yang D, Tang S, Jin X, Gao J, Fu J, Zhou Z, Wang J, Xiao X
Toxicology 2009 Feb 4;256(1-2):1-6
Toxicology 2009 Feb 4;256(1-2):1-6
ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition.
Herbst A, Bommer GT, Kriegl L, Jung A, Behrens A, Csanadi E, Gerhard M, Bolz C, Riesenberg R, Zimmermann W, Dietmaier W, Wolf I, Brabletz T, Göke B, Kolligs FT
Gastroenterology 2009 Aug;137(2):639-48, 648.e1-9
Gastroenterology 2009 Aug;137(2):639-48, 648.e1-9
The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine.
Agrawal A, Sharma M, Rai SK, Singh B, Tiwari M, Chandra R
Phytotherapy research : PTR 2008 Sep;22(9):1175-82
Phytotherapy research : PTR 2008 Sep;22(9):1175-82
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.
Holcomb VB, Rodier F, Choi Y, Busuttil RA, Vogel H, Vijg J, Campisi J, Hasty P
Cancer research 2008 Nov 15;68(22):9497-502
Cancer research 2008 Nov 15;68(22):9497-502
Conformationally altered p53: a novel Alzheimer's disease marker?
Lanni C, Racchi M, Mazzini G, Ranzenigo A, Polotti R, Sinforiani E, Olivari L, Barcikowska M, Styczynska M, Kuznicki J, Szybinska A, Govoni S, Memo M, Uberti D
Molecular psychiatry 2008 Jun;13(6):641-7
Molecular psychiatry 2008 Jun;13(6):641-7
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.
Reed KR, Meniel VS, Marsh V, Cole A, Sansom OJ, Clarke AR
BMC cancer 2008 Jun 5;8:162
BMC cancer 2008 Jun 5;8:162
Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy.
Terzi C, Canda AE, Sagol O, Atila K, Sonmez D, Fuzun M, Gorken IB, Oztop I, Obuz F
International journal of colorectal disease 2008 Jan;23(1):37-45
International journal of colorectal disease 2008 Jan;23(1):37-45
53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy.
Clarke AR, Jones N, Pryde F, Adachi Y, Sansom OJ
Oncogene 2007 Sep 20;26(43):6349-55
Oncogene 2007 Sep 20;26(43):6349-55
Growth stimulation of UV-induced DNA damage retaining epidermal basal cells gives rise to clusters of p53 overexpressing cells.
Nijhof JG, Mulder AM, Speksnijder EN, Hoogervorst EM, Mullenders LH, de Gruijl FR
DNA repair 2007 Nov;6(11):1642-50
DNA repair 2007 Nov;6(11):1642-50
Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis.
Vairaktaris E, Kalokerinos G, Goutzanis L, Spyridonidou S, Vassiliou S, Derka S, Nkenke E, Yapijakis C, Vylliotis A, Lazaris A, Patsouris E
Anticancer research 2007 May-Jun;27(3B):1465-73
Anticancer research 2007 May-Jun;27(3B):1465-73
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
Bifsha P, Landry K, Ashmarina L, Durand S, Seyrantepe V, Trudel S, Quiniou C, Chemtob S, Xu Y, Gravel RA, Sladek R, Pshezhetsky AV
Cell death and differentiation 2007 Mar;14(3):511-23
Cell death and differentiation 2007 Mar;14(3):511-23
Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals.
Preyer M, Shu CW, Wang JY
Cell death and differentiation 2007 Jun;14(6):1139-48
Cell death and differentiation 2007 Jun;14(6):1139-48
The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter.
Zhu Q, Wani G, Yao J, Patnaik S, Wang QE, El-Mahdy MA, Praetorius-Ibba M, Wani AA
Oncogene 2007 Jun 21;26(29):4199-208
Oncogene 2007 Jun 21;26(29):4199-208
Quantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays.
Ramalingam S, Honkanen P, Young L, Shimura T, Austin J, Steeg PS, Nishizuka S
Cancer research 2007 Jul 1;67(13):6247-52
Cancer research 2007 Jul 1;67(13):6247-52
Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell.
Wu ZQ, Zhang R, Chao C, Zhang JF, Zhang YQ
Chinese medical journal 2007 Dec 5;120(23):2112-8
Chinese medical journal 2007 Dec 5;120(23):2112-8
P53 expression between 13-27 weeks old human male fetus gonads.
Tosun M, Tosun E, Kalkan S, Avunduk MC
Journal of molecular histology 2007 Aug;38(4):271-4
Journal of molecular histology 2007 Aug;38(4):271-4
Multiple initial culture conditions enhance the establishment of cell lines from primary ovarian cancer specimens.
Bertozzi CC, Chang CY, Jairaj S, Shan X, Huang J, Weber BL, Chu CS, Carroll RG
In vitro cellular & developmental biology. Animal 2006 Mar-Apr;42(3-4):58-62
In vitro cellular & developmental biology. Animal 2006 Mar-Apr;42(3-4):58-62
Effects of extracellular matrix on the morphology and behaviour of rabbit auricular chondrocytes in culture.
Villar-Suárez V, Colaço B, Calles-Venal I, Bravo IG, Fernández-Alvarez JG, Fernández-Caso M, Villar-Lacilla JM
Journal of biomedicine & biotechnology 2005;2005(4):364-73
Journal of biomedicine & biotechnology 2005;2005(4):364-73
Cell death induced by taxanes in breast cancer cells: cytochrome C is released in resistant but not in sensitive cells.
Ehrlichová M, Koc M, Truksa J, Naldová Z, Václavíková R, Kovárr J
Anticancer research 2005 Nov-Dec;25(6B):4215-24
Anticancer research 2005 Nov-Dec;25(6B):4215-24
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S
Genes & development 2005 Nov 1;19(21):2560-70
Genes & development 2005 Nov 1;19(21):2560-70
A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers.
Rosas-Acosta G, Russell WK, Deyrieux A, Russell DH, Wilson VG
Molecular & cellular proteomics : MCP 2005 Jan;4(1):56-72
Molecular & cellular proteomics : MCP 2005 Jan;4(1):56-72
Mutations in Apc and p53 synergize to promote mammary neoplasia.
Méniel V, Hay T, Douglas-Jones A, Sansom OJ, Clarke AR
Cancer research 2005 Jan 15;65(2):410-6
Cancer research 2005 Jan 15;65(2):410-6
p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma.
Jayasurya R, Francis G, Kannan S, Lekshminarayanan K, Nalinakumari KR, Abraham T, Abraham EK, Nair MK
International journal of cancer 2004 May 1;109(5):710-6
International journal of cancer 2004 May 1;109(5):710-6
Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation.
Ali SH, Kasper JS, Arai T, DeCaprio JA
Journal of virology 2004 Mar;78(6):2749-57
Journal of virology 2004 Mar;78(6):2749-57
The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model.
Mathur S, Kaur P, Sharma M, Katyal A, Singh B, Tiwari M, Chandra R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004 Jul;11(5):452-60
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004 Jul;11(5):452-60
The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model.
Mathur S, Kaur P, Sharma M, Katyal A, Singh B, Tiwari M, Chandra R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004 Jul;11(5):452-60
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004 Jul;11(5):452-60
Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of phosphatidylinositol 3-kinase.
Facchetti M, Uberti D, Memo M, Missale C
Molecular endocrinology (Baltimore, Md.) 2004 Jan;18(1):162-72
Molecular endocrinology (Baltimore, Md.) 2004 Jan;18(1):162-72
Immunohistochemical studies concerning the neuronal cell cycle of the cat using PCNA, Ki-67 and p53 markers.
Gruber A, Schmidt P, Url A
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 2004 Dec;51(9-10):416-9
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 2004 Dec;51(9-10):416-9
p53 targets simian virus 40 large T antigen for acetylation by CBP.
Poulin DL, Kung AL, DeCaprio JA
Journal of virology 2004 Aug;78(15):8245-53
Journal of virology 2004 Aug;78(15):8245-53
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Hoogervorst EM, van Oostrom CT, Beems RB, van Benthem J, Gielis S, Vermeulen JP, Wester PW, Vos JG, de Vries A, van Steeg H
Cancer research 2004 Aug 1;64(15):5118-26
Cancer research 2004 Aug 1;64(15):5118-26
Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression.
Gingras B, Rodier G, Giasson E, Coulombe P, Chassagne C, Meloche S
Oncogene 2003 May 1;22(17):2633-42
Oncogene 2003 May 1;22(17):2633-42
Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers.
Masuda N, Kato H, Nakajima T, Sano T, Kashiwabara K, Oyama T, Kuwano H
Cancer science 2003 Jul;94(7):612-7
Cancer science 2003 Jul;94(7):612-7
Changes in expression and immunolocalization of protein associated with toxic bile salts-induced apoptosis in rat hepatocytes.
Oh SH, Yun KJ, Nan JX, Sohn DH, Lee BH
Archives of toxicology 2003 Feb;77(2):110-5
Archives of toxicology 2003 Feb;77(2):110-5
Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers.
Schwartz JL, Muscat JE, Baker V, Larios E, Stephenson GD, Guo W, Xie T, Gu X, Chung FL
Oral oncology 2003 Dec;39(8):842-54
Oral oncology 2003 Dec;39(8):842-54
Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers.
Schwartz JL, Muscat JE, Baker V, Larios E, Stephenson GD, Guo W, Xie T, Gu X, Chung FL
Oral oncology 2003 Dec;39(8):842-54
Oral oncology 2003 Dec;39(8):842-54
Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2.
Smith KS, Rhee JW, Cleary ML
Molecular and cellular biology 2002 Nov;22(21):7678-87
Molecular and cellular biology 2002 Nov;22(21):7678-87
The predictive value of neuroendocrine markers and p53 for response to chemotherapy and survival in patients with advanced non-small cell lung cancer.
Gajra A, Tatum AH, Newman N, Gamble GP, Lichtenstein S, Rooney MT, Graziano SL
Lung cancer (Amsterdam, Netherlands) 2002 May;36(2):159-65
Lung cancer (Amsterdam, Netherlands) 2002 May;36(2):159-65
The predictive value of neuroendocrine markers and p53 for response to chemotherapy and survival in patients with advanced non-small cell lung cancer.
Gajra A, Tatum AH, Newman N, Gamble GP, Lichtenstein S, Rooney MT, Graziano SL
Lung cancer (Amsterdam, Netherlands) 2002 May;36(2):159-65
Lung cancer (Amsterdam, Netherlands) 2002 May;36(2):159-65
The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.
Calabrò V, Mansueto G, Parisi T, Vivo M, Calogero RA, La Mantia G
The Journal of biological chemistry 2002 Jan 25;277(4):2674-81
The Journal of biological chemistry 2002 Jan 25;277(4):2674-81
Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients.
Uberti D, Carsana T, Bernardi E, Rodella L, Grigolato P, Lanni C, Racchi M, Govoni S, Memo M
Journal of cell science 2002 Aug 1;115(Pt 15):3131-8
Journal of cell science 2002 Aug 1;115(Pt 15):3131-8
Use of neuroendocrine markers, p53, and HER2 to predict response to chemotherapy in patients with stage III non-small cell lung cancer: a Cancer and Leukemia Group B study.
Graziano SL, Tatum A, Herndon JE 2nd, Box J, Memoli V, Green MR, Kern JA
Lung cancer (Amsterdam, Netherlands) 2001 Aug-Sep;33(2-3):115-23
Lung cancer (Amsterdam, Netherlands) 2001 Aug-Sep;33(2-3):115-23
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of p53 using p53 Monoclonal Antibody (Product # MA5-15244) on MDA231 Cells.
- Submitted by
- Invitrogen Antibodies (provider)
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- Experimental details
- Western blot analysis was performed on whole cell extracts (30 µg lysate) of COS-7 (Lane 1), A431 (Lane 2), and SK-OV-3 (Lane 3). The blots were probed with Anti-p53 Mouse Monoclonal Antibody (Product # MA5-15244, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Secondary Antibody, HRP conjugate (Product # 62-6520, 1:4000 dilution). A 53 kDa band corresponding to p53 was observed across cell lines tested except SK-OV-3. Known quantity of protein samples were electrophoresed using Novex® NuPAGE® 12 % Bis-Tris gel (Product # NP0342BOX), XCell SureLock™ Electrophoresis System (Product # EI0002) and Novex® Sharp Pre-Stained Protein Standard (Product # LC5800). Resolved proteins were then transferred onto a nitrocellulose membrane with iBlot® 2 Dry Blotting System (Product # IB21001). The membrane was probed with the relevant primary and secondary Antibody following blocking with 5 % skimmed milk. Chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).
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- Invitrogen Antibodies (provider)
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- Knockout of P53 was achieved by CRISPR-Cas9 genome editing using LentiArray™ Lentiviral sgRNA (Product # A32042, AssayID CRISPR718498_LV and CRISPR718517_LV) and LentiArray Cas9 Lentivirus (Product # A32064). Western blot analysis of P53 was performed by loading 30 µg of HeLa wild type (Lane 1), HeLa CAS9 (Lane 2) and HeLa P53 KO (Lane 3) whole cell extracts. The samples were electrophoresed using Novex® NuPAGE® 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with Anti-p53 Monoclonal Antibody (PAb 240) (Product # MA5-15244) using 1 µg/mL dilution and Goat anti-Mouse IgG (H+L), Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:4,000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005). Loss of signal upon CRISPR mediated knockout (KO) using the LentiArray™ CRISPR product line confirms that antibody is specific to P53. Uncharacterized bands were observed at ~30 kDa and 60 kDa in all the samples and ~80 kDa in HeLa CAS9 sample.
Supportive validation
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- Invitrogen Antibodies (provider)
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- Immunofluorescence analysis of p53 was done on 70% confluent log phase MCF-7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled p53 (PAb 240) Mouse Monoclonal Antibody (Product # MA5-15244) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). F-actin (Panel c: red) was stained with Alexa Fluor® 555 Rhodamine Phalloidin (Product # R415, 1:300). Panel d is a merged image showing cytoplasmic localization. Panel e is a no primary antibody control. The images were captured at 60X magnification.
Supportive validation
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- Invitrogen Antibodies (provider)
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- Formalin-fixed, paraffin-embedded human colon carcinoma stained with p53 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells.
Supportive validation
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- Invitrogen Antibodies (provider)
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- Enrichment of endogenous p53 Protein at specific gene loci using Anti-p53 Protein Mouse Monoclonal Antibody: Chromatin Immunoprecipitation (ChIP) was performed using Anti-p53 Protein Mouse Monoclonal Antibody (Product # MA5-15244, 5 µg) on sheared chromatin from 2 million MCF-7 cells, UV treated for 30 minutes using the "MAGnify ChIP system" kit (Product # 49-2024). Normal Rabbit IgG was used as a negative IP control. The purified DNA was analyzed by 7500 Fast qPCR system (Product # 4351106) with optimized PCR primer pairs for the promoter of active CDKN1A, CMBL, HES2, MKN2 gene, used as positive control target, and the SAT2, used as negative control target. Data is presented as fold enrichment of the antibody signal versus the negative control IgG using the comparative CT method.
Supportive validation
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- Invitrogen Antibodies (provider)
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- Immunoprecipitation of p53 using p53 Monoclonal Antibody (Product # MA5-15244) on denatured Human MDA231 Cells.
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- Invitrogen Antibodies (provider)
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- Immunoprecipitation of p53 using p53 Monoclonal Antibody (Product # MA5-15244) on Native Human SKBR3 Cells.
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- Invitrogen Antibodies (provider)
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- Figure 5 ( a ) ChIP assay control on synchronized NSCLC-N6-L16 with Anti-RNA Polymerase II Antibody and ChIP Positive Control Primers (GAPDH promoter) ( b ) ChIP assays on synchronized NSCLC-N6-L16 treated or not with A190 with p53 antibody and NEDD9 specific primers.