orb2653067

antibody from Biorbyt
Targeting: TP53 LFS1, p53
Provider product page for orb2653067
Western blot
ELISA
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry
Flow cytometry

Antibody data

Product number
orb2653067 - Provider product page
Provider
Biorbyt
Product name
Anti-p53 Biotin
Antibody type
Monoclonal
Description
The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.
Reactivity
Human, Simian
Conjugate
Biotin
Antibody clone number
BP53-12
Vial size
0.1 mg
Concentration
1 mg/ml
Storage
Store at 2-8°C. Do not freeze.
TP53 protein structure - orb2653067 shown in red.