BS4292

antibody from Bioworld Technology, Inc
Targeting: ARRB1 ARR1
Provider product page for BS4292
Western blot
Immunohistochemistry

Antibody data

Product number
BS4292 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Arrestin ÉÇ 1 (phospho S412) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human Arrestin-ÉÇ-1 around the phosphorylation site of Serine 412.
Description
Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ARRB1 protein structure - BS4292 shown in red.