Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 310702 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#310702, RRID:AB_345394
- Product name
- Purified anti-human CD193 (CCR3)
- Antibody type
- Monoclonal
- Antigen
- CCR3 (CD193)
- Description
- CC-chemokine receptor 3 (CCR3), also known as CC CKR3, MIP1-alpha receptor like-2, eotaxin receptor, and CD193, is a member of G protein-coupled seven transmembrane receptors family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CCR3 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CCR3 receptor is expressed on human eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references CCR7 is involved in the migration of neutrophils to lymph nodes.
Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry ML, Magistrelli G, Masternak K, Chevailler A, Delneste Y, Jeannin P
Blood 2011 Jan 27;117(4):1196-204
Blood 2011 Jan 27;117(4):1196-204
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