16791-1-AP

antibody from Proteintech Group

Targeting: METTL5 HSPC133

Provider product page for 16791-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [25]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 16791-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16791-1-AP, RRID:AB_2142051
Product name: METTL5 antibody
Antibody type: Polyclonal
Description: METTL5 antibody (Cat. #16791-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

METTL5 protein structure - 16791-1-AP shown in red.

Submitted references ZNF460 Promotes the m6A Modification of COPS6 to Facilitate Immune Escape in Colorectal Cancer.

Lun W, Liu Y, Luo C, Wu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71640

METTL5 promotes fatty acid metabolism by modulating peroxisome to induce hepatocellular carcinoma recurrence after thermal ablation.

Xie Z, Wang L, Wu Y, Zhang Y, Wang S, Zeng X, Liang R, Long J, Guo J, Peng S, Kuang M, Lin S, Dai Z, Chen S
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):1215-1233

The human 18S rRNA m6A methyltransferase METTL5 promotes tumorigenesis via DEPDC1 in lung squamous cell carcinoma.

Yan Y, Fu J
Frontiers in oncology 2025;15:1522157

METTL5 triggers the ferroptosis of cardiomyocytes in sepsis-induced myocardial injury.

Wang X, Tian Q, Li M, Liu Y
Free radical biology & medicine 2025 Sep;237:1-10

IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.

Sharma G, Gutierrez M, Jones AE, Kapoor S, Jaiswal AK, Neeb ZT, Rios A, Dorairaj P, Thaxton ML, Lin TL, Tran TM, Kabbani LES, Ritter AJ, Scherer GM, Sorrentino JP, Stiles L, Hoeve JT, Damoiseaux RD, Garg NK, Divakaruni AS, Sanford JR, Rao DS
Cell reports 2025 Oct 28;44(10):116330

Scutellarin suppresses ovarian cancer progression by targeting METTL5.

Ding L, Luo C, Weygant N, Chen W, Ru D, Lai Y, Wang Y, Li H
Scientific reports 2025 May 27;15(1):18472

METTL5 Promotes Tumor Progression in Oral Squamous Cell Carcinoma by Activating the Myc Pathway.

Huang R, Feng X, Zhou T, Lu J, Wang Y, Zhang S, Zhang W
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Feb;54(2):91-99

METTL4 and METTL5 as biomarkers for recurrence-free survival in hepatocellular carcinoma patients.

Zhao J, Sun R, Zhi L, Guo D, Ling S, Liang X, Li J, Jia C
Future oncology (London, England) 2025 Feb;21(3):331-340

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell-Induced Ferroptosis in Ovarian Cancer.

Hou J, Ju CW, Egan NA, Wei Y, Wang Y, Dang M, Zhou T, Shi L, Zheng N, Chen S, Guerrero AM, Liang X, Wu W, Akhtar A, Dhiman C, Roy Burman D, Gerges AE, Flores MD, Li H, Zhang LS, Kok M, Mao X, Wang L, Feng Q, Chen Y, Lee S, McGrail DJ, Sahni N, He C, Jazaeri AA, Peng W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e07718

METTL5 regulates SEPHS2-mediated selenoprotein synthesis to promote multiple myeloma survival and progression.

Jiang J, Zhong F, Xiao Z, Yao F, Liu J, Li M, Zeng H, Qiu Y, Zhang J, Zhang H, Li S, Huang T, Feng W, Huang Z, Huang B, Wang X
Cell death & disease 2025 Aug 2;16(1):585

METTL5 enhances the mRNA stability of TPRKB through m(6)A modification to facilitate the aggressive phenotypes of hepatocellular carcinoma cell.

Luo M, Luo X, Sun J, Ao X, Han H, Yang X
Experimental cell research 2024 Sep 1;442(1):114219

METTL5 promotes gastric cancer progression via sphingomyelin metabolism.

Zhang YQ, Li J, Qin Z, Li DM, Ye FZ, Bei SH, Zhang XH, Feng L
World journal of gastrointestinal oncology 2024 May 15;16(5):1925-1946

BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.

Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811

The m6A methyltransferase METTL5 promotes neutrophil extracellular trap network release to regulate hepatocellular carcinoma progression.

Wang Q, Huang Y, Zhu Y, Zhang W, Wang B, Du X, Dai Q, Zhang F, Fang Z
Cancer medicine 2024 Apr;13(7):e7165

METTL5 regulates cranial suture fusion via Wnt signaling.

Lei K, Xu R, Wang Q, Xiong Q, Zhou X, Li Q, Seriwatanachai D, Lin S, Zhou C, Yuan Q
Fundamental research 2023 May;3(3):369-376

METTL3 regulates breast cancer-associated alternative splicing switches.

Achour C, Bhattarai DP, Groza P, Román ÁC, Aguilo F
Oncogene 2023 Mar;42(12):911-925

N(6)-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis.

Chen B, Huang Y, He S, Yu P, Wu L, Peng H
Cell chemical biology 2023 Feb 16;30(2):144-158.e10

Loss of m(6)A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression.

Han Y, Du T, Guo S, Wang L, Dai G, Long T, Xu T, Zhuang X, Liu C, Li S, Zhang D, Liao X, Dong Y, Lui KO, Tan X, Lin S, Chen Y, Huang ZP
Frontiers in cardiovascular medicine 2022;9:852775

The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.

Sepich-Poore C, Zheng Z, Schmitt E, Wen K, Zhang ZS, Cui XL, Dai Q, Zhu AC, Zhang L, Sanchez Castillo A, Tan H, Peng J, Zhuang X, He C, Nachtergaele S
The Journal of biological chemistry 2022 Mar;298(3):101590

The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma.

Liu X, Ma H, Ma L, Li K, Kang Y
Bioengineered 2022 Mar;13(3):5525-5536

Long noncoding RNA UBA6-AS1 inhibits the malignancy of ovarian cancer cells via suppressing the decay of UBA6 mRNA.

Wang Y, Chen Z
Bioengineered 2022 Jan;13(1):178-189

Zhang J, Chen J, Lu Y, Yang Y, Chen W, Shen B, Hu J, Jia P, Xu S, Shi Y, Ning Y, Wang J, Fang Y, Zhao S, Li Y, Dai Y, Zhang X, Xiang M, Tian Y, Liu Z, Song N, Ding X
iScience 2022 Dec 22;25(12):105620

N(6)-methyladenosine (m(6)A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation.

Peng H, Chen B, Wei W, Guo S, Han H, Yang C, Ma J, Wang L, Peng S, Kuang M, Lin S
Nature metabolism 2022 Aug;4(8):1041-1054

The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation.

Xing M, Liu Q, Mao C, Zeng H, Zhang X, Zhao S, Chen L, Liu M, Shen B, Guo X, Ma H, Chen H, Zhang J
EMBO reports 2020 Oct 5;21(10):e49863

Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.

Rong B, Zhang Q, Wan J, Xing S, Dai R, Li Y, Cai J, Xie J, Song Y, Chen J, Zhang L, Yan G, Zhang W, Gao H, Han JJ, Qu Q, Ma H, Tian Y, Lan F
Cell reports 2020 Dec 22;33(12):108544

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: PC-3 cells were subjected to SDS PAGE followed by western blot with 16791-1-AP(METTL5 antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using METTL5 antibody 16791-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 16791-1-AP(METTL5 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 16791-1-AP(METTL5 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue