16485-1-AP

antibody from Proteintech Group

Targeting: CDC25C CDC25, PPP1R60

Provider product page for 16485-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [40]
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Validations
Western blot [1]

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Product number: 16485-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16485-1-AP, RRID:AB_2291330
Product name: CDC25C antibody
Antibody type: Polyclonal
Description: KD/KO validated CDC25C antibody (Cat. #16485-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CDC25C protein structure - 16485-1-AP shown in red.

Submitted references DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targeting IMPDH2 to inhibit triple-negative breast cancer.

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Acta pharmaceutica Sinica. B 2026 Jan;16(1):287-304

Novel driver gene FIRRM regulates the cell cycle for promoting tumor growth in hepatocellular carcinoma.

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Journal of gastroenterology 2026 Apr 20;

Ribociclib derivative Rib-CA suppresses breast cancer progression via p53-dependent apoptosis.

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Toxicology and applied pharmacology 2025 Oct;503:117475

α-hederin inhibits cervical cancer progression by inducing DNA damage-dependent cell cycle blockade and apoptosis.

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BMC cancer 2025 Oct 3;25(1):1503

The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway.

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KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis.

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Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation.

Zheng Y, Wang K, Mao W, Zhang G, Han X, Li H, Wang Y
International journal of oncology 2025 Apr;66(4)

CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy.

Gao X, Liu F, Zhang B, Ren T, Zheng Y, Niu Z, Ren H, Liu C, Jiang C, Wang C, Huang H, Ma L, Sun Q
Cell death & disease 2025 Apr 11;16(1):276

Kaempferol from Alpinia officinarum hance induces G2/M cell cycle arrest in hepatocellular carcinoma cells by regulating the ATM/CHEK2/KNL1 pathway.

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Journal of ethnopharmacology 2024 Oct 28;333:118430

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Xie C, Zhou X, Chen W, Ren D, Li X, Jiang R, Zhong C, Zhu J
Chemico-biological interactions 2024 Jul 1;397:111083

CSTB accelerates the progression of hepatocellular carcinoma via the ERK/AKT/mTOR signaling pathway.

Zhu W, Dong X, Tian N, Feng Z, Zhou W, Song W
Heliyon 2024 Jan 15;10(1):e23506

STEAP4 with copper reductase activity suppresses tumorigenesis by regulating the cell cycle in hepatocellular carcinoma cells.

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Cell division 2024 Dec 24;19(1):35

Pyrogallol promotes growth arrest by activating the p53-mediated up-regulation of p21 and p62/SQSTM1-dependent degradation of β-catenin in nonsmall cell lung cancer cells.

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Environmental toxicology 2024 Apr;39(4):2150-2165

Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.

Hou G, Hu W, Sang Y, Gan X, Xu H, Hu Q, Cao X
Biochemical pharmacology 2024 Apr;222:116110

Nanoengineered Gallium Ion Incorporated Formulation for Safe and Efficient Reversal of PARP Inhibition and Platinum Resistance in Ovarian Cancer.

Li Y, Cen Y, Tu M, Xiang Z, Tang S, Lu W, Zhang H, Xu J
Research (Washington, D.C.) 2023;6:0070

PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C.

Xu N, Ren Y, Bao Y, Shen X, Kang J, Wang N, Wang Z, Han X, Li Z, Zuo J, Wei GH, Wang Z, Zong WX, Liu W, Xie G, Wang Y
Cell reports 2023 Sep 26;42(9):113041

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Luo Q, Pan Y, Fu Q, Zhang X, Zhou S, Yu P, Tian H, Liu P, Chen S, Zhang H, Qin T
Cell biology and toxicology 2023 Oct;39(5):2069-2087

Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.

Fan R, Wang S, Wu Y, Feng Y, Gao M, Cao Y, Ma X, Xie S, Wang C, Gao L, Wang Y, Dai F
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673

Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects.

Wen C, Ruan Q, Li Z, Zhou X, Yang X, Xu P, Akuetteh PDP, Xu Z, Deng J
British journal of cancer 2022 Dec;127(12):2108-2117

Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.

Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL
Nature 2022 Aug;608(7922):413-420

ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.

Li Y, Sun C, Tan Y, Zhang H, Li Y, Zou H
International journal of biological sciences 2021;17(2):635-650

Therapeutic Targeting PLK1 by ON-01910.Na Is Effective in Local Treatment of Retinoblastoma.

Ma H, Nie C, Chen Y, Li J, Xie Y, Tang Z, Gao Y, Ai S, Mao Y, Sun Q, Lu R
Oncology research 2021 Sep 7;28(7):745-761

Characteristics and clinical significance of polyploid giant cancer cells in laryngeal carcinoma.

Liu HT, Xia T, You YW, Zhang QC, Ni HS, Liu YF, Liu YR, Xu YQ, You B, Zhang ZX
Laryngoscope investigative otolaryngology 2021 Oct;6(5):1228-1234

RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells.

Wang J, Wang J, Li L, Feng L, Wang YR, Wang Z, Tan NH
Journal of ethnopharmacology 2021 Feb 10;266:113438

E3 ubiquitin ligase TRIM7 negatively regulates NF-kappa B signaling pathway by degrading p65 in lung cancer.

Jin J, Lu Z, Wang X, Liu Y, Han T, Wang Y, Wang T, Gan M, Xie C, Wang J, Yu B
Cellular signalling 2020 May;69:109543

CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breast cancer.

Liu B, Liu Y, Wang Y, Xie C, Gan M, Han T, Cao J, Wang J
Pathology, research and practice 2019 Oct;215(10):152592

A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.

Wang Y, Han T, Gan M, Guo M, Xie C, Jin J, Zhang S, Wang P, Cao J, Wang JB
Cell cycle (Georgetown, Tex.) 2019 May;18(9):1019-1032

RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.

Guo D, Wang Y, Wang J, Song L, Wang Z, Mao B, Tan N
Molecules (Basel, Switzerland) 2019 May 12;24(9)

Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response.

Zhang Y, Liu Y, Duan J, Wang H, Zhang Y, Qiao K, Wang J
Cell cycle (Georgetown, Tex.) 2019 Dec;18(23):3337-3350

BECN1 promotes the migration of NSCLC cells through regulating the ubiquitination of Vimentin.

Cheng Z, Xin H, Han T
Cell adhesion & migration 2019 Dec;13(1):249-259

Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway.

Wang Y, Lv Y, Liu TS, Yan WD, Chen LY, Li ZH, Piao YS, An RB, Lin ZH, Ren XS
Life sciences 2019 Apr 15;223:110-119

Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.

Liu S, Liu B
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433

3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.

Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, Wang J, Ji T, Du G
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132

S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells.

Fan Y, Mao Y, Cao S, Xia G, Zhang Q, Zhang H, Qiu F, Kang N
Molecules (Basel, Switzerland) 2018 Dec 1;23(12)

PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT.

Shi WK, Zhu XD, Wang CH, Zhang YY, Cai H, Li XL, Cao MQ, Zhang SZ, Li KS, Sun HC
Cell death & disease 2018 Apr 1;9(4):428

Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells.

Wu W, Chen J, Wu J, Lin J, Yang S, Yu H
Oncology reports 2017 Oct;38(4):2480-2488

A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

Xu X, Fan Z, Liang C, Li L, Wang L, Liang Y, Wu J, Chang S, Yan Z, Lv Z, Fu J, Liu Y, Jin S, Wang T, Hong T, Dong Y, Ding L, Cheng L, Liu R, Fu S, Jiao S, Ye Q
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Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.

Huo Y, Zheng Z, Chen Y, Wang Q, Zhang Z, Deng H
Oncotarget 2016 Jul 19;7(29):45876-45888

TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.

Zhan W, Han T, Zhang C, Xie C, Gan M, Deng K, Fu M, Wang JB
PloS one 2015;10(11):e0142596

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CDC25C antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CDC25C. This antibody recognizes human antigen. The CDC25C antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 16485-1-AP.pdf

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