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- Antigen structure
- References [134]
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- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 24909-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- JUN antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated JUN antibody (Cat. #24909-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, hamster, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Hamster
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Anjiang formula inhibits PVN microglial activation and lowers blood pressure by targeting RhoA/ROCK2 pathway: a retrospective clinical and experimental study.
Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Huzhang-Xiangbaji compounds enhance the repair of meniscal cartilage by inhibiting ferroptosis and inflammatory microenvironment.
Subchronic, low-frequency polystyrene microplastic or nanoplastic exposure elicits molecular perturbations but minimal clinical phenotypes in the mouse gut-brain axis.
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression.
Pedunculoside ameliorates liver fibrosis by targeting c-Jun to inhibit hepatic stellate cell activation.
Effects of Lycium barbarum polysaccharide on the activation of pathogenic CD4 + T cells in a mouse model of multiple sclerosis.
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Multi-Targeted Therapeutic Mechanisms of Huangqi Guizhi Wuwu Decoction Against Rheumatoid Arthritis: An Integrated Approach Combining Serum Pharmacochemistry, Network Pharmacology, Metabolomics, and Experimental Validation.
NAD(+) sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis.
Mantis shrimp saddle-mimetic amorphous calcium (zinc) phosphate/chitin scaffolds with superior mechanical properties and bioactivity for bone regeneration.
CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway.
Wine-Processed Cornus officinalis Ameliorates Osteoarthritis via Modulating M1/M2 Macrophage Polarization.
PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation.
Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration.
Quercetin alleviates imatinib-induced premature ovarian insufficiency by regulating mitophagy via the ROS/JNK/c-JUN pathway.
Fibrosis suppressive effect and mechanism of CaSR positive allosteric modulators/p-dioxanone copolymers.
Mannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis.
Disruption of the Clock Component BMAL1 in HDM-induced Asthma Causes GC Resistance in Airway Epithelial Cells by Regulating GR Phosphorylation through the DUSP4-p38MAPK Pathway.
Transcriptome Sequencing Reveals the Molecular Mechanism of Heat Stroke-Induced Myocardial Injury.
Analysis and Validation of Autophagy-Related Gene Biomarkers and Immune Cell Infiltration Characteristic in Bronchopulmonary Dysplasia by Integrating Bioinformatics and Machine Learning.
Machine Learning-Based Identification and Experimental Validation of Hub Ferroptosis-Related Cuproptosis Genes in Lupus Nephritis.
METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification.
Identification of conserved gene expression changes across common glomerular diseases by spatial transcriptomics.
The chemokine CCL20 promotes hepatocyte cholesterol deposition during metabolic dysfunction-associated steatohepatitis by regulating OLR1 expression.
Integrating UHPLC-QE-MS and Bioinformatics with Experimental Validation Reveals MAPK/FOS-Mediated Podocyte Apoptosis as the Key Mechanism of Alpiniae oxyphyllae and Saposhnikovia divaricata in Treating Diabetic Kidney Disease.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Veillonella intestinal colonization promotes C. difficile infection in Crohn's disease.
Potential Mechanism of Qiju Dihuang Pill in Treating Primary Sjogren's Syndrome Revealed by Network Pharmacology and Experimental Verification.
Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma.
m(6)A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis.
scRNA-seq reveals an immune microenvironment and JUN-mediated NK cell exhaustion in relapsed T-ALL.
Multi-Omics Unveils Inflammatory Regulation of Fermented Sini Decoction Dregs in Broilers Infected with Avian Pathogenic Escherichia coli.
NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway.
Elevated Sphingosine Levels Suppress Profibrotic TGF-β Signaling via the PKC/miR-21/SMAD7 Axis in Sphingosine Kinase 2-Deficient Renal Fibroblasts and Unilateral Ureteral Obstruction-Induced Kidney Fibrosis.
TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis.
The upregulation of TNKS1 drives the phenotypic switching of vascular smooth muscle cells in aortic dissection through the activation of ferroptosis.
ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes.
The mechanism of Shancigu and its monomer in the development of colorectal cancer based on network pharmacology.
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis.
Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation.
Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells.
Downregulation of ferroptosis-related ATF3 alleviates lupus nephritis progression.
Material-driven immunomodulation and ECM remodeling reverse pulmonary fibrosis by local delivery of stem cell-laden microcapsules.
Corydalis decumbens and tetrahydropalmatrubin inhibit macrophages inflammation to relieve rheumatoid arthritis by targeting Fosl2.
Hic-5 deficiency attenuates MAFLD by inhibiting neutrophils migration via the CXCL1-CXCR2 axis.
Docosahexaenoic acid ameliorates autistic-like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats.
Artemisia argyi ethyl acetate fraction suppresses ovarian cancer progression via JUN/MAPK10 signaling: An integrated multi-omics investigation.
Tubuloside B alleviates con A-induced acute liver injury by inhibiting the IL-23/JAK2/STAT3 signaling pathway hyperactivation during Th17 cell differentiation.
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness.
Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy.
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.
Activated Schwann cells promote tumor growth in colon cancer.
Investigation of c-Fos/c-Jun Signaling Pathways in Periostracum Cicadae's Inhibition of EMT in Gastric Tissue.
Reshaping the chromatin landscape in HUVECs from small-for-gestational-age newborns.
Jatrorrhizine retard obesity by modulating transcription factor c-Jun/c-Fos to downregulate Mmp12-mediated inflammation.
Pulsatilla saponin D inhibited the growth of osteosarcoma by regulating the JNK/ATF3 signaling pathway.
Single-cell and spatial transcriptome assays reveal heterogeneity in gliomas through stress responses and pathway alterations.
CREB1 promotes cholangiocarcinoma metastasis through transcriptional regulation of the LAYN-mediated TLN1/β1 integrin axis: CREB1 promotes cholangiocarcinoma metastasis through regulating LAYN/TLN1/β1 integrin axis.
Jun and JunB members of the AP-1 complex are potential therapeutic targets for silicosis.
Systematic functional interrogation of genome-wide association studies locus 17p13.3 deciphered role and genetic control of FAM57A in colorectal cancer development.
The Inhibitory Effect and Mechanism of the Histidine-Rich Peptide rAj-HRP from Apostichopus japonicus on Human Colon Cancer HCT116 Cells.
RNA-binding motif protein 28 enhances angiogenesis by improving STAT3 translation in hepatocellular carcinoma.
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Oral Administration of Deer Bone Collagen Peptide Can Enhance the Skin Hydration Ability and Antioxidant Ability of Aging Mice Induced by D-Gal, and Regulate the Synthesis and Degradation of Collagen.
Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis.
Identification of osteoblastic autophagy-related genes for predicting diagnostic markers in osteoarthritis.
Inhibiting the SARM1-NAD(+) axis reduces oxidative stress-induced damage to retinal and nerve cells.
Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus.
MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis.
The EGR1/miR-139/NRF2 axis orchestrates radiosensitivity of non-small-cell lung cancer via ferroptosis.
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Discovery and validation of anti-arthritic ingredients and mechanisms of Qingfu Juanbi Tang, a Chinese herbal formulation, on rheumatoid arthritis.
Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines.
An anti-RAGE chimeric antibody alleviates CCl(4)-induced liver fibrosis via RAGE/NF-kB pathway in mice.
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
RG108 attenuates acute kidney injury by inhibiting P38 MAPK/FOS and JNK/JUN pathways.
Mechanism of Xing 9 ling tablet candy for alcoholic liver disease based on network pharmacology.
Up-regulated novel-miR-17 promotes hypothermic reperfusion arrhythmias by negatively targeting Gja1 and mediating activation of the PKC/c-Jun signaling pathway.
CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer.
Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog.
Tanshinone IIA Inhibits Triple-Negative Breast Cancer Cells MDA-MB-231 via G Protein-Coupled Estrogen Receptor- (GPER-) Dependent Signaling Pathway.
RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
Pien-tze-huang promotes wound healing in streptozotocin-induced diabetes models associated with improving oxidative stress via the Nrf2/ARE pathway.
Synovium is a sensitive tissue for mapping the negative effects of systemic iron overload in osteoarthritis: identification and validation of two potential targets.
SALL1 promotes proliferation and metastasis and activates phosphorylation of p65 and JUN in colorectal cancer cells.
Ring finger protein 10 improves pirarubicin-induced cardiac inflammation by regulating the AP-1/Meox2 signaling pathway.
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
Gene expression networks involved in multiple cellular programs coexist in individual hepatocellular cancer cells.
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis.
The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4.
Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN.
Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.
[High expression of MYH9 inhibits apoptosis of non-small cell lung cancer cells through activating the AKT/c-Myc pathway].
NF-κB and AP-1 are required for the lipopolysaccharide-induced expression of MCP-1, CXCL1, and Cx43 in cultured rat dorsal spinal cord astrocytes.
Integrating network pharmacology and experimental validation to clarify the anti-hyperuricemia mechanism of cortex phellodendri in mice.
Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease.
TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.
RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome.
Antioxidant and Immunomodulatory Properties of Partially purified Exopolysaccharide from Lactobacillus Casei Isolated from Chinese Northeast Sauerkraut.
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.
Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance.
Dual Regulation of Tank Binding Kinase 1 by BRG1 in Hepatocytes Contributes to Reactive Oxygen Species Production.
NAP1L1 Functions as a Tumor Promoter via Recruiting Hepatoma-Derived Growth Factor/c-Jun Signal in Hepatocellular Carcinoma.
Single-Cell Transcriptome Analysis of Chronic Antibody-Mediated Rejection After Renal Transplantation.
Angelica Dahurica Regulated the Polarization of Macrophages and Accelerated Wound Healing in Diabetes: A Network Pharmacology Study and In Vivo Experimental Validation.
NAP1L1 interacts with hepatoma-derived growth factor to recruit c-Jun inducing breast cancer growth.
Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.
Targeted regulation of lymphocytic ER stress response with an overall immunosuppression to alleviate allograft rejection.
Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway.
MMP12 is a potential therapeutic target for Adamantinomatous craniopharyngioma: Conclusions from bioinformatics analysis and in vitro experiments.
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy.
LEF1/Id3/HRAS axis promotes the tumorigenesis and progression of esophageal squamous cell carcinoma.
Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.
4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice.
miR-4721, Induced by EBV-miR-BART22, Targets GSK3β to Enhance the Tumorigenic Capacity of NPC through the WNT/β-catenin Pathway.
MicroRNA-139-5p upregulation is associated with diabetic endothelial cell dysfunction by targeting c-jun.
Mechanisms of stretch-mediated skin expansion at single-cell resolution.
Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice.
The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.
Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.
Light-induced Nrf2(-/-) mice as atrophic age-related macular degeneration model and treatment with nanoceria laden injectable hydrogel.
Adipose-derived mesenchymal stem cells ameliorate acute liver injury in rat model of CLP induced-sepsis via sTNFR1.
M1 macrophages regulate TLR4/AP1 via paracrine to promote alveolar bone destruction in periodontitis.
H(2)S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling.
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Expression of activator protein-1 in papillary thyroid carcinoma and its clinical significance.
Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression.
The mTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth.
Chen X, Chen J, Chen Z, Lian D, Wang J, Wu M, Luo J, Shen A, Chen L
Frontiers in pharmacology 2026;17:1795297
Frontiers in pharmacology 2026;17:1795297
Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Zhu J, Zhou T, Tang X, Gao Y, Teng Q, Zhang Y, Lv Z, Chen X, Zou J, Shi H
Biomaterials 2026 Sep;332:124170
Biomaterials 2026 Sep;332:124170
Huzhang-Xiangbaji compounds enhance the repair of meniscal cartilage by inhibiting ferroptosis and inflammatory microenvironment.
Li J, Zhou J, Zhang G, Ding N, Kuang Z, Wang J, Liu N, Jia G, Jiang M, Wu S, Yang J, Ding X, Lei Z, Nie Y, Zhang Y, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158008
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158008
Subchronic, low-frequency polystyrene microplastic or nanoplastic exposure elicits molecular perturbations but minimal clinical phenotypes in the mouse gut-brain axis.
Lee SH, Chang H, Yan YH, Chien CC, Cheng TJ
Environmental pollution (Barking, Essex : 1987) 2026 May 15;397:127957
Environmental pollution (Barking, Essex : 1987) 2026 May 15;397:127957
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression.
Qin J, Ma S, Wang J, Huang S, Luan J, He J, Hou G, Sun N, Zhang W, Gao M
Cell death & disease 2026 Mar 20;17(1)
Cell death & disease 2026 Mar 20;17(1)
Pedunculoside ameliorates liver fibrosis by targeting c-Jun to inhibit hepatic stellate cell activation.
Wang A, Dong H, Cui Y, Jin Y, Xiong Y, Jin L, Zhang Q, Zhu W, Ye J, Lin M, Luo W, Liang G, Sun J
International immunopharmacology 2026 Jun 15;179:116602
International immunopharmacology 2026 Jun 15;179:116602
Effects of Lycium barbarum polysaccharide on the activation of pathogenic CD4 + T cells in a mouse model of multiple sclerosis.
Guo M, Deng G, Huang B, Lin Z, Yang X, Dong L, Wang Z, Guo Y, Yi M, Wang W, Jiang ML, Zhang CJ
Neural regeneration research 2026 Jun 1;21(6):2563-2572
Neural regeneration research 2026 Jun 1;21(6):2563-2572
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Fan D, Zhong Y, Dong Y, Du M, Huang K, Li X
Journal of advanced research 2026 Jan;79:661-677
Journal of advanced research 2026 Jan;79:661-677
Multi-Targeted Therapeutic Mechanisms of Huangqi Guizhi Wuwu Decoction Against Rheumatoid Arthritis: An Integrated Approach Combining Serum Pharmacochemistry, Network Pharmacology, Metabolomics, and Experimental Validation.
Xu Z, Li Z, Qu J, Liang C, Zhang Y, Zhao Q, Li Q
Pharmaceuticals (Basel, Switzerland) 2026 Jan 29;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 29;19(2)
NAD(+) sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis.
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Cell reports 2026 Feb 24;45(2):116929
Cell reports 2026 Feb 24;45(2):116929
Mantis shrimp saddle-mimetic amorphous calcium (zinc) phosphate/chitin scaffolds with superior mechanical properties and bioactivity for bone regeneration.
Zhao Z, Gao J, Vecchio KS, Cao L, Liu X, Wang H, Yang R, Tang P, Li M, Zhang X
Bioactive materials 2026 Apr;58:738-754
Bioactive materials 2026 Apr;58:738-754
CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway.
Tao C, Li S, Sun D, Zhou J, Chen Y, Zhang R, Ni X
Journal of cellular and molecular medicine 2026 Apr;30(7):e71124
Journal of cellular and molecular medicine 2026 Apr;30(7):e71124
Wine-Processed Cornus officinalis Ameliorates Osteoarthritis via Modulating M1/M2 Macrophage Polarization.
Fu Y, Zhao M, Huang X, Ren Y, Wang W
Journal of cellular and molecular medicine 2026 Apr;30(7):e71113
Journal of cellular and molecular medicine 2026 Apr;30(7):e71113
PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation.
Chen H, Huang Z, Chang R, Gao W, Qiu Y, Sun B, Hua C, Lin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e23139
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e23139
Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration.
Huang Y, Lin W, Chen X, Lin F, Li J, Liu Y, Liu Y, Luo G, Du X, Duan L, Zhan Y, Zhao T
Journal of ethnopharmacology 2026 Apr 25;368:121771
Journal of ethnopharmacology 2026 Apr 25;368:121771
Quercetin alleviates imatinib-induced premature ovarian insufficiency by regulating mitophagy via the ROS/JNK/c-JUN pathway.
Li QH, Ji M, Weng SQ, Li X, Xiao Q, Zhou Y, Luo T, Liu ZX
International immunopharmacology 2026 Apr 15;175:116405
International immunopharmacology 2026 Apr 15;175:116405
Fibrosis suppressive effect and mechanism of CaSR positive allosteric modulators/p-dioxanone copolymers.
Feng C, Liu Y, Zhang C, Niu L, Dong J, Wang B
Drug delivery and translational research 2026 Apr 14;
Drug delivery and translational research 2026 Apr 14;
Mannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis.
Jin H, He H, Li J, Liu X, Cai Q, Shi J, Hao Z, He J
International journal of biological sciences 2025;21(4):1566-1584
International journal of biological sciences 2025;21(4):1566-1584
Disruption of the Clock Component BMAL1 in HDM-induced Asthma Causes GC Resistance in Airway Epithelial Cells by Regulating GR Phosphorylation through the DUSP4-p38MAPK Pathway.
Huang H, Liao H, Chen Y, Hu M, Jiang X, Yu Q, Gao Y, Yang H, Zhuo J, Liu D, Huang L, Zhang J, Li Y, Du Y, Lin X, Meng X, Zou F, Zou M, Wu J, Cai S, Dong H
International journal of biological sciences 2025;21(14):6482-6500
International journal of biological sciences 2025;21(14):6482-6500
Transcriptome Sequencing Reveals the Molecular Mechanism of Heat Stroke-Induced Myocardial Injury.
Xiang J, Shao S, Huang J, Yang N, Guo F, Tang B, Zhang L
Journal of inflammation research 2025;18:8033-8048
Journal of inflammation research 2025;18:8033-8048
Analysis and Validation of Autophagy-Related Gene Biomarkers and Immune Cell Infiltration Characteristic in Bronchopulmonary Dysplasia by Integrating Bioinformatics and Machine Learning.
Xiao S, Ding Y, Du C, Lv Y, Yang S, Zheng Q, Wang Z, Zheng Q, Huang M, Xiao Q, Ren Z, Bi G, Yang J
Journal of inflammation research 2025;18:549-563
Journal of inflammation research 2025;18:549-563
Machine Learning-Based Identification and Experimental Validation of Hub Ferroptosis-Related Cuproptosis Genes in Lupus Nephritis.
Zhang S, Hu W, Zhang Y, Huang C, He Z, Xu J, Lin S, Yang B, Chen X
Journal of inflammation research 2025;18:11335-11353
Journal of inflammation research 2025;18:11335-11353
METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification.
He D, Jiang X, Guo G, Ma J, Chen J, Zhang Y, Zhuang J, Xie P, Zhang Z
Frontiers in immunology 2025;16:1717319
Frontiers in immunology 2025;16:1717319
Identification of conserved gene expression changes across common glomerular diseases by spatial transcriptomics.
Cho JM, Kang M, Park S, Oh J, Ku H, Shin HY, Koh JH, Cho S, Kim Y, Lee S, Kim YC, Han SS, Joo KW, Kim YS, Yang SH, Moon KC, Lee H, Kim HJ, Kim DK, KORNERSTONE investigators
Journal of nephrology 2025 Sep;38(7):1819-1829
Journal of nephrology 2025 Sep;38(7):1819-1829
The chemokine CCL20 promotes hepatocyte cholesterol deposition during metabolic dysfunction-associated steatohepatitis by regulating OLR1 expression.
Yin M, Zhang Y, Liu S, Wang Q, Zhang Y, Min J, Yang J, Zhao Y, Zhou Z, Li X, Liu S
Metabolism: clinical and experimental 2025 Sep;170:156301
Metabolism: clinical and experimental 2025 Sep;170:156301
Integrating UHPLC-QE-MS and Bioinformatics with Experimental Validation Reveals MAPK/FOS-Mediated Podocyte Apoptosis as the Key Mechanism of Alpiniae oxyphyllae and Saposhnikovia divaricata in Treating Diabetic Kidney Disease.
Wang X, Zhang L, Tang R, Zhang W, Xie Y, Li K
Pharmaceuticals (Basel, Switzerland) 2025 Sep 27;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 27;18(10)
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Ma Y, Huang J, Gong J, Li L, Zhao Y, Jin Y, Gu J, Liu H, Wang Y, Sun Y
Chinese medicine 2025 Sep 22;20(1):146
Chinese medicine 2025 Sep 22;20(1):146
Veillonella intestinal colonization promotes C. difficile infection in Crohn's disease.
Yang Z, Wang J, Chen Y, Chen T, Shen Z, Wang Y, Jian Y, Xiang G, Ma X, Zhao N, Song Y, Shi B, Qin J, Liu Q, Cao Z, Otto M, Li M
Cell host & microbe 2025 Sep 10;33(9):1518-1534.e10
Cell host & microbe 2025 Sep 10;33(9):1518-1534.e10
Potential Mechanism of Qiju Dihuang Pill in Treating Primary Sjogren's Syndrome Revealed by Network Pharmacology and Experimental Verification.
Wang H, Cheng H, Li M, Zhu X, Wang X
Chemical biology & drug design 2025 Oct;106(4):e70186
Chemical biology & drug design 2025 Oct;106(4):e70186
Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma.
Zhang S, Jiang L, Cai S, Weng Z, Zhu Y, Cai ZW, Li H, Li Q, Hu LP, Yao HF, Hua R, Zhao Y, Li D, Yang XM, Zhang JF, Jiang SH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e11726
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e11726
m(6)A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis.
Tan Z, Yang J, Chen Y, Zhu H, Liu X, Xu H, Meng Q, Xiao M, Tang R, Rong Z, Yu X, Liang C, Xu J
Cell death & disease 2025 Nov 3;16(1):784
Cell death & disease 2025 Nov 3;16(1):784
scRNA-seq reveals an immune microenvironment and JUN-mediated NK cell exhaustion in relapsed T-ALL.
Liu Y, Du Z, Li L, Huang J, Liu S, Lu B, Duan Y, Cheng Y, Li T, Zhang J, Mo J, Yang Y, Wang W, Zou H, Liang T, Jiang M, Yang M, Chen Y, Ouyang C, Chen C
Cell reports. Medicine 2025 May 20;6(5):102098
Cell reports. Medicine 2025 May 20;6(5):102098
Multi-Omics Unveils Inflammatory Regulation of Fermented Sini Decoction Dregs in Broilers Infected with Avian Pathogenic Escherichia coli.
Mo S, Fang X, Xiao W, Huang B, Li C, Yang H, Wu Y, Wang Y, Ma H
Veterinary sciences 2025 May 15;12(5)
Veterinary sciences 2025 May 15;12(5)
NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway.
Yang R, Yu W, Lin L, Cui Z, Tang J, Li G, Jin M, Gu Y, Lu E
Journal of advanced research 2025 Jun;72:303-317
Journal of advanced research 2025 Jun;72:303-317
Elevated Sphingosine Levels Suppress Profibrotic TGF-β Signaling via the PKC/miR-21/SMAD7 Axis in Sphingosine Kinase 2-Deficient Renal Fibroblasts and Unilateral Ureteral Obstruction-Induced Kidney Fibrosis.
Oftring A, Wagner V, Thomas D, Huber LS, Geisslinger G, Schaefer L, Vutukuri R, Pfeilschifter J, Schwalm S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70768
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70768
TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis.
Shi Y, Huang M, Zhou W, Zhao Y, Zhao J, Zhong B, French SW, Tang X, Liu H
Journal of translational medicine 2025 Jun 3;23(1):621
Journal of translational medicine 2025 Jun 3;23(1):621
The upregulation of TNKS1 drives the phenotypic switching of vascular smooth muscle cells in aortic dissection through the activation of ferroptosis.
Xu X, Lin W, Liu T, Yuan C, Yan Y, Diao Y, Xiong J, Shao Y, Ni B
International immunopharmacology 2025 Jun 17;158:114722
International immunopharmacology 2025 Jun 17;158:114722
ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes.
Bando Y, Bandow K, Sakiyama K, Nagasaka A, Suzuki K, Toda-Fujii M, Owada Y, Amano O
Cell and tissue research 2025 Jul;401(1):29-42
Cell and tissue research 2025 Jul;401(1):29-42
The mechanism of Shancigu and its monomer in the development of colorectal cancer based on network pharmacology.
Li G, Zhu X, Zhao R, Zhang X, Huang C, Shu M, Liu L, Yuan J
Scientific reports 2025 Jul 2;15(1):23186
Scientific reports 2025 Jul 2;15(1):23186
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
Xiao S, Wei T, Xiao M, Shan M, An Z, Li N, Zhou J, Zhao S, Lu X
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis.
Hu C, Li H, Cui J, Li Y, Zhang F, Li H, Luo X, Hao Y
Translational psychiatry 2025 Jul 11;15(1):239
Translational psychiatry 2025 Jul 11;15(1):239
Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation.
Cui J, Li H, Hu C, Zhang F, Li Y, Weng Y, Yang L, Li Y, Yao M, Li H, Luo X, Hao Y
Neurobiology of disease 2025 Jan;204:106763
Neurobiology of disease 2025 Jan;204:106763
Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells.
Zhang X, Zheng Y, Yang J, Yang Y, He Q, Xu M, Long F, Yang Y
Scientific reports 2025 Jan 6;15(1):1013
Scientific reports 2025 Jan 6;15(1):1013
Downregulation of ferroptosis-related ATF3 alleviates lupus nephritis progression.
Xiao G, Tang S, Zhang Y, Yuan Q, Sun D, Wang W
Gene 2025 Jan 20;934:149009
Gene 2025 Jan 20;934:149009
Material-driven immunomodulation and ECM remodeling reverse pulmonary fibrosis by local delivery of stem cell-laden microcapsules.
Zhang Y, Zhao Y, An C, Guo Y, Ma Y, Shao F, Zhang Y, Sun K, Cheng F, Ren C, Zhang L, Sun B, Zhang Y, Wang H
Biomaterials 2025 Feb;313:122757
Biomaterials 2025 Feb;313:122757
Corydalis decumbens and tetrahydropalmatrubin inhibit macrophages inflammation to relieve rheumatoid arthritis by targeting Fosl2.
Gao P, Yuan S, Wang Y, Wang Y, Li X, Liu T, Zheng Y, Wang J, Liu D, Xu L, Jiang Y, Zeng K, Tu P
Journal of ethnopharmacology 2025 Feb 11;341:119348
Journal of ethnopharmacology 2025 Feb 11;341:119348
Hic-5 deficiency attenuates MAFLD by inhibiting neutrophils migration via the CXCL1-CXCR2 axis.
Ren B, Li H, Liu S, Huang Z, Bai J, Jiang Z, Xu T, Gu B, Yu W, Sun L, Tan P, Fu W
Journal of gastroenterology 2025 Dec;60(12):1535-1553
Journal of gastroenterology 2025 Dec;60(12):1535-1553
Docosahexaenoic acid ameliorates autistic-like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats.
Xu B, Yuan H, Li X, Yu Q, Dai C, Dong Z
Pediatric discovery 2025 Dec;3(4):e91
Pediatric discovery 2025 Dec;3(4):e91
Artemisia argyi ethyl acetate fraction suppresses ovarian cancer progression via JUN/MAPK10 signaling: An integrated multi-omics investigation.
Liu Y, Yu T, Liu M, Mo Y, Zheng Y, Xu J, Song Z, Gui C, Liu D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157533
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157533
Tubuloside B alleviates con A-induced acute liver injury by inhibiting the IL-23/JAK2/STAT3 signaling pathway hyperactivation during Th17 cell differentiation.
Luo J, Yu Z, An W, Li M, Wei H, Wang Z, He L, Xiao F, Wei H
International immunopharmacology 2025 Dec 3;166:115586
International immunopharmacology 2025 Dec 3;166:115586
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness.
Li Q, He XL, Chen SJ, Niu Q, Cao TZ, Cui XL, Jia ZH, Zhang HD, Feng X, Jiang YH, Liang LM, Cheng PP, Hu SH, Xiong L, Wang M, Ye H, Ma WL
The Journal of clinical investigation 2025 Dec 15;135(24)
The Journal of clinical investigation 2025 Dec 15;135(24)
Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy.
Ge X, Yu L, Zhang L, Jia L, Meng M, He J, Bu F, Song Y, Sun G, Lv S, Mei D, Yang Y, Xu D, Zhang J, Zhang S, Wang C, Jia D, Chen Y, Gao Y, He B
Nature communications 2025 Dec 14;17(1):623
Nature communications 2025 Dec 14;17(1):623
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.
Lu S, Cao J, Song Z, Gong F, Yang P, Ge J, He Y, Han Z, Hou G, Zhang Z, Yang Y, Teng Y, Zhang Z, Zou J, Cheng L, Yang H
Nature communications 2025 Aug 30;16(1):8127
Nature communications 2025 Aug 30;16(1):8127
Activated Schwann cells promote tumor growth in colon cancer.
He K, Wang H, Wu H, Li W, Huo R, Jiang L, Yu M, Xue J
Cancer letters 2025 Aug 28;626:217791
Cancer letters 2025 Aug 28;626:217791
Investigation of c-Fos/c-Jun Signaling Pathways in Periostracum Cicadae's Inhibition of EMT in Gastric Tissue.
Liang H, Jin X, He T, Zhou X, Liu Z, Gao W
Pharmaceuticals (Basel, Switzerland) 2025 Apr 7;18(4)
Pharmaceuticals (Basel, Switzerland) 2025 Apr 7;18(4)
Reshaping the chromatin landscape in HUVECs from small-for-gestational-age newborns.
Yan L, Zhou Z, Chen S, Feng X, Mao J, Luo F, Zhu J, Chen X, Hu Y, Wang Y, Wu B, Du L, Wang C, Gong L, Zhu Y
JCI insight 2025 Apr 22;10(8)
JCI insight 2025 Apr 22;10(8)
Jatrorrhizine retard obesity by modulating transcription factor c-Jun/c-Fos to downregulate Mmp12-mediated inflammation.
Ma Z, Li J, Zhu J, Yang Z, Li X, Wang H, Tang Q, Zhou Y, Manzoor R, Chen X, Ma H, Ye X
International immunopharmacology 2025 Apr 16;152:114405
International immunopharmacology 2025 Apr 16;152:114405
Pulsatilla saponin D inhibited the growth of osteosarcoma by regulating the JNK/ATF3 signaling pathway.
Jin K, Shen C, Yu W, Lin J, Zhu J, Tao H, Liu B
Chemico-biological interactions 2025 Apr 1;410:111420
Chemico-biological interactions 2025 Apr 1;410:111420
Single-cell and spatial transcriptome assays reveal heterogeneity in gliomas through stress responses and pathway alterations.
He Z, Liu Z, Wang Q, Sima X, Zhao W, He C, Yang W, Chen H, Gong B, Song S, Wang Y
Frontiers in immunology 2024;15:1452172
Frontiers in immunology 2024;15:1452172
CREB1 promotes cholangiocarcinoma metastasis through transcriptional regulation of the LAYN-mediated TLN1/β1 integrin axis: CREB1 promotes cholangiocarcinoma metastasis through regulating LAYN/TLN1/β1 integrin axis.
Liang S, Zhou S, Tang Y, Xiao M, Ye K
Heliyon 2024 Sep 15;10(17):e36595
Heliyon 2024 Sep 15;10(17):e36595
Jun and JunB members of the AP-1 complex are potential therapeutic targets for silicosis.
Qi Y, Zhao Y, Xia J, Hu B, Li X, Li Q, Yang Z, Yao W, Hao C
International journal of biological macromolecules 2024 Oct;277(Pt 1):134024
International journal of biological macromolecules 2024 Oct;277(Pt 1):134024
Systematic functional interrogation of genome-wide association studies locus 17p13.3 deciphered role and genetic control of FAM57A in colorectal cancer development.
Huang J, Mo J, Xu R, Yang X, Tian Y, Ning C, Song S, Chen X, Cai Y, Zhu Y, Li B, Huang C, Jin M, Miao X
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2024 Oct 30;36(5):562-576
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2024 Oct 30;36(5):562-576
The Inhibitory Effect and Mechanism of the Histidine-Rich Peptide rAj-HRP from Apostichopus japonicus on Human Colon Cancer HCT116 Cells.
Zhang Y, Gao S, Mao J, Song Y, Wang X, Jiang J, Lv L, Zhou Z, Wang J
Molecules (Basel, Switzerland) 2024 Nov 4;29(21)
Molecules (Basel, Switzerland) 2024 Nov 4;29(21)
RNA-binding motif protein 28 enhances angiogenesis by improving STAT3 translation in hepatocellular carcinoma.
Han H, Yuan Y, Li C, Liu L, Yu H, Han G, Wang Q, Lin M, Huang J
Cancer letters 2024 Nov 1;604:217191
Cancer letters 2024 Nov 1;604:217191
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Gao X, Xuan Y, Zhou Z, Chen C, Wen Wang D, Wen Z
International immunopharmacology 2024 May 30;133:112073
International immunopharmacology 2024 May 30;133:112073
Oral Administration of Deer Bone Collagen Peptide Can Enhance the Skin Hydration Ability and Antioxidant Ability of Aging Mice Induced by D-Gal, and Regulate the Synthesis and Degradation of Collagen.
Zhang K, Zhao C, Liu K, Feng R, Zhao Y, Zong Y, Du R
Nutrients 2024 May 21;16(11)
Nutrients 2024 May 21;16(11)
Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis.
Zhao Y, Ning J, Teng H, Deng Y, Sheldon M, Shi L, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L
Nature communications 2024 Mar 16;15(1):2384
Nature communications 2024 Mar 16;15(1):2384
Identification of osteoblastic autophagy-related genes for predicting diagnostic markers in osteoarthritis.
Cai R, Jiang Q, Chen D, Feng Q, Liang X, Ouyang Z, Liao W, Zhang R, Fang H
iScience 2024 Jun 21;27(6):110130
iScience 2024 Jun 21;27(6):110130
Inhibiting the SARM1-NAD(+) axis reduces oxidative stress-induced damage to retinal and nerve cells.
Zhang Y, Yao Y, Yang J, Zhou B, Zhu Y
International immunopharmacology 2024 Jun 15;134:112193
International immunopharmacology 2024 Jun 15;134:112193
Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus.
Gong X, Zhang Z, Shi X, Zhu Y, Ali F, Dong Y, Zhang F, Zhang B
Carbohydrate polymers 2024 Jun 1;333:121963
Carbohydrate polymers 2024 Jun 1;333:121963
MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis.
Ding L, Sun M, Sun Y, Li J, Zhang Z, Dang S, Zhang J, Yang B, Dai Y, Zhou Q, Zhou D, Li E, Peng S, Li G
Cancer medicine 2024 Jul;13(13):e7424
Cancer medicine 2024 Jul;13(13):e7424
The EGR1/miR-139/NRF2 axis orchestrates radiosensitivity of non-small-cell lung cancer via ferroptosis.
Zhang L, Xu Y, Cheng Z, Zhao J, Wang M, Sun Y, Mi Z, Yuan Z, Wu Z
Cancer letters 2024 Jul 28;595:217000
Cancer letters 2024 Jul 28;595:217000
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Zhu Q, Han Y, He Y, Meng P, Fu Y, Yang H, He G, Long M, Shi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Discovery and validation of anti-arthritic ingredients and mechanisms of Qingfu Juanbi Tang, a Chinese herbal formulation, on rheumatoid arthritis.
Peng M, Yao Z, Zhang J, Lin Y, Xu L, Zhang Q, Liao J, Cai X
Journal of ethnopharmacology 2024 Jul 15;329:118140
Journal of ethnopharmacology 2024 Jul 15;329:118140
Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
Jin H, Liu C, Liu X, Wang H, Zhang Y, Liu Y, Li J, Yu Z, Liu HX
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270
Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines.
Stachowicz-Suhs M, Łabędź N, Anisiewicz A, Banach J, Kłopotowska D, Milczarek M, Piotrowska A, Dzięgiel P, Maciejczyk A, Matkowski R, Wietrzyk J
Scientific reports 2024 Feb 15;14(1):3778
Scientific reports 2024 Feb 15;14(1):3778
An anti-RAGE chimeric antibody alleviates CCl(4)-induced liver fibrosis via RAGE/NF-kB pathway in mice.
Liu J, Li H, Chen H, Xiao X, Jin Z, Paerhati P, Bao W, Cui C, Zhu J, Yuan Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Dec;181:117737
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Dec;181:117737
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
Ma Z, Chen X, Xiong M, Wang H, Sun C, Tang W, Li J, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Dec 5;335:118644
Journal of ethnopharmacology 2024 Dec 5;335:118644
RG108 attenuates acute kidney injury by inhibiting P38 MAPK/FOS and JNK/JUN pathways.
Kong FX, Liu H, Xu T, Li SJ, Li W, Lu H, Ma NN, Wang YL, Shi JH, Yang YR, Wang FL
International immunopharmacology 2024 Dec 5;142(Pt A):113077
International immunopharmacology 2024 Dec 5;142(Pt A):113077
Mechanism of Xing 9 ling tablet candy for alcoholic liver disease based on network pharmacology.
Zhao X, Qu Q, Zhang Y, Zhao P, Zhang X, Tang Y, Lei X, Wei X, Song X
Analytical biochemistry 2024 Aug;691:115534
Analytical biochemistry 2024 Aug;691:115534
Up-regulated novel-miR-17 promotes hypothermic reperfusion arrhythmias by negatively targeting Gja1 and mediating activation of the PKC/c-Jun signaling pathway.
Yi J, Chen K, Cao Y, Wen C, An L, Tong R, Wu X, Gao H
Journal of molecular and cellular cardiology 2024 Aug;193:1-10
Journal of molecular and cellular cardiology 2024 Aug;193:1-10
CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer.
Cheng M, Chen S, Li K, Wang G, Xiong G, Ling R, Zhang C, Zhang Z, Han H, Chen Z, Wang X, Liang Y, Tian G, Zhou R, Zhu Y, Ma J, Liu J, Lin S, Xu H, Chen D, Li Y, Peng L
Nature communications 2024 Apr 1;15(1):2818
Nature communications 2024 Apr 1;15(1):2818
Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog.
Leu T, Denda J, Wrobeln A, Fandrey J
Molecular and cellular biology 2023;43(4):174-183
Molecular and cellular biology 2023;43(4):174-183
Tanshinone IIA Inhibits Triple-Negative Breast Cancer Cells MDA-MB-231 via G Protein-Coupled Estrogen Receptor- (GPER-) Dependent Signaling Pathway.
He Y, Yang K, Liu J, Shi D, Zhang Z, Yang J, Chen M, Zhao P
Disease markers 2023;2023:8371623
Disease markers 2023;2023:8371623
RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
Shi H, Duan L, Lan Y, He Q, Pu P, Tang H
Oxidative medicine and cellular longevity 2023;2023:7872193
Oxidative medicine and cellular longevity 2023;2023:7872193
Pien-tze-huang promotes wound healing in streptozotocin-induced diabetes models associated with improving oxidative stress via the Nrf2/ARE pathway.
Liu Y, Mo J, Liang F, Jiang S, Xiong J, Meng X, Mo Z
Frontiers in pharmacology 2023;14:1062664
Frontiers in pharmacology 2023;14:1062664
Synovium is a sensitive tissue for mapping the negative effects of systemic iron overload in osteoarthritis: identification and validation of two potential targets.
Jin Z, Zhang H, Bai L, Yue L, Zhang W, Liang J, Chang B, Yang Y, Hu Z, Chen L, Guo C
Journal of translational medicine 2023 Sep 23;21(1):661
Journal of translational medicine 2023 Sep 23;21(1):661
SALL1 promotes proliferation and metastasis and activates phosphorylation of p65 and JUN in colorectal cancer cells.
Yuan J, Li G, Zhong F, Liao J, Zeng Z, Ouyang S, Xie H, Deng Z, Tang H, Ou X
Pathology, research and practice 2023 Oct;250:154827
Pathology, research and practice 2023 Oct;250:154827
Ring finger protein 10 improves pirarubicin-induced cardiac inflammation by regulating the AP-1/Meox2 signaling pathway.
Duan L, Tang H, Lan Y, Shi H, Pu P, He Q
Toxicology and applied pharmacology 2023 Mar 1;462:116411
Toxicology and applied pharmacology 2023 Mar 1;462:116411
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
Deng CM, Zhang GG, Liu QW, Xu JJ, Liu ZC, Yang J, Xu TY, Li ZG, Zhang F, Li B
Cancer research 2023 Jun 2;83(11):1851-1865
Cancer research 2023 Jun 2;83(11):1851-1865
Gene expression networks involved in multiple cellular programs coexist in individual hepatocellular cancer cells.
Zhao J, Lu R, Jin C, Li S, Chen Y, Huang Q, Li X, Meng W, Wu H, Wen T, Mo X
Heliyon 2023 Jul;9(7):e18305
Heliyon 2023 Jul;9(7):e18305
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
Bai J, Qian B, Cai T, Chen Y, Li T, Cheng Y, Wu Z, Liu C, Ye M, Du Y, Fu W
Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis.
Sha L, Li J, Shen H, Wang Q, Meng P, Zhang X, Deng Y, Zhu W, Xu Q
Cell reports 2023 Aug 29;42(8):112975
Cell reports 2023 Aug 29;42(8):112975
The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4.
Primke TF, Ingelfinger R, Elewa MAF, Macinkovic I, Weigert A, Fabritius MP, Reichel CA, Ullrich A, Kazmaier U, Burgers LD, Fürst R
Cells 2023 Aug 21;12(16)
Cells 2023 Aug 21;12(16)
Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN.
Zhang Q, Chen L, Gao M, Wang S, Meng L, Guo L
Molecular and cellular biochemistry 2023 Apr;478(4):767-780
Molecular and cellular biochemistry 2023 Apr;478(4):767-780
Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.
Chen T, Zhang X, Ding X, Feng J, Zhang X, Xie D, Wang X
Molecular oncology 2023 Apr;17(4):695-709
Molecular oncology 2023 Apr;17(4):695-709
[High expression of MYH9 inhibits apoptosis of non-small cell lung cancer cells through activating the AKT/c-Myc pathway].
Liu F, Peng L, Xi J
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):527-536
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):527-536
NF-κB and AP-1 are required for the lipopolysaccharide-induced expression of MCP-1, CXCL1, and Cx43 in cultured rat dorsal spinal cord astrocytes.
Lu Y, Li B, Xu A, Liang X, Xu T, Jin H, Xie Y, Wang R, Liu X, Gao X, Han Y, Zeng J
Frontiers in molecular neuroscience 2022;15:859558
Frontiers in molecular neuroscience 2022;15:859558
Integrating network pharmacology and experimental validation to clarify the anti-hyperuricemia mechanism of cortex phellodendri in mice.
Xu L, Cheng J, Lu J, Lin G, Yu Q, Li Y, Chen J, Xie J, Su Z, Zhou Q
Frontiers in pharmacology 2022;13:964593
Frontiers in pharmacology 2022;13:964593
Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease.
Shi Y, Liu Y, Wang S, Huang J, Luo Z, Jiang M, Lu Y, Lin Q, Liu H, Cheng N, You J
Biomaterials 2022 Sep;288:121720
Biomaterials 2022 Sep;288:121720
TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.
Tong Q, Yi M, Kong P, Xu L, Huang W, Niu Y, Gan X, Zhan H, Tian R, Yan D
Cancer cell international 2022 Sep 6;22(1):278
Cancer cell international 2022 Sep 6;22(1):278
RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome.
Xiang R, Liu Y, Fan L, Jiang B, Wang F
Laboratory investigation; a journal of technical methods and pathology 2022 Oct;102(10):1088-1100
Laboratory investigation; a journal of technical methods and pathology 2022 Oct;102(10):1088-1100
Antioxidant and Immunomodulatory Properties of Partially purified Exopolysaccharide from Lactobacillus Casei Isolated from Chinese Northeast Sauerkraut.
Xu X, Qiao Y, Peng Q, Shi B, Dia VP
Immunological investigations 2022 May;51(4):748-765
Immunological investigations 2022 May;51(4):748-765
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Zhao J, Chen S, Yang C, Zhou M, Yang T, Sun B, Zhu J, Zhang H, Lu Q, Li L, Yang Z, Song B, Shen W, Yi S, Dai S
Biochemical pharmacology 2022 Jun;200:115047
Biochemical pharmacology 2022 Jun;200:115047
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.
Wu J, Feng Z, Chen L, Li Y, Bian H, Geng J, Zheng ZH, Fu X, Pei Z, Qin Y, Yang L, Zhao Y, Wang K, Chen R, He Q, Nan G, Jiang X, Chen ZN, Zhu P
Nature communications 2022 Feb 3;13(1):676
Nature communications 2022 Feb 3;13(1):676
Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance.
Rapchak K, Yagobian SD, Moore J, Khattri M, Shuda M
PLoS pathogens 2022 Dec;18(12):e1011039
PLoS pathogens 2022 Dec;18(12):e1011039
Dual Regulation of Tank Binding Kinase 1 by BRG1 in Hepatocytes Contributes to Reactive Oxygen Species Production.
Lv F, Shao T, Xue Y, Miao X, Guo Y, Wang Y, Xu Y
Frontiers in cell and developmental biology 2021;9:745985
Frontiers in cell and developmental biology 2021;9:745985
NAP1L1 Functions as a Tumor Promoter via Recruiting Hepatoma-Derived Growth Factor/c-Jun Signal in Hepatocellular Carcinoma.
Zhang YW, Chen Q, Li B, Li HY, Zhao XK, Xiao YY, Liu S, Zuo S
Frontiers in cell and developmental biology 2021;9:659680
Frontiers in cell and developmental biology 2021;9:659680
Single-Cell Transcriptome Analysis of Chronic Antibody-Mediated Rejection After Renal Transplantation.
Kong F, Ye S, Zhong Z, Zhou X, Zhou W, Liu Z, Lan J, Xiong Y, Ye Q
Frontiers in immunology 2021;12:767618
Frontiers in immunology 2021;12:767618
Angelica Dahurica Regulated the Polarization of Macrophages and Accelerated Wound Healing in Diabetes: A Network Pharmacology Study and In Vivo Experimental Validation.
Hu Y, Lei S, Yan Z, Hu Z, Guo J, Guo H, Sun B, Pan C
Frontiers in pharmacology 2021;12:678713
Frontiers in pharmacology 2021;12:678713
NAP1L1 interacts with hepatoma-derived growth factor to recruit c-Jun inducing breast cancer growth.
Liu S, Zhang Y, Cui S, Song D, Li B, Chen Q, Yao G, Gong B
Cancer cell international 2021 Nov 13;21(1):605
Cancer cell international 2021 Nov 13;21(1):605
Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.
Zhang S, Liu W, Wang P, Hu B, Lv X, Chen S, Wang B, Shao Z
Molecular and cellular biochemistry 2021 May;476(5):1979-1994
Molecular and cellular biochemistry 2021 May;476(5):1979-1994
Targeted regulation of lymphocytic ER stress response with an overall immunosuppression to alleviate allograft rejection.
Shi Y, Lu Y, Zhu C, Luo Z, Li X, Liu Y, Jiang M, Liu X, Luo L, Du Y, You J
Biomaterials 2021 May;272:120757
Biomaterials 2021 May;272:120757
Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway.
Cheng X, Wang J, Liu C, Jiang T, Yang N, Liu D, Zhao H, Xu Z
Journal of experimental & clinical cancer research : CR 2021 Jun 21;40(1):199
Journal of experimental & clinical cancer research : CR 2021 Jun 21;40(1):199
MMP12 is a potential therapeutic target for Adamantinomatous craniopharyngioma: Conclusions from bioinformatics analysis and in vitro experiments.
Li M, Zhou L, Li S, Fang L, Yang L, Wu X, Yang C, Bao Y, Lan S, Tong Z, Zheng S, Tang B, Zeng E, Xie S, Chen C, Hong T
Oncology letters 2021 Jul;22(1):536
Oncology letters 2021 Jul;22(1):536
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Wang X, Chen S, Zhao L, Shi X
International immunopharmacology 2021 Aug;97:107506
International immunopharmacology 2021 Aug;97:107506
Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy.
Wang Z, Wang X, Zhang N, Zhang H, Dai Z, Zhang M, Feng S, Cheng Q
Frontiers in cell and developmental biology 2020;8:795
Frontiers in cell and developmental biology 2020;8:795
LEF1/Id3/HRAS axis promotes the tumorigenesis and progression of esophageal squamous cell carcinoma.
Wang X, Zhao Y, Fei X, Lu Q, Li Y, Yuan Y, Lu C, Li C, Chen H
International journal of biological sciences 2020;16(13):2392-2404
International journal of biological sciences 2020;16(13):2392-2404
Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.
Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J
Nature communications 2020 Nov 19;11(1):5898
Nature communications 2020 Nov 19;11(1):5898
4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice.
Wang H, Wei X, Wei X, Sun X, Huang X, Liang Y, Xu W, Zhu X, Lin X, Lin J
International immunopharmacology 2020 Jun;83:106445
International immunopharmacology 2020 Jun;83:106445
miR-4721, Induced by EBV-miR-BART22, Targets GSK3β to Enhance the Tumorigenic Capacity of NPC through the WNT/β-catenin Pathway.
Tang Z, Chen W, Xu Y, Lin X, Liu X, Li Y, Liu Y, Luo Z, Liu Z, Fang W, Zhao M
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Oncotarget 2016 Aug 16;7(33):53269-53276
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 24909-1-AP( JUN Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The JUN antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human JUN. This antibody recognizes human, hamster antigen. The JUN antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
