ABIN361918

antibody from antibodies-online

Targeting: JUN AP-1, c-Jun

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN361918

Provider

antibodies-online

Product name

anti-Jun Proto-Oncogene (JUN) (pTyr170) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around phosphorylation site of pTyr170 (P-V-Y (p) -A-N) derived from Human c-Jun. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pTyr170

Isotype

IgG

Vial size

100 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

Barilá D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G
The EMBO journal 2000 Jan 17;19(2):273-81

---

The stress-activated protein kinase subfamily of c-Jun kinases.

Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR
Nature 1994 May 12;369(6476):156-60

---

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.

Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ
Cell 1994 Mar 25;76(6):1025-37

---

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain.

Binétruy B, Smeal T, Karin M
Nature 1991 May 9;351(6322):122-7

---

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73.

Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M
Nature 1991 Dec 12;354(6353):494-6