28891-1-AP

antibody from Proteintech Group

Targeting: JUN AP-1, c-Jun

Provider product page for 28891-1-AP

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ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [34]
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Product number: 28891-1-AP - Provider product page
Provider: Proteintech Group
Product name: Phospho-JUN (Ser73) antibody
Antibody type: Polyclonal
Description: Phospho-JUN (Ser73) antibody (Cat. #28891-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 100ul

JUN protein structure - 28891-1-AP shown in red.

Submitted references Pedunculoside ameliorates liver fibrosis by targeting c-Jun to inhibit hepatic stellate cell activation.

Wang A, Dong H, Cui Y, Jin Y, Xiong Y, Jin L, Zhang Q, Zhu W, Ye J, Lin M, Luo W, Liang G, Sun J
International immunopharmacology 2026 Jun 15;179:116602

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation.

Chen H, Huang Z, Chang R, Gao W, Qiu Y, Sun B, Hua C, Lin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e23139

Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration.

Huang Y, Lin W, Chen X, Lin F, Li J, Liu Y, Liu Y, Luo G, Du X, Duan L, Zhan Y, Zhao T
Journal of ethnopharmacology 2026 Apr 25;368:121771

Up-regulation of NGEF via the BRAF(V600E) /ERK/AP1 pathway enhances invasion and migration abilities of BRAF(V600E)-mutant thyroid cancer.

Fu Z, Wang Y, Wang CJ, Yu Z, Chen JQ
Biochemistry and biophysics reports 2025 Sep;43:102164

SP600125 decreases cAMP/PKA-dependent steroid production through ATF4/DDIT3 activation in MA-10 Leydig cells.

Basque A, Izichkis LS, Martin LJ
Molecular and cellular endocrinology 2025 Sep 15;607:112613

Potential Mechanism of Qiju Dihuang Pill in Treating Primary Sjogren's Syndrome Revealed by Network Pharmacology and Experimental Verification.

Wang H, Cheng H, Li M, Zhu X, Wang X
Chemical biology & drug design 2025 Oct;106(4):e70186

Metabolomics and network pharmacology revealing the transdermal moxibustion compounds and their therapeutic mechanisms for rheumatoid arthritis.

Lai J, Lan T, Wang T, Wang D, Yu M, Su Y, Song G, Tseng Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157479

Eravacycline improves the efficacy of anti-PD1 immunotherapy via AP1/CCL5 mediated M1 macrophage polarization in melanoma.

Liu N, Yan M, Lu C, Tao Q, Wu J, Zhou Z, Chen J, Chen X, Peng C
Biomaterials 2025 Mar;314:122815

The Activation of the CCND1 Promoter by AP-1 and SOX Transcription Factors in PC3 Prostate Cancer Cells Can Be Prevented by Anacardic Acid Analogs.

Brunie M, Robichaud MA, Touaibia M, Martin LJ
Cell biochemistry and biophysics 2025 Jun;83(2):2349-2364

CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target.

Zhang C, Zhu X, Gao R, Chen H, Yan C, Liu W, Yang L, Zeng X, Yang H, Liu J, Li Q, Ma D, Zhu T, Chen C
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102555

Sinomenine Ameliorates Liver Fibrosis by Blocking TGF-β/SMAD and c-JUN Signaling.

Du Y, Bai J, Ma T, Wu Z, Wang P, Zhong X, Fu W, He S
Phytotherapy research : PTR 2025 Jul;39(7):3182-3196

Astrocytes-Secreted WNT5B Disrupts the Blood-Brain Barrier Via ROR1/JNK/c-JUN Cascade During Meningitic Escherichia Coli Infection.

Qu X, Yang R, Tan C, Chen H, Wang X
Molecular neurobiology 2025 Jan;62(1):661-673

GRPEL2 Modulates Apoptosis in Esophageal Squamous Cell Carcinoma via the JNK Signaling Pathway.

Wen L, Pang J, Yao J, Zhang R, Zhao C, Tang J, Yang C, Liu Q, Ma J, Zhang M, Mu B
Molecular carcinogenesis 2025 Aug;64(8):1347-1361

Lactiplantibacillus plantarum promotes lactoferrin synthesis and secretion in bovine mammary epithelial cells through STAT3 and AP-1 transcription factor pathways.

Zhou J, Lian S, Geng Z, Yang Y, Wu R, Wang J
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):886-897

CREB1 promotes cholangiocarcinoma metastasis through transcriptional regulation of the LAYN-mediated TLN1/β1 integrin axis: CREB1 promotes cholangiocarcinoma metastasis through regulating LAYN/TLN1/β1 integrin axis.

Liang S, Zhou S, Tang Y, Xiao M, Ye K
Heliyon 2024 Sep 15;10(17):e36595

Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress.

Shen Z, Wang J, Chen Y, Fang P, Yuan A, Chen AF, Yan X, Lyu Y, Pu J
Redox biology 2024 Nov;77:103397

Protective Effects and Mechanisms of Esculetin against H(2)O(2)-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells.

Luo Y, Chang T, Huang S, Xiang J, Tang S, Shen H
Molecules (Basel, Switzerland) 2024 Mar 22;29(7)

SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma.

Hu Q, Liu Z, Liu Y, Qiu J, Zhang X, Sun J, Zhang B, Shi H
Journal of cellular and molecular medicine 2024 Jun;28(11):e18484

Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo.

Zhang Y, Yang N, Li Y, Tan C, Cai Y, Rui X, Liu Y, Fu Y, Liu G
Journal of virology 2024 Jun 13;98(6):e0046124

Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy.

Li D, Dai D, Wang J, Zhang C
Small (Weinheim an der Bergstrasse, Germany) 2024 Dec;20(50):e2403907

TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.

Meng Z, Wang Y, Wang X, Han X
Archives of oral biology 2024 Aug;164:105977

FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.

Yin Z, Guo X, Liang X, Wang Z
Medical oncology (Northwood, London, England) 2024 Apr 20;41(5):120

Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.

Zhao Z, Li Y, Guo S, Chen Y, Yin H, Li Y, Cheng G, Tian L
International journal of molecular sciences 2023 Sep 25;24(19)

SALL1 promotes proliferation and metastasis and activates phosphorylation of p65 and JUN in colorectal cancer cells.

Yuan J, Li G, Zhong F, Liao J, Zeng Z, Ouyang S, Xie H, Deng Z, Tang H, Ou X
Pathology, research and practice 2023 Oct;250:154827

JNK regulates ciliogenesis through the interflagellar transport complex and actin networks.

Chatzifrangkeskou M, Kouis P, Skourides PA
The Journal of cell biology 2023 Nov 6;222(11)

Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.

Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738

PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.

Cheng M, Cao H, Yao P, Guan J, Wu P, Ji H, Jiang S, Yuan Y, Fu L, Zheng Q, Li Q
Cell death & disease 2023 Aug 25;14(8):558

Integrating network pharmacology and experimental validation to clarify the anti-hyperuricemia mechanism of cortex phellodendri in mice.

Xu L, Cheng J, Lu J, Lin G, Yu Q, Li Y, Chen J, Xie J, Su Z, Zhou Q
Frontiers in pharmacology 2022;13:964593

Downregulation of exosomal miR-7-5p promotes breast cancer migration and invasion by targeting RYK and participating in the atypical WNT signalling pathway.

Liang Z, Liu L, Gao R, Che C, Yang G
Cellular & molecular biology letters 2022 Oct 9;27(1):88

Usp8 promotes tumor cell migration through activating the JNK pathway.

Zhao Y, Peng D, Liu Y, Zhang Q, Liu B, Deng Y, Ding W, Zhou Z, Liu Q
Cell death & disease 2022 Mar 31;13(3):286

Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.

Zhao J, Chen S, Yang C, Zhou M, Yang T, Sun B, Zhu J, Zhang H, Lu Q, Li L, Yang Z, Song B, Shen W, Yi S, Dai S
Biochemical pharmacology 2022 Jun;200:115047

Enterococcus faecium HDRsEf1 inhibits Lipopolysaccharide-induced downregulation of zona occludens -1 expression via toll-like receptor 2/4-mediated c-Jun N-terminal kinase/activator protein-1 signalling pathways.

Liu L, Li Y, He Y, Wang Z, Zhao H, Jin X, Shi D, Wang X
Journal of applied microbiology 2022 Jan;132(1):605-617

RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.

Zhang D, Jiang Q, Ge X, Shi Y, Ye T, Mi Y, Xie T, Li Q, Ye Q
International journal of biological sciences 2021;17(10):2622-2632

Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.

Tong X, Zhang S, Wang D, Zhang L, Huang J, Zhang T, Fan H
Frontiers in pharmacology 2021;12:709819

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