55082-1-AP

antibody from Proteintech Group

Targeting: MT-CO3 CO3, COIII, COX3, MTCO3

Provider product page for 55082-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [27]
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Product number: 55082-1-AP - Provider product page
Provider: Proteintech Group
Product name: MTCO3 antibody
Antibody type: Polyclonal
Description: MTCO3 antibody (Cat. #55082-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MT-CO3 protein structure - 55082-1-AP shown in red.

Submitted references Suppressive Genetic Interactions Between Haploinsufficient Mitochondrial Genes Encoded in the 22q11.2 Microdeletion Locus Define Brain and Cardiac Phenotypes.

Wynne M, Zlatic SA, Park AS, Crocker A, Mendez-Vazquez H, Liporace E, Gokhale A, Tower-Gilchrist C, Robinette M, Purcell RH, Bassell GJ, Werner E, Kwong JQ, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 9;

Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer.

Zhou L, Bao F, Zheng J, Ding Y, Xiao J, Zhang J, Qin Y, Yang L, Wu Y, Meng Q, Lu M, Long Q, Hu L, Li C, Wang H, Huang S, Li L, Wang J, Wang W, Lu G, Chan WY, Qin D, Chen G, Liu X
Molecular psychiatry 2025 Oct;30(10):4749-4763

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism-Dependent and -Independent Mechanisms.

Ji X, Zhang W, Xue F, Zeng J, Zhao Q, Sun X, Sun J, Zhou H, Xu Q, Ma G, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e07533

Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.

Fu XX, Wei B, Huang ZH, Duan R, Deng Y, E Y, Wang SY, Chen SY, Zhang YD, Jiang T
Journal of Alzheimer's disease : JAD 2025 Mar;104(1):209-220

Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis.

Cheng M, Lu D, Li K, Wang Y, Tong X, Qi X, Yan C, Ji K, Wang J, Wang W, Lv H, Zhang X, Kong W, Zhang J, Ma J, Li K, Wang Y, Feng J, Wei P, Li Q, Shen C, Fu XD, Ma Y, Zhang X
Nature neuroscience 2025 Apr;28(4):748-756

Temporal expression of mitochondrial life cycle markers during acute and chronic overload of rat plantaris muscles.

Hyatt JK, Lu EJ, McCall GE
Frontiers in physiology 2024;15:1420276

Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.

Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9

Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity.

Tong L, Chen Z, Li Y, Wang X, Yang C, Li Y, Zhu Y, Lu Y, Liu Q, Xu N, Shao S, Wu L, Zhang P, Wu G, Wu X, Chen X, Fang J, Jia R, Xu T, Li B, Zheng L, Liu J, Tong X
Cell metabolism 2024 May 7;36(5):1013-1029.e5

Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage.

Luo Y, Fujiwara-Tani R, Kawahara I, Goto K, Nukaga S, Nishida R, Nakashima C, Sasaki T, Miyagawa Y, Ogata R, Fujii K, Ohmori H, Kuniyasu H
International journal of molecular sciences 2024 Jun 27;25(13)

Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.

Lin Y, Wang D, Li B, Wang J, Xu L, Sun X, Ji K, Yan C, Liu F, Zhao Y
JCI insight 2024 Jun 25;9(15)

Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis.

Xu J, Shi C, Yuan F, Ding Y, Xie Y, Liu Y, Zhu F, Lu H, Duan C, Hu J, Jiang L
Bioactive materials 2024 Feb;32:427-444

Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.

He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883

Drosophila MIC10b can polymerize into cristae-shaping filaments.

Stephan T, Stoldt S, Barbot M, Carney TD, Lange F, Bates M, Bou Dib P, Inamdar K, Shcherbata HR, Meinecke M, Riedel D, Dennerlein S, Rehling P, Jakobs S
Life science alliance 2024 Apr;7(4)

Expanding DdCBE-mediated targeting scope to aC motif preference in rat.

Qi X, Tan L, Zhang X, Jin J, Kong W, Chen W, Wang J, Dong W, Gao L, Luo L, Lu D, Gong J, Guan F, Shu W, Huang X, Zhang L, Wang S, Shen B, Ma Y
Molecular therapy. Nucleic acids 2023 Jun 13;32:1-12

Dynamic mapping of proteome trafficking within and between living cells by TransitID.

Qin W, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
Cell 2023 Jul 20;186(15):3307-3324.e30

Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival.

Yang J, Chen Y, Zou T, Xue B, Yang F, Wang X, Huo Y, Yan B, Xu Y, He S, Yin Y, Wang J, Zhu X, Zhang L, Zhou Y, Tai Z, Shuai P, Yu M, Luo Q, Cheng Y, Gong B, Zhu X, Zhang J, Sun X, Lin Y, Zhang H, Yang Z
Science China. Life sciences 2023 Feb;66(2):211-225

Dynamic mapping of proteome trafficking within and between living cells by TransitID.

Xu WQ, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
bioRxiv : the preprint server for biology 2023 Feb 8;

Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells.

Baleva MV, Piunova U, Chicherin I, Vasilev R, Levitskii S, Kamenski P
International journal of molecular sciences 2023 Dec 20;25(1)

Pentatricopeptide Protein PTCD2 Regulates COIII Translation in Mitochondria of the HeLa Cell Line.

Baleva MV, Chicherin I, Piunova U, Zgoda V, Patrushev MV, Levitskii S, Kamenski P
International journal of molecular sciences 2022 Nov 17;23(22)

Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.

Averina OA, Laptev IG, Emelianova MA, Permyakov OA, Mariasina SS, Nikiforova AI, Manskikh VN, Grigorieva OO, Bolikhova AK, Kalabin GA, Dontsova OA, Sergiev PV
International journal of molecular sciences 2022 May 27;23(11)

DNA methylation at hepatitis B virus integrants and flanking host mitochondrially encoded cytochrome C oxidase III.

Oikawa R, Watanabe Y, Yotsuyanagi H, Yamamoto H, Itoh F
Oncology letters 2022 Dec;24(6):424

A novel nonsense variant in MT-CO3 causes MELAS syndrome.

Wang W, Sun Y, Lin Y, Xu X, Zhao D, Ji K, Li W, Zhao Y, Yan C
Neuromuscular disorders : NMD 2021 Jun;31(6):558-565

Active RNA interference in mitochondria.

Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X
Cell research 2021 Feb;31(2):219-228

Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts.

Xiao Y, Wang M, He Q, Xu L, Zhang Q, Meng F, Jia Z, Zhang F, Wang H, Guan MX
Nucleic acids research 2020 Nov 4;48(19):11113-11129

Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.

Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X
Diabetes 2020 Jul;69(7):1355-1367

Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.

Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849

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