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- Antibody Data
- Antigen structure
- References [216]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 12208-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12208-1-AP, RRID:AB_2245417
- Product name
- CREB1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CREB1 antibody (Cat. #12208-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Effect of ALA on preventing diabetic peripheral neuropathy in rats through mitochondrial axonal transport.
Targeting CAMK1D-engineered nanoactivator suppresses cancer stem cell maintenance and immune evasion in enzalutamide-resistant prostate cancer.
ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation.
Epimedium brevicornum Maxim and Ligustrum lucidum Ait enhance glucocorticoid-associated anti-inflammatory effects in asthma via the cAMP/PKA/CREB signaling pathway.
White-to-brown adipose switching promotes bladder cancer progression.
The adenylyl cyclase activator forskolin pretreatment reprograms CAR-T cells toward a stem-like state to enhance solid tumor therapy.
Guaiane-type sesquiterpenoids from patchouli oil and their potential anti-depressive effects.
UBE2K promotes breast cancer growth by ubiquitinating and degrading STUB1 to regulate the PKA/CREB1 signaling pathway, forming a feedback loop.
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated mitophagy.
TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma.
Integrating neurotrophic and anti-inflammatory pathways: press-needle acupuncture as a multi-target therapy for adolescent depression.
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Investigating the therapeutic potential of naringin in MK-801-induced schizophrenia model: focus on cognitive impairment and miR-25-3p-regulated pathways.
Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells.
Mechanistic study on Kai Xin San's regulation of DARPP-32 phosphorylation in anti-depressant effects based on multi-omics.
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway.
Mechanism of Atractylodis Rhizoma in improving cognitive dysfunction in Alzheimer's disease by regulating the cAMP/CREB/BDNF pathway.
KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress.
Effects of Short-Term Exposure to Polystyrene Nanoplastics on the Nervous System: Calcium Homeostasis, BDNF and Synaptic Plasticity.
Identification of monomethylsulochrin as a novel agent to ameliorate DSS-induced ulcerative colitis through dual modulation of the IL-17/TNF pathway and gut microbiota.
lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis.
Wheat grain moxibustion ameliorates oxidative stress in PTU-induced hypothyroid rats via cAMP/PKA pathway activation.
Histone lactylation-driven B7-H3 expression promotes tumor immune evasion.
Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons.
Insufficient S-sulfhydration of cAMP-response element binding protein 1 participates in hyperhomocysteinemia or cisplatin induced kidney fibrosis via promoting epithelial-mesenchymal transition.
Bisphenol AF exposure induced synaptic plasticity and neurobehavioral impairments via triggering the ROS-mediated PERK-eIF2α-ATF4 signaling pathway in adolescent mice.
The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior.
Biomimetic ferritin nanocages for synergistic co-delivery of metformin and rapamycin restore neurodevelopmental homeostasis in autism spectrum disorders.
Inhibition of spreading depolarizations by targeting GABA(A) receptors and voltage-gated sodium channels improves neurological deficits in rats with traumatic brain injury.
DST-3, a novel cryptotanshinone derivate, attenuates glutamate excitotoxicity after ischemic stroke via CREB-Homer1 axis activation.
HCAR2 inhibits prostate cancer invasion and metastasis by regulating cAMP signaling pathway.
DHYZ modulates hippocampal cholinergic pathway acetylation to ameliorate cognitive deficits post-ischemic stroke in rats.
Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.
Lactoferrin ameliorates cognitive impairment in D-galactose-induced aging mice by regulating the PI3K/Akt/mTOR signaling pathway and the microbiome-gut-brain axis.
INSL3 promotes macrophage polarization to an immunosuppressive phenotype via the cAMP downstream signaling pathway and Akt/mTOR pathway.
RAF1 in AgRP neurons involved in the regulation of energy metabolism via the MAPK signaling pathway.
MiR-134-5p/BDNF/TrkB/CREB signaling pathway involved in the depression-like behaviors in mice following exposure to benzo[a]pyrene.
LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis.
Esketamine mitigates endotoxin-induced hippocampal injury by regulating calcium transient and synaptic plasticity via the NF-α1/CREB pathway.
BCL6 Promotes Transcription of GPR61 to Suppress IL-1β-Induced Osteoarthritis Progression in C28/I2 Cells.
The sperm quality in DIO male mice is linked to the NF-κB signaling and Ppp2ca expression in the hypothalamus.
F-box protein FBXO21 overexpression inhibits the proliferation and metastasis of clear cell renal cell carcinoma and is closely related to the CREB pathway and tumor immune cell infiltration.
Polygonati Rhizoma Prevents Glucocorticoid-Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid.
GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice.
Effects of early-life F-53B exposure on thyroid function in juvenile rats: The role of the cAMP signaling pathway.
Piezo1 senses hyphae and initiates host defense against pathogenic fungi.
Aspirin Suppresses Aromatase-Mediated Estrogen Biosynthesis to Alleviate Polycystic Ovary Syndrome by the Inhibition of Adenylate Cyclase.
Thioredoxin-1 Downregulation in the SNpc Exacerbates the Cognitive Impairment Induced by MPTP.
Peiyuan Ningshen-ointment alleviates learning and memory impairment induced by sleep deprivation through activating the cAMP/PKA signaling pathway.
Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD(+)/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration.
Multi-omics study reveals gut microbiota dysbiosis and tryptophan metabolism alterations in GH-PitNET progression.
In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling.
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression.
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway.
Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice.
TRPM2 deficiency contributes to M2b macrophage polarization via the PI3K/AKT/CREB pathway in murine sepsis.
GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells.
Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells.
Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice.
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway.
1-NP hijacks endocrine-metabolic checkpoints and disrupts testicular steroidogenesis by suppressing the cAMP-PKA-CREB-HMGCR axis.
m1A methylation-mediated upregulation of RILsPL1 promotes colorectal cancer progression via the CaMKII/CREB signaling pathway.
Breast cancer cell-derived adrenomedullin confers cancer-associated adipose remodeling through the cAMP/Creb1/Zeb1 axis.
Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction.
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia.
Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility.
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.
Low-intensity millimeter waves ameliorate cognitive impairment induced by chronic REM sleep deprivation in rats by regulating CaMKII-CREB-BDNF pathway.
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.
PINK1-deficiency facilitates mitochondrial iron accumulation and colon tumorigenesis.
Estrogen Inhibits the Phenotypic Switching of Vascular Smooth Muscle Cells through ER-α/CREB in Aortic Dissection.
Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.
Administration of Liposomal-Based Pde3b Gene Therapy Protects Mice Against Collagen-Induced Rheumatoid Arthritis via Modulating Macrophage Polarization.
The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2.
Rice Protein Peptides Ameliorate DSS-Induced Cognitive Impairment and Depressive Behavior in Mice by Modulating Phenylalanine Metabolism and the BDNF/TRKB/CREB Pathway.
Tanshinone IIA promotes osteogenic differentiation potential and suppresses adipogenic differentiation potential of bone marrow mesenchymal stem cells.
GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease.
Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer.
Yeast Extract Peptides Alleviate Depression in Chronic Restraint Stress Rats by Alleviating Hippocampal Neuronal Apoptosis and Dysbiosis of the Gut Microbiota.
MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury.
Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F-53B Exposure: The Role of PKA Cytoplasmic Retention.
Neuroprotective effects of polyphyllin VI against rotenone-induced toxicity in SH-SY5Y cells.
The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl(4)-caused murine liver fibrosis in vivo.
Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
Maresin 1 Activates LGR6 to Alleviate Neuroinflammation via the CREB/JMJD3/IRF4 Pathway in a Rat Model of Subarachnoid Hemorrhage.
Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.
Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis.
BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin†.
Achyranthes bidentata polysaccharide ameliorates type 2 diabetes mellitus by gut microbiota-derived short-chain fatty acids-induced activation of the GLP-1/GLP-1R/cAMP/PKA/CREB/INS pathway.
CREB1 Silencing Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis Through Reducing RPL9 Expression and Blocking NF-κB Signaling.
Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice.
Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Osr2 functions as a biomechanical checkpoint to aggravate CD8(+) T cell exhaustion in tumor.
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress.
Molecular mechanism of Chang Shen Hua volatile oil modulating brain cAMP-PKA-CREB pathway to improve depression-like behavior in rats.
Disorder of neuroplasticity aggravates cognitive impairment via neuroinflammation associated with intestinal flora dysbiosis in chronic heart failure.
CENPN suppresses autophagy and increases paclitaxel resistance in nasopharyngeal carcinoma cells by inhibiting the CREB-VAMP8 signaling axis.
RNA-binding protein YBX3 promotes PPARγ-SLC3A2 mediated BCAA metabolism fueling brown adipogenesis and thermogenesis.
GR/P300 Regulates MKP1 Signaling Pathway and Mediates Depression-like Behavior in Prenatally Stressed Offspring.
Puerarin alleviates symptoms of preeclampsia through the repression of trophoblast ferroptosis via the CREB/HO-1 pathway.
Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway.
LncRNA-MSTRG.19083.1 Targets NTRK2 as a miR-429-y Sponge to Regulate Circadian Rhythm via the cAMP Pathway in Yak Testis and Cryptorchidism.
Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke.
A functional variant rs10409772 in FUT6 promoter regulates colorectal cancer progression through PKA/CREB signaling.
Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.
Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway.
A(2A)R regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration.
Electroacupuncture negatively regulates the Nesfatin-1/ERK/CREB pathway to alleviate HPA axis hyperactivity and anxiety-like behaviors caused by surgical trauma.
miR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring.
Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway.
The prenatal use of agmatine prevents social behavior deficits in VPA-exposed mice by activating the ERK/CREB/BDNF signaling pathway.
The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway.
A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.
Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression.
The SIK1/CRTC2/CREB1 and TWIST1/PI3K/Akt/GSK3β signaling pathways mediated by microRNA-25-3p are altered in the schizophrenic rat brain.
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity.
Lactate modulates iron metabolism by binding soluble adenylyl cyclase.
Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice.
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Long non-coding RNA PFI inhibits apoptosis of alveolar epithelial cells to alleviate lung injury via miR-328-3p/Creb1 axis.
The crucial role that hippocampus Cyclooxygenase-2 plays in memory.
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain.
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.
TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation.
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation.
Norepinephrine/β(2)-Adrenergic Receptor Pathway Promotes the Cell Proliferation and Nerve Growth Factor Production in Triple-Negative Breast Cancer.
LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation.
ZNRF2 as an oncogene is transcriptionally regulated by CREB1 in breast cancer models.
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway.
Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms.
Bisphenol A and Di(2-Ethylhexyl) Phthalate promote pulmonary carcinoma in female rats via estrogen receptor beta: In vivo and in silico analysis.
Dysfunctional microRNA-144-3p/ZBTB20/ERK/CREB1 signalling pathway is associated with MK-801-induced schizophrenia-like abnormalities.
Upregulated GPRC5A disrupting the Hippo pathway promotes the proliferation and migration of pancreatic cancer cells via the cAMP-CREB axis.
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus.
Mailuoning oral liquid attenuates convalescent cerebral ischemia by inhibiting AMPK/mTOR-associated apoptosis and promoting CREB/BDNF-mediated neuroprotection.
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Benzene, 1,2,4-Trimethoxy-5-(2-Methyl-1-Propen-1-yl) Attenuates D-galactose/AlCl(3)-induced Cognitive Impairment by Inhibiting Inflammation, Apoptosis, and improving Expression of Memory-Related Proteins.
Nitration of cAMP-Response Element Binding Protein Participates in Myocardial Infarction-Induced Myocardial Fibrosis via Accelerating Transcription of Col1a2 and Cxcl12.
The asymmetrical ESR1 signaling in muscle progenitor cells determines the progression of adolescent idiopathic scoliosis.
Cadmium-induced Sertoli Cell Injury Through p38-MAPK and Related Signaling Proteins-A Study by RNA Sequencing.
Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway.
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.
Parathyroid hormone alleviates non-alcoholic liver steatosis via activating the hepatic cAMP/PKA/CREB pathway.
Nrf2 Overexpression Decreases Vincristine Chemotherapy Sensitivity Through the PI3K-AKT Pathway in Adult B-Cell Acute Lymphoblastic Leukemia.
Upregulation of Neogenin-1 by a CREB1-BAF47 Complex in Vascular Endothelial Cells is Implicated in Atherogenesis.
Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats.
A 3D-printed molybdenum-containing scaffold exerts dual pro-osteogenic and anti-osteoclastogenic effects to facilitate alveolar bone repair.
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice.
Single-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors.
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Upregulation of Periostin Through CREB Participates in Myocardial Infarction-induced Myocardial Fibrosis.
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.
Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration.
CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.
A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway.
Metabotropic glutamate receptor 5 upregulation of γ-aminobutyric acid transporter 3 expression ameliorates cognitive impairment after traumatic brain injury in mice.
The role and mechanism of TLR4-siRNA in the impairment of learning and memory in young mice induced by isoflurane.
The BDNF-TrkB-CREB Signalling Pathway Is Involved in Bisphenol S-Induced Neurotoxicity in Male Mice by Regulating Methylation.
Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment.
WT1 suppresses follicle-stimulating hormone-induced progesterone secretion by regulating ERK1/2 pathway in chicken preovulatory granulosa cells.
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel K(Ca)3.1 in THP-1-Derived M(2) Macrophages.
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
m6A Modification-Mediated DUXAP8 Regulation of Malignant Phenotype and Chemotherapy Resistance of Hepatocellular Carcinoma Through miR-584-5p/MAPK1/ERK Pathway Axis.
CREB Ameliorates Osteoarthritis Progression Through Regulating Chondrocytes Autophagy via the miR-373/METTL3/TFEB Axis.
CREB1 and ATF1 Negatively Regulate Glutathione Biosynthesis Sensitizing Cells to Oxidative Stress.
LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation.
GluN2A/ERK/CREB Signaling Pathway Involved in Electroacupuncture Regulating Hypothalamic-Pituitary-Adrenal Axis Hyperactivity.
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.
KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.
Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells.
Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.
A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.
Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT(1A) receptor: Insights from transcriptomics.
Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic facto by mediating synaptic transmission.
Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons.
mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.
Duzhong Butiansu Prescription Improves Heat Stress-Induced Spermatogenic Dysfunction by Regulating Sperm Formation and Heat Stress Pathway.
LncRNA BLACAT1/miR-519d-3p/CREB1 Axis Mediates Proliferation, Apoptosis, Migration, Invasion, and Drug-Resistance in Colorectal Cancer Progression.
Homer1a Undergoes Bimodal Transcriptional Regulation by CREB and the Circadian Clock.
Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge.
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.
LncRNA MALAT1 inhibits apoptosis of endometrial stromal cells through miR-126-5p-CREB1 axis by activating PI3K-AKT pathway.
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.
PTEN participates in airway remodeling of asthma by regulating CD38/Ca(2+)/CREB signaling.
The potential role of Krüppel-like factor 13 (Aj-klf13) in the intestine regeneration of sea cucumber Apostichopus japonicus.
MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways.
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma.
Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway.
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS(2) nanoflowers.
Calretinin Participates in Regulating Steroidogenesis by PLC-Ca(2+)-PKC Pathway in Leydig Cells.
Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis.
Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus.
Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.
A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1-42)-Induced Rat Model of Alzheimer's Disease.
Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.
Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage Amyloid Precursor Protein/Presenilin 1 Mice.
LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p.
BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density during LTP via a Rab11-dependent pathway.
Tian J, An J, Song L, Zhang W, Chen D, Zhang T, Ben Y
PloS one 2026;21(4):e0346297
PloS one 2026;21(4):e0346297
Targeting CAMK1D-engineered nanoactivator suppresses cancer stem cell maintenance and immune evasion in enzalutamide-resistant prostate cancer.
Sun F, Yan Y, Sun D, Liu S, Dong Z, Pan G, Zhang L, Shao X, Xu Y, Qu Y, Li T
Theranostics 2026;16(6):2918-2935
Theranostics 2026;16(6):2918-2935
ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation.
Yuan Y, Li J, Rao D, Lu X, Chen M, Chen X, Long X, Zhang B, Liang H, Chen Q, Zhao J
Gut 2026 May 12;75(6):1186-1200
Gut 2026 May 12;75(6):1186-1200
Epimedium brevicornum Maxim and Ligustrum lucidum Ait enhance glucocorticoid-associated anti-inflammatory effects in asthma via the cAMP/PKA/CREB signaling pathway.
Ma Z, Zhao Z, Liu R, Xie Y, Ma Z, Li Y, Long Y, Tang X
Journal of ethnopharmacology 2026 May 10;362:121259
Journal of ethnopharmacology 2026 May 10;362:121259
White-to-brown adipose switching promotes bladder cancer progression.
Gao M, Li C, Li W, Xie J, Long J, Luo M, Hu J, Lai C, Lan T, Zhu D, Zhong W, He W
Neoplasia (New York, N.Y.) 2026 Mar;73:101282
Neoplasia (New York, N.Y.) 2026 Mar;73:101282
The adenylyl cyclase activator forskolin pretreatment reprograms CAR-T cells toward a stem-like state to enhance solid tumor therapy.
Hong J, Zhou M, Xu S, Wang Z, Liu Y, Li X, Xu L, Chen W, Hu J, Xu S, Pan F, Guo Z
International journal of biological macromolecules 2026 Mar;350:150949
International journal of biological macromolecules 2026 Mar;350:150949
Guaiane-type sesquiterpenoids from patchouli oil and their potential anti-depressive effects.
Zheng Q, Zhu H, Yang HP, Peng C, Wu GX, Zhou QM, Xiong L
Phytochemistry 2026 Mar;243:114738
Phytochemistry 2026 Mar;243:114738
UBE2K promotes breast cancer growth by ubiquitinating and degrading STUB1 to regulate the PKA/CREB1 signaling pathway, forming a feedback loop.
Mou J, Tang H, Hu X, Yang Z, Su H, Qian D, Li C, Liu H, Ye Z, Xu M, Liu S, Zheng Q, Liu X, Zeng X, Xu Q, Meng X
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168145
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168145
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated mitophagy.
Fang Y, Deng M, Huang K, Song H, Chu Y, Wei H, Chen D, Yang Y, Han C, Yuan H
Cell communication and signaling : CCS 2026 Mar 28;24(1)
Cell communication and signaling : CCS 2026 Mar 28;24(1)
TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma.
Guan B, Tang H, Yuan Z, Yao J, Cui D, Hao Z, Li X
Cellular and molecular life sciences : CMLS 2026 Mar 21;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 21;83(1)
Integrating neurotrophic and anti-inflammatory pathways: press-needle acupuncture as a multi-target therapy for adolescent depression.
Zhang H, Rong Y, Ning R, Yan Z, Zhao Y, Chen Y
The International journal of neuroscience 2026 Mar 12;:1-16
The International journal of neuroscience 2026 Mar 12;:1-16
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Fan D, Zhong Y, Dong Y, Du M, Huang K, Li X
Journal of advanced research 2026 Jan;79:661-677
Journal of advanced research 2026 Jan;79:661-677
Investigating the therapeutic potential of naringin in MK-801-induced schizophrenia model: focus on cognitive impairment and miR-25-3p-regulated pathways.
Pu Y, Xu Y, Zhuo Z, Xiao H, Xu X
The International journal of neuroscience 2026 Jan;136(1):109-122
The International journal of neuroscience 2026 Jan;136(1):109-122
Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells.
Yang F, Liang P, Guo H, Yan W, Wang G, Tang X, Liang Z
International journal of immunopathology and pharmacology 2026 Jan-Dec;40:3946320261427239
International journal of immunopathology and pharmacology 2026 Jan-Dec;40:3946320261427239
Mechanistic study on Kai Xin San's regulation of DARPP-32 phosphorylation in anti-depressant effects based on multi-omics.
Shan M, Xu L, Dong J, Zhang X, Fang X, Luo H
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120746
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120746
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway.
Yin H, Han X, Zhang Q, Li D, Wang F
European journal of histochemistry : EJH 2026 Jan 26;70(1)
European journal of histochemistry : EJH 2026 Jan 26;70(1)
Mechanism of Atractylodis Rhizoma in improving cognitive dysfunction in Alzheimer's disease by regulating the cAMP/CREB/BDNF pathway.
Xu X, Zhao Y, Ma H, Hu Y, Yu L, Su Y, Song J, Xie Z, Zhang Z, Wang P
International immunopharmacology 2026 Jan 1;168(Pt 2):115923
International immunopharmacology 2026 Jan 1;168(Pt 2):115923
KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress.
Liang M, Zhang M, Hou Y, Yuan F, Zhang H, Zhao M, Xu L, Liu Q, Su Y, Chu X, Li W, Wang J, Xie J, Wang C, Cui Q, Zhang J
Journal of lipid research 2026 Feb;67(2):100981
Journal of lipid research 2026 Feb;67(2):100981
Effects of Short-Term Exposure to Polystyrene Nanoplastics on the Nervous System: Calcium Homeostasis, BDNF and Synaptic Plasticity.
Zhao Y, Yan L, Wei Y, Ma J, Chen J, Liu X, Mi Y, Wang B, Zhang L, Tian L, Lin B
Toxics 2026 Feb 17;14(2)
Toxics 2026 Feb 17;14(2)
Identification of monomethylsulochrin as a novel agent to ameliorate DSS-induced ulcerative colitis through dual modulation of the IL-17/TNF pathway and gut microbiota.
Xing S, Cheng X, Hou S, Qin L, Wang J, Ding Y, Shen Z, Dai Z, Huang X, Liu Y, Zhu D
International immunopharmacology 2026 Apr 15;175:116451
International immunopharmacology 2026 Apr 15;175:116451
lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis.
Cheng Z, Hua Y, Cao Y, Qin J
Oncology research 2025;33(1):185-198
Oncology research 2025;33(1):185-198
Wheat grain moxibustion ameliorates oxidative stress in PTU-induced hypothyroid rats via cAMP/PKA pathway activation.
Qin J, Liu T, Zhang X, Chen X, Qin J, Aslam MS, Feng H, Zhang Y, Wang X, Zhang T, Hao C
Frontiers in endocrinology 2025;16:1612008
Frontiers in endocrinology 2025;16:1612008
Histone lactylation-driven B7-H3 expression promotes tumor immune evasion.
Ma Z, Yang J, Jia W, Li L, Li Y, Hu J, Luo W, Li R, Ye D, Lan P
Theranostics 2025;15(6):2338-2359
Theranostics 2025;15(6):2338-2359
Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons.
Li T, Shen F, Li L, Chen P, Zhu Z, Zheng Y, Li H, Suo G, Wang Y, Shi J, Wu Y
CNS neuroscience & therapeutics 2025 Sep;31(9):e70618
CNS neuroscience & therapeutics 2025 Sep;31(9):e70618
Insufficient S-sulfhydration of cAMP-response element binding protein 1 participates in hyperhomocysteinemia or cisplatin induced kidney fibrosis via promoting epithelial-mesenchymal transition.
Chen S, Xue K, Zhao R, Chai J, Zhu X, Kong X, Ding Y, Xu L, Wang W
Free radical biology & medicine 2025 Sep;237:312-325
Free radical biology & medicine 2025 Sep;237:312-325
Bisphenol AF exposure induced synaptic plasticity and neurobehavioral impairments via triggering the ROS-mediated PERK-eIF2α-ATF4 signaling pathway in adolescent mice.
Zhang C, Sun S, Lei LM, Jiang TT, Mao HY, Chen C, Di DS, Mei JY, Cao JY, Wan YH, Hao JH
Ecotoxicology and environmental safety 2025 Sep 15;303:118846
Ecotoxicology and environmental safety 2025 Sep 15;303:118846
The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior.
Wang XL, Ji YB, Li SX, Serchov T
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2025 Oct;50(11):1683-1694
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2025 Oct;50(11):1683-1694
Biomimetic ferritin nanocages for synergistic co-delivery of metformin and rapamycin restore neurodevelopmental homeostasis in autism spectrum disorders.
Shen Y, Yu L, Wang L, Jin J, Yu C, Fan Y, Lang Y, Xu H, Jones BC, Liu Y, Wu J, Gao S, Chen F, Feng S
Journal of nanobiotechnology 2025 Oct 14;23(1):670
Journal of nanobiotechnology 2025 Oct 14;23(1):670
Inhibition of spreading depolarizations by targeting GABA(A) receptors and voltage-gated sodium channels improves neurological deficits in rats with traumatic brain injury.
Yan R, Liu Q, Zhang D, Li K, Li Y, Nie Y, Zhang Y, Li P, Mao S, Li H
British journal of pharmacology 2025 Nov;182(21):5247-5268
British journal of pharmacology 2025 Nov;182(21):5247-5268
DST-3, a novel cryptotanshinone derivate, attenuates glutamate excitotoxicity after ischemic stroke via CREB-Homer1 axis activation.
Dai Y, Yu J, He G, Liang M, Wen YZ, Guan R, Ye X, Guo Y, Lu J, Chen J, Liu P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157223
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157223
HCAR2 inhibits prostate cancer invasion and metastasis by regulating cAMP signaling pathway.
Li Y, Chen H, Huang R
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2025 Nov 28;:10815589251406272
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2025 Nov 28;:10815589251406272
DHYZ modulates hippocampal cholinergic pathway acetylation to ameliorate cognitive deficits post-ischemic stroke in rats.
Liu Z, Shi X, Xu X, Hu Y, Wen Y, Wang X, Ye L, Gong J
Brain research 2025 Nov 1;1866:149926
Brain research 2025 Nov 1;1866:149926
Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.
Sun Y, Wang J, Ding W, Qin Q, Wang R, Yu R, Yan J, Hou R, Liu G, Cai X, Qu Z, Zhang W, Yu J, Xing C, Zhuang C
Redox biology 2025 May;82:103620
Redox biology 2025 May;82:103620
Lactoferrin ameliorates cognitive impairment in D-galactose-induced aging mice by regulating the PI3K/Akt/mTOR signaling pathway and the microbiome-gut-brain axis.
Wang M, Wang Y, Wang X, Qiu Y, Li C, Li H, Li H, Yu J
International journal of biological macromolecules 2025 May;309(Pt 4):143033
International journal of biological macromolecules 2025 May;309(Pt 4):143033
INSL3 promotes macrophage polarization to an immunosuppressive phenotype via the cAMP downstream signaling pathway and Akt/mTOR pathway.
Zhou M, Liu Y, Li C, Yang X, Ji C, Li W, Song M, Yang Z, Liu G, Liang X, Liang J, Zhang B, Wang L
International immunopharmacology 2025 May 8;154:114540
International immunopharmacology 2025 May 8;154:114540
RAF1 in AgRP neurons involved in the regulation of energy metabolism via the MAPK signaling pathway.
Chen Y, Ren L, Xu X, Sun Z, Dai M, Li Y, Ma X, Li J
Journal of biomedical research 2025 May 28;40(1):45-62
Journal of biomedical research 2025 May 28;40(1):45-62
MiR-134-5p/BDNF/TrkB/CREB signaling pathway involved in the depression-like behaviors in mice following exposure to benzo[a]pyrene.
Zhao T, Li H, Jia Y, Xia N, Li X, Zhang H
Metabolic brain disease 2025 May 23;40(5):210
Metabolic brain disease 2025 May 23;40(5):210
LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis.
Dong L, Wu H, Qi F, Chen W, Xu Y, Li M, Wang Y, Yan R, Cai P
Journal of ovarian research 2025 May 16;18(1):102
Journal of ovarian research 2025 May 16;18(1):102
Esketamine mitigates endotoxin-induced hippocampal injury by regulating calcium transient and synaptic plasticity via the NF-α1/CREB pathway.
Xu M, Wang J, Shi J, Wu X, Zhao Q, Shen H, Chen J, Yu J
Neuropharmacology 2025 May 15;269:110362
Neuropharmacology 2025 May 15;269:110362
BCL6 Promotes Transcription of GPR61 to Suppress IL-1β-Induced Osteoarthritis Progression in C28/I2 Cells.
Zeng G, Xu Y, Li Z, Deng G
Microbiology and immunology 2025 Mar;69(3):148-156
Microbiology and immunology 2025 Mar;69(3):148-156
The sperm quality in DIO male mice is linked to the NF-κB signaling and Ppp2ca expression in the hypothalamus.
Feng X, Xu M, Liu Y, Wang X, Duan Y, Zheng X, Yin W, Cai Y, Zhang W, Jiang Q, Pang J, Li J
iScience 2025 Mar 21;28(3):112110
iScience 2025 Mar 21;28(3):112110
F-box protein FBXO21 overexpression inhibits the proliferation and metastasis of clear cell renal cell carcinoma and is closely related to the CREB pathway and tumor immune cell infiltration.
Yang W, Jing T, Wu C, Lu M, Yao X, Xia D, Peng D
Journal of translational medicine 2025 Mar 15;23(1):335
Journal of translational medicine 2025 Mar 15;23(1):335
Polygonati Rhizoma Prevents Glucocorticoid-Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid.
Shi S, Li R, Han Y, Xie J, Wang S, Liu J, Wan F, Hou G, Liu Z, Sun X, Zuo B, Jia Z, Mei Z, Song T
Journal of cachexia, sarcopenia and muscle 2025 Jun;16(3):e13853
Journal of cachexia, sarcopenia and muscle 2025 Jun;16(3):e13853
GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice.
Zhang Z, Yuan Y, Zhang X, Gu L, Tang Y, Zhao Y, Dai J, Tao Y, Xie Z
Translational stroke research 2025 Jun;16(3):625-644
Translational stroke research 2025 Jun;16(3):625-644
Effects of early-life F-53B exposure on thyroid function in juvenile rats: The role of the cAMP signaling pathway.
Li SP, Zhao WH, Zhang J, Jiang WT, Zhu JY, Luo YX, Xiang P, Bloom M, Jalava P, Dong GH, Zeng XW
Journal of hazardous materials 2025 Jun 5;489:137751
Journal of hazardous materials 2025 Jun 5;489:137751
Piezo1 senses hyphae and initiates host defense against pathogenic fungi.
Shi Y, Yang B, Linghu Y, Liu Y, Li H, Xing Y, Wu B, Gao Y, Liao L, Zheng Y, Pan L, Sun X, Chen Q, Hou Y, Su D, Huang H, Han J, Cheng SC, Zhou D, Chen L
Cell reports 2025 Jun 24;44(6):115839
Cell reports 2025 Jun 24;44(6):115839
Aspirin Suppresses Aromatase-Mediated Estrogen Biosynthesis to Alleviate Polycystic Ovary Syndrome by the Inhibition of Adenylate Cyclase.
Shi XK, Sheng YW, Cao DY, Shi N, Zhang GL, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70688
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70688
Thioredoxin-1 Downregulation in the SNpc Exacerbates the Cognitive Impairment Induced by MPTP.
Zhang X, Yan F, He XJ, Chen Y, Gu R, Dong X, Wei Y, Bai L, Bai J
Antioxidants & redox signaling 2025 Jul;43(1-3):138-150
Antioxidants & redox signaling 2025 Jul;43(1-3):138-150
Peiyuan Ningshen-ointment alleviates learning and memory impairment induced by sleep deprivation through activating the cAMP/PKA signaling pathway.
Wei XY, Xu FP, Chen XB, Xu Q, Deng LY, Sun C, Chen XY, Tan F, Yang ZM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156469
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156469
Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD(+)/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration.
Chai G, Mao Y, Gong J, Bi S, Zhang Y, Wu J, Yang L, Gao T, Fu H, Yu C, Ren C, Zhang G, Zhu X, Guan X, Yu H, Tang C, Nie Y, Yu H
Cell death & disease 2025 Jul 7;16(1):499
Cell death & disease 2025 Jul 7;16(1):499
Multi-omics study reveals gut microbiota dysbiosis and tryptophan metabolism alterations in GH-PitNET progression.
Liu J, Ye Z, Zhang Y, You S, Sun S, Lu L, Su W, Liu J, Pu J, Pan H, Zhu H, Deng K, Yao Y, Hu X, Zhang S
Scientific reports 2025 Jul 7;15(1):24261
Scientific reports 2025 Jul 7;15(1):24261
In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling.
Tian Y, Bao X, Lei S, Huang Y, Wang X, Tu Y, He Q, Zhang F, Xu H, Ashrafizadeh M, Sethi G, Wang F, Zeng Z
Cell communication and signaling : CCS 2025 Jul 10;23(1):329
Cell communication and signaling : CCS 2025 Jul 10;23(1):329
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547
Bioorganic chemistry 2025 Jul 1;161:108547
Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression.
Cao L, Sun W, Chen X, Liu L, Zhao S, Liu J, Ou Y, Guo M, Qi C, Li Z, Shi J, Liu Y, Shuai Q, Zuo S, Hu H, Yu T, Wang Y, Feng M, Lv J, Wang H, Sun P, Zhang J, Wang L, Shi Y, Yang S
Nature communications 2025 Jul 1;16(1):6011
Nature communications 2025 Jul 1;16(1):6011
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway.
Luo ZH, Guo JS, Pang S, Dong W, Ma JX, Zhang L, Qi XL, Guan FF, Gao S, Gao X, Liu N, Pan S, Chen W, Zhang X, Zhang LF, Yang YJ
Acta pharmacologica Sinica 2025 Jan;46(1):66-80
Acta pharmacologica Sinica 2025 Jan;46(1):66-80
Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice.
Zhang S, Wang X, Liu S, Hu C, Meng Y
Brain, behavior, and immunity 2025 Jan;123:193-210
Brain, behavior, and immunity 2025 Jan;123:193-210
TRPM2 deficiency contributes to M2b macrophage polarization via the PI3K/AKT/CREB pathway in murine sepsis.
Shen Y, Dhar R, Liu J, Hong S, Tang H, Qian X
Innate immunity 2025 Jan-Dec;31:17534259251343377
Innate immunity 2025 Jan-Dec;31:17534259251343377
GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells.
Meng J, Xu L, Ma B, Hao C, Guo Y, Wang J, Chen J
Ecotoxicology and environmental safety 2025 Jan 1;289:117426
Ecotoxicology and environmental safety 2025 Jan 1;289:117426
Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells.
Zhao J, Xu Y, Yu H, Li X, Wang W, Mao D
Theriogenology 2025 Jan 1;231:62-72
Theriogenology 2025 Jan 1;231:62-72
Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice.
Huang LY, Liu YN, Chen J, Zhu HX, Li LL, Liang ZY, Song JX, Li YJ, Hu ZL, Demon D, Wullaert A, Wang W, Qi SH
Molecular neurobiology 2025 Feb;62(2):1705-1719
Molecular neurobiology 2025 Feb;62(2):1705-1719
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Ding K, Zhang Z, Han Z, Shi L, Li X, Liu Y, Li Z, Zhao C, Cui Y, Zhou L, Xu B, Zhou W, Zhao Y, Wang Z, Huang H, Xie L, Chen XW, Chen Z
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway.
Meng Q, Guo MH, Zhang R, Wei J, Chen Q, Zhao XC, Xu CQ, Wu YY, Kuai JJ, Zhao JM, Wu YJ, Ye CH, Wei HR, Zhu X, Jin Y, Zhang Z, Wei W
Acta pharmacologica Sinica 2025 Dec;46(12):3177-3189
Acta pharmacologica Sinica 2025 Dec;46(12):3177-3189
1-NP hijacks endocrine-metabolic checkpoints and disrupts testicular steroidogenesis by suppressing the cAMP-PKA-CREB-HMGCR axis.
Zhu XX, Zhang WW, Hao MY, Chen ZY, Wan BF, Niu MH, Li XL, Wei JH, Liu SY, Mi SL, Wang H, Xu DX, Gao L
Toxicology letters 2025 Dec;414:111781
Toxicology letters 2025 Dec;414:111781
m1A methylation-mediated upregulation of RILsPL1 promotes colorectal cancer progression via the CaMKII/CREB signaling pathway.
Yang S, Long X, Diao W, Yang J, Jiang A, Wu H
Biochimica et biophysica acta. General subjects 2025 Dec;1869(12):130856
Biochimica et biophysica acta. General subjects 2025 Dec;1869(12):130856
Breast cancer cell-derived adrenomedullin confers cancer-associated adipose remodeling through the cAMP/Creb1/Zeb1 axis.
Chen X, Cao L, Feng M, Shuai Q, Guo M, Li Z, Qi C, Shi J, Liu Y, Zuo S, Yu T, Hu H, Wang Y, Xue Y, Sun P, Shi Y, Wang H, Liu L, Yang S
British journal of cancer 2025 Dec;133(12):1815-1828
British journal of cancer 2025 Dec;133(12):1815-1828
Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction.
Zhang L, Gao S, Xiong X, Liu X, Li R, Wang X, Han L, Xiao X, Wang X, Li W, Chang Y, Du Y, Yang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e04817
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e04817
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia.
Chen Y, Zhou Y, Qi Y, Miao T, Shi J, Jin D, Zhong TP
Communications biology 2025 Dec 10;9(1):33
Communications biology 2025 Dec 10;9(1):33
Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility.
Chen Y, Yu Y, Kou J, Qi H, Zhang C, Wang F, Zhou L, Liang X, Xu K, Zhang C, Zhang A, Liu X, Zhang C, Gan G, Sun J, Zhu X
Neurobiology of disease 2025 Aug;212:106957
Neurobiology of disease 2025 Aug;212:106957
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.
Li J, Wang M, Qu K, Sun Y, Yin Z, Dong N, Sun X, Xu Y, Chen L, Zhang S, Xian X, Xu S, Ma L, Duan Y, Zhu H
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063
Low-intensity millimeter waves ameliorate cognitive impairment induced by chronic REM sleep deprivation in rats by regulating CaMKII-CREB-BDNF pathway.
Li YZ, Zhou L, Cheng J, Williams JP, Wang PC, An JX
Neuroscience 2025 Aug 16;581:83-94
Neuroscience 2025 Aug 16;581:83-94
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.
Li J, Wu X, Yan S, Shen J, Tong T, Aslam MS, Zeng J, Chen Y, Chen W, Li M, You Z, Gong K, Yang J, Zhu M, Meng X
Molecular neurobiology 2025 Apr;62(4):4221-4236
Molecular neurobiology 2025 Apr;62(4):4221-4236
PINK1-deficiency facilitates mitochondrial iron accumulation and colon tumorigenesis.
Arcos M, Goodla L, Kim H, Desai SP, Liu R, Yin K, Liu Z, Martin DR, Xue X
Autophagy 2025 Apr;21(4):737-753
Autophagy 2025 Apr;21(4):737-753
Estrogen Inhibits the Phenotypic Switching of Vascular Smooth Muscle Cells through ER-α/CREB in Aortic Dissection.
Pu Y, Zhou Y, Guo T, Chai X, Yang G
ACS omega 2025 Apr 22;10(15):15256-15271
ACS omega 2025 Apr 22;10(15):15256-15271
Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.
Xiang L, Pan W, Chen H, Du W, Xie S, Liang X, Yang F, Niu R, Huang C, Luo M, Xu Y, Geng L, Gong S, Xu W, Zhao J
Mediators of inflammation 2024;2024:7524314
Mediators of inflammation 2024;2024:7524314
Administration of Liposomal-Based Pde3b Gene Therapy Protects Mice Against Collagen-Induced Rheumatoid Arthritis via Modulating Macrophage Polarization.
Chen L, Zhou Q, Fang X, Xu Q, Zou Y, Zhang J
International journal of nanomedicine 2024;19:4411-4427
International journal of nanomedicine 2024;19:4411-4427
The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.
Luo Y, Gao H, Zhao J, Chen L, Shao J, Ju L
Frontiers in immunology 2024;15:1469740
Frontiers in immunology 2024;15:1469740
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
Gawargi FI, Mishra PK
iScience 2024 Sep 20;27(9):110622
iScience 2024 Sep 20;27(9):110622
Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2.
Shi XK, Peng T, Azimova B, Li XL, Li SS, Cao DY, Fu NJ, Zhang GL, Xiao WL, Wang F
Journal of ethnopharmacology 2024 Sep 15;331:118279
Journal of ethnopharmacology 2024 Sep 15;331:118279
Rice Protein Peptides Ameliorate DSS-Induced Cognitive Impairment and Depressive Behavior in Mice by Modulating Phenylalanine Metabolism and the BDNF/TRKB/CREB Pathway.
He Y, Tian Y, Xiong H, Deng Z, Zhang H, Guo F, Sun Y
Journal of agricultural and food chemistry 2024 Sep 11;72(36):19812-19825
Journal of agricultural and food chemistry 2024 Sep 11;72(36):19812-19825
Tanshinone IIA promotes osteogenic differentiation potential and suppresses adipogenic differentiation potential of bone marrow mesenchymal stem cells.
Wang W, Wu H, Feng S, Huang X, Xu H, Shen X, Fu Y, Fang S
Molecular medicine reports 2024 Oct;30(4)
Molecular medicine reports 2024 Oct;30(4)
GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease.
Niu R, Lan J, Liang D, Xiang L, Wu J, Zhang X, Li Z, Chen H, Geng L, Xu W, Gong S, Yang M
Cell communication and signaling : CCS 2024 Oct 4;22(1):474
Cell communication and signaling : CCS 2024 Oct 4;22(1):474
Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer.
Wang H, Chen J, Chen X, Liu Y, Wang J, Meng Q, Wang H, He Y, Song Y, Li J, Ju Z, Xiao P, Qian J, Song Z
Cancer research 2024 Oct 15;84(20):3371-3387
Cancer research 2024 Oct 15;84(20):3371-3387
Yeast Extract Peptides Alleviate Depression in Chronic Restraint Stress Rats by Alleviating Hippocampal Neuronal Apoptosis and Dysbiosis of the Gut Microbiota.
Zou Z, Xiao N, Chen Z, Lin X, Li Y, Li P, Cheng Q, Du B
Molecular nutrition & food research 2024 Nov;68(21):e2300467
Molecular nutrition & food research 2024 Nov;68(21):e2300467
MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury.
Zhuang K, Wang W, Zheng X, Guo X, Xu C, Ren X, Shen W, Han Q, Feng Z, Chen X, Cai G
Stem cell research & therapy 2024 Nov 19;15(1):438
Stem cell research & therapy 2024 Nov 19;15(1):438
Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F-53B Exposure: The Role of PKA Cytoplasmic Retention.
Li SP, Zeng HX, Qin SJ, Li QQ, Wu LY, Wu QZ, Lin LZ, Dong GH, Zeng XW
Environment & health (Washington, D.C.) 2024 Nov 15;2(11):776-785
Environment & health (Washington, D.C.) 2024 Nov 15;2(11):776-785
Neuroprotective effects of polyphyllin VI against rotenone-induced toxicity in SH-SY5Y cells.
Li L, Chen Z, Hao C
Brain research 2024 May 1;1830:148824
Brain research 2024 May 1;1830:148824
The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl(4)-caused murine liver fibrosis in vivo.
Liu B, Xie X, Yang X, Dou C, Tang H, Liu J
Human cell 2024 Mar;37(2):435-450
Human cell 2024 Mar;37(2):435-450
Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
Shi W, Wang J, Li Z, Xu S, Wang J, Zhang L, Yang H
Free radical biology & medicine 2024 Mar;213:343-358
Free radical biology & medicine 2024 Mar;213:343-358
Maresin 1 Activates LGR6 to Alleviate Neuroinflammation via the CREB/JMJD3/IRF4 Pathway in a Rat Model of Subarachnoid Hemorrhage.
Li Z, Yuan W, Yang X, Jiang J, Zhang QL, Yan XX, Zuo YC
Neuroscience 2024 Mar 26;542:21-32
Neuroscience 2024 Mar 26;542:21-32
Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.
Sun X, Pan Y, Luo Y, Guo H, Zhang Z, Wang D, Li C, Sun X
Journal of ethnopharmacology 2024 Mar 25;322:117672
Journal of ethnopharmacology 2024 Mar 25;322:117672
Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis.
Zhao Y, Ning J, Teng H, Deng Y, Sheldon M, Shi L, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L
Nature communications 2024 Mar 16;15(1):2384
Nature communications 2024 Mar 16;15(1):2384
BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin†.
Ni F, Wang F, Li J, Liu Y, Sun X, Chen J, Li J, Zhang Y, Jin J, Ye X, Tu M, Chen J, Chen C, Zhang D
Biology of reproduction 2024 Mar 13;110(3):615-631
Biology of reproduction 2024 Mar 13;110(3):615-631
Achyranthes bidentata polysaccharide ameliorates type 2 diabetes mellitus by gut microbiota-derived short-chain fatty acids-induced activation of the GLP-1/GLP-1R/cAMP/PKA/CREB/INS pathway.
Xia T, He W, Luo Z, Wang K, Tan X
International journal of biological macromolecules 2024 Jun;270(Pt 2):132256
International journal of biological macromolecules 2024 Jun;270(Pt 2):132256
CREB1 Silencing Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis Through Reducing RPL9 Expression and Blocking NF-κB Signaling.
Jian X, Yang D, Wang L, Wang H
Journal of cardiovascular translational research 2024 Jun;17(3):570-584
Journal of cardiovascular translational research 2024 Jun;17(3):570-584
Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice.
Feng Y, Wang J, Liu J, Zhou Y, Jiang Y, Zhou W, Wu F, Liu X, Luo L
Cells 2024 Jun 6;13(11)
Cells 2024 Jun 6;13(11)
Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Li T, Wei L, Zhang X, Fu B, Zhou Y, Yang M, Cao M, Chen Y, Tan Y, Shi Y, Wu L, Xuan C, Du Q, Hu R
Molecular cancer research : MCR 2024 Jun 4;22(6):538-554
Molecular cancer research : MCR 2024 Jun 4;22(6):538-554
Osr2 functions as a biomechanical checkpoint to aggravate CD8(+) T cell exhaustion in tumor.
Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi Y, Chen K, Nian C, Tang J, Pan L, Xing Y, Gao H, Yang B, Song Z, Cheng Y, Liu Y, Sun M, Linghu Y, Li J, Huang H, Lai Z, Zhou Z, Li Z, Sun X, Chen Q, Su D, Li W, Peng Z, Liu P, Chen W, Huang H, Chen Y, Xiao B, Ye L, Chen L, Zhou D
Cell 2024 Jun 20;187(13):3409-3426.e24
Cell 2024 Jun 20;187(13):3409-3426.e24
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress.
Lu J, Zhang X, Su K, Luo H, Liu C, Yang Y, He B, Wang C, Zhao Z, Liu X, Wang X, Meng P, Lv D, Wang C, Kelley KW, Wang L, Cui B, Liu Q, Peng F
Cell communication and signaling : CCS 2024 Jul 25;22(1):375
Cell communication and signaling : CCS 2024 Jul 25;22(1):375
Molecular mechanism of Chang Shen Hua volatile oil modulating brain cAMP-PKA-CREB pathway to improve depression-like behavior in rats.
Zhang S, Hu Y, Zhao Y, Feng Y, Wang X, Miao M, Miao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155729
Disorder of neuroplasticity aggravates cognitive impairment via neuroinflammation associated with intestinal flora dysbiosis in chronic heart failure.
Chen J, Wei X, Wu X, Zhang Q, Xia G, Xia H, Shang H, Lin S
Aging 2024 Jul 1;16(13):10882-10904
Aging 2024 Jul 1;16(13):10882-10904
CENPN suppresses autophagy and increases paclitaxel resistance in nasopharyngeal carcinoma cells by inhibiting the CREB-VAMP8 signaling axis.
Wang BR, Han JB, Jiang Y, Xu S, Yang R, Kong YG, Tao ZZ, Hua QQ, Zou Y, Chen SM
Autophagy 2024 Feb;20(2):329-348
Autophagy 2024 Feb;20(2):329-348
RNA-binding protein YBX3 promotes PPARγ-SLC3A2 mediated BCAA metabolism fueling brown adipogenesis and thermogenesis.
Chen LY, Wang LW, Wen J, Cao JD, Zhou R, Yang JL, Xiao Y, Su T, Huang Y, Guo Q, Zhou HY, Luo XH, Feng X
Molecular metabolism 2024 Dec;90:102053
Molecular metabolism 2024 Dec;90:102053
GR/P300 Regulates MKP1 Signaling Pathway and Mediates Depression-like Behavior in Prenatally Stressed Offspring.
Wei B, Shi Y, Yu X, Cai Y, Zhao Y, Song Y, Zhao Z, Huo M, Li L, Gao Q, Yu D, Wang B, Sun M
Molecular neurobiology 2024 Dec;61(12):10613-10628
Molecular neurobiology 2024 Dec;61(12):10613-10628
Puerarin alleviates symptoms of preeclampsia through the repression of trophoblast ferroptosis via the CREB/HO-1 pathway.
Yue X, Pang M, Chen Y, Cheng Z, Zhou R, Wang Y, Zha Z, Huang L
Placenta 2024 Dec;158:145-155
Placenta 2024 Dec;158:145-155
Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway.
Mo J, Liao W, Du J, Huang X, Li Y, Su A, Zhong L, Gong M, Wang P, Liu Z, Kuang H, Wang L
Journal of ethnopharmacology 2024 Dec 5;335:118636
Journal of ethnopharmacology 2024 Dec 5;335:118636
LncRNA-MSTRG.19083.1 Targets NTRK2 as a miR-429-y Sponge to Regulate Circadian Rhythm via the cAMP Pathway in Yak Testis and Cryptorchidism.
Li T, Yan Q, Nan J, Huang X, Wang R, Zhang Y, Zhao X, Wang Q
International journal of molecular sciences 2024 Dec 18;25(24)
International journal of molecular sciences 2024 Dec 18;25(24)
Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke.
Guo H, Li Y, Wang S, Yang Y, Xu T, Zhao J, Wang J, Zuo W, Wang P, Zhao G, Wang H, Hou W, Dong H, Cai Y
Redox biology 2024 Aug;74:103234
Redox biology 2024 Aug;74:103234
A functional variant rs10409772 in FUT6 promoter regulates colorectal cancer progression through PKA/CREB signaling.
Zhang J, Song Q, Hu W
Translational oncology 2024 Aug;46:102011
Translational oncology 2024 Aug;46:102011
Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.
Hu J, Lian Z, Weng Z, Xu Z, Gao J, Liu Y, Luo T, Wang X
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(31):e2405547
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(31):e2405547
Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway.
Chai Y, He S, Liang D, Gu C, Gong Q, Long L, Chen P, Wang L
Heliyon 2024 Aug 30;10(16):e35970
Heliyon 2024 Aug 30;10(16):e35970
A(2A)R regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration.
Liu W, Li Q, Fang W, Cai L, Wang Z, Kou B, Zhou C, Zhou Y, Yao Z, Wei M, Zhang S
European journal of medical research 2024 Aug 27;29(1):433
European journal of medical research 2024 Aug 27;29(1):433
Electroacupuncture negatively regulates the Nesfatin-1/ERK/CREB pathway to alleviate HPA axis hyperactivity and anxiety-like behaviors caused by surgical trauma.
Zheng J, Wang Y, Zhang C, Zhang A, Zhou Y, Xu Y, Yu J, Tian Z
Chinese medicine 2024 Aug 17;19(1):108
Chinese medicine 2024 Aug 17;19(1):108
miR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring.
Wang B, Zhu Y, Wei B, Zeng H, Zhang P, Li L, Wang H, Wu X, Zheng Y, Sun M
Molecular neurobiology 2024 Apr;61(4):1920-1935
Molecular neurobiology 2024 Apr;61(4):1920-1935
Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway.
Liu XR, Li SF, Mei WY, Liu XD, Zhou RB
Chinese journal of integrative medicine 2024 Apr;30(4):299-310
Chinese journal of integrative medicine 2024 Apr;30(4):299-310
The prenatal use of agmatine prevents social behavior deficits in VPA-exposed mice by activating the ERK/CREB/BDNF signaling pathway.
Chen S, Xu Q, Zhao L, Zhang M, Xu H
Birth defects research 2024 Apr;116(4):e2336
Birth defects research 2024 Apr;116(4):e2336
The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.
Zheng T, Shen B, Bai Y, Li E, Zhang X, Hu Y, Gao T, Dong Q, Zhu L, Jin R, Shi H, Liu H, Gao Y, Liu X, Cao C
Journal of virology 2024 Apr 16;98(4):e0156523
Journal of virology 2024 Apr 16;98(4):e0156523
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Pan W, Xiang L, Liang X, Du W, Zhao J, Zhang S, Zhou X, Geng L, Gong S, Xu W
Mediators of inflammation 2023;2023:6623329
Mediators of inflammation 2023;2023:6623329
Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway.
Guan Y, Yao W, Yu H, Feng Y, Zhao Y, Zhan X, Wang Y
International journal of biological sciences 2023;19(7):2006-2019
International journal of biological sciences 2023;19(7):2006-2019
A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.
Pan J, Liu M, Duan X, Wang D
PloS one 2023;18(6):e0286422
PloS one 2023;18(6):e0286422
Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression.
He J, Han D, Jia C, Xie J, Zhu F, Wei J, Li D, Wei D, Li Y, Tang L, Wei G, Yan J, Tong Y, Yang L, Tan X
Drug design, development and therapy 2023;17:717-735
Drug design, development and therapy 2023;17:717-735
The SIK1/CRTC2/CREB1 and TWIST1/PI3K/Akt/GSK3β signaling pathways mediated by microRNA-25-3p are altered in the schizophrenic rat brain.
Pan B, Zhu X, Han B, Weng J, Wang Y, Liu Y
Frontiers in cellular neuroscience 2023;17:1087335
Frontiers in cellular neuroscience 2023;17:1087335
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity.
Xu J, Zhang LW, Feng H, Tang Y, Fu SQ, Liu XM, Zhu XY
Frontiers in pharmacology 2023;14:1176443
Frontiers in pharmacology 2023;14:1176443
Lactate modulates iron metabolism by binding soluble adenylyl cyclase.
Liu W, Zhang S, Li Q, Wu Y, Jia X, Feng W, Li Z, Shi Y, Hou Q, Ma J, Liu Y, Gao P, Ganz T, Liu S
Cell metabolism 2023 Sep 5;35(9):1597-1612.e6
Cell metabolism 2023 Sep 5;35(9):1597-1612.e6
Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice.
Wei P, Jia M, Kong X, Lyu W, Feng H, Sun X, Li J, Yang JJ
Stem cell research & therapy 2023 Sep 21;14(1):263
Stem cell research & therapy 2023 Sep 21;14(1):263
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Zhang L, Liang S, Zhang Z, Wang K, Cao J, Yao M, Qin L, Qu C, Miao J
International journal of molecular sciences 2023 Sep 12;24(18)
International journal of molecular sciences 2023 Sep 12;24(18)
Long non-coding RNA PFI inhibits apoptosis of alveolar epithelial cells to alleviate lung injury via miR-328-3p/Creb1 axis.
Li Z, Jin T, Yang R, Guo J, Niu Z, Gao H, Song X, Zhang Q, Ning Z, Ren L, Wang Y, Fan X, Liang H, Li T, He W
Experimental cell research 2023 Sep 1;430(1):113685
Experimental cell research 2023 Sep 1;430(1):113685
The crucial role that hippocampus Cyclooxygenase-2 plays in memory.
Ni H, Guo Z, Wu Y, Wang J, Yang Y, Zhu Z, Wang D
The European journal of neuroscience 2023 Nov;58(10):4123-4136
The European journal of neuroscience 2023 Nov;58(10):4123-4136
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain.
Zhou HY, Feng X, Wang LW, Zhou R, Sun H, Chen X, Lu RB, Huang Y, Guo Q, Luo XH
Cell metabolism 2023 Nov 7;35(11):1915-1930.e8
Cell metabolism 2023 Nov 7;35(11):1915-1930.e8
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.
Gioia MD, Poli V, Tan PJ, Spreafico R, Chu A, Cuenca AG, Gordts PL, Pandolfi L, Meloni F, Witztum JL, Chou J, Springstead JR, Zanoni I
bioRxiv : the preprint server for biology 2023 Nov 21;
bioRxiv : the preprint server for biology 2023 Nov 21;
TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation.
Liu Y, He T, Li Z, Sun Z, Wang S, Shen H, Hou L, Li S, Wei Y, Zhuo B, Li S, Zhou C, Guo H, Zhang R, Li B
iScience 2023 Nov 17;26(11):108312
iScience 2023 Nov 17;26(11):108312
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation.
Wang S, Qiao C, Li J, Liu S, Li P
Carcinogenesis 2023 May 27;44(3):209-220
Carcinogenesis 2023 May 27;44(3):209-220
Norepinephrine/β(2)-Adrenergic Receptor Pathway Promotes the Cell Proliferation and Nerve Growth Factor Production in Triple-Negative Breast Cancer.
Jin M, Wang Y, Zhou T, Li W, Wen Q
Journal of breast cancer 2023 Jun;26(3):268-285
Journal of breast cancer 2023 Jun;26(3):268-285
LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation.
Compton SE, Kitchen-Goosen SM, DeCamp LM, Lau KH, Mabvakure B, Vos M, Williams KS, Wong KK, Shi X, Rothbart SB, Krawczyk CM, Jones RG
Molecular cell 2023 Jun 1;83(11):1872-1886.e5
Molecular cell 2023 Jun 1;83(11):1872-1886.e5
ZNRF2 as an oncogene is transcriptionally regulated by CREB1 in breast cancer models.
Liu JT, Sun ZX, Zhong R, Zhang YD, Wang T, Hou YD, Bao JH, Zhang L, Chen B
Human cell 2023 Jul;36(4):1501-1515
Human cell 2023 Jul;36(4):1501-1515
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway.
Ge J, Song J, Sun B, Yang X, Du B, Sun X, Zhang J, Ge J, Xie H
Mutation research 2023 Jul-Dec;827:111829
Mutation research 2023 Jul-Dec;827:111829
Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms.
Liu C, Liu Z, Fang Y, Liao Z, Zhang Z, Yuan X, Yu T, Yang Y, Xiong M, Zhang X, Zhang G, Meng L, Zhang Z
Environment international 2023 Jan;171:107696
Environment international 2023 Jan;171:107696
Bisphenol A and Di(2-Ethylhexyl) Phthalate promote pulmonary carcinoma in female rats via estrogen receptor beta: In vivo and in silico analysis.
Xiao M, Zhang Y, Zhang X, Zhang G, Jin C, Yang J, Wu S, Lu X
Ecotoxicology and environmental safety 2023 Jan 15;250:114496
Ecotoxicology and environmental safety 2023 Jan 15;250:114496
Dysfunctional microRNA-144-3p/ZBTB20/ERK/CREB1 signalling pathway is associated with MK-801-induced schizophrenia-like abnormalities.
Pan B, Han B, Zhu X, Wang Y, Ji H, Weng J, Liu Y
Brain research 2023 Jan 1;1798:148153
Brain research 2023 Jan 1;1798:148153
Upregulated GPRC5A disrupting the Hippo pathway promotes the proliferation and migration of pancreatic cancer cells via the cAMP-CREB axis.
Fang W, Yu X, Deng J, Yu B, Xiong J, Ma M
Discover oncology 2023 Feb 3;14(1):17
Discover oncology 2023 Feb 3;14(1):17
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus.
Yuan G, Xiao L, Xie Y, Si L, Xu H, Xu W, Wang G
Neuroscience letters 2023 Feb 28;798:137058
Neuroscience letters 2023 Feb 28;798:137058
Mailuoning oral liquid attenuates convalescent cerebral ischemia by inhibiting AMPK/mTOR-associated apoptosis and promoting CREB/BDNF-mediated neuroprotection.
Liu X, Fan L, Li J, Bai Z, Wang Y, Liu Y, Jiang H, Tao A, Li X, Zhang H, Tan N
Journal of ethnopharmacology 2023 Dec 5;317:116731
Journal of ethnopharmacology 2023 Dec 5;317:116731
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Chen M, Zhu JY, Mu WJ, Luo HY, Li Y, Li S, Yan LJ, Li RY, Guo L
Nature communications 2023 Dec 18;14(1):8391
Nature communications 2023 Dec 18;14(1):8391
Benzene, 1,2,4-Trimethoxy-5-(2-Methyl-1-Propen-1-yl) Attenuates D-galactose/AlCl(3)-induced Cognitive Impairment by Inhibiting Inflammation, Apoptosis, and improving Expression of Memory-Related Proteins.
Yang P, Liao C, Hu Q, Zhang J, Yang H, Xian S, Mao S
Neuroscience 2023 Aug 1;524:242-255
Neuroscience 2023 Aug 1;524:242-255
Nitration of cAMP-Response Element Binding Protein Participates in Myocardial Infarction-Induced Myocardial Fibrosis via Accelerating Transcription of Col1a2 and Cxcl12.
Xue K, Chen S, Chai J, Yan W, Zhu X, Ji D, Wu Y, Liu H, Wang W
Antioxidants & redox signaling 2023 Apr;38(10-12):709-730
Antioxidants & redox signaling 2023 Apr;38(10-12):709-730
The asymmetrical ESR1 signaling in muscle progenitor cells determines the progression of adolescent idiopathic scoliosis.
Shao X, Fu X, Yang J, Sui W, Li S, Yang W, Lin X, Zhang Y, Jia M, Liu H, Liu W, Han L, Yu Y, Deng Y, Zhang T, Yang J, Hu P
Cell discovery 2023 Apr 25;9(1):44
Cell discovery 2023 Apr 25;9(1):44
Cadmium-induced Sertoli Cell Injury Through p38-MAPK and Related Signaling Proteins-A Study by RNA Sequencing.
Wang L, Li X, Bu T, Wu X, Li L, Gao S, Yun D, Zhang Y, Chen H, Sun F, Cheng CY
Endocrinology 2023 Apr 17;164(6)
Endocrinology 2023 Apr 17;164(6)
Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway.
Zhao Y, Li Y, Li H, Shi S
Experimental cell research 2023 Apr 15;425(2):113542
Experimental cell research 2023 Apr 15;425(2):113542
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.
Fu Y, Yuan P, Zheng Y, Wei Y, Gao L, Ruan Y, Chen Y, Li P, Feng W, Zheng X
International journal of nanomedicine 2022;17:1549-1566
International journal of nanomedicine 2022;17:1549-1566
Parathyroid hormone alleviates non-alcoholic liver steatosis via activating the hepatic cAMP/PKA/CREB pathway.
Feng X, Xiao Y, Guo Q, Peng H, Zhou HY, Wang JP, Xia ZY
Frontiers in endocrinology 2022;13:899731
Frontiers in endocrinology 2022;13:899731
Nrf2 Overexpression Decreases Vincristine Chemotherapy Sensitivity Through the PI3K-AKT Pathway in Adult B-Cell Acute Lymphoblastic Leukemia.
Wang L, Liu X, Kang Q, Pan C, Zhang T, Feng C, Chen L, Wei S, Wang J
Frontiers in oncology 2022;12:876556
Frontiers in oncology 2022;12:876556
Upregulation of Neogenin-1 by a CREB1-BAF47 Complex in Vascular Endothelial Cells is Implicated in Atherogenesis.
Li N, Liu H, Xue Y, Chen J, Kong X, Zhang Y
Frontiers in cell and developmental biology 2022;10:803029
Frontiers in cell and developmental biology 2022;10:803029
Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats.
Nie Q, Dong W, Shen B, Yang G, Yu H, Zhang R, Peng Y, Yu Y, Hong S, Li L
Annals of translational medicine 2022 Sep;10(18):985
Annals of translational medicine 2022 Sep;10(18):985
A 3D-printed molybdenum-containing scaffold exerts dual pro-osteogenic and anti-osteoclastogenic effects to facilitate alveolar bone repair.
Tian B, Li X, Zhang J, Zhang M, Gan D, Deng D, Sun L, He X, Wu C, Chen F
International journal of oral science 2022 Sep 5;14(1):45
International journal of oral science 2022 Sep 5;14(1):45
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
Liu J, Shi D, Ma Q, Zhao P
Journal of ethnopharmacology 2022 Sep 15;295:115398
Journal of ethnopharmacology 2022 Sep 15;295:115398
Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice.
Li H, Li J, Zhang T, Xie X, Gong J
Biochemical and biophysical research communications 2022 Sep 10;620:56-62
Biochemical and biophysical research communications 2022 Sep 10;620:56-62
Single-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors.
Chen Y, Dong Y, Yan J, Wang L, Yu S, Jiao K, Paquet-Durand F
International journal of molecular sciences 2022 Oct 12;23(20)
International journal of molecular sciences 2022 Oct 12;23(20)
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fan Y, Wu H, Xiong L, Luo F, Li Q, Wang D, Zhong T
Fitoterapia 2022 Nov;163:105314
Fitoterapia 2022 Nov;163:105314
Upregulation of Periostin Through CREB Participates in Myocardial Infarction-induced Myocardial Fibrosis.
Xue K, Chen S, Chai J, Yan W, Zhu X, Dai H, Wang W
Journal of cardiovascular pharmacology 2022 May 1;79(5):687-697
Journal of cardiovascular pharmacology 2022 May 1;79(5):687-697
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.
Wang J, Ren P, Zeng Z, Ma L, Li Y, Zhang H, Guo W
Bioengineered 2022 Mar;13(3):7457-7470
Bioengineered 2022 Mar;13(3):7457-7470
Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration.
Roy A, Tolone A, Hilhorst R, Groten J, Tomar T, Paquet-Durand F
Cell death discovery 2022 Mar 3;8(1):93
Cell death discovery 2022 Mar 3;8(1):93
CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.
Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, Bai B, Gu S, Zhao W, Zhan Q
Molecular cancer 2022 Jun 30;21(1):140
Molecular cancer 2022 Jun 30;21(1):140
A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway.
You JY, Liu XW, Bao YX, Shen ZN, Wang Q, He GY, Lu J, Zhang JG, Chen JW, Liu PQ
European journal of pharmacology 2022 Jun 15;925:174987
European journal of pharmacology 2022 Jun 15;925:174987
Metabotropic glutamate receptor 5 upregulation of γ-aminobutyric acid transporter 3 expression ameliorates cognitive impairment after traumatic brain injury in mice.
Xu P, Huang X, Niu W, Yu D, Zhou M, Wang H
Brain research bulletin 2022 Jun 1;183:104-115
Brain research bulletin 2022 Jun 1;183:104-115
The role and mechanism of TLR4-siRNA in the impairment of learning and memory in young mice induced by isoflurane.
Lin L, Chen D, Yu X, Zhong W, Liu Y, Feng Y, Luo H
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2022 Jul;31(7):769-780
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2022 Jul;31(7):769-780
The BDNF-TrkB-CREB Signalling Pathway Is Involved in Bisphenol S-Induced Neurotoxicity in Male Mice by Regulating Methylation.
Li YZ, Wu ZY, Zhu BQ, Wang YX, Kan YQ, Zeng HC
Toxics 2022 Jul 23;10(8)
Toxics 2022 Jul 23;10(8)
Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.
Li W, Lu L, Zhu D, Liu J, Shi Y, Zeng H, Yu X, Guo J, Wei B, Cai Y, Sun M
Ecotoxicology and environmental safety 2022 Jul 1;239:113682
Ecotoxicology and environmental safety 2022 Jul 1;239:113682
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H
Nature cancer 2022 Jan;3(1):75-89
Nature cancer 2022 Jan;3(1):75-89
Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment.
Wang C, Zhu T, Zhao Z, Chen B, Chen T, Dong Q, Liu M, Zhuang S, Yang F, Liu Y, Yang M, Gu Y, Liang H
FEBS letters 2022 Feb;596(4):449-464
FEBS letters 2022 Feb;596(4):449-464
WT1 suppresses follicle-stimulating hormone-induced progesterone secretion by regulating ERK1/2 pathway in chicken preovulatory granulosa cells.
Tang S, Li X, Wu X, Gong Y
Gene 2022 Feb 20;812:146097
Gene 2022 Feb 20;812:146097
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Gu X, Liu H, Luo W, Wang X, Wang H, Li L
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel K(Ca)3.1 in THP-1-Derived M(2) Macrophages.
Ohya S, Matsui M, Kajikuri J, Kito H, Endo K
International journal of molecular sciences 2022 Aug 3;23(15)
International journal of molecular sciences 2022 Aug 3;23(15)
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
Wang B, Wang M, Jia S, Li T, Yang M, Ge F
Journal of proteome research 2022 Apr 1;21(4):1137-1152
Journal of proteome research 2022 Apr 1;21(4):1137-1152
m6A Modification-Mediated DUXAP8 Regulation of Malignant Phenotype and Chemotherapy Resistance of Hepatocellular Carcinoma Through miR-584-5p/MAPK1/ERK Pathway Axis.
Liu Z, Lu J, Fang H, Sheng J, Cui M, Yang Y, Tang B, Zhang X
Frontiers in cell and developmental biology 2021;9:783385
Frontiers in cell and developmental biology 2021;9:783385
CREB Ameliorates Osteoarthritis Progression Through Regulating Chondrocytes Autophagy via the miR-373/METTL3/TFEB Axis.
Zhang H, Li X, Li Y, Yang X, Liao R, Wang H, Yang J
Frontiers in cell and developmental biology 2021;9:778941
Frontiers in cell and developmental biology 2021;9:778941
CREB1 and ATF1 Negatively Regulate Glutathione Biosynthesis Sensitizing Cells to Oxidative Stress.
Zhao L, Xia W, Jiang P
Frontiers in cell and developmental biology 2021;9:698264
Frontiers in cell and developmental biology 2021;9:698264
LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation.
Kuang Y, Bing Z, Jin X, Li Q
BioMed research international 2021;2021:1728352
BioMed research international 2021;2021:1728352
GluN2A/ERK/CREB Signaling Pathway Involved in Electroacupuncture Regulating Hypothalamic-Pituitary-Adrenal Axis Hyperactivity.
Wang Y, Han J, Zhu J, Zhang M, Ju M, Du Y, Tian Z
Frontiers in neuroscience 2021;15:703044
Frontiers in neuroscience 2021;15:703044
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Yang Y, Yi J, Pan M, Hu B, Duan H
Drug design, development and therapy 2021;15:1409-1422
Drug design, development and therapy 2021;15:1409-1422
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
Frontiers in pharmacology 2021;12:612083
Frontiers in pharmacology 2021;12:612083
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.
Zhang L, Zhang Y, Zhu M, Pei L, Deng F, Chen J, Zhang S, Cong Z, Du W, Xiao X
Frontiers in pharmacology 2021;12:590602
Frontiers in pharmacology 2021;12:590602
KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.
Wei H, Ma W, Lu X, Liu H, Lin K, Wang Y, Ye Z, Sun L, Huang Z, Pan T, Zhou Z, Cheng EY, Zhang H, Gao P, Zhong X
Cancer communications (London, England) 2021 Sep;41(9):904-920
Cancer communications (London, England) 2021 Sep;41(9):904-920
Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
Duffy MP, Sup ME, Guo XE
Biochemical and biophysical research communications 2021 Oct 8;573:145-150
Biochemical and biophysical research communications 2021 Oct 8;573:145-150
miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells.
Liu Q, Tian R, Yu P, Shu M
FEBS letters 2021 Nov;595(22):2829-2843
FEBS letters 2021 Nov;595(22):2829-2843
Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.
He QZ, Zhu BQ, Xu XN, Zeng HC
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.
Tang Q, Chen S, Wu H, Song H, Wang Y, Shi J, Wu Y
Cell death discovery 2021 Jun 14;7(1):143
Cell death discovery 2021 Jun 14;7(1):143
A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.
Fu Y, Xin Z, Ling Z, Xie H, Xiao T, Shen X, Lin J, Xu L, Jiang H
Molecular medicine (Cambridge, Mass.) 2021 Jul 22;27(1):81
Molecular medicine (Cambridge, Mass.) 2021 Jul 22;27(1):81
Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT(1A) receptor: Insights from transcriptomics.
Qiao YL, Zhou JJ, Liang JH, Deng XP, Zhang ZJ, Huang HL, Li S, Dai SF, Liu CQ, Luan ZL, Yu ZL, Sun CP, Ma XC
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153436
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153436
Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic facto by mediating synaptic transmission.
Wu L, Zhang T, Chen K, Lu C, Liu XF, Zhou JL, Huang YK, Yan H, Chen Y, Zhang CJ, Li JF, Shi SQ, Ren P, Huang X
Phytotherapy research : PTR 2021 Jan;35(1):404-414
Phytotherapy research : PTR 2021 Jan;35(1):404-414
Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons.
Zhang J, Lai ZP, Chen P, Ying Y, Zhuang J, Yu KM
Neural regeneration research 2021 Feb;16(2):394-400
Neural regeneration research 2021 Feb;16(2):394-400
mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.
Merle DA, Provenzano F, Jarboui MA, Kilger E, Clark SJ, Deleidi M, Armento A, Ueffing M
Antioxidants (Basel, Switzerland) 2021 Dec 3;10(12)
Antioxidants (Basel, Switzerland) 2021 Dec 3;10(12)
Duzhong Butiansu Prescription Improves Heat Stress-Induced Spermatogenic Dysfunction by Regulating Sperm Formation and Heat Stress Pathway.
Hou Y, Yuan P, Fu Y, Zhang Q, Wei Y, Gao L, Liu L, Wang X, Zheng X, Feng W
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6723204
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6723204
LncRNA BLACAT1/miR-519d-3p/CREB1 Axis Mediates Proliferation, Apoptosis, Migration, Invasion, and Drug-Resistance in Colorectal Cancer Progression.
Chen R, Zhou S, Chen J, Lin S, Ye F, Jiang P
Cancer management and research 2020;12:13137-13148
Cancer management and research 2020;12:13137-13148
Homer1a Undergoes Bimodal Transcriptional Regulation by CREB and the Circadian Clock.
Sato S, Bunney BG, Vawter MP, Bunney WE, Sassone-Corsi P
Neuroscience 2020 May 10;434:161-170
Neuroscience 2020 May 10;434:161-170
Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge.
Li W, Lu Q, Li X, Liu H, Sun L, Lu X, Zhao Y, Liu P
Food & function 2020 Mar 1;11(3):2067-2079
Food & function 2020 Mar 1;11(3):2067-2079
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.
Yuan C, Dai C, Li Z, Zheng L, Zhao M, Dong S
Neurochemical research 2020 Jul;45(7):1500-1509
Neurochemical research 2020 Jul;45(7):1500-1509
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.
He J, Huang Z, He M, Liao J, Zhang Q, Wang S, Xie L, Ouyang L, Koeffler HP, Yin D, Liu A
Molecular cancer 2020 Jan 28;19(1):17
Molecular cancer 2020 Jan 28;19(1):17
LncRNA MALAT1 inhibits apoptosis of endometrial stromal cells through miR-126-5p-CREB1 axis by activating PI3K-AKT pathway.
Feng Y, Tan BZ
Molecular and cellular biochemistry 2020 Dec;475(1-2):185-194
Molecular and cellular biochemistry 2020 Dec;475(1-2):185-194
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Liu XF, Tang CX, Zhang L, Tong SY, Wang Y, Abdulrahman AA, Ji GQ, Gao Y, Gao DS, Zhang BL
Neurochemical research 2020 Dec;45(12):2915-2925
Neurochemical research 2020 Dec;45(12):2915-2925
Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.
Qin T, Yuan Z, Yu J, Fu X, Deng X, Fu Q, Ma Z, Ma S
Clinical and translational medicine 2020 Dec;10(8):e243
Clinical and translational medicine 2020 Dec;10(8):e243
PTEN participates in airway remodeling of asthma by regulating CD38/Ca(2+)/CREB signaling.
Wu Y, Lu Y, Zou F, Fan X, Li X, Zhang H, Chen H, Sun X, Liu Y
Aging 2020 Aug 27;12(16):16326-16340
Aging 2020 Aug 27;12(16):16326-16340
The potential role of Krüppel-like factor 13 (Aj-klf13) in the intestine regeneration of sea cucumber Apostichopus japonicus.
Chen L, Yao F, Qin Y, Shao Y, Fang L, Yu X, Wang S, Hou L
Gene 2020 Apr 20;735:144407
Gene 2020 Apr 20;735:144407
MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways.
Ma M, Dai J, Tang H, Xu T, Yu S, Si L, Cui C, Sheng X, Chi Z, Mao L, Wu X, Yang L, Yu H, Li S, Lian B, Tang B, Wang X, Yan X, Bai X, Zhou L, Kong Y, Guo J
Theranostics 2019;9(4):945-960
Theranostics 2019;9(4):945-960
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Li Q, Wang Y, Wu S, Zhou Z, Ding X, Shi R, Thorne RF, Zhang XD, Hu W, Wu M
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Cell metabolism 2019 Jul 2;30(1):157-173.e7
ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma.
Shang Y, Li Y, Zhang Y, Wang J
Biochemical and biophysical research communications 2019 Aug 6;515(4):572-578
Biochemical and biophysical research communications 2019 Aug 6;515(4):572-578
Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway.
Han X, Wang B, Sun Y, Huang J, Wang X, Ma W, Zhu Y, Xu R, Jin H, Liu N
Frontiers in pharmacology 2018;9:1266
Frontiers in pharmacology 2018;9:1266
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS(2) nanoflowers.
Bai D, Li Q, Wang J, Zhao J, Deng X, Yuan L, Wu P
Toxicology research 2018 Nov 1;7(6):1267-1279
Toxicology research 2018 Nov 1;7(6):1267-1279
Calretinin Participates in Regulating Steroidogenesis by PLC-Ca(2+)-PKC Pathway in Leydig Cells.
Xu W, Zhu Q, Liu S, Dai X, Zhang B, Gao C, Gao L, Liu J, Cui Y
Scientific reports 2018 May 9;8(1):7403
Scientific reports 2018 May 9;8(1):7403
Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis.
Lv X, Wang D, Ma Y, Long Z
International journal of molecular medicine 2018 Mar;41(3):1349-1356
International journal of molecular medicine 2018 Mar;41(3):1349-1356
Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus.
Niu R, Chen H, Manthari RK, Sun Z, Wang J, Zhang J, Wang J
Chemosphere 2018 Mar;194:628-633
Chemosphere 2018 Mar;194:628-633
Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.
Cao Q, Xiao ZM, Wang X, Weng C, Ding M, Zhu F, Lu ZN
Neurochemical research 2018 Jun;43(6):1227-1241
Neurochemical research 2018 Jun;43(6):1227-1241
A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.
Yan L, You WQ, Sheng NQ, Gong JF, Hu LD, Tan GW, Chen HQ, Wang ZG
Aging 2018 Dec 6;10(12):3774-3793
Aging 2018 Dec 6;10(12):3774-3793
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1-42)-Induced Rat Model of Alzheimer's Disease.
Sheng C, Xu P, Zhou K, Deng D, Zhang C, Wang Z
BioMed research international 2017;2017:7464872
BioMed research international 2017;2017:7464872
Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.
Avila DV, Barker DF, Zhang J, McClain CJ, Barve S, Gobejishvili L
The Journal of pathology 2016 Sep;240(1):96-107
The Journal of pathology 2016 Sep;240(1):96-107
Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage Amyloid Precursor Protein/Presenilin 1 Mice.
Zhang Z, Wu H, Huang H
Pharmacognosy magazine 2016 May;12(Suppl 2):S139-46
Pharmacognosy magazine 2016 May;12(Suppl 2):S139-46
LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p.
Bian Z, Jin L, Zhang J, Yin Y, Quan C, Hu Y, Feng Y, Liu H, Fei B, Mao Y, Zhou L, Qi X, Huang S, Hua D, Xing C, Huang Z
Scientific reports 2016 Apr 5;6:23892
Scientific reports 2016 Apr 5;6:23892
BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density during LTP via a Rab11-dependent pathway.
Huang SH, Wang J, Sui WH, Chen B, Zhang XY, Yan J, Geng Z, Chen ZY
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 22;33(21):9214-30
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 22;33(21):9214-30
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CREB1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CREB1. This antibody recognizes human, mouse, rat, monkey antigen. The CREB1 antibody has been validated for the following applications: ELISA, IP, WB, IF, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HEK-293 cells using 12208-1-AP( CREB1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CREB1 (IP:12208-1-AP, 3ug; Detection:12208-1-AP 1:600) with HEK-293 cells lysate 2000ug.
- Sample type
- cell line
