BS4053

antibody from Bioworld Technology, Inc
Targeting: CREB1
Provider product page for BS4053
Western blot
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
BS4053 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS4053, RRID:AB_1664096
Product name
CREB (phospho S133) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human CREB around the phosphorylation site of Serine 133.
Description
Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CREB1 protein structure - BS4053 shown in red.