Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations [0]
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- Product number
- 55410-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- ND5 antibody
- Antibody type
- Polyclonal
- Description
- ND5 antibody (Cat. #55410-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits.
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations.
Mitochondrial Genome-Encoded lncND5 Regulates Mitophagy in Hypoxic Pulmonary Artery Smooth Muscle Cell.
PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma.
Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.
Novel biallelic TK2 mutations cause mitochondrial DNA depletion syndrome with infantile early-onset lipid storage myopathy.
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma.
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B(1) cytotoxicity.
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression.
MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.
Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures.
Proteomic analysis illustrates the potential involvement of dysregulated ribosome-related pathways and disrupted metabolism during retinoic acid-induced cleft palate development.
Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells.
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice.
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin.
Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species.
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation.
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
MCART1/SLC25A51 is required for mitochondrial NAD transport.
Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males.
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex.
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Liu W, Wang C, Tang H, Tian Z, Li D, Chen G, Wang A
Ecotoxicology and environmental safety 2025 Oct 15;305:119187
Ecotoxicology and environmental safety 2025 Oct 15;305:119187
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations.
Chang HC, Tsai CY, Hsu CL, Tai TS, Cheng ML, Chuang YM, Tang HY, Lin KJ, Chen JJ, Chang SH, Ko YC, Chi YW, Liu H, Tan BC, Shen CR, Yang CW, Ho PC, Yang HY
Nature metabolism 2025 May;7(5):918-927
Nature metabolism 2025 May;7(5):918-927
Mitochondrial Genome-Encoded lncND5 Regulates Mitophagy in Hypoxic Pulmonary Artery Smooth Muscle Cell.
Bai J, He S, Wang X, Zhang L, Ma C, Gao D, Yuan H, Mei J, Guan X, Yu H, Wan K, Zhu D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70618
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70618
PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma.
Kalita B, Martinez-Cebrian G, McEvoy J, Allensworth M, Knight M, Magli A, Perlingeiro RCR, Dyer MA, Stewart E, Dynlacht BD
Cell 2025 May 15;188(10):2757-2777.e22
Cell 2025 May 15;188(10):2757-2777.e22
Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.
Fu XX, Wei B, Huang ZH, Duan R, Deng Y, E Y, Wang SY, Chen SY, Zhang YD, Jiang T
Journal of Alzheimer's disease : JAD 2025 Mar;104(1):209-220
Journal of Alzheimer's disease : JAD 2025 Mar;104(1):209-220
Novel biallelic TK2 mutations cause mitochondrial DNA depletion syndrome with infantile early-onset lipid storage myopathy.
Li D, Shi Y, Sun H, Yan C, Lin Y
Orphanet journal of rare diseases 2025 Mar 17;20(1):130
Orphanet journal of rare diseases 2025 Mar 17;20(1):130
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L, Gao P, Zhang H
Nature chemical biology 2025 Jun;21(6):926-938
Nature chemical biology 2025 Jun;21(6):926-938
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma.
Zhu L, Liu F, Shi C, Su X, Tan M, Xie S, Yu M, Zou S, Tan Y, Xie S, Liu J, Yan Q, Neculai D, Sun Q, Liu W, Ding Y, Fu X, Shao J, Li X, Ding K, Yuan Y, Zhou T, Lin A
Molecular cell 2025 Jun 19;85(12):2303-2319.e7
Molecular cell 2025 Jun 19;85(12):2303-2319.e7
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B(1) cytotoxicity.
Yang H, Ji X, Zhong H, Yang X, Hu D, Cai G, Wu Z
Science China. Life sciences 2025 Jul;68(7):2121-2136
Science China. Life sciences 2025 Jul;68(7):2121-2136
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression.
Li C, Lu Y, Li Y, Liu T, Deng H, Gao M, Zhou B, Liu J, Cai J, Huang D, Yang L, Jin J, Kuang D, Su S
Cell metabolism 2025 Dec 2;37(12):2402-2422.e18
Cell metabolism 2025 Dec 2;37(12):2402-2422.e18
MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.
Ji X, Xue F, Wang Y, Gao D, Sun J, Dong T, Mu Q, Xu Q, Sun S, Liu Y, Wan Q
Cell death & disease 2025 Aug 26;16(1):646
Cell death & disease 2025 Aug 26;16(1):646
Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures.
Wang J, Lin Y, Xu Z, Yan C, Zhao Y, Ji K
Cerebellum (London, England) 2024 Oct;23(5):1824-1838
Cerebellum (London, England) 2024 Oct;23(5):1824-1838
Proteomic analysis illustrates the potential involvement of dysregulated ribosome-related pathways and disrupted metabolism during retinoic acid-induced cleft palate development.
Zhang W, Chen L, Ma A, Jiang W, Xu M, Bai X, Zhou J, Tang S
BMC medical genomics 2024 Nov 29;17(1):280
BMC medical genomics 2024 Nov 29;17(1):280
Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells.
Lin YH, Lin KL, Wang XW, Lee JJ, Wang FS, Wang PW, Lan MY, Liou CW, Lin TK
Mitochondrion 2024 May;76:101856
Mitochondrion 2024 May;76:101856
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Cell metabolism 2024 May 7;36(5):1059-1075.e9
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
Tian Z, Li J, Tang H, Liu W, Hou H, Wang C, Li D, Chen G, Xia T, Wang A
Journal of hazardous materials 2024 Jun 5;471:134331
Journal of hazardous materials 2024 Jun 5;471:134331
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.
Lin Y, Wang D, Li B, Wang J, Xu L, Sun X, Ji K, Yan C, Liu F, Zhao Y
JCI insight 2024 Jun 25;9(15)
JCI insight 2024 Jun 25;9(15)
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice.
Li W, Li J, Li J, Wei C, Laviv T, Dong M, Lin J, Calubag M, Colgan LA, Jin K, Zhou B, Shen Y, Li H, Cui Y, Gao Z, Li T, Hu H, Yasuda R, Ma H
Science (New York, N.Y.) 2024 Dec 20;386(6728):eadp6547
Science (New York, N.Y.) 2024 Dec 20;386(6728):eadp6547
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin.
Yu L, Chen Z, Zhou X, Teng F, Bai QR, Li L, Li Y, Liu Y, Zeng Q, Wang Y, Wang M, Xu Y, Tang X, Wang X
Journal of pineal research 2024 Aug;76(5):e12998
Journal of pineal research 2024 Aug;76(5):e12998
Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species.
Sang Y, Yang Q, Guo Y, Liu X, Shen D, Jiang C, Wang X, Li K, Wang H, Yang C, Ding L, Sun H, Guo X, Li C
The Journal of biological chemistry 2023 Oct;299(10):105183
The Journal of biological chemistry 2023 Oct;299(10):105183
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Ji X, Chu L, Su D, Sun J, Song P, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
iScience 2023 May 19;26(5):106656
iScience 2023 May 19;26(5):106656
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Qin W, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
Cell 2023 Jul 20;186(15):3307-3324.e30
Cell 2023 Jul 20;186(15):3307-3324.e30
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Tian Z, Li J, Song L, Xie L, Li D, Xia T, Wang A
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Xu WQ, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
bioRxiv : the preprint server for biology 2023 Feb 8;
bioRxiv : the preprint server for biology 2023 Feb 8;
Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation.
Wang J, Ji Y, Ai C, Chen JR, Gan D, Zhang J, Mo JQ, Guan MX
Journal of biomedical science 2023 Aug 3;30(1):63
Journal of biomedical science 2023 Aug 3;30(1):63
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
Li D, Zhao Q, Xie L, Wang C, Tian Z, Tang H, Xia T, Wang A
The Science of the total environment 2023 Apr 15;869:161738
The Science of the total environment 2023 Apr 15;869:161738
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6
Molecular cell 2022 May 19;82(10):1821-1835.e6
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Xie QE, Wang MY, Cao ZP, Du X, Ji DM, Liang D, Cao YX, Liu YJ
Mitochondrion 2021 Nov;61:44-53
Mitochondrion 2021 Nov;61:44-53
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT
Cell metabolism 2021 May 4;33(5):1027-1041.e8
Cell metabolism 2021 May 4;33(5):1027-1041.e8
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Gu X, Liu Y, Wang N, Zhen J, Zhang B, Hou S, Cui Z, Wan Q, Feng H
Free radical biology & medicine 2021 Feb 20;164:329-340
Free radical biology & medicine 2021 Feb 20;164:329-340
MCART1/SLC25A51 is required for mitochondrial NAD transport.
Kory N, Uit de Bos J, van der Rijt S, Jankovic N, Güra M, Arp N, Pena IA, Prakash G, Chan SH, Kunchok T, Lewis CA, Sabatini DM
Science advances 2020 Oct;6(43)
Science advances 2020 Oct;6(43)
Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males.
Ma J, Chen Q, Wang S, Ma R, Jing J, Yang Y, Feng Y, Zou Z, Zhang Y, Ge X, Xue T, Liang K, Cao S, Wang D, Chen L, Yao B
Aging 2020 May 7;12(9):8321-8338
Aging 2020 May 7;12(9):8321-8338
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983
Carcinogenesis 2020 Jul 14;41(7):972-983
MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex.
Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P
EMBO reports 2020 Jan 7;21(1):e48833
EMBO reports 2020 Jan 7;21(1):e48833
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Ma Y, Zhu S, Lv T, Gu X, Feng H, Zhen J, Xin W, Wan Q
iScience 2020 Aug 21;23(8):101428
iScience 2020 Aug 21;23(8):101428
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Fu R, Yang P, Li Z, Liu W, Amin S, Li Z
Cell death & disease 2019 Aug 7;10(8):593
Cell death & disease 2019 Aug 7;10(8):593
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG Jr, Liu XS, Zhang Q
The EMBO journal 2015 Dec 2;34(23):2953-70
The EMBO journal 2015 Dec 2;34(23):2953-70
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