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- References [130]
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- Product number
- 55090-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- CYTB antibody
- Antibody type
- Polyclonal
- Description
- CYTB antibody (Cat. #55090-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitochondrial Haplogroups Influence Mitochondrial Structure and Function, Oxidative Stress, Autophagy, and Lipid Metabolism of Chicken Hepatocytes in Response to Energy Stimulation.
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Hyperglycemia impairs cognitive function by inducing mitochondrial damage through lactylation of LRPPRC at K223.
TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.
Hypoxia-induced tRF-3(Thr-CGT) promotes hepatocellular carcinoma progression via mitochondrial energy metabolism remodeling dependent on the mtDNA-translation mechanism.
POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis.
Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.
Effects of Nutritional Disturbances on the Structure and Function of Mitochondria, Oxidative Stress Level, and Fat Deposition in Chicken Liver Cells.
Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits.
Mitochondrial ribosomal protein L12 mediates metabolic reorganization in clear cell renal cell carcinoma by regulating mitochondrial biosynthesis.
Electroacupuncture at Huantiao (GB30) and Zusanli (ST36) acupoints promotes peripheral nerve regeneration by enhancing energy metabolism in mice.
Engineering mtDNA deletions by reconstituting end joining in human mitochondria.
PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma.
Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.
TBCK-deficiency leads to compartment-specific mRNA and lysosomal trafficking defects in patient-derived neurons.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Electrical stimulation promotes peripheral nerve regeneration by upregulating glycolysis and oxidative phosphorylation.
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma.
TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancer.
Selection of initiator tRNA and start codon by mammalian mitochondrial initiation factor 3 in leaderless mRNA translation.
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Trimethylamine N-oxide induces pyroptosis in HTR8-S/Vneo cells through the ten-eleven translocation 2-cytochrome b-reactive oxygen species pathway.
Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis.
Ceria Nanoparticles Improve the Quality of Aging Oocytes in Mice by Enhancing ROS Scavenging Ability.
Loss of ELF2 drives topotecan resistance in retinoblastoma revealed by genome-wide CRISPR-Cas9 screening.
MRPL37 promotes hepatocellular carcinoma progression through modulating mitochondrial energy metabolism.
MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.
Uncovering a Novel Pathogenic Mechanism of BCS1L in Mitochondrial Disorders: Insights from Functional Studies on the c.38A>G Variant.
Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy.
Temporal expression of mitochondrial life cycle markers during acute and chronic overload of rat plantaris muscles.
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis.
UBASH3B-mediated MRPL12 Y60 dephosphorylation inhibits LUAD development by driving mitochondrial metabolism reprogramming.
Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes.
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Potential Impact of Hypoxic Astrocytes on the Aggravation of Depressive Symptoms in Parkinson's Disease.
Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation.
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury.
THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma.
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation.
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin.
Combination of RNA-seq and proteomics reveals the mechanism of DL0410 treatment in APP/PS1 transgenic mouse model of Alzheimer's disease.
Queuine ameliorates impaired mitochondrial function caused by mt-tRNA(Asn) variants.
Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS.
Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits.
MT-TN mutations lead to progressive mitochondrial encephalopathy and promotes mitophagy.
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species.
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression.
Alleviation of Photoreceptor Degeneration Based on Fullerenols in rd1 Mice by Reversing Mitochondrial Dysfunction via Modulation of Mitochondrial DNA Transcription and Leakage.
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation.
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor.
Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function.
Expanding DdCBE-mediated targeting scope to aC motif preference in rat.
NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities.
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency.
Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells.
MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis.
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins.
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.
MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose.
Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
Targeting mitochondrial tyrosyl-tRNA synthetase YARS2 suppresses colorectal cancer progression.
Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation.
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis.
Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature.
TMT-Based Proteomic Explores the Influence of DHEA on the Osteogenic Differentiation of hBMSCs.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Mechanistic insights into mitochondrial tRNA(Ala) 3'-end metabolism deficiency.
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
A deafness-associated tRNA mutation caused pleiotropic effects on the m1G37 modification, processing, stability and aminoacylation of tRNAIle and mitochondrial translation.
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNA(Thr) Gene.
Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts.
Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNA(His) mutation.
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNAMet, all 8 tRNAs and ND6 mRNA in the light-strand transcript.
FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function.
Mitochondrial stress response triggered by defects in protein synthesis quality control.
A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis.
Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNA(Ser(UCN)) 7511A>G mutation.
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Leber's hereditary optic neuropathy caused by a mutation in mitochondrial tRNA(Thr) in eight Chinese pedigrees.
RNA modification landscape of the human mitochondrial tRNA(Lys) regulates protein synthesis.
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Contribution of the tRNA(Ile) 4317A→G mutation to the phenotypic manifestation of the deafness-associated mitochondrial 12S rRNA 1555A→G mutation.
Leber's hereditary optic neuropathy (LHON)-associated ND5 12338T > C mutation altered the assembly and function of complex I, apoptosis and mitophagy.
A hypertension-associated mitochondrial DNA mutation introduces an m(1)G37 modification into tRNA(Met), altering its structure and function.
Protein profiling and functional analysis of liver mitochondria from rats with nonalcoholic steatohepatitis.
Late onset nonsyndromic hearing loss in a Dongxiang Chinese family is associated with the 593T>C variant in the mitochondrial tRNA(Phe) gene.
Biochemical Evidence for a Nuclear Modifier Allele (A10S) in TRMU (Methylaminomethyl-2-thiouridylate-methyltransferase) Related to Mitochondrial tRNA Modification in the Phenotypic Manifestation of Deafness-associated 12S rRNA Mutation.
Novel GFM2 variants associated with early-onset neurological presentations of mitochondrial disease and impaired expression of OXPHOS subunits.
A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNA(Leu(UUR)).
A Deafness- and Diabetes-associated tRNA Mutation Causes Deficient Pseudouridinylation at Position 55 in tRNAGlu and Mitochondrial Dysfunction.
A Hypertension-Associated tRNAAla Mutation Alters tRNA Metabolism and Mitochondrial Function.
The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation.
A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function.
Zhang P, Zhu S, Xing Y, Zhou X, Imtiaz A, Ge J, Gao Y, Jia X, Geng T
Animals : an open access journal from MDPI 2026 Mar 1;16(5)
Animals : an open access journal from MDPI 2026 Mar 1;16(5)
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Zhang Y, Shen X, Shen Y, Wang C, Yu C, Han J, Cao S, Qian L, Ma M, Huang S, Wen W, Yin M, Lei QY
Nature 2026 Jan;649(8098):1022-1031
Nature 2026 Jan;649(8098):1022-1031
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fu T, Sun S, Wang Z, Zhao F, Zhen J, Ji X, Xue F, Mu Q, Wang Y, Liu Y, Wan Q
Cardiovascular diabetology 2026 Feb 3;25(1)
Cardiovascular diabetology 2026 Feb 3;25(1)
Hyperglycemia impairs cognitive function by inducing mitochondrial damage through lactylation of LRPPRC at K223.
Xu J, Hao Y, Cao J, Yang X, Gao Y, Sun X, Nie R, Zhong Q, Zhong Y, Zhong J, Zheng T
EMBO molecular medicine 2026 Apr 6;
EMBO molecular medicine 2026 Apr 6;
TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.
Xia L, Wang Z, Chen X
Journal of inflammation research 2025;18:8719-8733
Journal of inflammation research 2025;18:8719-8733
Hypoxia-induced tRF-3(Thr-CGT) promotes hepatocellular carcinoma progression via mitochondrial energy metabolism remodeling dependent on the mtDNA-translation mechanism.
Qu X, Liu B, Jin D, Ma Y, Liu M, Yan X, Su J, Zhou L
Frontiers in pharmacology 2025;16:1549373
Frontiers in pharmacology 2025;16:1549373
POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis.
Zhang T, Gao Y, Harhai M, Jourdain AA, Marti TM, Vassella E, Yang Z, Zhou Q, Dorn P, Peng RW
Redox biology 2025 Sep;85:103758
Redox biology 2025 Sep;85:103758
Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.
Li D, Duan H, Jiang Z, Zhou C, Cao C, Ni M, He L, Zhu X, Jin L, Liu W, Gu L, Li H, Liu D, Zhao X, Zhao G, Li J
Free radical biology & medicine 2025 Sep;237:270-284
Free radical biology & medicine 2025 Sep;237:270-284
Effects of Nutritional Disturbances on the Structure and Function of Mitochondria, Oxidative Stress Level, and Fat Deposition in Chicken Liver Cells.
Zhu S, Zhang P, Xing Y, Zhou X, Ge J, Jia X, Gao Y, Geng T
Animals : an open access journal from MDPI 2025 Oct 30;15(21)
Animals : an open access journal from MDPI 2025 Oct 30;15(21)
Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits.
Liu W, Wang C, Tang H, Tian Z, Li D, Chen G, Wang A
Ecotoxicology and environmental safety 2025 Oct 15;305:119187
Ecotoxicology and environmental safety 2025 Oct 15;305:119187
Mitochondrial ribosomal protein L12 mediates metabolic reorganization in clear cell renal cell carcinoma by regulating mitochondrial biosynthesis.
Sun S, Su D, Dong T, Wang B, Ji X, Chu L, Lu S, Zhang T, Sun X, Liu Y, Wan Q
Cell communication and signaling : CCS 2025 Oct 14;23(1):435
Cell communication and signaling : CCS 2025 Oct 14;23(1):435
Electroacupuncture at Huantiao (GB30) and Zusanli (ST36) acupoints promotes peripheral nerve regeneration by enhancing energy metabolism in mice.
Ji Q, Zhang N, Zhang B, Chen Y, Zhang Q, Yao X, Zhang M, Zheng Q, Ni G, Shan F
Neuroreport 2025 Oct 1;36(14):874-885
Neuroreport 2025 Oct 1;36(14):874-885
Engineering mtDNA deletions by reconstituting end joining in human mitochondria.
Fu Y, Land M, Kavlashvili T, Cui R, Kim M, DeBitetto E, Lieber T, Ryu KW, Choi E, Masilionis I, Saha R, Takizawa M, Baker D, Tigano M, Lareau CA, Reznik E, Sharma R, Chaligne R, Thompson CB, Pe'er D, Sfeir A
Cell 2025 May 15;188(10):2778-2793.e21
Cell 2025 May 15;188(10):2778-2793.e21
PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma.
Kalita B, Martinez-Cebrian G, McEvoy J, Allensworth M, Knight M, Magli A, Perlingeiro RCR, Dyer MA, Stewart E, Dynlacht BD
Cell 2025 May 15;188(10):2757-2777.e22
Cell 2025 May 15;188(10):2757-2777.e22
Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.
Fu XX, Wei B, Huang ZH, Duan R, Deng Y, E Y, Wang SY, Chen SY, Zhang YD, Jiang T
Journal of Alzheimer's disease : JAD 2025 Mar;104(1):209-220
Journal of Alzheimer's disease : JAD 2025 Mar;104(1):209-220
TBCK-deficiency leads to compartment-specific mRNA and lysosomal trafficking defects in patient-derived neurons.
Flores-Mendez M, Tintos-Hernández JA, Ramos-Rodriguez L, Miles L, Lo TY, Song Y, Ortiz-González XR
bioRxiv : the preprint server for biology 2025 Mar 7;
bioRxiv : the preprint server for biology 2025 Mar 7;
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
Electrical stimulation promotes peripheral nerve regeneration by upregulating glycolysis and oxidative phosphorylation.
Zhang N, Yao X, Zhang Q, Zhang C, Zheng Q, Wang Y, Shan F
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167804
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167804
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma.
Zhu L, Liu F, Shi C, Su X, Tan M, Xie S, Yu M, Zou S, Tan Y, Xie S, Liu J, Yan Q, Neculai D, Sun Q, Liu W, Ding Y, Fu X, Shao J, Li X, Ding K, Yuan Y, Zhou T, Lin A
Molecular cell 2025 Jun 19;85(12):2303-2319.e7
Molecular cell 2025 Jun 19;85(12):2303-2319.e7
TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancer.
Jia Y, Liao J, Yang X, Hu H, Zhao W, Zhao L, Ai C, Xue Y, Tan S, Zhang Y
Biology direct 2025 Jul 1;20(1):75
Biology direct 2025 Jul 1;20(1):75
Selection of initiator tRNA and start codon by mammalian mitochondrial initiation factor 3 in leaderless mRNA translation.
Lee M, Wakigawa T, Jia Q, Liu C, Huang R, Huang S, Nagao A, Suzuki T, Tomita K, Iwasaki S, Takeuchi-Tomita N
Nucleic acids research 2025 Jan 24;53(3)
Nucleic acids research 2025 Jan 24;53(3)
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Song Y, Zhu X, Wang B, Li Q, Song B
Scientific reports 2025 Jan 10;15(1):1614
Scientific reports 2025 Jan 10;15(1):1614
Trimethylamine N-oxide induces pyroptosis in HTR8-S/Vneo cells through the ten-eleven translocation 2-cytochrome b-reactive oxygen species pathway.
Liang L, Rao Y, Wang J, Zhao J, He L, Meng J, Wu P, Wang Z
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16237
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16237
Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis.
Morishima T, Fakruddin M, Kanamori Y, Masuda T, Ogawa A, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Akaike T, Moroishi T, Tomizawa K, Suda T, Wei FY, Takizawa H
Science advances 2025 Feb 21;11(8):eadu3011
Science advances 2025 Feb 21;11(8):eadu3011
Ceria Nanoparticles Improve the Quality of Aging Oocytes in Mice by Enhancing ROS Scavenging Ability.
Wang Y, Zhong C, Ma X, Liu X, Zhang B, Min C, Zhang K, Wang X, Hou S, Zhao J, Wang J, Fang Y, Liu H, Ding H, Guo J, Cheng Y, Lu W
ACS applied bio materials 2025 Feb 17;8(2):992-1001
ACS applied bio materials 2025 Feb 17;8(2):992-1001
Loss of ELF2 drives topotecan resistance in retinoblastoma revealed by genome-wide CRISPR-Cas9 screening.
Jiang J, Jiang Z, Luo Q, Chen X, Zhuang J, Chen J, Mu Q, Qiu J, Li Y, Chen S, Zhang P, Yu K, Chen S, Liu GS, Zhuang J
Cell death & disease 2025 Dec 23;17(1):128
Cell death & disease 2025 Dec 23;17(1):128
MRPL37 promotes hepatocellular carcinoma progression through modulating mitochondrial energy metabolism.
Zhang Y, Chen M, Li H, Deng H, Chen S, Ni J, Hu J, Lei S, Huang L, Dang S, Yang Z, Zhou W, Ding D, Dong Y, Meng Z
iScience 2025 Dec 19;28(12):114052
iScience 2025 Dec 19;28(12):114052
MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.
Ji X, Xue F, Wang Y, Gao D, Sun J, Dong T, Mu Q, Xu Q, Sun S, Liu Y, Wan Q
Cell death & disease 2025 Aug 26;16(1):646
Cell death & disease 2025 Aug 26;16(1):646
Uncovering a Novel Pathogenic Mechanism of BCS1L in Mitochondrial Disorders: Insights from Functional Studies on the c.38A>G Variant.
Capaci V, Zupin L, Magistrati M, Bonati MT, Celsi F, Marrone I, Baldo F, Ura B, Spedicati B, Morgan A, Bruno I, Zeviani M, Dallabona C, Girotto G, Magnolato A
International journal of molecular sciences 2025 Apr 12;26(8)
International journal of molecular sciences 2025 Apr 12;26(8)
Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy.
Xiao Y, Zhang Y, Xie K, Huang X, Liu X, Luo J, Tan S
International journal of biological sciences 2024;20(7):2658-2685
International journal of biological sciences 2024;20(7):2658-2685
Temporal expression of mitochondrial life cycle markers during acute and chronic overload of rat plantaris muscles.
Hyatt JK, Lu EJ, McCall GE
Frontiers in physiology 2024;15:1420276
Frontiers in physiology 2024;15:1420276
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis.
Zhao M, Li J, Li Z, Yang D, Wang D, Sun Z, Wen P, Gou F, Dai Y, Ji Y, Li W, Zhao D, Yang L
International journal of molecular sciences 2024 Sep 7;25(17)
International journal of molecular sciences 2024 Sep 7;25(17)
UBASH3B-mediated MRPL12 Y60 dephosphorylation inhibits LUAD development by driving mitochondrial metabolism reprogramming.
Ji X, Zhang T, Sun J, Song X, Ma G, Xu L, Cao X, Jing Y, Xue F, Zhang W, Sun S, Wan Q, Liu Y
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):268
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):268
Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes.
Khan B, Lanzuolo C, Rosti V, Santarelli P, Pich A, Kraft T, Amrute-Nayak M, Nayak A
iScience 2024 Oct 18;27(10):110913
iScience 2024 Oct 18;27(10):110913
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
Chen X, Meng F, Chen C, Li S, Chou Z, Xu B, Mo JQ, Guo Y, Guan MX
The Journal of biological chemistry 2024 May;300(5):107235
The Journal of biological chemistry 2024 May;300(5):107235
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Cell metabolism 2024 May 7;36(5):1059-1075.e9
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
Kodavati M, Wang H, Guo W, Mitra J, Hegde PM, Provasek V, Rao VHM, Vedula I, Zhang A, Mitra S, Tomkinson AE, Hamilton DJ, Van Den Bosch L, Hegde ML
Nature communications 2024 Mar 9;15(1):2156
Nature communications 2024 Mar 9;15(1):2156
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Zhang N, Ji Q, Chen Y, Wen X, Shan F
Cell death & disease 2024 Mar 7;15(3):193
Cell death & disease 2024 Mar 7;15(3):193
Potential Impact of Hypoxic Astrocytes on the Aggravation of Depressive Symptoms in Parkinson's Disease.
Peng Y, He J, Xiang H, Xie L, She J, Cheng D, Liu B, Hu J, Qian H
Journal of molecular neuroscience : MN 2024 Mar 5;74(1):28
Journal of molecular neuroscience : MN 2024 Mar 5;74(1):28
Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation.
Shi D, Wang B, Li H, Lian Y, Ma Q, Liu T, Cao M, Ma Y, Shi L, Yuan W, Shi J, Chu Y
iScience 2024 Mar 15;27(3):109265
iScience 2024 Mar 15;27(3):109265
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury.
Hu C, Li M, Chen Y, Cheng W, Wang H, Zhou Y, Teng F, Ling T, Pan J, Xu H, Zheng Y, Ji G, Zhao T, You Q
Cell death discovery 2024 Mar 1;10(1):107
Cell death discovery 2024 Mar 1;10(1):107
THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma.
Wang ZH, Wang J, Liu F, Sun S, Zheng Q, Hu X, Yin Z, Xie C, Wang H, Wang T, Zhang S, Wang YP
FEBS letters 2024 Jun;598(12):1513-1531
FEBS letters 2024 Jun;598(12):1513-1531
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
Tian Z, Li J, Tang H, Liu W, Hou H, Wang C, Li D, Chen G, Xia T, Wang A
Journal of hazardous materials 2024 Jun 5;471:134331
Journal of hazardous materials 2024 Jun 5;471:134331
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.
Lin Y, Wang D, Li B, Wang J, Xu L, Sun X, Ji K, Yan C, Liu F, Zhao Y
JCI insight 2024 Jun 25;9(15)
JCI insight 2024 Jun 25;9(15)
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation.
Hilander T, Awadhpersad R, Monteuuis G, Broda KL, Pohjanpelto M, Pyman E, Singh SK, Nyman TA, Crevel I, Taylor RW, Saada A, Balboa D, Battersby BJ, Jackson CB, Carroll CJ
iScience 2024 Jul 19;27(7):110185
iScience 2024 Jul 19;27(7):110185
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
Shi L, Tan Y, Zheng W, Cao G, Zhou H, Li P, Cui J, Song Y, Feng L, Li H, Shan W, Zhang B, Yi W
Cell death discovery 2024 Jan 26;10(1):53
Cell death discovery 2024 Jan 26;10(1):53
LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
Ma J, Dong D, Qi H, Li J, Yu H, Hu X, Sun L, Shen L
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167453
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167453
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin.
Yu L, Chen Z, Zhou X, Teng F, Bai QR, Li L, Li Y, Liu Y, Zeng Q, Wang Y, Wang M, Xu Y, Tang X, Wang X
Journal of pineal research 2024 Aug;76(5):e12998
Journal of pineal research 2024 Aug;76(5):e12998
Combination of RNA-seq and proteomics reveals the mechanism of DL0410 treatment in APP/PS1 transgenic mouse model of Alzheimer's disease.
Zhang B, Zhao J, Yan C, Bai Y, Guo P, Wang C, Wang Z, Du G, Liu A
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116940
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116940
Queuine ameliorates impaired mitochondrial function caused by mt-tRNA(Asn) variants.
Lin Y, Wang J, Zhuang X, Zhao Y, Wang W, Wang D, Zhao Y, Yan C, Ji K
Journal of translational medicine 2024 Aug 22;22(1):780
Journal of translational medicine 2024 Aug 22;22(1):780
Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS.
Xu Y, Li G, Ge D, Chen Y, Hou B, Hao Z
Urolithiasis 2024 Aug 13;52(1):117
Urolithiasis 2024 Aug 13;52(1):117
Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits.
Ding XY, Zhang H, Qiu YM, Xie MD, Wang H, Xiong ZY, Li TT, He CN, Dong W, Tang XL
Current medical science 2024 Apr;44(2):450-461
Current medical science 2024 Apr;44(2):450-461
MT-TN mutations lead to progressive mitochondrial encephalopathy and promotes mitophagy.
Duan H, Pan C, Wu T, Peng J, Yang L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167043
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167043
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
Xiao Y, Liu X, Xie K, Luo J, Zhang Y, Huang X, Luo J, Tan S
Clinical and translational medicine 2024 Apr;14(4):e1653
Clinical and translational medicine 2024 Apr;14(4):e1653
LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.
Li Y, Huang D, Jia L, Shangguan F, Gong S, Lan L, Song Z, Xu J, Yan C, Chen T, Tan Y, Liu Y, Huang X, Suzuki CK, Yang Z, Yang G, Lu B
Research (Washington, D.C.) 2023;6:0175
Research (Washington, D.C.) 2023;6:0175
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Liu Y, Zhang H, Liu Y, Zhang S, Su P, Wang L, Li Y, Liang Y, Wang X, Zhao W, Chen B, Luo D, Zhang N, Yang Q
Autophagy 2023 Sep;19(9):2443-2463
Autophagy 2023 Sep;19(9):2443-2463
Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species.
Sang Y, Yang Q, Guo Y, Liu X, Shen D, Jiang C, Wang X, Li K, Wang H, Yang C, Ding L, Sun H, Guo X, Li C
The Journal of biological chemistry 2023 Oct;299(10):105183
The Journal of biological chemistry 2023 Oct;299(10):105183
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
Lee Q, Chan WC, Qu X, Sun Y, Abdelkarim H, Le J, Saqib U, Sun MY, Kruse K, Banerjee A, Hitchinson B, Geyer M, Huang F, Guaiquil V, Mutso AA, Sanders M, Rosenblatt MI, Maienschein-Cline M, Lawrence MS, Gaponenko V, Malik AB, Komarova YA
Cell reports. Medicine 2023 Oct 17;4(10):101223
Cell reports. Medicine 2023 Oct 17;4(10):101223
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S
Nature communications 2023 Oct 10;14(1):6344
Nature communications 2023 Oct 10;14(1):6344
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression.
Kramer NJ, Prakash G, Isaac RS, Choquet K, Soto I, Petrova B, Merens HE, Kanarek N, Churchman LS
Nature cell biology 2023 Nov;25(11):1575-1589
Nature cell biology 2023 Nov;25(11):1575-1589
Alleviation of Photoreceptor Degeneration Based on Fullerenols in rd1 Mice by Reversing Mitochondrial Dysfunction via Modulation of Mitochondrial DNA Transcription and Leakage.
Yang J, Chen X, A L, Gao H, Zhao M, Ge L, Li M, Yang C, Gong Y, Gu Z, Xu H
Small (Weinheim an der Bergstrasse, Germany) 2023 Nov;19(44):e2205998
Small (Weinheim an der Bergstrasse, Germany) 2023 Nov;19(44):e2205998
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D
Nature communications 2023 Nov 30;14(1):7889
Nature communications 2023 Nov 30;14(1):7889
GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation.
Wang L, Hilander T, Liu X, Tsang HY, Eriksson O, Jackson CB, Varjosalo M, Zhao H
Cellular and molecular life sciences : CMLS 2023 Nov 16;80(12):361
Cellular and molecular life sciences : CMLS 2023 Nov 16;80(12):361
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
Zhang J, Simpson CM, Berner J, Chong HB, Fang J, Ordulu Z, Weiss-Sadan T, Possemato AP, Harry S, Takahashi M, Yang TY, Richter M, Patel H, Smith AE, Carlin AD, Hubertus de Groot AF, Wolf K, Shi L, Wei TY, Dürr BR, Chen NJ, Vornbäumen T, Wichmann NO, Mahamdeh MS, Pooladanda V, Matoba Y, Kumar S, Kim E, Bouberhan S, Oliva E, Rueda BR, Soberman RJ, Bardeesy N, Liau BB, Lawrence M, Stokes MP, Beausoleil SA, Bar-Peled L
Cell 2023 May 25;186(11):2361-2379.e25
Cell 2023 May 25;186(11):2361-2379.e25
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Ji X, Chu L, Su D, Sun J, Song P, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
iScience 2023 May 19;26(5):106656
iScience 2023 May 19;26(5):106656
Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor.
Jin J, Xu F, Zhang Y, Guan J, Fu J
Molecular immunology 2023 Mar;155:27-43
Molecular immunology 2023 Mar;155:27-43
Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function.
Huang M, Coral D, Ardalani H, Spegel P, Saadat A, Claussnitzer M, Mulder H, Franks PW, Kalamajski S
eLife 2023 Mar 6;12
eLife 2023 Mar 6;12
Expanding DdCBE-mediated targeting scope to aC motif preference in rat.
Qi X, Tan L, Zhang X, Jin J, Kong W, Chen W, Wang J, Dong W, Gao L, Luo L, Lu D, Gong J, Guan F, Shu W, Huang X, Zhang L, Wang S, Shen B, Ma Y
Molecular therapy. Nucleic acids 2023 Jun 13;32:1-12
Molecular therapy. Nucleic acids 2023 Jun 13;32:1-12
NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities.
Debar L, Ishak L, Moretton A, Anoosheh S, Morel F, Jenninger L, Garreau-Balandier I, Vernet P, Hofer A, van den Wildenberg S, Farge G
Mitochondrion 2023 Jul;71:93-103
Mitochondrion 2023 Jul;71:93-103
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Qin W, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
Cell 2023 Jul 20;186(15):3307-3324.e30
Cell 2023 Jul 20;186(15):3307-3324.e30
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Tian Z, Li J, Song L, Xie L, Li D, Xia T, Wang A
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Xu WQ, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
bioRxiv : the preprint server for biology 2023 Feb 8;
bioRxiv : the preprint server for biology 2023 Feb 8;
Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
Xu Y, Xu H, Ling T, Cui Y, Zhang J, Mu X, Zhou D, Zhao T, Li Y, Su Z, You Q
Cell biology and toxicology 2023 Dec;39(6):2709-2724
Cell biology and toxicology 2023 Dec;39(6):2709-2724
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency.
Zhao Y, Lin Y, Wang B, Liu F, Zhao D, Wang W, Ren H, Wang J, Xu Z, Yan C, Ji K
Neuromolecular medicine 2023 Dec;25(4):489-500
Neuromolecular medicine 2023 Dec;25(4):489-500
Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells.
Baleva MV, Piunova U, Chicherin I, Vasilev R, Levitskii S, Kamenski P
International journal of molecular sciences 2023 Dec 20;25(1)
International journal of molecular sciences 2023 Dec 20;25(1)
MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis.
Ding Y, Gui X, Chu X, Sun Y, Zhang S, Tong H, Ju W, Li Y, Sun Z, Xu M, Li Z, Andrews RK, Gardiner EE, Zeng L, Xu K, Qiao J
Nature communications 2023 Aug 10;14(1):4829
Nature communications 2023 Aug 10;14(1):4829
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
Li D, Zhao Q, Xie L, Wang C, Tian Z, Tang H, Xia T, Wang A
The Science of the total environment 2023 Apr 15;869:161738
The Science of the total environment 2023 Apr 15;869:161738
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Tan L, Qi X, Kong W, Jin J, Lu D, Zhang X, Wang Y, Wang S, Dong W, Shi X, Chen W, Wang J, Li K, Xie Y, Gao L, Guan F, Gao K, Li C, Wang C, Hu Z, Zhang L, Guo X, Shen B, Ma Y
Science advances 2023 Apr 14;9(15):eadf2695
Science advances 2023 Apr 14;9(15):eadf2695
TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.
Zhang J, Zhou X, Wan D, Yu L, Chen X, Yan T, Wu Z, Zheng M, Zhu F, Zhu H
Frontiers in cell and developmental biology 2022;10:757042
Frontiers in cell and developmental biology 2022;10:757042
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Nucleic acids research 2022 Sep 9;50(16):9368-9381
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1.
Liu X, Chen J, Zhang S, Liu X, Long X, Lan J, Zhou M, Zheng L, Zhou J
EMBO reports 2022 Sep 5;23(9):e54128
EMBO reports 2022 Sep 5;23(9):e54128
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins.
Miller CE, Xu F, Zhao Y, Luo W, Zhong W, Meyer K, Jayswal R, Weiss HL, St Clair WH, St Clair DK, Chaiswing L
Antioxidants (Basel, Switzerland) 2022 Oct 27;11(11)
Antioxidants (Basel, Switzerland) 2022 Oct 27;11(11)
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Lan B, Zhao H, He Y, Zhao Z, Wang N, Gao Y
Experimental cell research 2022 Nov 15;420(2):113358
Experimental cell research 2022 Nov 15;420(2):113358
Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes.
Zhang Y, Liang X, Guan J, Jin J, Zhang Y, Xu F, Fu J
Toxicology and applied pharmacology 2022 Mar 15;439:115929
Toxicology and applied pharmacology 2022 Mar 15;439:115929
MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose.
Hyatt JK
Physiological reports 2022 Jul;10(13):e15377
Physiological reports 2022 Jul;10(13):e15377
Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
Sun J, Leng P, Li X, Guo Q, Zhao J, Liang Y, Zhang X, Yang X, Li J
Adipocyte 2022 Dec;11(1):562-571
Adipocyte 2022 Dec;11(1):562-571
Targeting mitochondrial tyrosyl-tRNA synthetase YARS2 suppresses colorectal cancer progression.
Fang Q, Lin J, Gao L, Pan R, Zheng X
Cancer biology & therapy 2022 Dec 31;23(1):1-8
Cancer biology & therapy 2022 Dec 31;23(1):1-8
Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation.
Tillo M, Lamanna WC, Dwyer CA, Sandoval DR, Pessentheiner AR, Al-Azzam N, Sarrazin S, Gonzales JC, Kan SH, Andreyev AY, Schultheis N, Thacker BE, Glass CA, Dickson PI, Wang RY, Selleck SB, Esko JD, Gordts PLSM
The Journal of biological chemistry 2022 Aug;298(8):102159
The Journal of biological chemistry 2022 Aug;298(8):102159
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Liang C, Zhang S, Robinson D, Ploeg MV, Wilson R, Nah J, Taylor D, Beh S, Lim R, Sun L, Muoio DM, Stroud DA, Ho L
Cell reports 2022 Aug 16;40(7):111204
Cell reports 2022 Aug 16;40(7):111204
Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis.
Sidarala V, Zhu J, Levi-D'Ancona E, Pearson GL, Reck EC, Walker EM, Kaufman BA, Soleimanpour SA
Nature communications 2022 Apr 29;13(1):2340
Nature communications 2022 Apr 29;13(1):2340
Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature.
Wang S, Wu T, Sun J, Li Y, Yuan Z, Sun W
Frontiers in cell and developmental biology 2021;9:800157
Frontiers in cell and developmental biology 2021;9:800157
TMT-Based Proteomic Explores the Influence of DHEA on the Osteogenic Differentiation of hBMSCs.
Liang X, He M, Zhu B, Zhu Y, He X, Liu D, Wei Q
Frontiers in cell and developmental biology 2021;9:726549
Frontiers in cell and developmental biology 2021;9:726549
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.
Xu L, Xu C, Liu X, Li X, Li T, Yu X, Xue M, Yang J, Kosmas CE, Moris D, Sanchis-Gomar F, Yoshida N, Berger NA, Aronow WS, Sun B, Chen L
Frontiers in physiology 2021;12:745058
Frontiers in physiology 2021;12:745058
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT
Cell metabolism 2021 May 4;33(5):1027-1041.e8
Cell metabolism 2021 May 4;33(5):1027-1041.e8
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Acoba MG, Alpergin ESS, Renuse S, Fernández-Del-Río L, Lu YW, Khalimonchuk O, Clarke CF, Pandey A, Wolfgang MJ, Claypool SM
Cell reports 2021 Mar 16;34(11):108869
Cell reports 2021 Mar 16;34(11):108869
Mechanistic insights into mitochondrial tRNA(Ala) 3'-end metabolism deficiency.
Ji Y, Nie Z, Meng F, Hu C, Chen H, Jin L, Chen M, Zhang M, Zhang J, Liang M, Wang M, Guan MX
The Journal of biological chemistry 2021 Jul;297(1):100816
The Journal of biological chemistry 2021 Jul;297(1):100816
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437
The Journal of biological chemistry 2021 Jan-Jun;296:100437
A deafness-associated tRNA mutation caused pleiotropic effects on the m1G37 modification, processing, stability and aminoacylation of tRNAIle and mitochondrial translation.
Meng F, Zhou M, Xiao Y, Mao X, Zheng J, Lin J, Lin T, Ye Z, Cang X, Fu Y, Wang M, Guan MX
Nucleic acids research 2021 Jan 25;49(2):1075-1093
Nucleic acids research 2021 Jan 25;49(2):1075-1093
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Gu X, Liu Y, Wang N, Zhen J, Zhang B, Hou S, Cui Z, Wan Q, Feng H
Free radical biology & medicine 2021 Feb 20;164:329-340
Free radical biology & medicine 2021 Feb 20;164:329-340
Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNA(Thr) Gene.
Li K, Wu L, Liu J, Lin W, Qi Q, Zhao T
Journal of diabetes research 2020;2020:2057187
Journal of diabetes research 2020;2020:2057187
Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts.
Xiao Y, Wang M, He Q, Xu L, Zhang Q, Meng F, Jia Z, Zhang F, Wang H, Guan MX
Nucleic acids research 2020 Nov 4;48(19):11113-11129
Nucleic acids research 2020 Nov 4;48(19):11113-11129
Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.
Zhang S, Reljić B, Liang C, Kerouanton B, Francisco JC, Peh JH, Mary C, Jagannathan NS, Olexiouk V, Tang C, Fidelito G, Nama S, Cheng RK, Wee CL, Wang LC, Duek Roggli P, Sampath P, Lane L, Petretto E, Sobota RM, Jesuthasan S, Tucker-Kellogg L, Reversade B, Menschaert G, Sun L, Stroud DA, Ho L
Nature communications 2020 Mar 11;11(1):1312
Nature communications 2020 Mar 11;11(1):1312
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983
Carcinogenesis 2020 Jul 14;41(7):972-983
Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNA(His) mutation.
Gong S, Wang X, Meng F, Cui L, Yi Q, Zhao Q, Cang X, Cai Z, Mo JQ, Liang Y, Guan MX
The Journal of biological chemistry 2020 Jan 24;295(4):940-954
The Journal of biological chemistry 2020 Jan 24;295(4):940-954
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Ma Y, Zhu S, Lv T, Gu X, Feng H, Zhen J, Xin W, Wan Q
iScience 2020 Aug 21;23(8):101428
iScience 2020 Aug 21;23(8):101428
Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNAMet, all 8 tRNAs and ND6 mRNA in the light-strand transcript.
Zhao X, Cui L, Xiao Y, Mao Q, Aishanjiang M, Kong W, Liu Y, Chen H, Hong F, Jia Z, Wang M, Jiang P, Guan MX
Nucleic acids research 2019 Nov 4;47(19):10340-10356
Nucleic acids research 2019 Nov 4;47(19):10340-10356
FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function.
Wang L, Yan Z, Vihinen H, Eriksson O, Wang W, Soliymani R, Lu Y, Xue Y, Jokitalo E, Li J, Zhao H
The Journal of cell biology 2019 Jan 7;218(1):97-111
The Journal of cell biology 2019 Jan 7;218(1):97-111
Mitochondrial stress response triggered by defects in protein synthesis quality control.
Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ
Life science alliance 2019 Feb;2(1)
Life science alliance 2019 Feb;2(1)
A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis.
Jia Z, Zhang Y, Li Q, Ye Z, Liu Y, Fu C, Cang X, Wang M, Guan MX
Nucleic acids research 2019 Feb 28;47(4):2056-2074
Nucleic acids research 2019 Feb 28;47(4):2056-2074
Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNA(Ser(UCN)) 7511A>G mutation.
Fan W, Zheng J, Kong W, Cui L, Aishanjiang M, Yi Q, Wang M, Cang X, Tang X, Chen Y, Mo JQ, Sondheimer N, Ge W, Guan MX
The Journal of biological chemistry 2019 Dec 13;294(50):19292-19305
The Journal of biological chemistry 2019 Dec 13;294(50):19292-19305
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Fu R, Yang P, Li Z, Liu W, Amin S, Li Z
Cell death & disease 2019 Aug 7;10(8):593
Cell death & disease 2019 Aug 7;10(8):593
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G
Nature communications 2019 Apr 5;10(1):1566
Nature communications 2019 Apr 5;10(1):1566
Leber's hereditary optic neuropathy caused by a mutation in mitochondrial tRNA(Thr) in eight Chinese pedigrees.
Zhang J, Ji Y, Liu X, Chen J, Wang B, Zhang M, Guan MX
Mitochondrion 2018 Sep;42:84-91
Mitochondrion 2018 Sep;42:84-91
RNA modification landscape of the human mitochondrial tRNA(Lys) regulates protein synthesis.
Richter U, Evans ME, Clark WC, Marttinen P, Shoubridge EA, Suomalainen A, Wredenberg A, Wedell A, Pan T, Battersby BJ
Nature communications 2018 Sep 27;9(1):3966
Nature communications 2018 Sep 27;9(1):3966
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Aulas A, Lyons SM, Fay MM, Anderson P, Ivanov P
Cell death & disease 2018 Nov 13;9(11):1129
Cell death & disease 2018 Nov 13;9(11):1129
Contribution of the tRNA(Ile) 4317A→G mutation to the phenotypic manifestation of the deafness-associated mitochondrial 12S rRNA 1555A→G mutation.
Meng F, He Z, Tang X, Zheng J, Jin X, Zhu Y, Ren X, Zhou M, Wang M, Gong S, Mo JQ, Shu Q, Guan MX
The Journal of biological chemistry 2018 Mar 2;293(9):3321-3334
The Journal of biological chemistry 2018 Mar 2;293(9):3321-3334
Leber's hereditary optic neuropathy (LHON)-associated ND5 12338T > C mutation altered the assembly and function of complex I, apoptosis and mitophagy.
Zhang J, Ji Y, Lu Y, Fu R, Xu M, Liu X, Guan MX
Human molecular genetics 2018 Jun 1;27(11):1999-2011
Human molecular genetics 2018 Jun 1;27(11):1999-2011
A hypertension-associated mitochondrial DNA mutation introduces an m(1)G37 modification into tRNA(Met), altering its structure and function.
Zhou M, Xue L, Chen Y, Li H, He Q, Wang B, Meng F, Wang M, Guan MX
The Journal of biological chemistry 2018 Jan 26;293(4):1425-1438
The Journal of biological chemistry 2018 Jan 26;293(4):1425-1438
Protein profiling and functional analysis of liver mitochondria from rats with nonalcoholic steatohepatitis.
You Y, Zhang Y, Lu Y, Hu K, Qu X, Liu Y, Lu B, Jin L
Molecular medicine reports 2017 Sep;16(3):2379-2388
Molecular medicine reports 2017 Sep;16(3):2379-2388
Late onset nonsyndromic hearing loss in a Dongxiang Chinese family is associated with the 593T>C variant in the mitochondrial tRNA(Phe) gene.
Chen X, Nie Z, Wang F, Wang J, Liu XW, Zheng J, Guo YF, Guan MX
Mitochondrion 2017 Jul;35:111-118
Mitochondrion 2017 Jul;35:111-118
Biochemical Evidence for a Nuclear Modifier Allele (A10S) in TRMU (Methylaminomethyl-2-thiouridylate-methyltransferase) Related to Mitochondrial tRNA Modification in the Phenotypic Manifestation of Deafness-associated 12S rRNA Mutation.
Meng F, Cang X, Peng Y, Li R, Zhang Z, Li F, Fan Q, Guan AS, Fischel-Ghosian N, Zhao X, Guan MX
The Journal of biological chemistry 2017 Feb 17;292(7):2881-2892
The Journal of biological chemistry 2017 Feb 17;292(7):2881-2892
Novel GFM2 variants associated with early-onset neurological presentations of mitochondrial disease and impaired expression of OXPHOS subunits.
Glasgow RIC, Thompson K, Barbosa IA, He L, Alston CL, Deshpande C, Simpson MA, Morris AAM, Neu A, Löbel U, Hall J, Prokisch H, Haack TB, Hempel M, McFarland R, Taylor RW
Neurogenetics 2017 Dec;18(4):227-235
Neurogenetics 2017 Dec;18(4):227-235
A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNA(Leu(UUR)).
Zhou M, Wang M, Xue L, Lin Z, He Q, Shi W, Chen Y, Jin X, Li H, Jiang P, Guan MX
The Journal of biological chemistry 2017 Aug 25;292(34):13934-13946
The Journal of biological chemistry 2017 Aug 25;292(34):13934-13946
A Deafness- and Diabetes-associated tRNA Mutation Causes Deficient Pseudouridinylation at Position 55 in tRNAGlu and Mitochondrial Dysfunction.
Wang M, Liu H, Zheng J, Chen B, Zhou M, Fan W, Wang H, Liang X, Zhou X, Eriani G, Jiang P, Guan MX
The Journal of biological chemistry 2016 Sep 30;291(40):21029-21041
The Journal of biological chemistry 2016 Sep 30;291(40):21029-21041
A Hypertension-Associated tRNAAla Mutation Alters tRNA Metabolism and Mitochondrial Function.
Jiang P, Wang M, Xue L, Xiao Y, Yu J, Wang H, Yao J, Liu H, Peng Y, Liu H, Li H, Chen Y, Guan MX
Molecular and cellular biology 2016 Jul 15;36(14):1920-30
Molecular and cellular biology 2016 Jul 15;36(14):1920-30
The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation.
Jiang P, Jin X, Peng Y, Wang M, Liu H, Liu X, Zhang Z, Ji Y, Zhang J, Liang M, Zhao F, Sun YH, Zhang M, Zhou X, Chen Y, Mo JQ, Huang T, Qu J, Guan MX
Human molecular genetics 2016 Feb 1;25(3):584-96
Human molecular genetics 2016 Feb 1;25(3):584-96
A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function.
Wang M, Peng Y, Zheng J, Zheng B, Jin X, Liu H, Wang Y, Tang X, Huang T, Jiang P, Guan MX
Nucleic acids research 2016 Dec 15;44(22):10974-10985
Nucleic acids research 2016 Dec 15;44(22):10974-10985
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYTB antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human CYTB. This antibody recognizes human, mouse antigen. The CYTB antibody has been validated for the following applications: ELISA, WB analysis.
