CABT-L648

antibody from Creative Diagnostics

Targeting: CCNB1 CCNB

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-L648

Provider

Creative Diagnostics

Product name

Rabbit Anti-AMPK alpha 1 monoclonal antibody, clone TV14-59

Antibody type

Monoclonal

Description

AMPK (for 5'-AMP-activated protein kinase) is a heterotrimeric complex com-prising a catalytic Ï« subunit and regulatory ÉÇ and ÎÛ subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming bio-synthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKÏ«1 and AMPKÏ«2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKÉÇ1 encodes a 271 amino acid protein and human AMPKÉÇ2 encodes a 272 amino acid protein. The human AMPKÎÛ1 gene encodes a 331 amino acid protein. Human AMPKÎÛ2 and AMPKÎÛ3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TV14-59

Vial size

100 _l

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.