BS6359

antibody from Bioworld Technology, Inc
Targeting: ELK1
Provider product page for BS6359
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6359 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Elk1 (phospho S383) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human Elk-1 around the phosphorylation site of Serine 383.
Description
Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element. Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ELK1 protein structure - BS6359 shown in red.