Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 10423-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10423-1-AP, RRID:AB_2099483
- Product name
- ENOX2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ENOX2 antibody (Cat. #10423-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells.
Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells.
Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.
Capsaicin acts through tNOX (ENOX2) to induce autophagic apoptosis in p53-mutated HSC-3 cells but autophagy in p53-functional SAS oral cancer cells.
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient up-regulation of tNOX (ENOX2) protein.
Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo.
Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells.
Down-regulation of tumor-associated NADH oxidase, tNOX (ENOX2), enhances capsaicin-induced inhibition of gastric cancer cell growth.
RNA interference targeting tNOX attenuates cell migration via a mechanism that involves membrane association of Rac.
Islam A, Chang YC, Chen XC, Weng CW, Chen CY, Wang CW, Chen MK, Tikhomirov AS, Shchekotikhin AE, Chueh PJ
eLife 2024 Apr 3;12
eLife 2024 Apr 3;12
Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells.
Chang JS, Chen CY, Tikhomirov AS, Islam A, Liang RH, Weng CW, Wu WH, Shchekotikhin AE, Chueh PJ
Cancers 2022 Sep 28;14(19)
Cancers 2022 Sep 28;14(19)
Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.
Islam A, Hsieh PF, Liu PF, Chou JC, Liao JW, Hsieh MK, Chueh PJ
American journal of cancer research 2021;11(9):4199-4219
American journal of cancer research 2021;11(9):4199-4219
Capsaicin acts through tNOX (ENOX2) to induce autophagic apoptosis in p53-mutated HSC-3 cells but autophagy in p53-functional SAS oral cancer cells.
Chang CF, Islam A, Liu PF, Zhan JH, Chueh PJ
American journal of cancer research 2020;10(10):3230-3247
American journal of cancer research 2020;10(10):3230-3247
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
Tikhomirov AS, Shchekotikhin AE, Lee YH, Chen YA, Yeh CA, Tatarskiy VV Jr, Dezhenkova LG, Glazunova VA, Balzarini J, Shtil AA, Preobrazhenskaya MN, Chueh PJ
Journal of medicinal chemistry 2015 Dec 24;58(24):9522-34
Journal of medicinal chemistry 2015 Dec 24;58(24):9522-34
Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient up-regulation of tNOX (ENOX2) protein.
Su YC, Lin YH, Zeng ZM, Shao KN, Chueh PJ
Biochimica et biophysica acta 2012 Nov;1820(11):1744-52
Biochimica et biophysica acta 2012 Nov;1820(11):1744-52
Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo.
Liu NC, Hsieh PF, Hsieh MK, Zeng ZM, Cheng HL, Liao JW, Chueh PJ
Journal of agricultural and food chemistry 2012 Mar 14;60(10):2758-65
Journal of agricultural and food chemistry 2012 Mar 14;60(10):2758-65
Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells.
Zeng ZM, Chuang SM, Chang TC, Hong CW, Chou JC, Yang JJ, Chueh PJ
Experimental cell research 2012 Aug 15;318(14):1759-66
Experimental cell research 2012 Aug 15;318(14):1759-66
Down-regulation of tumor-associated NADH oxidase, tNOX (ENOX2), enhances capsaicin-induced inhibition of gastric cancer cell growth.
Wang HM, Chuang SM, Su YC, Li YH, Chueh PJ
Cell biochemistry and biophysics 2011 Nov;61(2):355-66
Cell biochemistry and biophysics 2011 Nov;61(2):355-66
RNA interference targeting tNOX attenuates cell migration via a mechanism that involves membrane association of Rac.
Liu SC, Yang JJ, Shao KN, Chueh PJ
Biochemical and biophysical research communications 2008 Jan 25;365(4):672-7
Biochemical and biophysical research communications 2008 Jan 25;365(4):672-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF-7 cells were subjected to SDS PAGE followed by western blot with 10423-1-AP( ENOX2 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 10423-1-AP(ENOX2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ENOX2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ENOX2. This antibody recognizes human antigen. The ENOX2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.