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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN362800 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (AA 219-223) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around AA 219-223 (A-N-S-F-V) derived from Human MEK1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- AA 219-223
- Isotype
- IgG
- Vial size
- 100 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia.
Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.
MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells.
Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth.
Zebisch A, Staber PB, Delavar A, Bodner C, Hiden K, Fischereder K, Janakiraman M, Linkesch W, Auner HW, Emberger W, Windpassinger C, Schimek MG, Hoefler G, Troppmair J, Sill H
Cancer research 2006 Apr 1;66(7):3401-8
Cancer research 2006 Apr 1;66(7):3401-8
Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
Luciano BS, Hsu S, Channavajhala PL, Lin LL, Cuozzo JW
The Journal of biological chemistry 2004 Dec 10;279(50):52117-23
The Journal of biological chemistry 2004 Dec 10;279(50):52117-23
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.
Gopalbhai K, Jansen G, Beauregard G, Whiteway M, Dumas F, Wu C, Meloche S
The Journal of biological chemistry 2003 Mar 7;278(10):8118-25
The Journal of biological chemistry 2003 Mar 7;278(10):8118-25
MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells.
Wang X, Jin DY, Wong HL, Feng H, Wong YC, Tsao SW
Oncogene 2003 Jan 9;22(1):109-16
Oncogene 2003 Jan 9;22(1):109-16
Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth.
Ling MT, Wang X, Ouyang XS, Lee TK, Fan TY, Xu K, Tsao SW, Wong YC
Oncogene 2002 Dec 5;21(55):8498-505
Oncogene 2002 Dec 5;21(55):8498-505
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