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Learn14485-1-AP
antibody from Proteintech Group
Targeting: RPS6KB1
p70(S6K)-alpha, PS6K, S6K, S6K1, STK14A
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [159]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 14485-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14485-1-AP, RRID:AB_2269787
- Product name
- p70(S6K) antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated p70(S6K) antibody (Cat. #14485-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Maternal docosahexaenoic acid supplementation during lactation improves exercise performance, enhances intestinal glucose absorption and modulates gut microbiota in weaning offspring mice.
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.
TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells.
Untargeted metabolomic reveals the changes in muscle metabolites of mice during exercise recovery and the mechanisms of whey protein and whey protein hydrolysate in promoting muscle repair.
Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.
Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics.
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.
FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway.
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the mTORC1/TFEB/ABCA1-SCARB1 signal axis.
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function.
Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression.
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells.
Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia.
Berberine ameliorates collagen-induced arthritis in mice by restoring macrophage polarization via AMPK/mTORC1 pathway switching glycolytic reprogramming.
Synergistic anti-tumour activity of ginsenoside Rg3 and doxorubicin on proliferation, metastasis and angiogenesis in osteosarcoma by modulating mTOR/HIF-1α/VEGF and EMT signalling pathways.
Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation.
Resistance to anti-HER2 therapy associated with the TSC2 nonsynonymous variant c.4349 C > G (p.Pro1450Arg) is reversed by CDK4/6 inhibitor in HER2-positive breast cancer.
ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells.
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs.
Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration.
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Newly identified lncRNA-45 promotes breast cancer metastasis through activating the mTOR signaling pathway.
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia.
Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.
RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma.
The Degree of Hydrolysis and Peptide Profile Affect the Anti-Fatigue Activities of Whey Protein Hydrolysates in Promoting Energy Metabolism in Exercise Mice.
LOXL3 Inhibits Autophagy of Chondrocytes by Activating Rheb in Osteoarthritis.
Protocol for high-sensitivity western blot on murine hematopoietic stem cells.
Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics.
The Key Role of Initiation Timing on Stroke Rehabilitation by Remote Ischemic Conditioning with Exercise (RICE).
Beneficial effects of whey protein peptides on muscle loss in aging mice models.
Comparison of the Effects of Inorganic or Amino Acid-Chelated Zinc on Mouse Myoblast Growth in vitro and Growth Performance and Carcass Traits in Growing-Finishing Pigs.
Alpha-Ketoglutarate Alleviates Neuronal Apoptosis Induced by Central Insulin Resistance through Inhibiting S6K1 Phosphorylation after Subarachnoid Hemorrhage.
Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation.
Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway.
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.
Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Potential nutritional healthy-aging strategy: enhanced protein metabolism by balancing branched-chain amino acids in a finishing pig model.
Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis.
Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.
Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.
mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens.
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis.
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.
S6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer.
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.
mTOR pathway regulates the differentiation of peripheral blood Th2/Treg cell subsets in patients with pemphigus vulgaris.
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.
Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor.
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma.
GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway.
Treadmill running prevents atrophy differently in fast- versus slow-twitch muscles in a rat model of rheumatoid arthritis.
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model.
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
KRT17 Functions as a Tumor Promoter and Regulates Proliferation, Migration and Invasion in Pancreatic Cancer via mTOR/S6k1 Pathway.
Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.
TIPRL, a Novel Tumor Suppressor, Suppresses Cell Migration, and Invasion Through Regulating AMPK/mTOR Signaling Pathway in Gastric Cancer.
Optimized platelet rich plasma releasate (O-rPRP) repairs galactosemia-induced ovarian follicular loss in rats by activating mTOR signaling and inhibiting apoptosis.
Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer.
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Rationally designed rapamycin-encapsulated ZIF-8 nanosystem for overcoming chemotherapy resistance.
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1.
Glucosylation by the Legionella Effector SetA Promotes the Nuclear Localization of the Transcription Factor TFEB.
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer.
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.
A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo.
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling.
The oncogenic role of CB2 in the progression of non-small-cell lung cancer.
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro.
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway.
mTOR-S6K1 pathway mediates cytoophidium assembly.
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway.
Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats.
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling.
MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma.
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Role of mTOR signaling in the regulation of high glucose-induced podocyte injury.
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway.
Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling.
LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway.
XRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer.
MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II (EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the Expressions of ZO-1, Occludin and Claudin-5.
Identification of WDR12 as a novel oncogene involved in hepatocellular carcinoma propagation.
CircZNF609 promotes breast cancer cell growth, migration, and invasion by elevating p70S6K1 via sponging miR-145-5p.
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47.
Auranofin Enhances Ibrutinib's Anticancer Activity in EGFR-Mutant Lung Adenocarcinoma.
USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma.
Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway.
Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells.
New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy.
EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer.
Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area.
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer.
The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Telmisartan inhibits NSCLC A549 cell proliferation and migration by regulating the PI3K/AKT signaling pathway.
Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR.
The role of long non-coding RNA PCA3 in epithelial ovarian carcinoma tumorigenesis and progression.
DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression.
The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow.
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
Role of the lncRNA ABHD11-AS(1) in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC.
MicroRNA-490 inhibits tumorigenesis and progression in breast cancer.
p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes.
Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.
Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.
ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells.
Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells.
Lu D, Yao D, Hu G, Zhou J, Shen X, Qian L
Frontiers in nutrition 2024;11:1423576
Frontiers in nutrition 2024;11:1423576
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.
Ren D, Li W, Zeng R, Liu X, Liang H, Xiong W, Yang C, Jin X
Cell death and differentiation 2024 May;31(5):592-604
Cell death and differentiation 2024 May;31(5):592-604
TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells.
Lv S, Zhang Z, Li Z, Ke Q, Ma X, Li N, Zhao X, Zou Q, Sun L, Song T
The Journal of biological chemistry 2024 May;300(5):107270
The Journal of biological chemistry 2024 May;300(5):107270
Untargeted metabolomic reveals the changes in muscle metabolites of mice during exercise recovery and the mechanisms of whey protein and whey protein hydrolysate in promoting muscle repair.
Zhao C, Gong Y, Zheng L, Zhao M
Food research international (Ottawa, Ont.) 2024 May;184:114261
Food research international (Ottawa, Ont.) 2024 May;184:114261
Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.
Xu M, Zhong W, Yang C, Liu M, Yuan X, Lu T, Li D, Zhang G, Liu H, Zeng Y, Yang X, Zhou Y, Zhou L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155392
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155392
Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.
Han T, Wang Y, Cheng M, Hu Q, Wan X, Huang M, Liu Y, Xun W, Xu J, Wang L, Luo R, Yuan Y, Wang K, Wang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307834
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307834
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Ou X, Tan Y, Xie J, Yuan J, Deng X, Shao R, Song C, Cao X, Xie X, He R, Li Y, Tang H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics.
Zhou J, Wang J, Li D, Zhang Z, Wang C, Zhang X, Xu X, Gao J
American journal of physiology. Gastrointestinal and liver physiology 2024 Mar 1;326(3):G216-G227
American journal of physiology. Gastrointestinal and liver physiology 2024 Mar 1;326(3):G216-G227
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Zhao ZX, Li S, Liu LX
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.
Lottes EN, Ciger F, Bhattacharjee S, Timmins EA, Tete B, Tran T, Matta J, Patel AA, Cox DN
Cells 2024 Jun 13;13(12)
Cells 2024 Jun 13;13(12)
FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
Wang L, Mao X, Yu X, Su J, Li Z, Chen Z, Ren Y, Huang H, Wang W, Zhao C, Hu Y
Cancer letters 2024 Jul 1;593:216841
Cancer letters 2024 Jul 1;593:216841
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Wei L, Li X, Yao Y, Wang S, Ai X, Liu S
Chemical biology & drug design 2024 Jan;103(1):e14421
Chemical biology & drug design 2024 Jan;103(1):e14421
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Tian X, Wei J
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234741
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234741
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway.
Ding Y, Wang Z, Chen C, Li D, Wang W, Jia Y, Qin Y
Carcinogenesis 2024 Feb 12;45(1-2):45-56
Carcinogenesis 2024 Feb 12;45(1-2):45-56
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
Du Y, Wu M, Song S, Bian Y, Shi Y
Renal failure 2024 Dec;46(1):2338933
Renal failure 2024 Dec;46(1):2338933
Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the mTORC1/TFEB/ABCA1-SCARB1 signal axis.
Li Y, Pan J, Yu JJJ, Wu X, Yang G, Pan X, Sui G, Wang M, Cheng M, Zhu S, Tai H, Xiao H, Xu L, Wu J, Yang Y, Tang J, Gong L, Jia L, Min D
Journal of cellular and molecular medicine 2024 Apr;28(8):e18257
Journal of cellular and molecular medicine 2024 Apr;28(8):e18257
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Zhong C, Xiong G, Yang H, Du X, Du J, Yao F, Fang W, Deng Y
International journal of biological sciences 2023;19(4):1110-1122
International journal of biological sciences 2023;19(4):1110-1122
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Zhang T, Liu MQ, Xie GS, Wu DM, Luo PW, Liu T, Deng SH, Wang YY, He S, Zhou Y, Zhou J, Xu Y
Journal of Cancer 2023;14(8):1350-1361
Journal of Cancer 2023;14(8):1350-1361
Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function.
Niu F, Li Z, Ren Y, Li Z, Guan H, Li Y, Zhang Y, Li Y, Yang J, Qian L, Shi W, Fan X, Li J, Shi L, Yu Y, Xiong Y
Redox biology 2023 Sep;65:102824
Redox biology 2023 Sep;65:102824
Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression.
Wu T, Zhang Y, Han Q, Lu X, Cheng Y, Chen J, Sha J, Xia W
Oncogene 2023 Sep;42(38):2801-2815
Oncogene 2023 Sep;42(38):2801-2815
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C
Cell death and differentiation 2023 Sep;30(9):2135-2150
Cell death and differentiation 2023 Sep;30(9):2135-2150
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells.
Zheng Y, Shi D, Chen L, Yang Y, Yao M
Aging 2023 Oct 9;15(19):10593-10606
Aging 2023 Oct 9;15(19):10593-10606
Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia.
Ma H, Cui J, Liu Z, Fang W, Lu S, Cao S, Zhang Y, Chen JA, Lu L, Xie Q, Wang Y, Huang Y, Li K, Tong H, Huang J, Lu W
Oncogene 2023 Nov;42(45):3331-3343
Oncogene 2023 Nov;42(45):3331-3343
Berberine ameliorates collagen-induced arthritis in mice by restoring macrophage polarization via AMPK/mTORC1 pathway switching glycolytic reprogramming.
Cheng JW, Yu Y, Zong SY, Cai WW, Wang Y, Song YN, Xian H, Wei F
International immunopharmacology 2023 Nov;124(Pt B):111024
International immunopharmacology 2023 Nov;124(Pt B):111024
Synergistic anti-tumour activity of ginsenoside Rg3 and doxorubicin on proliferation, metastasis and angiogenesis in osteosarcoma by modulating mTOR/HIF-1α/VEGF and EMT signalling pathways.
Zeng X, Liu S, Yang H, Jia M, Liu W, Zhu W
The Journal of pharmacy and pharmacology 2023 Nov 23;75(11):1405-1417
The Journal of pharmacy and pharmacology 2023 Nov 23;75(11):1405-1417
Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation.
Yang T, Wang Y, Cao X, Peng Y, Huang J, Chen L, Pang J, Jiang Z, Qian S, Liu Y, Ying C, Wang T, Zhang F, Lu Q, Yin X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154703
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154703
Resistance to anti-HER2 therapy associated with the TSC2 nonsynonymous variant c.4349 C > G (p.Pro1450Arg) is reversed by CDK4/6 inhibitor in HER2-positive breast cancer.
Yang Z, Feng J, Jing J, Huang Y, Ye WW, Lei L, Wang XJ, Cao WM
NPJ breast cancer 2023 May 9;9(1):36
NPJ breast cancer 2023 May 9;9(1):36
ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells.
Hu Q, Dai J, Zhang Z, Yu H, Zhang J, Zhu X, Qin Y, Zhang L, Zhang P
Cancer research 2023 May 15;83(10):1646-1665
Cancer research 2023 May 15;83(10):1646-1665
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
Zhou YJ, Qiao QF, Wang LQ, Sheng TY, Cui MX, Chen QD, Wang CY, Zhang YX
Toxicology 2023 May 1;489:153497
Toxicology 2023 May 1;489:153497
Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs.
Rudar M, Naberhuis JK, Suryawan A, Nguyen HV, Fiorotto ML, Davis TA
Pediatric research 2023 Jul;94(1):143-152
Pediatric research 2023 Jul;94(1):143-152
Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
Fan L, Zhang X, Huang Y, Zhang B, Li W, Shi Q, Lin Y, Wu F
Phytotherapy research : PTR 2023 Jul;37(7):3025-3041
Phytotherapy research : PTR 2023 Jul;37(7):3025-3041
PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration.
Wang R, Zhong T, Bian Q, Zhang S, Ma X, Li L, Xu Y, Gu Y, Yuan A, Hu W, Qin C, Gao J
Small methods 2023 Jan;7(1):e2201293
Small methods 2023 Jan;7(1):e2201293
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
He W, Cheng Z, Huo Z, Lin B, Wang X, Sun Y, Yu S, Cao S, Xue J, Liu R, Lv W, Li Y, Hong S, Xiao H
Endocrinology 2023 Jan 9;164(3)
Endocrinology 2023 Jan 9;164(3)
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Song R, Ma S, Xu J, Ren X, Guo P, Liu H, Li P, Yin F, Liu M, Wang Q, Yu L, Liu J, Duan B, Rahman NA, Wołczyński S, Li G, Li X
Molecular cancer 2023 Jan 23;22(1):16
Molecular cancer 2023 Jan 23;22(1):16
Newly identified lncRNA-45 promotes breast cancer metastasis through activating the mTOR signaling pathway.
Qiu J, Guo Y, Wang S, Ren Q, Dong Z, Gao M, Ma J, Chen S, Liu S
Biochemical and biophysical research communications 2023 Jan 15;640:40-49
Biochemical and biophysical research communications 2023 Jan 15;640:40-49
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia.
Li XW, Ran JH, Zhou H, He JZ, Qiu ZW, Wang SY, Wu MN, Zhu S, An YP, Ma A, Li M, Quan YZ, Li NN, Ren CQ, Yang BX
Acta pharmacologica Sinica 2023 Feb;44(2):406-420
Acta pharmacologica Sinica 2023 Feb;44(2):406-420
Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.
Li F, Liu H, Wu X, Song Z, Tang H, Gong M, Liu L, Li F
International journal of molecular sciences 2023 Feb 4;24(4)
International journal of molecular sciences 2023 Feb 4;24(4)
RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma.
Qin H, Sun R, Guo X, Fang L, Xu M, Teng Y, Zhen N, Wang A, Liu J
Aging 2023 Feb 24;15(4):1039-1051
Aging 2023 Feb 24;15(4):1039-1051
The Degree of Hydrolysis and Peptide Profile Affect the Anti-Fatigue Activities of Whey Protein Hydrolysates in Promoting Energy Metabolism in Exercise Mice.
Zhao C, Gong Y, Zheng L, Zhao M
Journal of agricultural and food chemistry 2023 Feb 15;71(6):3010-3021
Journal of agricultural and food chemistry 2023 Feb 15;71(6):3010-3021
LOXL3 Inhibits Autophagy of Chondrocytes by Activating Rheb in Osteoarthritis.
Zheng GP, Liu C, Zhang L, Zhong Q, Zhang Y, Huang ZM
Current medical science 2023 Dec;43(6):1195-1200
Current medical science 2023 Dec;43(6):1195-1200
Protocol for high-sensitivity western blot on murine hematopoietic stem cells.
Li C, Guan J, Li Y, Tian X, Zhao Y, Liu W, Tian H, Tian H, Yang Y, Zhao M
STAR protocols 2023 Dec 15;4(4):102578
STAR protocols 2023 Dec 15;4(4):102578
Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics.
Zhong Y, Jin R, Luo R, Liu J, Ren L, Zhang Y, Shan Z, Peng X
Nutrients 2023 Aug 11;15(16)
Nutrients 2023 Aug 11;15(16)
The Key Role of Initiation Timing on Stroke Rehabilitation by Remote Ischemic Conditioning with Exercise (RICE).
Wang Q, Wehbe A, Wills M, Li F, Geng X, Ding Y
Neurological research 2023 Apr;45(4):334-345
Neurological research 2023 Apr;45(4):334-345
Beneficial effects of whey protein peptides on muscle loss in aging mice models.
Wu X, Yu X, Zhu N, Xu M, Li Y
Frontiers in nutrition 2022;9:897821
Frontiers in nutrition 2022;9:897821
Comparison of the Effects of Inorganic or Amino Acid-Chelated Zinc on Mouse Myoblast Growth in vitro and Growth Performance and Carcass Traits in Growing-Finishing Pigs.
Zhang L, Guo Q, Duan Y, Lin X, Ni H, Zhou C, Li F
Frontiers in nutrition 2022;9:857393
Frontiers in nutrition 2022;9:857393
Alpha-Ketoglutarate Alleviates Neuronal Apoptosis Induced by Central Insulin Resistance through Inhibiting S6K1 Phosphorylation after Subarachnoid Hemorrhage.
Ding PF, Zhu Q, Sheng B, Yang H, Xu HJ, Tao T, Peng Z, Chen XX, Li XJ, Zhou Y, Zhang HS, Gao YY, Zhuang Z, Hang CH, Li W
Oxidative medicine and cellular longevity 2022;2022:9148257
Oxidative medicine and cellular longevity 2022;2022:9148257
Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation.
Ding X, Yang X, Zhao Y, Wang Y, Fei J, Niu Z, Dong X, Wang X, Liu B, Li H, Hao X, Zhao Y
Heliyon 2022 Oct;8(10):e11179
Heliyon 2022 Oct;8(10):e11179
Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway.
Hao Q, Wang L, Zhang M, Wang Z, Li M, Gao X
The British journal of nutrition 2022 Nov 28;128(10):1875-1886
The British journal of nutrition 2022 Nov 28;128(10):1875-1886
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.
Zhao C, Yu H, Fan X, Niu W, Fan J, Sun S, Gong M, Zhao B, Fang Z, Chen X
Oncogenesis 2022 May 23;11(1):28
Oncogenesis 2022 May 23;11(1):28
Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.
Chen J, Li K, Chen J, Wang X, Ling R, Cheng M, Chen Z, Chen F, He Q, Li S, Zhang C, Jiang Y, Chen Q, Wang A, Chen D
Cancer communications (London, England) 2022 Mar;42(3):223-244
Cancer communications (London, England) 2022 Mar;42(3):223-244
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Tian H, Wang G, Wang Q, Zhang B, Jiang G, Li H, Chai D, Fang L, Wang M, Zheng J
Cancer science 2022 Mar;113(3):875-890
Cancer science 2022 Mar;113(3):875-890
Potential nutritional healthy-aging strategy: enhanced protein metabolism by balancing branched-chain amino acids in a finishing pig model.
Zhang L, Guo Q, Duan Y, Wang W, Yang Y, Yin Y, Gong S, Han M, Li F, Yin Y
Food & function 2022 Jun 6;13(11):6217-6232
Food & function 2022 Jun 6;13(11):6217-6232
Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.
Li MZ, Liu EJ, Zhou QZ, Li SH, Liu SJ, Yu HT, Pan QH, Sun F, He T, Wang WJ, Ke D, Feng YQ, Li J, Wang JZ
Military Medical Research 2022 Jul 7;9(1):38
Military Medical Research 2022 Jul 7;9(1):38
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis.
Li C, Wu B, Li Y, Chen J, Ye Z, Tian X, Wang J, Xu X, Pan S, Zheng Y, Cai X, Jiang L, Zhao M
Cell stem cell 2022 Jul 7;29(7):1119-1134.e7
Cell stem cell 2022 Jul 7;29(7):1119-1134.e7
Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.
Hou Y, Zhang F, Min W, Yuan K, Kuang W, Wang X, Zhu Y, Sun C, Xia F, Wang Y, Zhang H, Wang L, Yang P
Journal of medicinal chemistry 2022 Jul 28;65(14):9873-9892
Journal of medicinal chemistry 2022 Jul 28;65(14):9873-9892
Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.
Lu Z, Huang L, Li Y, Xu Y, Zhang R, Zhou Q, Sun Q, Lu Y, Chen J, Shen Y, Li J, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(2):e2102669
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(2):e2102669
mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens.
Li HC, Zhang JM, Xu R, Wang YH, Xu W, Chen R, Wan XM, Zhang HL, Wang L, Wang XJ, Jiang LH, Liu B, Zhao Y, Chen YY, Dai YP, Li M, Zhang HQ, Yang Z, Bai L, Zhang J, Wang HB, Tian JW, Zhao YL, Cen XB
Acta pharmacologica Sinica 2022 Feb;43(2):295-306
Acta pharmacologica Sinica 2022 Feb;43(2):295-306
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
Ouyang S, Zeng Z, Liu Z, Zhang Z, Sun J, Wang X, Ma M, Ye X, Yu J, Kang W
Cell death discovery 2022 Feb 2;8(1):45
Cell death discovery 2022 Feb 2;8(1):45
MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis.
Han F, Shen L, Ma H, Wang L, Guo H, Wu X
International immunopharmacology 2022 Dec;113(Pt A):109279
International immunopharmacology 2022 Dec;113(Pt A):109279
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.
Liu K, Peng Y, Lin L, Gong Z, Xiao W, Li Y
Nutrients 2022 Dec 28;15(1)
Nutrients 2022 Dec 28;15(1)
S6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer.
Mo H, Liu X, Xue Y, Chen H, Guo S, Li Z, Wang S, Li C, Han J, Fu M, Song Y, Li D, Ma F
Molecular cancer 2022 Aug 30;21(1):171
Molecular cancer 2022 Aug 30;21(1):171
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Liu M, Yue Z, Zhang B, Li F, Liu L, Li F
Metabolites 2022 Aug 25;12(9)
Metabolites 2022 Aug 25;12(9)
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L, Xu GT
Stem cell research & therapy 2022 Apr 1;13(1):136
Stem cell research & therapy 2022 Apr 1;13(1):136
Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
Chen J, Hu Y, Teng Y, Yang B
Frontiers in cell and developmental biology 2021;9:732786
Frontiers in cell and developmental biology 2021;9:732786
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Liu Y, Zhong W, Zhang J, Chen W, Lu Y, Qiao Y, Zeng Z, Huang H, Cai S, Dong H
Frontiers in pharmacology 2021;12:739220
Frontiers in pharmacology 2021;12:739220
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Zhang M, Hou G, Hu P, Feng D, Wang J, Zhu W
The British journal of nutrition 2021 Sep 28;126(6):801-812
The British journal of nutrition 2021 Sep 28;126(6):801-812
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Li L, Wang J, Feng L, Fan J, Wang J, Tan N, Wang Z
Journal of ethnopharmacology 2021 Sep 15;277:114184
Journal of ethnopharmacology 2021 Sep 15;277:114184
UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma.
Zhang M, Chen H, Qin P, Cai T, Li L, Chen R, Liu S, Chen H, Lin W, Chen H, Strickland AL, Xiong H, Jiang Q
Aging 2021 Sep 14;13(17):21202-21215
Aging 2021 Sep 14;13(17):21202-21215
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Xia Z, Huang R, Zhou X, Chai Y, Chen H, Ma L, Yu Q, Li Y, Li W, He Y
European journal of medicinal chemistry 2021 Nov 15;224:113711
European journal of medicinal chemistry 2021 Nov 15;224:113711
Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.
Wu K, Chen GH, Hogstrand C, Ling SC, Wu LX, Luo Z
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2021 May;65:126732
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2021 May;65:126732
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.
Ye D, Xu H, Xia H, Zhang C, Tang Q, Bi F
Journal of experimental & clinical cancer research : CR 2021 May 18;40(1):173
Journal of experimental & clinical cancer research : CR 2021 May 18;40(1):173
mTOR pathway regulates the differentiation of peripheral blood Th2/Treg cell subsets in patients with pemphigus vulgaris.
Lai K, Zhang W, Li S, Zhang Z, Xie S, Xu M, Li C, Zeng K
Acta biochimica et biophysica Sinica 2021 Mar 26;53(4):438-445
Acta biochimica et biophysica Sinica 2021 Mar 26;53(4):438-445
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Xia B, Huang X, Sun G, Tao W
Journal of ethnopharmacology 2021 Mar 25;268:113665
Journal of ethnopharmacology 2021 Mar 25;268:113665
Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.
Rudar M, Naberhuis JK, Suryawan A, Nguyen HV, Stoll B, Style CC, Verla MA, Olutoye OO, Burrin DG, Fiorotto ML, Davis TA
American journal of physiology. Endocrinology and metabolism 2021 Mar 1;320(3):E551-E565
American journal of physiology. Endocrinology and metabolism 2021 Mar 1;320(3):E551-E565
Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor.
Ponsford AH, Ryan TA, Raimondi A, Cocucci E, Wycislo SA, Fröhlich F, Swan LE, Stagi M
Autophagy 2021 Jun;17(6):1500-1518
Autophagy 2021 Jun;17(6):1500-1518
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
Chen N, Mu L, Yang Z, Du C, Wu M, Song S, Yuan C, Shi Y
Journal of cellular physiology 2021 Jan;236(1):625-640
Journal of cellular physiology 2021 Jan;236(1):625-640
Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma.
Dou R, Qian J, Wu W, Zhang Y, Yuan Y, Guo M, Wei R, Yang S, Jurczyszyn A, Janz S, Beksac M, Gu C, Yang Y
Cell death & disease 2021 Feb 24;12(2):206
Cell death & disease 2021 Feb 24;12(2):206
GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway.
Liu Y, Wang D, Lei M, Gao J, Cui Y, Jin X, Yu Q, Jiang Y, Guo Y, Liu Y, Cai L, Chen X
Aging 2021 Feb 11;13(4):5858-5874
Aging 2021 Feb 11;13(4):5858-5874
Treadmill running prevents atrophy differently in fast- versus slow-twitch muscles in a rat model of rheumatoid arthritis.
Kamada Y, Toyama S, Arai Y, Inoue H, Nakagawa S, Fujii Y, Kaihara K, Kishida T, Mazda O, Takahashi K
Journal of muscle research and cell motility 2021 Dec;42(3-4):429-441
Journal of muscle research and cell motility 2021 Dec;42(3-4):429-441
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
Ji K, Liang H, Ren M, Ge X, Pan L, Yu H
Scientific reports 2021 Dec 13;11(1):23843
Scientific reports 2021 Dec 13;11(1):23843
Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model.
Rudar M, Naberhuis JK, Suryawan A, Nguyen HV, Stoll B, Style CC, Verla MA, Olutoye OO, Burrin DG, Fiorotto ML, Davis TA
American journal of physiology. Endocrinology and metabolism 2021 Dec 1;321(6):E737-E752
American journal of physiology. Endocrinology and metabolism 2021 Dec 1;321(6):E737-E752
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
An Y, Zhang J, Cheng X, Li B, Tian Y, Zhang X, Zhao F
Cancer cell international 2020;20:237
Cancer cell international 2020;20:237
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Zhang X, Chen Y, Wang K, Tang J, Chen Y, Jin G, Liu X
International journal of clinical and experimental pathology 2020;13(9):2228-2239
International journal of clinical and experimental pathology 2020;13(9):2228-2239
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194
Cancer management and research 2020;12:2185-2194
KRT17 Functions as a Tumor Promoter and Regulates Proliferation, Migration and Invasion in Pancreatic Cancer via mTOR/S6k1 Pathway.
Li D, Ni XF, Tang H, Zhang J, Zheng C, Lin J, Wang C, Sun L, Chen B
Cancer management and research 2020;12:2087-2095
Cancer management and research 2020;12:2087-2095
Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.
Zhang J, Zhu S, Tan Q, Cheng D, Dai Q, Yang Z, Zhang L, Li F, Zuo Y, Dai W, Chen L, Gu E, Xu G, Wei Z, Cao Y, Liu X
Theranostics 2020;10(11):4885-4899
Theranostics 2020;10(11):4885-4899
TIPRL, a Novel Tumor Suppressor, Suppresses Cell Migration, and Invasion Through Regulating AMPK/mTOR Signaling Pathway in Gastric Cancer.
Luan M, Shi SS, Shi DB, Liu HT, Ma RR, Xu XQ, Sun YJ, Gao P
Frontiers in oncology 2020;10:1062
Frontiers in oncology 2020;10:1062
Optimized platelet rich plasma releasate (O-rPRP) repairs galactosemia-induced ovarian follicular loss in rats by activating mTOR signaling and inhibiting apoptosis.
El Bakly W, Medhat M, Shafei M, Tash R, Elrefai M, Shoukry Y, Omar NN
Heliyon 2020 Sep;6(9):e05006
Heliyon 2020 Sep;6(9):e05006
Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer.
Zheng C, Zhang T, Li D, Huang C, Tang H, Ni XF, Chen B
Oncology reports 2020 Sep;44(3):1003-1012
Oncology reports 2020 Sep;44(3):1003-1012
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Liu J, Shangguan Y, Sun J, Cong W, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
Yang Y, Wang Q, Song D, Zen R, Zhang L, Wang Y, Yang H, Zhang D, Jia J, Zhang J, Wang J
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):197
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):197
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Yang ZH, Li J, Chen WZ, Kong FS
Cell biochemistry and function 2020 Oct;38(7):943-954
Cell biochemistry and function 2020 Oct;38(7):943-954
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J
International immunopharmacology 2020 Nov;88:107003
International immunopharmacology 2020 Nov;88:107003
Rationally designed rapamycin-encapsulated ZIF-8 nanosystem for overcoming chemotherapy resistance.
Xu M, Hu Y, Ding W, Li F, Lin J, Wu M, Wu J, Wen LP, Qiu B, Wei PF, Li P
Biomaterials 2020 Nov;258:120308
Biomaterials 2020 Nov;258:120308
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
Jiang L, He C, Zhang X, Chen Y, Li G
Translational cancer research 2020 Mar;9(3):1851-1860
Translational cancer research 2020 Mar;9(3):1851-1860
miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1.
Chen Y, Liu C, Xie B, Chen S, Zhuang Y, Zhang S
Molecular medicine reports 2020 Jul;22(1):543-550
Molecular medicine reports 2020 Jul;22(1):543-550
Glucosylation by the Legionella Effector SetA Promotes the Nuclear Localization of the Transcription Factor TFEB.
Beck WHJ, Kim D, Das J, Yu H, Smolka MB, Mao Y
iScience 2020 Jul 24;23(7):101300
iScience 2020 Jul 24;23(7):101300
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer.
Ma J, Qi J, Li S, Zhang C, Wang H, Shao L, Yuan X, Sha Q
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820926591
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820926591
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.
Lin L, Zeng L, Liu A, Peng Y, Yuan D, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Food & function 2020 Feb 26;11(2):1798-1809
Food & function 2020 Feb 26;11(2):1798-1809
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484
Nature 2020 Dec;588(7838):479-484
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
He X, Li M, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y, Cheng S, Yin H
PLoS biology 2020 Dec;18(12):e3000803
PLoS biology 2020 Dec;18(12):e3000803
Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.
Chen Y, Gao H, Liu Q, Xie W, Li B, Cheng S, Guo J, Fang Q, Zhu H, Wang Z, Wang J, Li C, Zhang Y
Aging 2020 Dec 29;13(1):1422-1439
Aging 2020 Dec 29;13(1):1422-1439
A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo.
Ma Y, Zhu Q, Liang J, Li Y, Li M, Zhang Y, Wang X, Zeng Y, Jiao Y
Signal transduction and targeted therapy 2020 Aug 19;5(1):152
Signal transduction and targeted therapy 2020 Aug 19;5(1):152
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Sun X, Yang S, Song W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Zhang C, Wang B, Wang X, Sheng X, Cui Y
Cancer cell international 2019;19:339
Cancer cell international 2019;19:339
KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling.
Li L, Yu S, Wu Q, Dou N, Li Y, Gao Y
International journal of biological sciences 2019;15(5):953-961
International journal of biological sciences 2019;15(5):953-961
The oncogenic role of CB2 in the progression of non-small-cell lung cancer.
Xu S, Ma H, Bo Y, Shao M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109080
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109080
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
Zheng R, Huang S, Zhu J, Lin W, Xu H, Zheng X
Cell and tissue research 2019 Oct;378(1):113-125
Cell and tissue research 2019 Oct;378(1):113-125
Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro.
Guo S, Xu N, Chen P, Liu Y, Qi X, Liu S, Li C, Tang J
Journal of the Association for Research in Otolaryngology : JARO 2019 Oct;20(5):475-487
Journal of the Association for Research in Otolaryngology : JARO 2019 Oct;20(5):475-487
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
Yue G, Chen C, Bai L, Wang G, Huang Y, Wang Y, Cui H, Xiao Y
Molecular medicine reports 2019 Nov;20(5):4551-4557
Molecular medicine reports 2019 Nov;20(5):4551-4557
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Lan Y, Sullivan PM, Hu F
Autophagy 2019 May;15(5):871-885
Autophagy 2019 May;15(5):871-885
UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway.
Wang Q, Shi W
Oncology letters 2019 Mar;17(3):2976-2982
Oncology letters 2019 Mar;17(3):2976-2982
mTOR-S6K1 pathway mediates cytoophidium assembly.
Sun Z, Liu JL
Journal of genetics and genomics = Yi chuan xue bao 2019 Feb;46(2):65-74
Journal of genetics and genomics = Yi chuan xue bao 2019 Feb;46(2):65-74
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Zhang X, Liu J, Gu Y, Sun C, Qu F
Cell biology international 2019 Feb;43(2):158-166
Cell biology international 2019 Feb;43(2):158-166
JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway.
Zhao B, Hu T
Oncology letters 2019 Feb;17(2):1939-1945
Oncology letters 2019 Feb;17(2):1939-1945
Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats.
Bian X, Bai Y, Su X, Zhao G, Sun G, Li D
Journal of cellular physiology 2019 Dec;234(12):22857-22873
Journal of cellular physiology 2019 Dec;234(12):22857-22873
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Wang J, Li L, Wang J, Song L, Tan N, Wang Z
Cells 2019 Dec 7;8(12)
Cells 2019 Dec 7;8(12)
PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling.
Gao H, Zhang J, Ren X
Bioscience reports 2019 Dec 20;39(12)
Bioscience reports 2019 Dec 20;39(12)
MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma.
Song T, Ma K, Zhao C, Yang J, Liu J
Oncology letters 2019 Aug;18(2):2043-2049
Oncology letters 2019 Aug;18(2):2043-2049
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Liang H, Mokrani A, Chisomo-Kasiya H, Ji K, Ge X, Ren M, Liu B, Xi B, Sun A
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Role of mTOR signaling in the regulation of high glucose-induced podocyte injury.
Li Q, Zeng Y, Jiang Q, Wu C, Zhou J
Experimental and therapeutic medicine 2019 Apr;17(4):2495-2502
Experimental and therapeutic medicine 2019 Apr;17(4):2495-2502
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway.
Huang T, Liu D, Wang Y, Li P, Sun L, Xiong H, Dai Y, Zou M, Yuan X, Qiu H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1332-1345
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1332-1345
Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling.
Jin J, Hu K, Ye M, Wu D, He Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(2):765-772
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(2):765-772
LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway.
Chen S, Wang LL, Sun KX, Liu Y, Guan X, Zong ZH, Zhao Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(4):1578-1588
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(4):1578-1588
XRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer.
Li Q, Ma R, Zhang M
OncoTargets and therapy 2018;11:8435-8444
OncoTargets and therapy 2018;11:8435-8444
MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II (EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the Expressions of ZO-1, Occludin and Claudin-5.
Chen L, Xue Y, Zheng J, Liu X, Liu J, Chen J, Li Z, Xi Z, Teng H, Wang P, Liu L, Liu Y
Frontiers in molecular neuroscience 2018;11:35
Frontiers in molecular neuroscience 2018;11:35
Identification of WDR12 as a novel oncogene involved in hepatocellular carcinoma propagation.
Yin Y, Zhou L, Zhan R, Zhang Q, Li M
Cancer management and research 2018;10:3985-3993
Cancer management and research 2018;10:3985-3993
CircZNF609 promotes breast cancer cell growth, migration, and invasion by elevating p70S6K1 via sponging miR-145-5p.
Wang S, Xue X, Wang R, Li X, Li Q, Wang Y, Xie P, Kang Y, Meng R, Feng X
Cancer management and research 2018;10:3881-3890
Cancer management and research 2018;10:3881-3890
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Du Y, Wang L, Chen S, Liu Y, Zhao Y
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47.
Jiang QQ, Liu WB
Medecine sciences : M/S 2018 Oct;34 Focus issue F1:59-65
Medecine sciences : M/S 2018 Oct;34 Focus issue F1:59-65
Auranofin Enhances Ibrutinib's Anticancer Activity in EGFR-Mutant Lung Adenocarcinoma.
Hu J, Zhang H, Cao M, Wang L, Wu S, Fang B
Molecular cancer therapeutics 2018 Oct;17(10):2156-2163
Molecular cancer therapeutics 2018 Oct;17(10):2156-2163
USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma.
Zhang H, Han B, Lu H, Zhao Y, Chen X, Meng Q, Cao M, Cai L, Hu J
Cancer letters 2018 Oct 1;433:186-198
Cancer letters 2018 Oct 1;433:186-198
Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway.
Qiao J, Wang WJ, Zhang Y
Oncology letters 2018 Nov;16(5):6417-6422
Oncology letters 2018 Nov;16(5):6417-6422
Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells.
Tian T, Sun J, Wang J, Liu Y, Liu H
Oncology letters 2018 Nov;16(5):6133-6139
Oncology letters 2018 Nov;16(5):6133-6139
New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy.
Zhang L, Liu W, Wang Q, Li Q, Wang H, Wang J, Teng T, Chen M, Ji A, Li Y
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer.
Wu Z, Zhu Q, Zhang Y, Yin Y, Kang D, Cao R, Tian Q, Lu S, Liu P
Molecular medicine reports 2018 Jun;17(6):7875-7885
Molecular medicine reports 2018 Jun;17(6):7875-7885
Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area.
Li C, Zhang J, Xu H, Chang M, Lv C, Xue W, Song Z, Zhang L, Zhang X, Tian X
Neuropharmacology 2018 Jun;135:151-162
Neuropharmacology 2018 Jun;135:151-162
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Wang SJ, Wang Q, Ma J, Yu PH, Wang ZM, Wang B
Neural regeneration research 2018 Jan;13(1):112-118
Neural regeneration research 2018 Jan;13(1):112-118
SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer.
Tian T, Qiu R, Qiu X
Oncotarget 2018 Jan 5;9(2):2128-2139
Oncotarget 2018 Jan 5;9(2):2128-2139
The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Chen S, Wang LL, Sun KX, Xiu YL, Zong ZH, Chen X, Zhao Y
Molecular carcinogenesis 2018 Feb;57(2):225-234
Molecular carcinogenesis 2018 Feb;57(2):225-234
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Telmisartan inhibits NSCLC A549 cell proliferation and migration by regulating the PI3K/AKT signaling pathway.
Zhang S, Wang Y
Oncology letters 2018 Apr;15(4):5859-5864
Oncology letters 2018 Apr;15(4):5859-5864
Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR.
Cui X, Long C, Zhu J, Tian J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(2):598-608
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(2):598-608
The role of long non-coding RNA PCA3 in epithelial ovarian carcinoma tumorigenesis and progression.
Liu Y, Zong ZH, Guan X, Wang LL, Zhao Y
Gene 2017 Oct 30;633:42-47
Gene 2017 Oct 30;633:42-47
DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression.
Wang LL, Sun KX, Wu DD, Xiu YL, Chen X, Chen S, Zong ZH, Sang XB, Liu Y, Zhao Y
Journal of cellular and molecular medicine 2017 Nov;21(11):3055-3065
Journal of cellular and molecular medicine 2017 Nov;21(11):3055-3065
The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow.
Zhang YP, Huang YT, Huang TS, Pang W, Zhu JJ, Liu YF, Tang RZ, Zhao CR, Yao WJ, Li YS, Chien S, Zhou J
Scientific reports 2017 Nov 8;7(1):14996
Scientific reports 2017 Nov 8;7(1):14996
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, Tan N
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Sun KX, Wu DD, Chen S, Zhao Y, Zong ZH
Apoptosis : an international journal on programmed cell death 2017 Dec;22(12):1543-1552
Apoptosis : an international journal on programmed cell death 2017 Dec;22(12):1543-1552
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
Li M, Jin C, Xu M, Zhou L, Li D, Yin Y
Cell communication and signaling : CCS 2017 Dec 16;15(1):52
Cell communication and signaling : CCS 2017 Dec 16;15(1):52
Role of the lncRNA ABHD11-AS(1) in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC.
Wu DD, Chen X, Sun KX, Wang LL, Chen S, Zhao Y
Molecular cancer 2017 Aug 17;16(1):138
Molecular cancer 2017 Aug 17;16(1):138
MicroRNA-490 inhibits tumorigenesis and progression in breast cancer.
Zhao L, Zheng XY
OncoTargets and therapy 2016;9:4505-16
OncoTargets and therapy 2016;9:4505-16
p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes.
Yu X, Jin D, Yu A, Sun J, Chen X, Yang Z
Gene 2016 Sep 1;589(1):12-19
Gene 2016 Sep 1;589(1):12-19
Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.
Dou N, Yu S, Ye X, Yang D, Li Y, Gao Y
Oncotarget 2016 Dec 27;7(52):86161-86173
Oncotarget 2016 Dec 27;7(52):86161-86173
Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.
Li LD, Sun HF, Liu XX, Gao SP, Jiang HL, Hu X, Jin W
PloS one 2015;10(12):e0144441
PloS one 2015;10(12):e0144441
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, Zhao W, Chang C, Lu Q, Chen W, Zhang S, Ji C, Cao L, Guo H
Oncotarget 2015 Oct 13;6(31):32177-92
Oncotarget 2015 Oct 13;6(31):32177-92
Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.
Bai Y, Xuan B, Liu H, Zhong J, Yu D, Qian Z
Journal of virology 2015 Aug;89(15):7625-35
Journal of virology 2015 Aug;89(15):7625-35
ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells.
Ci Y, Shi K, An J, Yang Y, Hui K, Wu P, Shi L, Xu C
Cell death & disease 2014 Nov 27;5(11):e1542
Cell death & disease 2014 Nov 27;5(11):e1542
Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells.
Salhia B, Van Cott C, Tegeler T, Polpitiya A, Duquette RA, Gale M, Hostteter G, Petritis K, Carpten J
Human mutation 2012 Aug;33(8):1216-27
Human mutation 2012 Aug;33(8):1216-27
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14485-1-AP(p70(S6K) antibody) at dilution of 1:1200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The p70S6K antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human p70S6K. This antibody recognizes human,mouse,rat antigen. The p70S6K antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14485-1-AP(p70(S6K) antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14485-1-AP(p70(S6K) antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
