Antibody data
- Antibody Data
- Antigen structure
- References [31]
- Comments [0]
- Validations [0]
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- Product number
- 66520-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- PARP1 antibody
- Antibody type
- Monoclonal
- Description
- PARP1 antibody (Cat. #66520-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1D7D4
- Vial size
- 20ul, 150ul
Submitted references Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis.
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence.
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
MiR-124 Negatively Regulated PARP1 to Alleviate Renal Ischemia-reperfusion Injury by Inhibiting TNFα/RIP1/RIP3 Pathway.
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer.
m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis.
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer.
Knockdown of GTF2E2 inhibits the growth and progression of lung adenocarcinoma via RPS4X in vitro and in vivo.
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Calvatia Lilacina Extracts Exert Anti-Breast-Cancer Bioactivity through the Apoptosis Induction Dependent on Mitochondrial Reactive Oxygen Species and Caspase Activation.
Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells.
Poly(ADP-ribose) polymerase-1 inhibitor ameliorates dextran sulfate sodium-induced colitis in mice by regulating the balance of Th17/Treg cells and inhibiting the NF-κB signaling pathway.
Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling.
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
The Roles of GSK-3β in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma.
Long Noncoding RNA UCA1 Is Related to Autophagy and Apoptosis in Endometrial Stromal Cells.
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells.
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
PARP-1 mediated cell death is directly activated by ZIKV infection.
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells.
SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish.
Combination of sorafenib and Valproic acid synergistically induces cell apoptosis and inhibits hepatocellular carcinoma growth via down-regulating Notch3 and pAkt.
Yi T, Chen H, Zhan J, Li Y, Long Z, Wu Z, Yang M, Peng T, Li H
Experimental biology and medicine (Maywood, N.J.) 2022 Jan;247(2):165-173
Experimental biology and medicine (Maywood, N.J.) 2022 Jan;247(2):165-173
Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis.
Zhou Y, Zhao X, Zhang L, Xia Q, Peng Y, Zhang H, Yan D, Yang Z, Li J
Toxicology 2022 Jan 15;465:153050
Toxicology 2022 Jan 15;465:153050
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Ma N, Yang X, Qi C, Yu Q, Zhu C, Ren H
Oxidative medicine and cellular longevity 2021;2021:8847844
Oxidative medicine and cellular longevity 2021;2021:8847844
One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence.
Qing Y, Li H, Zhao Y, Hu P, Wang X, Yu X, Zhu M, Wang H, Wang Z, Guo Q, Hui H
Oxidative medicine and cellular longevity 2021;2021:5529518
Oxidative medicine and cellular longevity 2021;2021:5529518
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
Yang K, Wu K, Feng J, Yutian L, Zhu X, Xu D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581
MiR-124 Negatively Regulated PARP1 to Alleviate Renal Ischemia-reperfusion Injury by Inhibiting TNFα/RIP1/RIP3 Pathway.
Ke J, Zhao F, Luo Y, Deng F, Wu X
International journal of biological sciences 2021;17(8):2099-2111
International journal of biological sciences 2021;17(8):2099-2111
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Liao W, Yang W, Xu J, Yan Z, Pan M, Xu X, Zhou S, Zhu Y, Lan J, Zeng M, Han X, Li S, Li Y, Liang K, Gao Y, Peng Q
Frontiers in pharmacology 2021;12:658197
Frontiers in pharmacology 2021;12:658197
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Zhu X, Li R, Wang C, Zhou S, Fan Y, Ma S, Gao D, Gai N, Yang J
Frontiers in oncology 2021;11:661184
Frontiers in oncology 2021;11:661184
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Wang Y, Zhang Y, Zhang S, Kim B, Hull VL, Xu J, Prabhu P, Gregory M, Martinez-Cerdeno V, Zhan X, Deng W, Guo F
Cell reports 2021 Oct 5;37(1):109695
Cell reports 2021 Oct 5;37(1):109695
UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer.
Wang D, He J, Dong J, Wu S, Liu S, Zhu H, Xu T
Cancer letters 2021 Oct 28;519:2-19
Cancer letters 2021 Oct 28;519:2-19
m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis.
Yang J, Zhang M, Yang D, Ma Y, Tang Y, Xing M, Li L, Chen L, Jin Y, Ma C
Experimental & molecular medicine 2021 Nov;53(11):1723-1734
Experimental & molecular medicine 2021 Nov;53(11):1723-1734
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622
Cancer cell international 2021 Nov 25;21(1):622
Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer.
Zheng S, Wang J, Ding N, Chen W, Chen H, Xue M, Chen F, Ni J, Wang Z, Lin Z, Jiang H, Liu X, Wang L
Journal of nanobiotechnology 2021 Nov 21;19(1):381
Journal of nanobiotechnology 2021 Nov 21;19(1):381
Knockdown of GTF2E2 inhibits the growth and progression of lung adenocarcinoma via RPS4X in vitro and in vivo.
Bi G, Zhu D, Bian Y, Huang Y, Zhan C, Yang Y, Wang Q
Cancer cell international 2021 Mar 23;21(1):181
Cancer cell international 2021 Mar 23;21(1):181
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Ma Y, Yang X, Han H, Wen Z, Yang M, Zhang Y, Fu J, Wang X, Yin T, Lu G, Qi J, Lin H, Wang X, Yang Y
Bioorganic chemistry 2021 Jun;111:104872
Bioorganic chemistry 2021 Jun;111:104872
Calvatia Lilacina Extracts Exert Anti-Breast-Cancer Bioactivity through the Apoptosis Induction Dependent on Mitochondrial Reactive Oxygen Species and Caspase Activation.
Zeng Q, Singh R, Ye Y, Cheng S, Fan C, Zeng Q
Nutrition and cancer 2021 Jun 12;:1-13
Nutrition and cancer 2021 Jun 12;:1-13
Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells.
Hong X, Li ZX, Hou J, Zhang HY, Zhang CY, Zhang J, Sun H, Pang LH, Wang T, Deng ZH
BMC cancer 2021 Jan 7;21(1):33
BMC cancer 2021 Jan 7;21(1):33
Poly(ADP-ribose) polymerase-1 inhibitor ameliorates dextran sulfate sodium-induced colitis in mice by regulating the balance of Th17/Treg cells and inhibiting the NF-κB signaling pathway.
Peng S, Shen L, Tian MX, Li HM, Wang SS
Experimental and therapeutic medicine 2021 Feb;21(2):134
Experimental and therapeutic medicine 2021 Feb;21(2):134
Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling.
Pan S, Zhang Y, Huang M, Deng Z, Zhang A, Pei L, Wang L, Zhao W, Ma L, Zhang Q, Cui D
Biomaterials 2021 Aug;275:120946
Biomaterials 2021 Aug;275:120946
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Lin HY, Han HW, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH, Wang XM, Qi JL, Yang YH
Chinese medicine 2020;15:23
Chinese medicine 2020;15:23
The Roles of GSK-3β in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma.
Zhang S, Gao W, Tang J, Zhang H, Zhou Y, Liu J, Chen K, Liu F, Li W, To SKY, Wong AST, Zhang XK, Zhou H, Zeng JZ
Theranostics 2020;10(3):1230-1244
Theranostics 2020;10(3):1230-1244
Long Noncoding RNA UCA1 Is Related to Autophagy and Apoptosis in Endometrial Stromal Cells.
Jiang L, Wan Y, Feng Z, Liu D, Ouyang L, Li Y, Liu K
Frontiers in oncology 2020;10:618472
Frontiers in oncology 2020;10:618472
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
Fan Z, Chen X, Liu L, Zhu C, Xu J, Yin X, Sheng Y, Zhu Z, Wen L, Zuo X, Zheng X, Zhang Y, Xu J, Huang H, Zhou F, Sun L, Luo J, Zhang D, Chen X, Cui Y, Hao Y, Cui Y, Zhang X, Chen R
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Li S, Li XY, Zhang TJ, Kamara MO, Liang JW, Zhu J, Meng FH
Bioorganic chemistry 2020 Jan;94:103385
Bioorganic chemistry 2020 Jan;94:103385
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells.
Yao X, Zhao CR, Yin H, Wang K, Gao JJ
Acta pharmacologica Sinica 2020 Dec;41(12):1609-1620
Acta pharmacologica Sinica 2020 Dec;41(12):1609-1620
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Chen X, Ji S, Si J, Zhang X, Wang X, Guo Y, Zou X
Molecular medicine reports 2020 Dec;22(6):5243-5250
Molecular medicine reports 2020 Dec;22(6):5243-5250
PARP-1 mediated cell death is directly activated by ZIKV infection.
Xu G, Li S, Liu X, Gao P, Chen X, Wang H, Zhang M, Yang Y, Gao GF, Zhang F
Virology 2019 Nov;537:254-262
Virology 2019 Nov;537:254-262
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Shen J, Wang J, Du J, Wang L, Zhou X, Chang X, Li Z, Zhai X, Zuo D, Wu Y
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells.
Hong X, Li S, Li W, Xie M, Wei Z, Guo H, Wei W, Zhang S
Biochemical and biophysical research communications 2019 Jan 15;508(3):986-990
Biochemical and biophysical research communications 2019 Jan 15;508(3):986-990
SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish.
Zhao L, Tan J, Li D, Jiang L, Li T, Yang Y, Wang G, Shang Z, Wang J, Zhou J
Biochemical and biophysical research communications 2019 Apr 16;511(4):896-902
Biochemical and biophysical research communications 2019 Apr 16;511(4):896-902
Combination of sorafenib and Valproic acid synergistically induces cell apoptosis and inhibits hepatocellular carcinoma growth via down-regulating Notch3 and pAkt.
Zhu W, Liang Q, Yang X, Yu Y, Shen X, Sun G
American journal of cancer research 2017;7(12):2503-2514
American journal of cancer research 2017;7(12):2503-2514
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