12919-1-AP

antibody from Proteintech Group

Targeting: PRKCB PKCB, PKCβ, PRKCB1, PRKCB2

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

12919-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#12919-1-AP, RRID:AB_2237469

Product name

PKC Beta antibody

Antibody type

Polyclonal

Description

PKC Beta antibody (Cat. #12919-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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A genome-wide association study identified PRKCB as a causal gene and therapeutic target for Mycobacterium avium complex disease.

Zheng R, Li Z, Fang W, Lou H, Liu F, Sun Q, Shi X, Liu H, Chen Q, Shen X, Yao L, Guan L, Chen J, Xie Y, Yang Y, Yang H, Wang L, Qin L, Huang X, Wang J, Liu Z, Liu H, Ge B, Xu J, Sha W
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Protein kinase C activity modulates nuclear Lamin A/C dynamics in HeLa cells.

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Scientific reports 2024 Mar 16;14(1):6388

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Journal of cell science 2024 Dec 1;137(23)

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Up-regulated novel-miR-17 promotes hypothermic reperfusion arrhythmias by negatively targeting Gja1 and mediating activation of the PKC/c-Jun signaling pathway.

Yi J, Chen K, Cao Y, Wen C, An L, Tong R, Wu X, Gao H
Journal of molecular and cellular cardiology 2024 Aug;193:1-10

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Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages.

Higashi T, Handa H, Mai Y, Maenaka K, Tadokoro T
Journal of pharmacological sciences 2023 Sep;153(1):22-25

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Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation.

Liu LL, Han Y, Zhang ZJ, Wang YQ, Hu YW, Kaznacheyeva E, Ding JQ, Guo DK, Wang GH, Li B, Ren HG
Acta pharmacologica Sinica 2023 Oct;44(10):1948-1961

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In vitro fertilization with frozen embryo transfer increased histamine-mediated contractile sensitivity via PKCβ in human umbilical vein.

Tang J, Qi L, He Y, Li N, Zhang Z, Zhou X, Su H, Zheng Q, Zhang Y, Tao J, Xu Z
Reproductive biology and endocrinology : RB&E 2023 Jun 13;21(1):54

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Perinatal Fat-Diets Increased Angiotensin II-Mediated Ca(2+) through PKC-L-Type Calcium Channel Axis in Resistance Arteries via Agtr1a-Prkcb Gene Methylation.

Zheng Q, He Y, Li L, Rui C, Li N, Zhang Y, Ye Y, Zhang Z, Yang X, Tang J, Xu Z
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PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.

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Heliyon 2022 Sep;8(9):e10657

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POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.

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Integrated proteogenomic characterization of urothelial carcinoma of the bladder.

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Prostaglandin E(3) attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization.

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LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.

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Inflammatory bowel diseases 2021 Jul 27;27(8):1302-1315

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Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCβ Ser(660) phosphorylation and intracellular calcium.

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Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCβ/Mitochondrial Oxidant Signaling.

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Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse brain tissue were subjected to SDS PAGE followed by western blot with 12919-1-AP(PRKCB antibody) at dilution of 1:1000

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human pancreas cancer using 12919-1-AP(PRKCB antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The PKC beta antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PKC beta. This antibody recognizes human, mouse, rat antigen. The PKC beta antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

12919-1-AP.pdf

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