Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 12919-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12919-1-AP, RRID:AB_2237469
- Product name
- PKC Beta antibody
- Antibody type
- Polyclonal
- Description
- PKC Beta antibody (Cat. #12919-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Protein kinase C activity modulates nuclear Lamin A/C dynamics in HeLa cells.
Comprehensive single-cell transcriptomic profiling reveals molecular subtypes and prognostic biomarkers with implications for targeted therapy in esophageal squamous cell carcinoma.
Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages.
Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation.
In vitro fertilization with frozen embryo transfer increased histamine-mediated contractile sensitivity via PKCβ in human umbilical vein.
Perinatal Fat-Diets Increased Angiotensin II-Mediated Ca(2+) through PKC-L-Type Calcium Channel Axis in Resistance Arteries via Agtr1a-Prkcb Gene Methylation.
PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.
POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.
Integrated proteogenomic characterization of urothelial carcinoma of the bladder.
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Prostaglandin E(3) attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization.
LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.
Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCβ Ser(660) phosphorylation and intracellular calcium.
Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCβ/Mitochondrial Oxidant Signaling.
In utero hypoxia altered Ang II-induced contraction via PKCβ in fetal cerebral arteries.
PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats.
Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.
p66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke.
Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing.
Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function.
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway.
Wesley CC, North DV, Levy DL
Scientific reports 2024 Mar 16;14(1):6388
Scientific reports 2024 Mar 16;14(1):6388
Comprehensive single-cell transcriptomic profiling reveals molecular subtypes and prognostic biomarkers with implications for targeted therapy in esophageal squamous cell carcinoma.
Zhang D, Zhao F, Li J, Guo P, Liu H, Lu T, Li S, Li Z, Li Y
Translational oncology 2024 Jun;44:101948
Translational oncology 2024 Jun;44:101948
Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages.
Higashi T, Handa H, Mai Y, Maenaka K, Tadokoro T
Journal of pharmacological sciences 2023 Sep;153(1):22-25
Journal of pharmacological sciences 2023 Sep;153(1):22-25
Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation.
Liu LL, Han Y, Zhang ZJ, Wang YQ, Hu YW, Kaznacheyeva E, Ding JQ, Guo DK, Wang GH, Li B, Ren HG
Acta pharmacologica Sinica 2023 Oct;44(10):1948-1961
Acta pharmacologica Sinica 2023 Oct;44(10):1948-1961
In vitro fertilization with frozen embryo transfer increased histamine-mediated contractile sensitivity via PKCβ in human umbilical vein.
Tang J, Qi L, He Y, Li N, Zhang Z, Zhou X, Su H, Zheng Q, Zhang Y, Tao J, Xu Z
Reproductive biology and endocrinology : RB&E 2023 Jun 13;21(1):54
Reproductive biology and endocrinology : RB&E 2023 Jun 13;21(1):54
Perinatal Fat-Diets Increased Angiotensin II-Mediated Ca(2+) through PKC-L-Type Calcium Channel Axis in Resistance Arteries via Agtr1a-Prkcb Gene Methylation.
Zheng Q, He Y, Li L, Rui C, Li N, Zhang Y, Ye Y, Zhang Z, Yang X, Tang J, Xu Z
Nutrients 2023 Jan 3;15(1)
Nutrients 2023 Jan 3;15(1)
PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.
Liu S, Zhang Y, Yang Q, Zhang Y, Liu H, Huang MH, Wang R, Lu F
Heliyon 2022 Sep;8(9):e10657
Heliyon 2022 Sep;8(9):e10657
POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.
Xiao W, Geng W, Zhou M, Xu J, Wang S, Huang Q, Sun Y, Li Y, Yang G, Jin Y
Cell death & disease 2022 May 3;13(5):427
Cell death & disease 2022 May 3;13(5):427
Integrated proteogenomic characterization of urothelial carcinoma of the bladder.
Xu N, Yao Z, Shang G, Ye D, Wang H, Zhang H, Qu Y, Xu F, Wang Y, Qin Z, Zhu J, Zhang F, Feng J, Tian S, Liu Y, Zhao J, Hou J, Guo J, Hou Y, Ding C
Journal of hematology & oncology 2022 Jun 3;15(1):76
Journal of hematology & oncology 2022 Jun 3;15(1):76
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Fan JH, Xu MM, Zhou LM, Gui ZW, Huang L, Li XG, Ye XL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
Prostaglandin E(3) attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization.
Cui J, Shan K, Yang Q, Qi Y, Qu H, Li J, Wang R, Jia L, Chen W, Feng N, Chen YQ
Journal of cellular and molecular medicine 2021 Jun;25(12):5586-5601
Journal of cellular and molecular medicine 2021 Jun;25(12):5586-5601
LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.
Su X, Wei J, Qi H, Jin M, Zhang Q, Zhang Y, Zhang C, Yang R
Inflammatory bowel diseases 2021 Jul 27;27(8):1302-1315
Inflammatory bowel diseases 2021 Jul 27;27(8):1302-1315
Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCβ Ser(660) phosphorylation and intracellular calcium.
Chen X, Qi L, Su H, He Y, Li N, Gao Q, Li H, Xu T, Lu L, Xu Z, Tang J
Life sciences 2020 Nov 15;261:118364
Life sciences 2020 Nov 15;261:118364
Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCβ/Mitochondrial Oxidant Signaling.
Snow JB, Norton CE, Sands MA, Weise-Cross L, Yan S, Herbert LM, Sheak JR, Gonzalez Bosc LV, Walker BR, Kanagy NL, Jernigan NL, Resta TC
American journal of respiratory cell and molecular biology 2020 Jun;62(6):732-746
American journal of respiratory cell and molecular biology 2020 Jun;62(6):732-746
In utero hypoxia altered Ang II-induced contraction via PKCβ in fetal cerebral arteries.
Su H, Chen X, Zhang Y, Qi L, He Y, Lv J, Zhang Y, Li X, Tang J, Xu Z
The Journal of endocrinology 2020 Jan;244(1):213-222
The Journal of endocrinology 2020 Jan;244(1):213-222
PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats.
Sheak JR, Yan S, Weise-Cross L, Ahmadian R, Walker BR, Jernigan NL, Resta TC
American journal of physiology. Heart and circulatory physiology 2020 Feb 1;318(2):H470-H483
American journal of physiology. Heart and circulatory physiology 2020 Feb 1;318(2):H470-H483
Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.
Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, Zhang H, Chai Y
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126
p66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke.
Zhang M, Tang J, Shan H, Zhang Q, Yang X, Zhang J, Li Y
Oxidative medicine and cellular longevity 2018;2018:5837123
Oxidative medicine and cellular longevity 2018;2018:5837123
Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing.
Gu Q, Guo S, Wang D, Zhou T, Wang L, Wang Z, Ma J
Journal of molecular histology 2017 Jun;48(3):199-208
Journal of molecular histology 2017 Jun;48(3):199-208
Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function.
Wu JF, Ji J, Dong SY, Li BB, Yu ML, Wu DD, Tao L, Tong XH
Oncology reports 2016 Dec;36(6):3251-3258
Oncology reports 2016 Dec;36(6):3251-3258
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Zhang Y, Zhan Y, Zhang D, Dai B, Ma W, Qi J, Liu R, He L
Scientific reports 2014 Jul 1;4:5518
Scientific reports 2014 Jul 1;4:5518
Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway.
Luo W, Wang X, Zheng L, Zhan Y, Zhang D, Zhang J, Zhang Y
Journal of cellular and molecular medicine 2013 Oct;17(10):1316-24
Journal of cellular and molecular medicine 2013 Oct;17(10):1316-24
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 12919-1-AP(PRKCB antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 12919-1-AP(PRKCB antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PKC beta antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PKC beta. This antibody recognizes human, mouse, rat antigen. The PKC beta antibody has been validated for the following applications: ELISA, WB, IHC analysis.