BS4789

antibody from Bioworld Technology, Inc

Targeting: EIF2AK2 EIF2AK1, PKR, PPP1R83, PRKR

Western blot (Data presented on provider website)

Antibody Data

Product number

BS4789

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#BS4789, RRID:AB_1662341

Product name

PKR (phospho T446) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human PKR around the phosphorylation site of Threonine 446.

Description

An interferon-inducible, RNA-dependent protein serine/threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the Ï« subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2Ï« on serine-51 results in inhibition of translation. Molecular cDNA clones have been isolated from both human and mouse cells. The serine/threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. Three kinds of regulation of PKR enzymatic activity have been described.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.