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- Antigen structure
- References [18]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 13482-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13482-1-AP, RRID:AB_2169485
- Product name
- PPP2CA antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PPP2CA antibody (Cat. #13482-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function.
Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation.
Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation.
Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid.
BRG1 Activates PR65A Transcription to Regulate NO Bioavailability in Vascular Endothelial Cells.
The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα-SOD2 pathway.
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Mouse 4T1 Breast Cancer Cell-Derived Exosomes Induce Proinflammatory Cytokine Production in Macrophages via miR-183.
Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids.
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis-Infected Macrophages.
Role of type 2A phosphatase regulatory subunit B56α in regulating cardiac responses to β-adrenergic stimulation in vivo.
KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.
MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.
Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor.
Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells.
Cardiac function is regulated by B56α-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates.
Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.
Xu X, Ding G, Liu C, Ding Y, Chen X, Huang X, Zhang CS, Lu S, Zhang Y, Huang Y, Chen Z, Wei W, Liao L, Lin SH, Li J, Liu W, Li J, Lin SC, Ma X, Wong J
Cell research 2022 Jan;32(1):54-71
Cell research 2022 Jan;32(1):54-71
Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation.
Sun B, Zhong FJ, Xu C, Li YM, Zhao YR, Cao MM, Yang LY
Cell death & disease 2021 Sep 14;12(9):849
Cell death & disease 2021 Sep 14;12(9):849
Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation.
Yee YH, Chong SJF, Kong LR, Goh BC, Pervaiz S
Redox biology 2021 May;41:101834
Redox biology 2021 May;41:101834
Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid.
Pan Y, Zhang Y, Liu N, Lu W, Yang J, Li Y, Liu Z, Wei Y, Lou Y, Kong J
ACS chemical neuroscience 2021 Apr 21;12(8):1343-1350
ACS chemical neuroscience 2021 Apr 21;12(8):1343-1350
BRG1 Activates PR65A Transcription to Regulate NO Bioavailability in Vascular Endothelial Cells.
Chen B, Zhao Q, Xu T, Yu L, Zhuo L, Yang Y, Xu Y
Frontiers in cell and developmental biology 2020;8:774
Frontiers in cell and developmental biology 2020;8:774
The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα-SOD2 pathway.
Xie Y, Gao Y, Gao R, Yang W, Dong Z, Moses RE, Sun A, Li X, Ge J
Cell death and differentiation 2020 Oct;27(10):2952-2972
Cell death and differentiation 2020 Oct;27(10):2952-2972
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Zheng H, Qi Y, Hu S, Cao X, Xu C, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX, Xu Y
Science (New York, N.Y.) 2020 Nov 27;370(6520)
Science (New York, N.Y.) 2020 Nov 27;370(6520)
Mouse 4T1 Breast Cancer Cell-Derived Exosomes Induce Proinflammatory Cytokine Production in Macrophages via miR-183.
Guo J, Duan Z, Zhang C, Wang W, He H, Liu Y, Wu P, Wang S, Song M, Chen H, Chen C, Si Q, Xiang R, Luo Y
Journal of immunology (Baltimore, Md. : 1950) 2020 Nov 15;205(10):2916-2925
Journal of immunology (Baltimore, Md. : 1950) 2020 Nov 15;205(10):2916-2925
Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids.
Hu Z, Ban H, Zheng H, Liu M, Chang J, Guo JT
PLoS pathogens 2020 Jul;16(7):e1008669
PLoS pathogens 2020 Jul;16(7):e1008669
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
He X, Li M, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y, Cheng S, Yin H
PLoS biology 2020 Dec;18(12):e3000803
PLoS biology 2020 Dec;18(12):e3000803
PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis-Infected Macrophages.
Hussain T, Zhao D, Shah SZA, Sabir N, Wang J, Liao Y, Song Y, Hussain Mangi M, Yao J, Dong H, Yang L, Zhou X
International journal of molecular sciences 2019 Nov 29;20(23)
International journal of molecular sciences 2019 Nov 29;20(23)
Role of type 2A phosphatase regulatory subunit B56α in regulating cardiac responses to β-adrenergic stimulation in vivo.
Puhl SL, Weeks KL, Güran A, Ranieri A, Boknik P, Kirchhefer U, Müller FU, Avkiran M
Cardiovascular research 2019 Mar 1;115(3):519-529
Cardiovascular research 2019 Mar 1;115(3):519-529
KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.
Zhao L, Zhang D, Shen Q, Jin M, Lin Z, Ma H, Huang S, Zhou P, Wu G, Zhang T
Oncogene 2019 Feb;38(7):935-949
Oncogene 2019 Feb;38(7):935-949
MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.
Shi Q, Xiong B, Zhong J, Wang H, Ma D, Miao C
Molecular immunology 2017 Aug;88:79-88
Molecular immunology 2017 Aug;88:79-88
Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor.
Petta I, Bougarne N, Vandewalle J, Dejager L, Vandevyver S, Ballegeer M, Desmet S, Thommis J, De Cauwer L, Lievens S, Libert C, Tavernier J, De Bosscher K
Scientific reports 2017 Aug 21;7(1):8941
Scientific reports 2017 Aug 21;7(1):8941
Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells.
Gao YE, Wang Y, Chen FQ, Feng JY, Yang G, Feng GX, Yang Z, Ye LH, Zhang XD
Acta pharmacologica Sinica 2016 Jul;37(7):898-907
Acta pharmacologica Sinica 2016 Jul;37(7):898-907
Cardiac function is regulated by B56α-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates.
Kirchhefer U, Brekle C, Eskandar J, Isensee G, Kučerová D, Müller FU, Pinet F, Schulte JS, Seidl MD, Boknik P
The Journal of biological chemistry 2014 Dec 5;289(49):33862-73
The Journal of biological chemistry 2014 Dec 5;289(49):33862-73
Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.
Yang Y, Huang Q, Lu Y, Li X, Huang S
Journal of cellular biochemistry 2012 Apr;113(4):1314-22
Journal of cellular biochemistry 2012 Apr;113(4):1314-22
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 13482-1-AP(PPP2CA antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP result of anti-PPP2CA (13482-1-AP for IP and Detection) with HeLa cells.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13482-1-AP(PPP2CA antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13482-1-AP(PPP2CA antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
