Ab124023

antibody from Aladdin Scientific
Targeting: PTK2B CADTK, CAKB, FAK2, PTK, PYK2, RAFTK
Provider product page for Ab124023

Antibody data

Product number
Ab124023 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant PYK2 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human PTK2B Antibody, Recombinant, could be used for WB, IHC and so on.Application:á WB: 1/500-1/1000á IHC: 1/50-1/100Protein FunctionInvolved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation. In concert with SRC, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. The Tyr-402 phosphorylated form serves as a docking site for SRC and is important for the organization of the osteoclast actin cytoskeleton and attachment sites and for bone resorption.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 1-19
Vial size
100_l,10_l,1ml,50_l
Concentration
0,2 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
PTK2B protein structure - Ab124023 shown in red.