16674-1-AP

antibody from Proteintech Group

Targeting: STAT2 STAT113

Provider product page for 16674-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [45]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 16674-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16674-1-AP, RRID:AB_10644445
Product name: STAT2 antibody
Antibody type: Polyclonal
Description: STAT2 antibody (Cat. #16674-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

STAT2 protein structure - 16674-1-AP shown in red.

Submitted references IFITM3-mediated neuroinflammation in epilepsy regulated by the let-7g-5p/STAT2 axis.

Liu J, Sheng D, Li X, Yazgulyyeva B, Wang Y, Xiao B, Liu W
Scientific reports 2026 Mar 18;16(1)

Novel Duck Orthoreovirus σA Protein Inhibits Interferon Signaling by Impeding STAT1/STAT2 Nuclear Translocation.

Xu B, Jiang C, Di L, Zhou L, Wang Z, Tang Y, Fang R, Wang H
Transboundary and emerging diseases 2025;2025:8440800

Physical exercise protects neurons from energy deficit and improves cognitive function by upregulating astrocytic Slc2a1 in Alzheimer's disease.

Li S, Zheng F, Liu S, Wu R, Zhang L, He X, Li M, Li L
Experimental neurology 2025 Oct 6;395:115493

Identifying a novel region in the Tembusu virus NS5 protein antagonizing type I interferon signaling.

Zhang J, Fan Y, An D, Mao M, Guo Z, Yang J, Li Q, Zhu S, Li G, Chen X, Zhou Z, Hou S, Diao Y, Tang Y
Journal of virology 2025 Oct 23;99(10):e0131025

Multimodal characterization of the responsiveness of eight hepatitis D virus genotype isolates to interferon-alpha treatment.

Ding Y, Li Q, Sha Y, Si R, Feng C, Liu M, Feng Z, Ding X, Li Y, Fu H, Liang S, Yao Q, Zhang Z, Li F, Urban S, Guo H, Wang W
Journal of virology 2025 Oct 23;99(10):e0128025

Kaempferide enhances type I interferon signaling as a novel broad-spectrum antiviral agent.

Du R, Sun J, Zhang C, Chen C, Chen Z, Anirudhan V, Cui Q, Wang H, Rong L, Ning YJ
Antiviral research 2025 May;237:106141

The effect and mechanism of sanguinarine against PCV2 based on the analysis of network pharmacology and TMT quantitative proteomics.

Zhang S, Li H, Wang X, Sun P, Zhang H, Yin W, Fan K, Yang H, Zhang Z, Zhong J, Sun Y, Sun N
International journal of biological macromolecules 2025 Mar;296:139767

Bardoxolone displays potent activity against triple negative breast cancer by inhibiting the TRIP13/STAT3 circuit.

Deng JH, Li HY, Liu ZY, Liang JP, Ren Y, Zeng YY, Wang YL, Mao XL
Acta pharmacologica Sinica 2025 Jun;46(6):1733-1741

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus.

Zhang S, Zhong R, Zhou M, Li K, Lv H, Wang H, Xu Y, Liu D, Ma Q, Chen L, Zhang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415948

Cyanidin-3-O-glucoside mitigates Staphylococcus aureus-induced mastitis by suppressing inflammatory responses and Ferroptosis mediated by SESN2/Nrf2.

Pang Y, Ke Y, Amona FM, Chen X, Liu Z, Chen J, Liang Y, Wang F, Wang Y, Fang X, Chen X, Zhang C
International immunopharmacology 2025 Jun 26;159:114868

African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.

Yao M, Li P, Li X, Li W, Qian P
Veterinary research 2025 Jul 5;56(1):137

MCAM interacts with integrin β1 to promote EGFR-TKI resistance in lung adenocarcinoma through the JAK3 signalling pathway.

Zhang S, Chen Y, Li C, Zhao J, Jiao M, Zhang M, Ma C, Wang A, Li J, Zeng Y, Zhu J, Mu C, Huang JA, Liu Z
Journal of translational medicine 2025 Jul 25;23(1):831

Protein kinase a suppresses antiproliferative effect of interferon-α in hepatocellular carcinoma by activation of protein tyrosine phosphatase SHP2.

Sheng Y, Lin Y, Qiang Z, Shen X, He Y, Li L, Li S, Zhang G, Wang F
The Journal of biological chemistry 2025 Feb;301(2):108195

Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis.

Amona FM, Pang Y, Chen X, Liu Z, Su C, Yang J, Liu K, Wu Q, Liu B, Chen X, Zhang C
Materials today. Bio 2025 Dec;35:102491

Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy.

Ge X, Yu L, Zhang L, Jia L, Meng M, He J, Bu F, Song Y, Sun G, Lv S, Mei D, Yang Y, Xu D, Zhang J, Zhang S, Wang C, Jia D, Chen Y, Gao Y, He B
Nature communications 2025 Dec 14;17(1):623

LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.

Li JY, Li YQ, Dai JH, Gong S, He QM, Bai JW, Huang SW, Lu YQ, Duan YF, Feng SY, Tan XR, Liang XY, Ma J, Guo R, Liu N
The Journal of clinical investigation 2025 Dec 1;135(23)

The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy.

Huang Z, Gao C, Huang S, Lin S, Zhang W, You J, Chen X, Zhou P, Zhang G, Gong L
Autophagy 2025 Aug;21(8):1644-1661

Camel-Milk-Derived Extracellular Vesicles Mitigate High-Fat-Diet-Induced Obesity by Enhancing Thermogenesis and Modulating Lipid Metabolism in Mice.

Wang S, Liu S, He T, Shen H, Mo C, Zhu Y, Xie W, Li B, Li W, Zhang J
Journal of agricultural and food chemistry 2025 Aug 27;73(34):21404-21421

Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.

Liu M, Wang Y, Wang H, Qi L, Shang Y, Song J, Feng X, Chen Y, Memon WA, Shen Y, Wu X, Cao J, Zhao Y, Jiang Z, Liu D, Shafique S, Li S, Lu G, Wei Z, Liu Z, Zhou K, Quan Y, Zhang X, Zou X, Wang X, Liu N, Zhang Y, Hu Y, Han C, Wang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411889

Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity.

Wang F, Amona FM, Pang Y, Zhang Q, Liang Y, Chen X, Ke Y, Chen J, Song C, Wang Y, Li Z, Zhang C, Fang X, Chen X
Journal of virology 2025 Apr 15;99(4):e0158524

Increased Thyroid Hormone Action Alleviates Hippocampal Damage by Downregulating Neuronal Type I Interferon Signaling/Necroptosis in Diabetes-Associated Cognitive Dysfunction.

Tian L, Li X, Zeng X, Han Y, Qian M, Ye Y, Lin L, Li Y, Zhang J, Liu Y, Sun Y
Thyroid : official journal of the American Thyroid Association 2024 Oct;34(10):1292-1307

pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection.

Huang Z, Kong C, Zhang W, You J, Gao C, Yi J, Mai Z, Chen X, Zhou P, Gong L, Zhang G, Wang H
PLoS pathogens 2024 Oct;20(10):e1012613

Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response.

Xue W, Chu H, Wang J, Sun Y, Qiu X, Song C, Tan L, Ding C, Liao Y
PLoS pathogens 2024 Nov;20(11):e1012097

Deacetylase Sirtuin 1 mitigates type I IFN- and type II IFN-induced signaling and antiviral immunity.

Yu S-S, Tang R-C, Zhang A, Geng S, Yu H, Zhang Y, Sun X-Y, Zhang J
Journal of virology 2024 Mar 19;98(3):e0008824

Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis.

Huang J, Jin S, Guo R, Wu W, Yang C, Qin Y, Chen Q, He X, Qu J, Yang Z
RNA (New York, N.Y.) 2024 Mar 18;30(4):435-447

Fangchinoline induces antiviral response by suppressing STING degradation.

Wang J, Xie F, Jia X, Wang X, Kong L, Li Y, Liang X, Zhang M, He Y, Feng W, Luo T, Wang Y, Xu A
Journal of pharmaceutical analysis 2024 Jun;14(6):100972

African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to inhibit IFN-I signaling.

Huang Z, Mai Z, Kong C, You J, Lin S, Gao C, Zhang W, Chen X, Xie Q, Wang H, Tang S, Zhou P, Gong L, Zhang G
The Journal of biological chemistry 2024 Jul;300(7):107472

Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance.

Tajima Y, Shibasaki F, Masai H
Cancer gene therapy 2024 Jan;31(1):158-173

Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis.

Thomsen MM, Skouboe MK, Møhlenberg M, Zhao J, de Keukeleere K, Heinz JL, Werner M, Hollensen AK, Lønskov J, Nielsen I, Carter-Timofte ME, Zhang B, Mikkelsen JG, Fisker N, Paludan SR, Assing K, Mogensen TH
Journal of clinical immunology 2024 Jan 26;44(2):56

PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.

Tang J, He J, Guo H, Lin H, Li M, Yang T, Wang HY, Li D, Liu J, Li L, Xia H, Zhuo Z, Miao L
Research (Washington, D.C.) 2023;6:0033

Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.

Huang HX, Zhao CC, Lei XX, Zhang XY, Li YY, Lan T, Zhao BP, Lu JY, Sun WC, Lu HJ, Jin NY
Frontiers in immunology 2023;14:1196031

Interferon inhibits a model RNA virus via a limited set of inducible effector genes.

McDougal MB, De Maria AM, Ohlson MB, Kumar A, Xing C, Schoggins JW
EMBO reports 2023 Sep 6;24(9):e56901

The RhoA GTPase regulates Type I Interferon Signaling in Systemic lupus erythematosus.

Fan W, Wei B, Chen X, Zhang Y, Xiao P, Li K, Zhang YQ, Huang J, Leng L, Bucala R
Research square 2023 Sep 20;

Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.

Zhang MQ, Jia X, Cheng CQ, Wang YX, Li YY, Kong LD, Li QQ, Xie F, Yu YL, He YT, Dong QT, Jia ZH, Wang Y, Xu AL
Acta pharmacologica Sinica 2023 Nov;44(11):2253-2264

The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genes.

Song L, Wang D, Abbas G, Li M, Cui M, Wang J, Lin Z, Zhang XE
The Journal of biological chemistry 2023 Mar;299(3):102990

HHLA2 Activates the JAK/STAT Signaling Pathway by Binding to TMIGD2 in Hepatocellular Carcinoma Cells.

Guo H, Zhang C, Tang X, Zhang T, Liu Y, Yu H, Li Y, Wang R
Inflammation 2022 Aug;45(4):1585-1599

A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase.

Peng T, Wonganan O, Zhang Z, Yu J, Xi R, Cao Y, Suksamrarn A, Zhang G, Wang F
International journal of molecular sciences 2021 Mar 25;22(7)

Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.

Zong X, Xiao X, Kai L, Cheng Y, Fu J, Xu W, Wang Y, Zhao K, Jin M
International journal of biological macromolecules 2021 Jan 15;167:76-84

Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.

Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885

Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

Zhang M, Fu M, Li M, Hu H, Gong S, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292

Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.

Ran M, Huang J, Liang H, Jiang J, Liang B, Ning C, Zang N, Liao W, Liu H, Qin F, Yang Q, Ho W, Ye L, Chen H
Journal of medical virology 2018 Jun;90(6):1112-1120

Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.

Igbe I, Shen XF, Jiao W, Qiang Z, Deng T, Li S, Liu WL, Liu HW, Zhang GL, Wang F
Oncotarget 2017 Dec 26;8(69):113734-113748

6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.

Wonganan O, He YJ, Shen XF, Wongkrajang K, Suksamrarn A, Zhang GL, Wang F
Toxicology and applied pharmacology 2017 Dec 1;336:31-39

STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.

Jackson JD, Markert JM, Li L, Carroll SL, Cassady KA
Molecular cancer research : MCR 2016 May;14(5):482-92

Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells.

Zhu M, Lu J, Dong X, Zheng N, Li T, Chen Z, Pan X, Zhu Y, Yan H, Shen Y, Ying S, Hu C
Molecular medicine reports 2015 Nov;12(5):7176-80

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 16674-1-AP(STAT2 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 16674-1-AP(STAT2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The STAT2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human STAT2. This antibody recognizes human, mouse, rat antigen. The STAT2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 16674-1-AP.pdf

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