130-10034-200

antibody from RayBiotech, Inc.

Targeting: HTRA2 OMI, PARK13, PRSS25

ELISA (Recommended by provider)

Antibody Data

Product number

130-10034-200

Provider

RayBiotech, Inc.

Proper citation

RayBiotech Cat#130-10034-200, RRID:AB_11220402

Product name

Rabbit Anti-Human HTRA2/Omi

Antibody type

Polyclonal

Antigen

Synthetic peptide derived from human HTRA2/Omi.

Description

HTRA2 also called Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HTRA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HTRA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP)-binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HTRA2 has known to contribute both to caspase-dependent and caspase-independent cell death. Defects in HTRA2 are the cause of Parkinson disease type 13. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography.

Reactivity

Human

Host

Rabbit

Antigen sequence

This antibody was produced from a r
abbit immunized with the immunogen.
The IgG fraction was purified from
rabbit serum followed by Protein A
/G affinity chromatography.


Isotype

IgG

Vial size

200 µg

Handling

Supplied as lyophilized and purified antibody originally containing PBS, without Preservative Stabilizers, such as Sodium Azide. The final concentration is indicated on the shipping vial. The antibody is stable for at least years from the data of receipt when stored at -20°C to -70°C. Reconstituted antibody (suggesting with sterile PBS) can also be aliquotted and stored frozen at -20°C to -70°C in a manual defrost freezer for months without detectable loss activity. Upon reconstitution, the antibody can also be stored over months at 4°C. Please avoid freeze-thaw cycles.