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- References [25]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15775-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15775-1-AP, RRID:AB_2122835
- Product name
- HTRA2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HTRA2 antibody (Cat. #15775-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references 5-OH-TMT mitigates colitis through HTRA2 binding-mediated activation of the Dectin-1 signaling pathway.
Astrocytic-HSP60 Depletion Contributed to Autophagy Defects of Astrocytes and Depressive-Like Behaviors in Male Mice.
Paraquat induced neuro-immunotoxicity: Dysregulated microglial antigen processing and mitochondrial activated mechanisms.
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production.
Ribosome-associated pathological TDP-43 alters the expression of multiple mRNAs in the monkey brain.
Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy.
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière's disease.
An in vivo "turning model" reveals new RanBP9 interactions in lung macrophages.
Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function.
Neuroretinal Cell Culture Model as a Tool for the Development of New Therapeutic Approaches for Oxidative Stress-Induced Ocular Diseases, with a Focus on Glaucoma.
CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex.
Age-related changes in the mitochondrial, synthesis of steroids, and cellular homeostasis of the chicken ovary.
HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma.
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
Protease-independent control of parthanatos by HtrA2/Omi.
The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus.
Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses.
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.
Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy.
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
Protective effects of ghrelin on brain mitochondria after cardiac arrest and resuscitation.
Mitochondrial Proteome Changes Correlating with β-Amyloid Accumulation.
Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells.
Association of Omi/HtrA2 with γ-secretase in mitochondria.
Xiao CX, Wu WY, Li SC, Dong ML, Bian YH, Yu M, Lv X, Chen WG, Hong M, Zhou J, Sun Y, Ma HY, Zhu YY
Acta pharmacologica Sinica 2026 Apr 2;
Acta pharmacologica Sinica 2026 Apr 2;
Astrocytic-HSP60 Depletion Contributed to Autophagy Defects of Astrocytes and Depressive-Like Behaviors in Male Mice.
Li W, Zhu W, Zhu Z, Xie H, Ali T, Yu Z, Li S
Glia 2025 Oct;73(10):2130-2146
Glia 2025 Oct;73(10):2130-2146
Paraquat induced neuro-immunotoxicity: Dysregulated microglial antigen processing and mitochondrial activated mechanisms.
Shi G, Wang K, Liu Q, Wu C, Zhang Q, Ma Y, Qi A, Huang M
Chemico-biological interactions 2025 Nov 1;421:111721
Chemico-biological interactions 2025 Nov 1;421:111721
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production.
Otsuka Y, Yano M
FEBS open bio 2025 May;15(5):738-753
FEBS open bio 2025 May;15(5):738-753
Ribosome-associated pathological TDP-43 alters the expression of multiple mRNAs in the monkey brain.
Deng FY, Zhu GL, Ou KL, Zhu LH, Jia QQ, Wang X, Guo MW, Li B, Li SH, Li XJ, Yin P
Zoological research 2025 Mar 18;46(2):263-276
Zoological research 2025 Mar 18;46(2):263-276
Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy.
Zheng N, Li K, Cao J, Wang Z, Zhang L, Zhao Z, He J, Wang Y, Zhu X, Chen Y, Meng J, Zhao D, Niu M, Luo H, Zhang X, Sun H, Zhang YW
Translational psychiatry 2025 Jan 10;15(1):5
Translational psychiatry 2025 Jan 10;15(1):5
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière's disease.
Harhai M, Foged MM, Zarges C, Landoni JC, Chollet S, Simonelli M, Recazens E, Lisci M, Laban N, Manley S, Riemer J, Lopez-Escamez JA, Lysakowski A, Jourdain AA
Cell reports 2025 Aug 26;44(8):116069
Cell reports 2025 Aug 26;44(8):116069
An in vivo "turning model" reveals new RanBP9 interactions in lung macrophages.
Kajimura Y, Dong S, Tessari A, Orlacchio A, Thoms A, Cufaro MC, Di Marco F, Amari F, Chen M, Soliman SHA, Rizzotto L, Zhang L, Sunilkumar D, Amann JM, Carbone DP, Ahmed A, Fiermonte G, Freitas MA, Lodi A, Del Boccio P, Tessarollo L, Palmieri D, Coppola V
Cell death discovery 2025 Apr 13;11(1):171
Cell death discovery 2025 Apr 13;11(1):171
Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function.
Rawnsley DR, Islam M, Zhao C, Kargar Gaz Kooh Y, Mendoza A, Navid H, Kumari M, Guan X, Murphy JT, Nigro J, Kovacs A, Mani K, Huebsch N, Ma X, Diwan A
bioRxiv : the preprint server for biology 2024 Nov 26;
bioRxiv : the preprint server for biology 2024 Nov 26;
Neuroretinal Cell Culture Model as a Tool for the Development of New Therapeutic Approaches for Oxidative Stress-Induced Ocular Diseases, with a Focus on Glaucoma.
Fomo KN, Perumal N, Manicam C, Pfeiffer N, Grus FH
Cells 2024 May 1;13(9)
Cells 2024 May 1;13(9)
CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex.
Baker MJ, Blau KU, Anderson AJ, Palmer CS, Fielden LF, Crameri JJ, Milenkovic D, Thorburn DR, Frazier AE, Langer T, Stojanovski D
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
Age-related changes in the mitochondrial, synthesis of steroids, and cellular homeostasis of the chicken ovary.
Zhan XZ, Luo P, Zhang C, Zhang LJ, Shen X, Jiang DL, Liu WJ
Animal reproduction science 2024 Aug;267:107540
Animal reproduction science 2024 Aug;267:107540
HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma.
Chen Y, Yang J, Jin H, Wen W, Xu Y, Zhang X, Wang Y
PeerJ 2023;11:e16237
PeerJ 2023;11:e16237
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T
Cell reports 2023 May 30;42(5):112454
Cell reports 2023 May 30;42(5):112454
Protease-independent control of parthanatos by HtrA2/Omi.
Weiß J, Heib M, Korn T, Hoyer J, Fuchslocher Chico J, Voigt S, Koudelka T, Tholey A, Adam D
Cellular and molecular life sciences : CMLS 2023 Aug 18;80(9):258
Cellular and molecular life sciences : CMLS 2023 Aug 18;80(9):258
The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus.
Qi Y, Xue HL, Zheng YJ, Yin YF, Xu WL, Xu JH, Wu M, Chen L, Xu LX
Animals : an open access journal from MDPI 2022 Dec 16;12(24)
Animals : an open access journal from MDPI 2022 Dec 16;12(24)
Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses.
Straub IR, Weraarpachai W, Shoubridge EA
Human molecular genetics 2021 May 17;30(8):687-705
Human molecular genetics 2021 May 17;30(8):687-705
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Khodayari N, Wang RL, Oshins R, Lu Y, Millett M, Aranyos AM, Mostofizadeh S, Scindia Y, Flagg TO, Brantly M
International journal of molecular sciences 2021 Dec 9;22(24)
International journal of molecular sciences 2021 Dec 9;22(24)
Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.
Xue Y, Li M, Xue Y, Jin W, Han X, Zhang J, Chu X, Li Z, Chu L
Molecular medicine reports 2020 Dec;22(6):4663-4674
Molecular medicine reports 2020 Dec;22(6):4663-4674
Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy.
Ye T, Yao H, Xu Y, Zhao X, Lu H, Zhang R
Cancer biomarkers : section A of Disease markers 2019;26(3):249-259
Cancer biomarkers : section A of Disease markers 2019;26(3):249-259
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
Botham A, Coyaud E, Nirmalanandhan VS, Gronda M, Hurren R, Maclean N, St-Germain J, Mirali S, Laurent E, Raught B, Schimmer A
Proteomics 2019 Dec;19(24):e1900139
Proteomics 2019 Dec;19(24):e1900139
Protective effects of ghrelin on brain mitochondria after cardiac arrest and resuscitation.
Xu H, Li Y, Liu R, Wu L, Zhang C, Ding N, Ma A, Zhang J, Xie X
Neuropeptides 2019 Aug;76:101936
Neuropeptides 2019 Aug;76:101936
Mitochondrial Proteome Changes Correlating with β-Amyloid Accumulation.
Völgyi K, Háden K, Kis V, Gulyássy P, Badics K, Györffy BA, Simor A, Szabó Z, Janáky T, Drahos L, Dobolyi Á, Penke B, Juhász G, Kékesi KA
Molecular neurobiology 2017 Apr;54(3):2060-2078
Molecular neurobiology 2017 Apr;54(3):2060-2078
Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells.
Wang J, Song X, Guo C, Wang Y, Yin Y
Cancer science 2016 Dec;107(12):1888-1897
Cancer science 2016 Dec;107(12):1888-1897
Association of Omi/HtrA2 with γ-secretase in mitochondria.
Behbahani H, Pavlov PF, Wiehager B, Nishimura T, Winblad B, Ankarcrona M
Neurochemistry international 2010 Nov;57(6):668-75
Neurochemistry international 2010 Nov;57(6):668-75
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 15775-1-AP(HTRA2 antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15775-1-AP(HTRA2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HTRA2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HTRA2. This antibody recognizes human,mouse,rat, monkey antigen. The HTRA2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
