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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN362266 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pThr45) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pThr45 (S-T-T (p) -P-G) derived from Human 4E-BP1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pThr45
- Isotype
- IgG
- Vial size
- 100 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A.
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation.
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.
Moody CA, Scott RS, Amirghahari N, Nathan CO, Young LS, Dawson CW, Sixbey JW
Journal of virology 2005 May;79(9):5499-506
Journal of virology 2005 May;79(9):5499-506
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr
Genes & development 2004 Dec 1;18(23):2893-904
Genes & development 2004 Dec 1;18(23):2893-904
Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation.
Kumar V, Pandey P, Sabatini D, Kumar M, Majumder PK, Bharti A, Carmichael G, Kufe D, Kharbanda S
The EMBO journal 2000 Mar 1;19(5):1087-97
The EMBO journal 2000 Mar 1;19(5):1087-97
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM
Proceedings of the National Academy of Sciences of the United States of America 1998 Feb 17;95(4):1432-7
Proceedings of the National Academy of Sciences of the United States of America 1998 Feb 17;95(4):1432-7
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.
Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N
Genes & development 1998 Feb 15;12(4):502-13
Genes & development 1998 Feb 15;12(4):502-13
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