25890-1-AP

antibody from Proteintech Group

Targeting: TRPC5 PPP1R159

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

25890-1-AP

Provider

Proteintech Group

Product name

TRPC5 antibody

Antibody type

Polyclonal

Description

TRPC5 antibody (Cat. #25890-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Morphine Tolerance Gated through EZH2-Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice.

Wan L, Zhang M, Guo H, Xu Y, Xu C, Hu F, Pan Y, Wang X, Liu W, Jiang CY
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e07908

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N-palmitoyl glycine differentially modulates TRPM4 and TRPC5 and is causally linked to Brugada syndrome.

Xu H, Li B, Chen Y, Lin Y, Zhang A, Wu L
Communications biology 2025 Nov 28;8(1):1854

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Mechanism of (-)-Englerin A and calcium binding on the human TRPC5 channel.

Chen Y, Song K, Guo W, Wei M, Chen L
Protein science : a publication of the Protein Society 2025 Aug;34(8):e70218

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Pharmacological manipulation of TRPC5 by kaempferol attenuates metastasis of gastrointestinal cancer via inhibiting calcium involved in the formation of filopodia.

Yu S, Deng R, Wang W, Zou D, He L, Wei Z, Pan Y, Li X, Wu Y, Wang A, Chen W, Zhao Y, Lu Y
International journal of biological sciences 2024;20(12):4922-4940

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RGS5(+) lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism.

Qiu C, Tang C, Tang Y, Su K, Chai X, Zhan Z, Niu X, Li J
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101149

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Endothelial cell Orai1 is essential for endothelium-dependent contraction of mouse carotid arteries in normotensive and hypertensive mice.

Li X, Lei ZC, Lo CY, Jan TY, Lau CW, Yao XQ
Acta pharmacologica Sinica 2024 May;45(5):975-987

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Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway.

Kidokoro K, Kadoya H, Cherney DZI, Kondo M, Wada Y, Umeno R, Kishi S, Nagasu H, Nagai K, Suzuki T, Sasaki T, Yamamoto M, Kanwar YS, Kashihara N
Kidney360 2023 Oct 1;4(10):1454-1466

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Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition.

Zhou F, Yang L, Yang L, Wang X, Guo N, Sun W, Ma H
Biochemical and biophysical research communications 2022 Nov 19;630:1-7

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TRPC5 is essential in endothelium-dependent contraction of aorta from diet-induced obese mice.

Zhu Y, Wang S, Chu Y, Zhang K, Wen X, Feng L, Yu F, Ma X
Fundamental research 2022 May;2(3):429-436

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TRPC5 mediates endothelium-dependent contraction in the carotid artery of diet-induced obese mice.

Chu Y, Wang S, Zhu Y, Yu F, Zhang K, Ma X
Hypertension research : official journal of the Japanese Society of Hypertension 2022 Dec;45(12):1945-1953

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TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway.

Lin DC, Zheng SY, Zhang ZG, Luo JH, Zhu ZL, Li L, Chen LS, Lin X, Sham JSK, Lin MJ, Zhou RX
Cancer letters 2021 Oct 28;519:211-225

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Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.

Huo S, Ren J, Ma Y, Ozathaley A, Yuan W, Ni H, Li D, Liu Z
Journal of neuroinflammation 2021 Nov 26;18(1):275

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Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.

Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife 2021 Mar 8;10

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Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries.

Liang C, Zhang Y, Zhuo D, Lo CY, Yu L, Lau CW, Kwan YW, Tse G, Huang Y, Yao X
Biochemical pharmacology 2019 Jan;159:11-24

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TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.

Li Z, Meng Z, Lu J, Chen FM, Wong WT, Tse G, Zheng C, Keung W, Tse K, Li RA, Jiang L, Yao X
Journal of molecular and cellular cardiology 2018 Jul;120:1-11

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An abnormal TRPV4-related cytosolic Ca(2+) rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients.

Lu J, Lee YK, Ran X, Lai WH, Li RA, Keung W, Tse K, Tse HF, Yao X
Biochimica et biophysica acta. Molecular basis of disease 2017 Nov;1863(11):2964-2972