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- References [397]
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- Product number
- 10929-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10929-2-AP, RRID:AB_2169568
- Product name
- AMPK Alpha 1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AMPK Alpha 1 antibody (Cat. #10929-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Qingyi Decoction Alleviates Alcoholic Pancreatitis by Improving Glycerolipid Homeostasis via the AMPK/SREBP-1c/PPARα Pathway.
Endothelial KSR2 regulated by genetic variation protects against atherosclerosis through AMPKα1 stabilization.
The effect of 4.3 GHz high-power microwave exposure on human corneal epithelial cells.
Mo-Rubbing abdominal improves metabolic homeostasis in type 2 diabetes mellitus mice via a jejunum-specific GLP1-dependent mechanism.
Optineurin enhances the chemoresistance by activating mitophagy in acute myeloid leukemia with NPM1 mutation.
Serine Supplementation Attenuates High-Selenium-Induced Insulin Resistance via Feedback Inhibition of PHGDH in Mice.
Fibroblast growth factor 21 with molybdenum nanodots in a self-contracting thermosensitive hydrogel promotes diabetic wound repair by reprogramming lipid metabolism.
Macrophage AMPK activated by oxidative stress drives profibrotic crosstalk with tubular cells to accelerate renal fibrosis after ischemic and reperfusion injury.
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT.
Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short-Chain Fatty Acids.
Betaine supplementation attenuates high-Se induced insulin resistance in C57BL/6 mice.
Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage.
Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.
Polygoni Multiflori Radix Improves Dyslipidemia by Regulating Hepatocyte Lipid Metabolism Mediated via the AMPK/SREBP-2/PCSK9/LDLR Signaling Pathway.
Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility.
Lutein attenuates sodium fluoride (NaF) and gamma-irradiation induced hepatotoxicity via AMPK-PGC1α mitochondrial biogenesis induction.
Integrating multi-omics approaches to elucidate the mechanism of XiaoPi Decoction in treating hyperplasia of mammary glands via AMPK signaling pathway activation.
Costunolide Ameliorates Hepatic Steatosis and Insulin Resistance in a Diet-Induced Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK/ACC1 Signalling Pathway.
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Sevoflurane induces developmental cardiotoxicity via AMPKα2 dysregulation in zebrafish.
Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pathogenesis of polycystic ovary syndrome.
Insights on the enhanced wound healing potential of russelioside B isolated from Caralluma quadrangula via modulation of AMPK/Beclin-1 and P-62 autophagy pathway.
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Ferulic acid improves growth performance and lipid metabolism and bile acid level partially by activating the PPAR and CYP7A1 pathways in broilers.
Research on the compatibility mechanism of the Tingli Dazao Xiefei Decoction by multi-organ metabolomics strategy.
Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway.
ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells.
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Anti-Diabetic Effects of Ayanin, a Flavonoid Compound, in STZ/HFD-Induced Diabetic Mice by Upregulating GLUT4 and Suppressing Macrophage-Driven Inflammation in Adipose Tissues.
Yangjingzhongyu Decoction regulates primordial follicle initiation via LncRNA-Smad1/AMPK dual pathways in diminished ovarian reserve.
Oxytocin Attenuates Metabolic Dysfunction-associated Steatotic Liver Disease via AMPK/SREBP1c/FAS-mediated Suppression of Hepatic Lipogenesis.
A Molecular and Functional Investigation of the Anabolic Effect of an Essential Amino Acids' Blend Which Is Active In Vitro in Supporting Muscle Function.
Neuroprotective Effects of Desert Milk Exosomes in LPS-Induced Cognitive Decline: Role of Microglial M2 Polarization and AMPK Signaling.
Corin inhibits microglial inflammatory activation by suppressing mitochondrial dysfunction in intracerebral hemorrhage.
Bacteroides acidifaciens alleviates high-fat diet-induced obesity-related osteoporosis by regulating gut microbiota and bile acid metabolism via the gut-bone axis.
Chondroitin Sulfate A-Selenium Nanoparticles Activate Autophagy Through the AMPK-mTOR Pathway to Alleviate Oxidative Stress and Mitochondrial Dysfunction to Repair Kashin-Beck Disease Chondrocytes.
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
AE-MXene-modified titanium alloy promotes osseointegration by regulating the AMPK-MTOR-autophagy pathway in macrophage.
N-Lac-Phe Ameliorates Myocardial Cell Death by Improving Mitochondrial Dysfunction, Ultimately Improving TAC-induced Heart Failure.
Foodborne PET Microplastic Contamination Compromises Intestinal Barrier through a Mitochondrial-AMPK-DNA Damage Pathway.
Systematic characterization of in vivo exposure and pharmacokinetic features of Tongmaijiangzhi capsule in humans using integrated HRMS and intelligent data processing.
miR-17-5p inhibits classical swine fever virus replication by targeting the PKD2-regulated AMPK/mTOR autophagy pathway.
L1TD1 promotes colorectal mucinous adenocarcinoma progression by enhancing ABCC3 mRNA stability.
Pinobanksin alleviates 4℃ semen preservation-induced oxidative damage and apoptosis in Wenchang Pig spermatozoa via the CaMKKβ/AMPK/Nrf2 pathway.
SIRT3-mediated mitochondrial fatty acid oxidation protects against hepatic lipid deposition in fatty liver hemorrhagic syndrome.
Fluoride Damages the Ovary by Inhibiting LKB1-AMPK Signaling to Promote Mitochondrial Injury-Induced Inflammation and Oxidative Stress.
Buyang Huanwu Decoction suppresses atherosclerosis by targeting IFITM1‑mediated lipid metabolism in vascular smooth muscle cells.
The tumor suppressor NDRG2 promotes ACC1 proteasomal degradation and inhibits de novo lipogenesis in hepatocellular carcinoma.
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.
Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network.
Aerobic exercise improved liver steatosis by modulating miR-34a-mediated PPARα/SIRT1-AMPK signaling pathway.
α-ALA Attenuates Cardiac Injury in Diabetic Heart Disease Mice by Modulating Inflammation and AMPKα1.
Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury.
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.
Luteolin attenuates LPS-induced damage in IPEC-J2 cells by enhancing mitophagy via AMPK signaling pathway activation.
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Targeted energy metabolomics analysis-based mitochondrial restoration: Nutritional intervention of dairy-derived MFG-E8 synergistic with egg yolk phosphatidylcholine in skeletal muscle regeneration.
Selective and iron-independent ferroptosis in cancer cells induced by manipulation of mitochondrial fatty acid oxidation.
Kuntai Capsules Improve Premature Ovarian Failure by Regulating AMPK-Mediated Autophagy.
Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.
Irisin/FNDC5 Regulates Endothelial Function to Improve Post-Stroke-Induced Cognitive Dysfunction by Stimulating AMPK-eNOS Signaling.
Yangxinshi tablet protects against myocardial injury and increases skeletal muscle exercise capacity by regulating mitochondrial bioenergetics.
Chondroitin sulfate A-selenium nanoparticles protect chondrocytes from T-2 toxin-induced oxidative stress and mitochondrial dysfunction through activating autophagy by the SIRT1-AMPK-FOXO3 pathway.
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway.
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
5-HT regulates resistance to aumolertinib by attenuating ferroptosis in lung adenocarcinoma.
POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?
Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation.
Melatonin Activates AMPK Pathway to Regulate the Regeneration of Slow Muscle Fibers in Skeletal Muscle Injury Repair.
Reversal of Myofibroblast Apoptosis Resistance and Collagen Deposition by Phaseoloidin-Induced Autophagy Attenuates Pulmonary Fibrosis.
AMP-activated protein kinase-Caspase 6 axis regulation alleviates the combined apoptotic damage caused by deoxynivalenol and fumonisin B1 in mammary glands.
Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism.
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine.
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
A Novel Role of Adipokine 'Intelectin-1': Ameliorating Renal Fibrosis Through Inhibition of Renal Tubular Epithelial Cell Senescence.
Mechanism of adenosine monophosphate-activated protein kinase promoting lower extremity varicose veins development via cytoskeletal dynamics.
Association of metformin with risk of digestive tract cancers from a drug target mendelian randomization and cell experiments.
Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells.
Orientin attenuates UVB-induced skin photodamage by inhibiting ROS generation via the AMPK/Nrf2 axis.
Bufei Yishen formula alleviates airway epithelial cell senescence in COPD by activating AMPK-Sirt1-FoxO3a pathway and promoting autophagy.
Mechanistic insights into GLP-1 receptor agonist-induced weight loss through ceRNA network analysis.
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis.
The Effects of Sika Deer Antler Peptides on 3T3-L1 Preadipocytes and C57BL/6 Mice via Activating AMPK Signaling and Gut Microbiota.
Exploring the effect of chlorogenic acid on oxidative stress and autophagy in dry eye mice via the AMPK/ULK1 pathway.
Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.
PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.
GLA deficiency causes cardiac hypertrophy via enhanced autophagy.
β-Sitosterol Ameliorates Ulcerative Colitis Through Modulation of the AMPK/MLCK Anti-Inflammatory Pathway.
Targeting LKB1-AMPK-SIRT1-induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice.
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing.
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice with myocardial infarction via the AMPK/SIRT1/PGC-1α pathway.
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
Alisol B alleviates MASLD by activating liver autophagy and fatty acid oxidation via Ces2a.
Enzymatic Synthesis and Evaluation of Eight Methylated Quercetin Products: In Vitro Chemical Properties and Adipogenesis Regulation.
Exosomal miR-202-5p derived from iPSC-MSCs protects against myocardial infarction through inhibition of cardiomyocyte pyroptosis.
Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy.
Impact of ATF6 deletion on the embryonic brain development.
AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions.
Medium-chain triglyceride attenuates obesity by activating brown adipose tissue via upregulating the AMPK signaling pathway.
AdipoR2 enhances adipocyte thermogenesis in Tibetan pigs via AMPK-ACC signaling.
Characterization of the Avian Mitochondrial-Derived Peptide MOTS-c and Its Potential Role as a Metabolic Regulator.
Increased ROS levels activate AMPK-ULK1-mediated mitophagy to promote pseudorabies virus replication.
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
Targeted therapy for KIF3C: A study on the mechanism of combined therapy with KIF3C signaling pathway, afatinib, and MT-DC (ac)phosphoramide in regulating gastric cancer cell proliferation.
Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway.
Cinnamic acid alleviates endothelial dysfunction and oxidative stress by targeting PPARδ in obesity and diabetes.
Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction.
Alogliptin attenuates STZ-induced diabetic nephropathy in rats through the modulation of autophagy, apoptosis, and inflammation pathways: Targeting NF-κB and AMPK/mTOR pathway.
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway.
Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation.
THSWD upregulates the LTF/AMPK/mTOR/Becn1 axis and promotes lysosomal autophagy in hepatocellular carcinoma cells by regulating gut flora and metabolic reprogramming.
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification.
Ferulic acid from Angelica sinensis (Oliv.) Diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways.
In vitro-Digested Cervus nippon Velvet Antler Polypeptides Alleviate Alcoholic Liver Disease by Suppressing CYP2E1 Activity and Enhancing AMPK Signaling Pathway.
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function.
Oxyberberine Inhibits Hepatic Gluconeogenesis via AMPK-Mediated Suppression of FoxO1 and CRTC2 Signaling Axes.
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside.
Multi-strategy profiling identifies limonin's dual role in gout: restoring uric acid homeostasis and suppressing inflammatory response.
SGLT2i continuously prevents cardiac hypertrophy by reducing ferroptosis via AMPK up-regulation.
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
Hydroxysafflor yellow A ameliorates myocardial ischemia/reperfusion injury by promoting MDH1-mediated mitochondrial metabolic homeostasis.
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism.
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria.
Engineered MSCs Break Endothelial-Myofibroblast Crosstalk in Pulmonary Fibrosis: Reconstructing the Vascular Niche.
Fine-tuned calcium homeostasis is crucial for murine erythropoiesis.
Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer.
The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.
Progranulin enhances M2 macrophage polarization and renal fibrosis by modulating autophagy in chronic kidney disease.
Epimedii Folium and Ligustri Lucidi Fructus synergistically delay renal aging through AMPK/ULK1/Bcl2L13-mediated mitophagy.
Anthocyanins prevent the development and progression of urethane-induced lung cancer by regulating energy metabolism in mice.
GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway.
Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.
Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway.
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism.
LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney disease.
Nobiletin alleviates macrophage M2 polarization by activating AMPK-mTOR-mediated autophagy in pulmonary fibrosis mice.
Exposure to Succinate Leads to Steatosis in Non-Obese Non-Alcoholic Fatty Liver Disease by Inhibiting AMPK/PPARα/FGF21-Dependent Fatty Acid Oxidation.
Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism.
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Autophagy aggravates multi-walled carbon nanotube-induced ferroptosis by suppressing PGC-1 dependent-mitochondrial biogenesis in lung epithelial cells.
Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death.
Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.
Potential Anti-Obesity Effect of Hazel Leaf Extract in Mice and Network Pharmacology of Selected Polyphenols.
Characteristics of Myocardial Structure and Central Carbon Metabolism during the Early and Compensatory Stages of Cardiac Hypertrophy.
Er-Dong-Xiao-Ke decoction regulates lipid metabolism via PPARG-mediated UCP2/AMPK signaling to alleviate diabetic meibomian gland dysfunction.
Bioenergetic-active exosomes for cartilage regeneration and homeostasis maintenance.
Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner.
Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells in vitro by activating AMPK/mTOR-mediated autophagy.
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
β-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway.
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation.
Pretreatment with growth differentiation factor 15 augments cardioprotection by mesenchymal stem cells in myocardial infarction by improving their survival.
Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis.
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition.
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway.
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway.
Probiotic-fermented tomato with hepatic lipid metabolism modulation effects: analysis of physicochemical properties, bioactivities, and potential bioactive compounds.
Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy.
AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy.
Cisplatin induces acute kidney injury by downregulating miR-30e-5p that targets Galnt3 to activate the AMPK signaling pathway.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.
FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA.
Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice.
Protective effects of l-cysteine and N-acetyl-l-cysteine on boar sperm quality during hypothermic liquid storage with bovine serum albumin as a protectant.
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
TGF β1 promotes the polarization of M2-type macrophages and activates PI3K/mTOR signaling pathway by inhibiting ISG20 to sensitize ovarian cancer to cisplatin.
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
Mechanism Research of DHEA Treatment Improving Diminished Ovarian Reserve by Attenuating the AMPK-SIRT1 Signaling and Mitophagy.
Identification of a novel hypoglycemic small molecule, trans-2, 4-dimethoxystilbene by rectifying gut microbiota and activating hepatic AMPKα-PPARγ pathway through gut-liver axis.
Dasabuvir alleviates 5-fluorouracil-induced intestinal injury through anti-senescence and anti-inflammatory.
GPR30 selective agonist G-1 induced insulin resistance in ovariectomized mice on high fat diet and its mechanism.
Tangeretin Enhances Muscle Endurance and Aerobic Metabolism in Mice via Targeting AdipoR1 to Increase Oxidative Myofibers.
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Palmatine improves cognitive dysfunction in Alzheimer's disease model rats through autophagy pathway and regulation of gut microbiota.
Low selenium and T-2 toxin may be involved in the pathogenesis of Kashin-Beck disease by affecting AMPK/mTOR/ULK1 pathway mediated autophagy.
High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis.
Real-time monitoring of glucose metabolism and effects of metformin on HepG2 cells using (13)C in-cell NMR spectroscopy.
CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.
Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1.
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis.
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Calpain-1 Up-Regulation Promotes Bleomycin-Induced Pulmonary Fibrosis by Activating Ferroptosis.
Astragaloside IV and cycloastragenol promote liver regeneration through regulation of hepatic oxidative homeostasis and glucose/lipid metabolism.
Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.
Notoginsenoside R1-Protocatechuic aldehyde reduces vascular inflammation and calcification through increasing the release of nitric oxide to inhibit TGFβR1-YAP/TAZ pathway in vascular smooth muscle cells.
Adiponectin receptor 1-mediated basolateral amygdala-prelimbic cortex circuit regulates methamphetamine-associated memory.
Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK/NRF2/SLC7A11 axis.
Apigenin Reduces Lipid Droplet Accumulation in Hepatocytes by Enhancing Chaperone-Mediated Autophagy via AMPK.
Chronic microcystin-leucine-arginine exposure induces osteoporosis by breaking the balance of osteoblasts and osteoclasts.
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway.
Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1.
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
GPRASP2 deficiency contributes to apoptosis in the spiral ganglion cells via the AMPK/DRP1 signaling pathway.
Capsaicin combined with cisplatin inhibits TGF-β1-induced EMT and TSCC cells migration via the Claudin-1/PI3K/AKT/mTOR signaling pathway.
Regulatory effect of β-glucan secreted by Rhizobium pusense on triglyceride metabolism and their relationships with the modulation of intestinal microbiota in mice fed a high-fat diet.
Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth-retarded suckling piglets associated with activation of FGF21-AMPKα pathway.
Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor.
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Complexes of Soluble Dietary Fiber and Polyphenols from Lotus Root Regulate High-Fat Diet-Induced Hyperlipidemia in Mice.
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM.
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure.
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways.
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway.
Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway.
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Gallotannin Isolated from Pericarp of Water Caltrop Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Regulation of Paracellular Fluxes of Amino Acids by Claudin-8 in Normal Mouse Intestinal MCE301 Cells.
Ferrostatin-1 improves BMSC survival by inhibiting ferroptosis.
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Modulation of the Microbiome-Fat-Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice.
Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.
Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis.
Recombinant human angiotensin-converting enzyme 2 plays a protective role in mice with sepsis-induced cardiac dysfunction through multiple signaling pathways dependent on converting angiotensin II to angiotensin 1-7.
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Quantification and Proteomic Characterization of β-Hydroxybutyrylation Modification in the Hearts of AMPKα2 Knockout Mice.
A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector.
Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.
The Degree of Hydrolysis and Peptide Profile Affect the Anti-Fatigue Activities of Whey Protein Hydrolysates in Promoting Energy Metabolism in Exercise Mice.
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Increase in Paracellular Leakage of Amino Acids Mediated by Aging-Induced Reduction of Claudin-4 Expression.
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo.
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway.
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Caffeic Acid Phenethyl Ester (CAPE) Improves Boar Sperm Quality and Antioxidant Capacity in Liquid Preservation (17°C) Linked to AMPK Activity Maintenance.
Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway.
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.
Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function.
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3.
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.
A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.
Copper Depletion Strongly Enhances Ferroptosis via Mitochondrial Perturbation and Reduction in Antioxidative Mechanisms.
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition.
Empagliflozin inhibits macrophage inflammation through AMPK signaling pathway and plays an anti-atherosclerosis role.
Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency.
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions.
Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion.
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation.
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Metformin and MiR-365 synergistically promote the apoptosis of gastric cancer cells via MiR-365-PTEN-AMPK axis.
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Mdivi-1 improves postoperative neurocognitive disorders in aged rats undergoing splenectomy by inhibiting dynamin-related protein-1.
Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic β-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux.
Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways.
Effects of Fluorine on Neutrophil Extracellular Trap Formation through Regulating AMPK/p38 Signaling Pathway.
Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway.
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Simvastatin-romidepsin combination kills bladder cancer cells synergistically.
Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.
Co-modification with MSC membrane and PDA prevents Fe(3)O(4)-induced pulmonary toxicity in mice via AMPK-ULK1 axis.
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1α axis in the development of benign prostatic hyperplasia.
Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.
Angiotensin II-mediated improvement of renal mitochondrial function via the AMPK/PGC-1α/NRF-2 pathway is superior to norepinephrine in a rat model of septic shock associated with acute renal injury.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
The antitumor role of a newly discovered α-d-glucan from Holotrichia diomphalia Bates as a selective blocker of aldolase A.
Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE(-/-) mice.
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
SCF(JFK) is functionally linked to obesity and metabolic syndrome.
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
The Dual Histone Deacetylase-Proteasome Inhibitor RTS-V5 Acts Synergistically With Ritonavir to Induce Endoplasmic Reticulum Stress in Bladder Cancer Cells.
Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1α signaling pathway in mice and C2C12 myotubes.
Danqi Tablet () Regulates Energy Metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway.
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice.
Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway.
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis.
S -1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway.
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Gypenoside A protects ischemia/reperfusion injuries by suppressing miR-143-3p level via the activation of AMPK/Foxo1 pathway.
The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma.
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells.
UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration.
Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression.
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
The balance of apoptosis and autophagy via regulation of the AMPK signal pathway in aging rat striatum during regular aerobic exercise.
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells.
Lopinavir-Ritonavir Combination Induces Endoplasmic Reticulum Stress and Kills Urological Cancer Cells.
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy.
Effect of CAPE-pNO(2) against type 2 diabetes mellitus via the AMPK/GLUT4/ GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice.
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway.
The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.
Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis.
Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria.
Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells.
PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.
Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy.
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1.
Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model.
MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene.
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5.
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration.
Nelfinavir and Ritonavir Kill Bladder Cancer Cells Synergistically by Inducing Endoplasmic Reticulum Stress.
AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.
Delanzomib Interacts with Ritonavir Synergistically to Cause Endoplasmic Reticulum Stress in Renal Cancer Cells.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress.
Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway.
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells.
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control.
Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio).
SIRT1/PGC-1α Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration.
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Chronic metformin treatment facilitates seizure termination.
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.
AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
AMP-activated protein kinase and cAMP response element-binding protein activity are associated with distinct postoperative behavioral changes in rats.
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
The Effect of Hippocampal Cognitive Impairment and XIAP on Glucose and Lipids Metabolism in Rats.
Activation of AMPK α2 inhibits airway smooth muscle cells proliferation.
Knockdown of AMPKα2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27(Kip1) Signaling Pathway.
Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis.
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth.
Zhang J, Qi Y, Jiang Y, Wei T, Ma S, Fu K, Shen J, Chen C, Li X, Wang G, Leng A, Shang D, Qu J
Journal of inflammation research 2026;19:537259
Journal of inflammation research 2026;19:537259
Endothelial KSR2 regulated by genetic variation protects against atherosclerosis through AMPKα1 stabilization.
Liu M, Fu X, Zhang H, Pan J, Jia Q, Zhang C, An F
Theranostics 2026;16(5):2598-2626
Theranostics 2026;16(5):2598-2626
The effect of 4.3 GHz high-power microwave exposure on human corneal epithelial cells.
Gao A, Zhao X, Wu S, Liu X, Wang X, Tan L, Li Z, Dong G, Wang C
Frontiers in cell and developmental biology 2026;14:1729198
Frontiers in cell and developmental biology 2026;14:1729198
Mo-Rubbing abdominal improves metabolic homeostasis in type 2 diabetes mellitus mice via a jejunum-specific GLP1-dependent mechanism.
Zhang Z, Gan L, Camille C, He X, Li L, Chen Y, Xu H, Hu J, Wei Q, Liu W, Wu Y
Diabetes, obesity & metabolism 2026 May;28(5):3819-3838
Diabetes, obesity & metabolism 2026 May;28(5):3819-3838
Optineurin enhances the chemoresistance by activating mitophagy in acute myeloid leukemia with NPM1 mutation.
Tang L, Wu N, Xiao Q, Yang J, Ren J, Chen X, Zhao W, Liu Y, Hu J, Yang Z, Gao X, Zhang L
Free radical biology & medicine 2026 May;248:162-176
Free radical biology & medicine 2026 May;248:162-176
Serine Supplementation Attenuates High-Selenium-Induced Insulin Resistance via Feedback Inhibition of PHGDH in Mice.
Wang J, Wang Q, Han F, Xiang X, Huang J, Fang C, Liu Y, Huang Z
Biological trace element research 2026 May;204(5):3309-3326
Biological trace element research 2026 May;204(5):3309-3326
Fibroblast growth factor 21 with molybdenum nanodots in a self-contracting thermosensitive hydrogel promotes diabetic wound repair by reprogramming lipid metabolism.
Zhang D, Jin C, Xue K, Jin M, Zhang Y, Li J, Wu Y, Huang J, Dong X, Du S, Chen Z, Wang J, Shi K, Lu Y, Jiang X, Xia W, Li Z, Li X, Xiao J
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114802
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114802
Macrophage AMPK activated by oxidative stress drives profibrotic crosstalk with tubular cells to accelerate renal fibrosis after ischemic and reperfusion injury.
Tao Y, Zhang M, Chen L, Jia H, Yang Y, Wu Y, Li P, Wen Z, Zhang X, Chen X, Chen X, Li X, Zhou H
Redox biology 2026 Mar;90:104002
Redox biology 2026 Mar;90:104002
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT.
Ma X, Lei P, Ren B, Xie S, Zhang Y, Wang Y, Ma W
Archives of pharmacal research 2026 Mar;49(3):357-374
Archives of pharmacal research 2026 Mar;49(3):357-374
Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short-Chain Fatty Acids.
Wang A, Miao Z, Huang B, Zeng J, Yuan M, Yan D
Phytotherapy research : PTR 2026 Mar;40(3):1060-1073
Phytotherapy research : PTR 2026 Mar;40(3):1060-1073
Betaine supplementation attenuates high-Se induced insulin resistance in C57BL/6 mice.
Wang J, Zhang X, Wang Q, Han F, Xiang X, Huang J, Fang C, Liu Y, Huang Z
The Journal of nutritional biochemistry 2026 Mar;149:110205
The Journal of nutritional biochemistry 2026 Mar;149:110205
Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage.
Bai S, La X, Yang Y, Li Y, Wang D, Ren Y, Fang H, Li X, Song X, Cheng X, Xu D
Biology 2026 Mar 6;15(5)
Biology 2026 Mar 6;15(5)
Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.
Gong Y, Fang H, Wu L, Zhang J, Wen Y, Rao Y, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 4;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 4;
Polygoni Multiflori Radix Improves Dyslipidemia by Regulating Hepatocyte Lipid Metabolism Mediated via the AMPK/SREBP-2/PCSK9/LDLR Signaling Pathway.
Wang T, Zhang L, Wang Y, Xing J, Xu L, Hu X, Su W, Zheng R
Metabolites 2026 Mar 31;16(4)
Metabolites 2026 Mar 31;16(4)
Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility.
Ng C, Fung TS, Li D, Kropp KN, Somarribas Patterson LF, Markovitz A, Weinberg DN, Jones O, Kim JY, Zhang G, Koche R, Monetti M, Tang H, He Y, Xu Z, Cai X, Yu Z, Bhagavatula G, Colgan SP, Lin YH, Li Z, Steinert EM, Klebanoff CA, Vardhana SA, Chandel NS, Wu L, Thompson CB
bioRxiv : the preprint server for biology 2026 Mar 28;
bioRxiv : the preprint server for biology 2026 Mar 28;
Lutein attenuates sodium fluoride (NaF) and gamma-irradiation induced hepatotoxicity via AMPK-PGC1α mitochondrial biogenesis induction.
Abd-ElRaouf A, Abdou FY, Ali MM, Habieb ME
Molecular biology reports 2026 Mar 25;53(1)
Molecular biology reports 2026 Mar 25;53(1)
Integrating multi-omics approaches to elucidate the mechanism of XiaoPi Decoction in treating hyperplasia of mammary glands via AMPK signaling pathway activation.
Chen L, Hu M, Ding XQ, Chen YG, Zeng QY, Zhang Z, Wang X, Liu HT
Journal of ethnopharmacology 2026 Mar 25;359:121060
Journal of ethnopharmacology 2026 Mar 25;359:121060
Costunolide Ameliorates Hepatic Steatosis and Insulin Resistance in a Diet-Induced Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK/ACC1 Signalling Pathway.
Jiang W, Ye C, Hu T, Liang J, Chen Y
Phytotherapy research : PTR 2026 Mar 17;
Phytotherapy research : PTR 2026 Mar 17;
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Chen SX, Qi X, Zheng XT, Bi ZM, Zhang Y, Wang YM
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Sevoflurane induces developmental cardiotoxicity via AMPKα2 dysregulation in zebrafish.
Hao H, Li Y, Li X, Zhang Q, Bai R, Shi K, Yang X, Duan F, Xu J, Yu Z, Chen D
Cell & bioscience 2026 Mar 12;16(1)
Cell & bioscience 2026 Mar 12;16(1)
Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pathogenesis of polycystic ovary syndrome.
Liu K, Hong Y, Gao Q, Huang J, Liu L, Li Y, Liang Y, Zhang S, He X, Nie X
Cellular and molecular life sciences : CMLS 2026 Mar 11;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 11;83(1)
Insights on the enhanced wound healing potential of russelioside B isolated from Caralluma quadrangula via modulation of AMPK/Beclin-1 and P-62 autophagy pathway.
Ali MM, Al-Mokaddem AK, Abdel-Sattar E, El-Shiekh RA, Al-Hawshabi OSS, Farag MM, Aljuaydi SH, Shaheed IB
Burns : journal of the International Society for Burn Injuries 2026 Jun;52(5):108008
Burns : journal of the International Society for Burn Injuries 2026 Jun;52(5):108008
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Niu Z, Fan Y, Chen J, Ji L, Tong Y, Yao L, Ding S, Xu H, Chen J, Zhang Q, Zhao C, Chen J, Bi Q, Xia C
Materials today. Bio 2026 Jun;38:103038
Materials today. Bio 2026 Jun;38:103038
Ferulic acid improves growth performance and lipid metabolism and bile acid level partially by activating the PPAR and CYP7A1 pathways in broilers.
Long F, Lou Z, Qi J, Li W, Liang Y, Yu D, Zhuang S, Han Y, Chen Q, Zhong X
Journal of the science of food and agriculture 2026 Jun;106(8):4600-4612
Journal of the science of food and agriculture 2026 Jun;106(8):4600-4612
Research on the compatibility mechanism of the Tingli Dazao Xiefei Decoction by multi-organ metabolomics strategy.
Wang RF, Yuan PP, Chen L, Zhang ZK, Zhang BX, Chen L, Yuan SM, Zhao YF, Zhou N, Zheng XK, Feng WS
Journal of ethnopharmacology 2026 Jun 28;365:121548
Journal of ethnopharmacology 2026 Jun 28;365:121548
Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway.
Xue H, Yang X, Kuai S, Zhang Y, Jia Y, Wu Z, Zhao P
Journal of affective disorders 2026 Jun 15;403:121439
Journal of affective disorders 2026 Jun 15;403:121439
ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells.
Chen S, Jia S, Fan X, Zhu L, Qi B, Yan F, Gao X, Zhang L, Gao S, Shao J, Yang T, Li S, Chen G, Xiong H, Li Z, Hao Y, Meng C
Bioactive materials 2026 Jul;61:534-554
Bioactive materials 2026 Jul;61:534-554
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Hsieh CP, Hsu YW, Pan TM, Lee CL
Molecular nutrition & food research 2026 Jan;70(1):e70342
Molecular nutrition & food research 2026 Jan;70(1):e70342
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Zhang Y, Shen X, Shen Y, Wang C, Yu C, Han J, Cao S, Qian L, Ma M, Huang S, Wen W, Yin M, Lei QY
Nature 2026 Jan;649(8098):1022-1031
Nature 2026 Jan;649(8098):1022-1031
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Gao X, Zhang J, Lin Y, Tian K, Tu J, Wu Z, Lv X, Hu H, Liu X, Lin S, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Anti-Diabetic Effects of Ayanin, a Flavonoid Compound, in STZ/HFD-Induced Diabetic Mice by Upregulating GLUT4 and Suppressing Macrophage-Driven Inflammation in Adipose Tissues.
Lv Y, Wu C, Yang W, Wang C, Huang J, Wang J, Xia X, Wu D, Yang K, Guo Z, Liao S
Food science & nutrition 2026 Jan;14(1):e71429
Food science & nutrition 2026 Jan;14(1):e71429
Yangjingzhongyu Decoction regulates primordial follicle initiation via LncRNA-Smad1/AMPK dual pathways in diminished ovarian reserve.
Li W, Zhang J, Shi D, Wang J, Luo S, Yang J, Deng D
Journal of ovarian research 2026 Jan 5;19(1):43
Journal of ovarian research 2026 Jan 5;19(1):43
Oxytocin Attenuates Metabolic Dysfunction-associated Steatotic Liver Disease via AMPK/SREBP1c/FAS-mediated Suppression of Hepatic Lipogenesis.
Xu Y, Lu S, Wu H, Wu H, Li M, Zhou M, Chen T, Wang X, Qu L, Jin Q, Liu J
Journal of clinical and translational hepatology 2026 Jan 28;14(1):11-22
Journal of clinical and translational hepatology 2026 Jan 28;14(1):11-22
A Molecular and Functional Investigation of the Anabolic Effect of an Essential Amino Acids' Blend Which Is Active In Vitro in Supporting Muscle Function.
d'Adduzio L, Fanzaga M, Musco MS, Sindaco M, D'Incecco P, Boschin G, Bollati C, Lammi C
Nutrients 2026 Jan 20;18(2)
Nutrients 2026 Jan 20;18(2)
Neuroprotective Effects of Desert Milk Exosomes in LPS-Induced Cognitive Decline: Role of Microglial M2 Polarization and AMPK Signaling.
Li Y, Lu W, Qian W, Liao X, Wang P, Wang Y, Jiao W, Wang M, Zhao J, Yang J, Gao H, Li H
Nutrients 2026 Jan 19;18(2)
Nutrients 2026 Jan 19;18(2)
Corin inhibits microglial inflammatory activation by suppressing mitochondrial dysfunction in intracerebral hemorrhage.
Yin R, Qiu C, Shen Q, Wang Z
BMB reports 2026 Feb;59(2):143-150
BMB reports 2026 Feb;59(2):143-150
Bacteroides acidifaciens alleviates high-fat diet-induced obesity-related osteoporosis by regulating gut microbiota and bile acid metabolism via the gut-bone axis.
Zheng C, Xie J, Tang F, Wang Z, Liu L, Pi Y, Zhong Y, He Z, Liu T, Zheng J, Luo J
Microbiological research 2026 Feb;303:128393
Microbiological research 2026 Feb;303:128393
Chondroitin Sulfate A-Selenium Nanoparticles Activate Autophagy Through the AMPK-mTOR Pathway to Alleviate Oxidative Stress and Mitochondrial Dysfunction to Repair Kashin-Beck Disease Chondrocytes.
Deng H, Qiao L, Jiang Y, Amhare AF, Han J
Biological trace element research 2026 Feb;204(2):1099-1112
Biological trace element research 2026 Feb;204(2):1099-1112
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Sun Y, Wei T, Xu H, Li H, Zhou C, Liu X, Li Y, Huang S, Zhang Q, Duan X
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
AE-MXene-modified titanium alloy promotes osseointegration by regulating the AMPK-MTOR-autophagy pathway in macrophage.
Chao R, Sun L, Xu X, Liu Z, Xu X, Ren Z, Chen X, Xu W, Chen X, Hu Y, Zhang S
Journal of nanobiotechnology 2026 Feb 3;24(1):130
Journal of nanobiotechnology 2026 Feb 3;24(1):130
N-Lac-Phe Ameliorates Myocardial Cell Death by Improving Mitochondrial Dysfunction, Ultimately Improving TAC-induced Heart Failure.
Sha L, Du A, Xu X, Li Z, Xu B, Kang L
Cardiovascular drugs and therapy 2026 Feb 26;
Cardiovascular drugs and therapy 2026 Feb 26;
Foodborne PET Microplastic Contamination Compromises Intestinal Barrier through a Mitochondrial-AMPK-DNA Damage Pathway.
Zhang C, Yan Y, Li X, An J, Li W, Shao J, Guo Z
Journal of agricultural and food chemistry 2026 Feb 18;74(6):5718-5730
Journal of agricultural and food chemistry 2026 Feb 18;74(6):5718-5730
Systematic characterization of in vivo exposure and pharmacokinetic features of Tongmaijiangzhi capsule in humans using integrated HRMS and intelligent data processing.
Yang Y, Zhu C, Xu Q, Xarpidin B, Zhang D, Zhang H, Luo X, Tian W, Chen H, Wu C
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Feb 1;1270:124907
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Feb 1;1270:124907
miR-17-5p inhibits classical swine fever virus replication by targeting the PKD2-regulated AMPK/mTOR autophagy pathway.
Wang X, Yang S, Xie L, Qi S, Gao L, Li Y, Li Q, Bi J, Liu J, Li Y, Yin G
Virulence 2026 Dec;17(1):2629657
Virulence 2026 Dec;17(1):2629657
L1TD1 promotes colorectal mucinous adenocarcinoma progression by enhancing ABCC3 mRNA stability.
He H, Yuan J, Wang H, Chen L, Liu B, Cui Z, Xu Y, Zhang G, Yang H
Oncogene 2026 Apr;45(12):1071-1086
Oncogene 2026 Apr;45(12):1071-1086
Pinobanksin alleviates 4℃ semen preservation-induced oxidative damage and apoptosis in Wenchang Pig spermatozoa via the CaMKKβ/AMPK/Nrf2 pathway.
Yang D, He S, Tian X, Cheng C, Fan W, Peng H
Veterinary journal (London, England : 1997) 2026 Apr;316:106599
Veterinary journal (London, England : 1997) 2026 Apr;316:106599
SIRT3-mediated mitochondrial fatty acid oxidation protects against hepatic lipid deposition in fatty liver hemorrhagic syndrome.
Cao P, Chen J, Zeng C, Hu Y, Yuan J, Guo X, Cao H, Zhang C, Zhuang Y, Hu G
Poultry science 2026 Apr 7;105(7):106901
Poultry science 2026 Apr 7;105(7):106901
Fluoride Damages the Ovary by Inhibiting LKB1-AMPK Signaling to Promote Mitochondrial Injury-Induced Inflammation and Oxidative Stress.
Tian M, Liu Y, Yang B, Yang X, Cheng J, Chen X, Zhou Y, Wei B, Tang D, Liu Y, Wang F, Li Y
Biological trace element research 2026 Apr 30;
Biological trace element research 2026 Apr 30;
Buyang Huanwu Decoction suppresses atherosclerosis by targeting IFITM1‑mediated lipid metabolism in vascular smooth muscle cells.
Huang Q, Tang X, Huang Q, Zhi S, Zheng X, Deng Q, Zhu J, Huang M, Pan Z, Hou J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 20;156:158224
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 20;156:158224
The tumor suppressor NDRG2 promotes ACC1 proteasomal degradation and inhibits de novo lipogenesis in hepatocellular carcinoma.
Shi Q, Bai Y, Wang J, Ru M, Zhang K, Guo Y, Bai Z, Shen L
Molecular biomedicine 2026 Apr 17;7(1)
Molecular biomedicine 2026 Apr 17;7(1)
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.
Zhao Y, Liu M, Zang X, Li J, Zhang G, Du P, Zhang T, Sun X, Li C, Liu L
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355
Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network.
Wang J, Qi X, Zhao W, Hao Z, Wang K, Li Y, Wang Y, Zhang Y
PloS one 2025;20(8):e0329847
PloS one 2025;20(8):e0329847
Aerobic exercise improved liver steatosis by modulating miR-34a-mediated PPARα/SIRT1-AMPK signaling pathway.
Wu B, Zhang Z, Xu C, Zhao J
PloS one 2025;20(11):e0333872
PloS one 2025;20(11):e0333872
α-ALA Attenuates Cardiac Injury in Diabetic Heart Disease Mice by Modulating Inflammation and AMPKα1.
Liu X, Wang L, Dong W, Wang Y, Li D
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:3491-3503
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:3491-3503
Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury.
Jiang W, Zhang J, Zhang Y, Huang Z
International journal of general medicine 2025;18:1917-1931
International journal of general medicine 2025;18:1917-1931
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Yan Y, Fang M, Zhao C, Lin X, Tong C, Xiang C, Ran Y, Wang X, Li S, Chen G, Fu L
Frontiers in pharmacology 2025;16:1542296
Frontiers in pharmacology 2025;16:1542296
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.
Zhang Z, Chen M, Xu Y, Wang Z, Liu Z, He C, Zhang F, Feng X, Ni X, Chen Y, Wang J, Liang X, Xie Z, Li J, Banach M, Pelisek J, Huo Y, Hu Y, Evans PC, Wang L, Tian XY, Xiao J, Shang Y, Zheng Y, Xian X, Weng J, Xu S
Theranostics 2025;15(10):4325-4344
Theranostics 2025;15(10):4325-4344
Luteolin attenuates LPS-induced damage in IPEC-J2 cells by enhancing mitophagy via AMPK signaling pathway activation.
Yuan J, Zhang K, Yang L, Cheng X, Chen J, Guo X, Cao H, Zhang C, Xing C, Hu G, Zhuang Y
Frontiers in nutrition 2025;12:1552890
Frontiers in nutrition 2025;12:1552890
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Yan Y, Huang Z, Cheng L, Zhao S, Gao H, Chen K, Huang F, Mou L, Chen G, Fu L, Xu G
Toxicology and applied pharmacology 2025 Sep;502:117424
Toxicology and applied pharmacology 2025 Sep;502:117424
Targeted energy metabolomics analysis-based mitochondrial restoration: Nutritional intervention of dairy-derived MFG-E8 synergistic with egg yolk phosphatidylcholine in skeletal muscle regeneration.
Guan K, Liu X, Liu R, Xiao R, Lu W, Ma Y, Wang R, Niu T
International journal of biological macromolecules 2025 Sep;323(Pt 2):147215
International journal of biological macromolecules 2025 Sep;323(Pt 2):147215
Selective and iron-independent ferroptosis in cancer cells induced by manipulation of mitochondrial fatty acid oxidation.
Gao Y, Song Z, Gan W, Zou X, Bai Y, Zhao X, Chen D, Qiao M
Biomaterials 2025 Sep;320:123259
Biomaterials 2025 Sep;320:123259
Kuntai Capsules Improve Premature Ovarian Failure by Regulating AMPK-Mediated Autophagy.
Ye X, Chen M, Zhong J, Chen H, Lin X
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):2970-2984
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):2970-2984
Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.
Zhao Y, Wang Y, Gong W, Duan C, Ren J, Zhang H, Nie X
Journal of environmental sciences (China) 2025 Sep;155:475-487
Journal of environmental sciences (China) 2025 Sep;155:475-487
Irisin/FNDC5 Regulates Endothelial Function to Improve Post-Stroke-Induced Cognitive Dysfunction by Stimulating AMPK-eNOS Signaling.
Guo HH, Liang JJ, Pan RH, Zheng MF, Qiu YX, Jiang SS, Fu XY, Tsang HW, Yau SY, Ou HN
Brain and behavior 2025 Sep;15(9):e70767
Brain and behavior 2025 Sep;15(9):e70767
Yangxinshi tablet protects against myocardial injury and increases skeletal muscle exercise capacity by regulating mitochondrial bioenergetics.
Song H, Liu C, Yang Z, Liu D, Li J, Mei Z, Xu J, Pan J, Zhang X, Yan C, Han Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156990
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156990
Chondroitin sulfate A-selenium nanoparticles protect chondrocytes from T-2 toxin-induced oxidative stress and mitochondrial dysfunction through activating autophagy by the SIRT1-AMPK-FOXO3 pathway.
Deng H, Lin J, Jiang Y, Amhare AF, Qiao L, Wang J, Han J
Ecotoxicology and environmental safety 2025 Sep 15;303:118797
Ecotoxicology and environmental safety 2025 Sep 15;303:118797
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway.
Chen Q, Lin H, Huang X, Yu W
Tissue & cell 2025 Oct;96:102984
Tissue & cell 2025 Oct;96:102984
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Wang M, Han Q, Zhang X, Dong X, Ran J, Wei F, Luo Y, Sun X
Chinese herbal medicines 2025 Oct;17(4):756-767
Chinese herbal medicines 2025 Oct;17(4):756-767
5-HT regulates resistance to aumolertinib by attenuating ferroptosis in lung adenocarcinoma.
Feng Y, He Y, Zuo R, Gong W, Gao Y, Wang Y, Wang Y, Chen W, Chen L, Luo Y, Yuan D, Chen P, Guo H
EMBO molecular medicine 2025 Oct;17(10):2586-2611
EMBO molecular medicine 2025 Oct;17(10):2586-2611
POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?
Liu H, Li X, Li M, Sun Z, Wang X, Li J, Xu B, Chen Q, Fan C, Ruan H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e07951
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e07951
Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation.
Zeng S, Wang J, Guan C, Yao Z, Zhang Y, Li Y, Zheng J, Wang H
BMC pharmacology & toxicology 2025 Oct 7;26(1):160
BMC pharmacology & toxicology 2025 Oct 7;26(1):160
Melatonin Activates AMPK Pathway to Regulate the Regeneration of Slow Muscle Fibers in Skeletal Muscle Injury Repair.
Xie W, Hong Z, Xie Y, Hou K, Li S, Fang M, Guan Y, Zhang Z, Zhang M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71123
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71123
Reversal of Myofibroblast Apoptosis Resistance and Collagen Deposition by Phaseoloidin-Induced Autophagy Attenuates Pulmonary Fibrosis.
Li S, Qian J, Deng L, Liu W, Tang S, Xie W
Biomedicines 2025 Oct 31;13(11)
Biomedicines 2025 Oct 31;13(11)
AMP-activated protein kinase-Caspase 6 axis regulation alleviates the combined apoptotic damage caused by deoxynivalenol and fumonisin B1 in mammary glands.
Cao L, Li G, Liu K, Gao W, Dong Y, Yang Z, Luo J, Lei L, Du X, Song Y, Li X, Gao W, Liu G
NPJ science of food 2025 Nov 25;9(1):259
NPJ science of food 2025 Nov 25;9(1):259
Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism.
Miao Z, Long J, Huang B, Yan D, Wang A
iScience 2025 Nov 21;28(11):113892
iScience 2025 Nov 21;28(11):113892
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Zhang Y, Fan T
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.
Wang N, Gao Z, Zhan H, Jing L, Meng F, Chen M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 May;199:115335
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 May;199:115335
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
Su J, Fan X, Zou Y, Fu G, Feng S, Wang X, Yu Y, Li L, Bian Z, Huang R, Qin L, Chen J, Zeng Q, Yan K, Gao C, Lian Z, Li X, Li Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2409154
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2409154
Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine.
Huang J, Yang J, Yang Y, Lu X, Xu J, Lu S, Pan H, Zhou W, Li W, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2415227
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2415227
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
Duan C, Zhao Y, Xiao Y, Hou Y, Gong W, Zhang H, Wang Y, Nie X
Journal of hazardous materials 2025 May 5;488:137420
Journal of hazardous materials 2025 May 5;488:137420
A Novel Role of Adipokine 'Intelectin-1': Ameliorating Renal Fibrosis Through Inhibition of Renal Tubular Epithelial Cell Senescence.
Zhang Y, Shen M, Zhang B, Li X, Cheng H, Feng D, Han Y, Luo Z, Zhou Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70653
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70653
Mechanism of adenosine monophosphate-activated protein kinase promoting lower extremity varicose veins development via cytoskeletal dynamics.
Zhang Y, Ju Z, Dai K, Wan L, Zhou G, Ji Y, Qiu J
BMC cardiovascular disorders 2025 May 31;25(1):423
BMC cardiovascular disorders 2025 May 31;25(1):423
Association of metformin with risk of digestive tract cancers from a drug target mendelian randomization and cell experiments.
Wang Y, Cao X, Ren J, Chen R, Zhang X, Liu C, Jia Y, Lin T
Discover oncology 2025 May 23;16(1):869
Discover oncology 2025 May 23;16(1):869
Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells.
Yin H, Shan Y, Zhu Q, Yuan L, Ju F, Shi Y, Han Y, Wu R, Xia T, Zhang K, You Y, You B
Cancer & metabolism 2025 May 23;13(1):24
Cancer & metabolism 2025 May 23;13(1):24
Orientin attenuates UVB-induced skin photodamage by inhibiting ROS generation via the AMPK/Nrf2 axis.
Ma T, He J, Long Q, Wang Y, Chen F, Chen S, Xu K, Cao Y
International immunopharmacology 2025 May 16;155:114655
International immunopharmacology 2025 May 16;155:114655
Bufei Yishen formula alleviates airway epithelial cell senescence in COPD by activating AMPK-Sirt1-FoxO3a pathway and promoting autophagy.
Cheng M, Yang M, Tian Y, Liu X, Li J, Zhao P
Scientific reports 2025 May 13;15(1):16584
Scientific reports 2025 May 13;15(1):16584
Mechanistic insights into GLP-1 receptor agonist-induced weight loss through ceRNA network analysis.
Li W, Zhang X, Song J, Yang L, Wang D, Yuan G, Zhao L
Genomics 2025 Mar;117(2):110988
Genomics 2025 Mar;117(2):110988
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis.
Qin Y, Zhang RY, Zhang Y, Zhao YQ, Hao HF, Wang JP
World journal of gastroenterology 2025 Mar 7;31(9):100271
World journal of gastroenterology 2025 Mar 7;31(9):100271
The Effects of Sika Deer Antler Peptides on 3T3-L1 Preadipocytes and C57BL/6 Mice via Activating AMPK Signaling and Gut Microbiota.
Sun T, Hao Z, Meng F, Li X, Wang Y, Zhu H, Li Y, Ding Y
Molecules (Basel, Switzerland) 2025 Mar 6;30(5)
Molecules (Basel, Switzerland) 2025 Mar 6;30(5)
Exploring the effect of chlorogenic acid on oxidative stress and autophagy in dry eye mice via the AMPK/ULK1 pathway.
Chen H, Shi J, Tang Y, Chen X, Wang Z, Liu Q, Wu K, Yao X
European journal of pharmacology 2025 Mar 15;991:177311
European journal of pharmacology 2025 Mar 15;991:177311
Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.
Bai HX, Gao YX, Wang S, Ma GY, Zhao W, Li XQ, Wang YF, Nong QN, Wang YB, Tan J, Duan Q, Cao W
Carbohydrate polymers 2025 Mar 15;352:123153
Carbohydrate polymers 2025 Mar 15;352:123153
PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.
Zhang L, Cheng L, Ma Y, Li J, Zhong Y, Zhu X, Leng X, Xie F
Medical oncology (Northwood, London, England) 2025 Mar 12;42(4):102
Medical oncology (Northwood, London, England) 2025 Mar 12;42(4):102
GLA deficiency causes cardiac hypertrophy via enhanced autophagy.
Ou W, Li X, Tang K, Ding L, Sun T, Li Q, Li T
Science China. Life sciences 2025 Jun;68(6):1689-1702
Science China. Life sciences 2025 Jun;68(6):1689-1702
β-Sitosterol Ameliorates Ulcerative Colitis Through Modulation of the AMPK/MLCK Anti-Inflammatory Pathway.
Zhang Y, Jin X, Xia H, Wu X, Chen W, Zhuang M, Tang S
Journal of biochemical and molecular toxicology 2025 Jun;39(6):e70287
Journal of biochemical and molecular toxicology 2025 Jun;39(6):e70287
Targeting LKB1-AMPK-SIRT1-induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice.
Li Y, Wang T, Li H, Jiang Y, Shen X, Kang N, Guo Z, Zhang R, Lu X, Kang T, Li M, Hou Y, Wu Y
Free radical biology & medicine 2025 Jun;233:400-418
Free radical biology & medicine 2025 Jun;233:400-418
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing.
Luo Z, Zheng S, Hu Z, Li P, Zeng J, Lu Y, Ali M, Chen Z, Wang Q, Qi F
Free radical biology & medicine 2025 Jun;233:302-316
Free radical biology & medicine 2025 Jun;233:302-316
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Wu Y, Duan Z, Qu L, Liu Y, Ma X, Fan D
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice with myocardial infarction via the AMPK/SIRT1/PGC-1α pathway.
Fan X, Wei X, Wang W, Chai W, Xiao J, Han J, Li F, Guo S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156727
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156727
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
Cheng N, Luo Q, Yang Y, Shao N, Nie T, Deng X, Chen J, Zhang S, Huang Y, Hu K, Luo L, Xiao Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(24):e2410590
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(24):e2410590
Alisol B alleviates MASLD by activating liver autophagy and fatty acid oxidation via Ces2a.
Zhang C, Chen L, Jiang Y, Qiu J, Lin Y, Ren G, Xu F, Xi J, Yu Z, Rong X, Dou X
International immunopharmacology 2025 Jun 5;157:114768
International immunopharmacology 2025 Jun 5;157:114768
Enzymatic Synthesis and Evaluation of Eight Methylated Quercetin Products: In Vitro Chemical Properties and Adipogenesis Regulation.
Ang B, Yang T, Jiang H, Cheng Y, Chen Y, Qie X, Yin L, Wang T, Chen Q, Wang Z, Zeng M, Adhikari B, He Z, Chen J
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13973-13984
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13973-13984
Exosomal miR-202-5p derived from iPSC-MSCs protects against myocardial infarction through inhibition of cardiomyocyte pyroptosis.
Chen J, Liang X, Han Q, He H, Huang X, Shen Y, Qiu J, Lin F, Mai C, Li Z, Ma K, Hu B, Li X, Zhang Y
Stem cell research & therapy 2025 Jun 3;16(1):282
Stem cell research & therapy 2025 Jun 3;16(1):282
Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy.
Qin Y, Wang X, Zhao M, Liu Y, Hou H, Wang T, Pei Y, Zhang J, Shen Z, Wu F, Zheng L, Li J, Ni Z, Shi J
Acta biochimica et biophysica Sinica 2025 Jun 25;58(2):383-395
Acta biochimica et biophysica Sinica 2025 Jun 25;58(2):383-395
Impact of ATF6 deletion on the embryonic brain development.
Nguyen LD, Nguyen LH, Dao DX, Hattori T, Takarada-Iemata M, Ishii H, Tamatani T, Kawasaki H, Shinmyo Y, Onoue K, Yonemura S, Zhang J, Miyake M, Oyadomari S, Mori K, Hori O
iScience 2025 Jun 20;28(6):112569
iScience 2025 Jun 20;28(6):112569
AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions.
Wang X, Sun X, Zhang X, Shen N, Xia J, Wang L, Ye S
Archives of biochemistry and biophysics 2025 Jul;769:110433
Archives of biochemistry and biophysics 2025 Jul;769:110433
Medium-chain triglyceride attenuates obesity by activating brown adipose tissue via upregulating the AMPK signaling pathway.
Jia M, Yue H, Wang X, Zong A, Xu T, Xu YJ, Liu Y
The Journal of nutritional biochemistry 2025 Jul;141:109914
The Journal of nutritional biochemistry 2025 Jul;141:109914
AdipoR2 enhances adipocyte thermogenesis in Tibetan pigs via AMPK-ACC signaling.
Liu S, Yang Z, Yang Y, Cai Y, Zhao S
Journal of thermal biology 2025 Jul;131:104209
Journal of thermal biology 2025 Jul;131:104209
Characterization of the Avian Mitochondrial-Derived Peptide MOTS-c and Its Potential Role as a Metabolic Regulator.
Shu X, Liu J, Xu B, Wang H, Liu L, Zheng X, Chen J
Animals : an open access journal from MDPI 2025 Jul 29;15(15)
Animals : an open access journal from MDPI 2025 Jul 29;15(15)
Increased ROS levels activate AMPK-ULK1-mediated mitophagy to promote pseudorabies virus replication.
Zhao Y, Qi X, Zhu Z, Wang W, Wen W, Li X
Veterinary research 2025 Jul 21;56(1):156
Veterinary research 2025 Jul 21;56(1):156
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
Liu W, Hu J, Wang Y, Gan T, Ding Y, Wang X, Xu Q, Xiong J, Xiong N, Lu S, Wang Y, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156241
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156241
Targeted therapy for KIF3C: A study on the mechanism of combined therapy with KIF3C signaling pathway, afatinib, and MT-DC (ac)phosphoramide in regulating gastric cancer cell proliferation.
Diallo MT, Chen B, Yan Z, Sun Q, Liu G, Wang Y, Ren J, Wang D
Cellular signalling 2025 Jan;125:111514
Cellular signalling 2025 Jan;125:111514
Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway.
Zhong X, Sun Y, Lin Y, Deng S, Wang H, Zhou X, Lu J, Zheng Y, Luo R, Huang M, Song J
Scientific reports 2025 Jan 28;15(1):3569
Scientific reports 2025 Jan 28;15(1):3569
Cinnamic acid alleviates endothelial dysfunction and oxidative stress by targeting PPARδ in obesity and diabetes.
Bai Y, Tan D, Deng Q, Miao L, Wang Y, Zhou Y, Yang Y, Wang S, Vong CT, Cheang WS
Chinese medicine 2025 Jan 24;20(1):13
Chinese medicine 2025 Jan 24;20(1):13
Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction.
Qu X, Yang P, Jiao L, Yin Y
Frontiers in bioscience (Landmark edition) 2025 Jan 20;30(1):25565
Frontiers in bioscience (Landmark edition) 2025 Jan 20;30(1):25565
Alogliptin attenuates STZ-induced diabetic nephropathy in rats through the modulation of autophagy, apoptosis, and inflammation pathways: Targeting NF-κB and AMPK/mTOR pathway.
Selim SM, El Fayoumi HM, El-Sayed NM, Mehanna ET, Hazem RM
Life sciences 2025 Jan 15;361:123307
Life sciences 2025 Jan 15;361:123307
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway.
Kuang G, Zhao Y, Wang L, Wen T, Liu P, Ma B, Peng Q, Xu F, Ye L, Fan J
Phytotherapy research : PTR 2025 Feb;39(2):733-746
Phytotherapy research : PTR 2025 Feb;39(2):733-746
Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation.
Song L, Huang Y, Liu L, Chang X, Hu L, Wang G, Xu L, Zhang T, Wang Y, Xiao Y, Yang H, Ran S, Shi Q, Wang T, Shi M, Zhou Y, Guo B
Cell reports 2025 Feb 25;44(2):115246
Cell reports 2025 Feb 25;44(2):115246
THSWD upregulates the LTF/AMPK/mTOR/Becn1 axis and promotes lysosomal autophagy in hepatocellular carcinoma cells by regulating gut flora and metabolic reprogramming.
Zhu Z, Zuo S, Zhu Z, Wang C, Du Y, Chen F
International immunopharmacology 2025 Feb 20;148:114091
International immunopharmacology 2025 Feb 20;148:114091
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Xia H, Tai XJ, Cheng W, Wu Y, He D, Wang LF, Liu H, Zhang SY, Sun YT, Liu HZ, Liu DD, Zhao HZ, Ji FY, Li XH
Scientific reports 2025 Feb 19;15(1):6081
Scientific reports 2025 Feb 19;15(1):6081
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification.
Mao Z, Liu W, Zou R, Sun L, Huang S, Wu L, Chen L, Wu J, Lu S, Song Z, Li X, Huang Y, Rao Y, Huang YY, Li B, Hu Z, Li J
Signal transduction and targeted therapy 2025 Feb 17;10(1):67
Signal transduction and targeted therapy 2025 Feb 17;10(1):67
Ferulic acid from Angelica sinensis (Oliv.) Diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways.
Lu J, Wang C
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119118
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119118
In vitro-Digested Cervus nippon Velvet Antler Polypeptides Alleviate Alcoholic Liver Disease by Suppressing CYP2E1 Activity and Enhancing AMPK Signaling Pathway.
Hao Z, Wang Y, Yang H, Zhang C, Li Y, Wang Y, Yan Y, Huang X, Ding Y
Journal of food science 2025 Dec;90(12):e70711
Journal of food science 2025 Dec;90(12):e70711
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function.
Yang X, Wang S, Liu H, Zhang T, Cheng S, Du M
Journal of advanced research 2025 Dec;78:47-62
Journal of advanced research 2025 Dec;78:47-62
Oxyberberine Inhibits Hepatic Gluconeogenesis via AMPK-Mediated Suppression of FoxO1 and CRTC2 Signaling Axes.
Wu F, Lu F, Dong H, Hu M, Xu L, Wang D
Phytotherapy research : PTR 2025 Dec;39(12):5434-5449
Phytotherapy research : PTR 2025 Dec;39(12):5434-5449
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside.
Li S, Qian R, Xie W, Lin M, Huang X, Deng L, Xiong D, Liu W, Tang S
Chinese journal of natural medicines 2025 Dec;23(12):100005
Chinese journal of natural medicines 2025 Dec;23(12):100005
Multi-strategy profiling identifies limonin's dual role in gout: restoring uric acid homeostasis and suppressing inflammatory response.
Zeng M, Zhong M, Zhong X, Zhang Y, Chen X, Lin J, Zhang Y, Zheng Y, Lu J, Huang M
Food & function 2025 Dec 8;16(24):9572-9592
Food & function 2025 Dec 8;16(24):9572-9592
SGLT2i continuously prevents cardiac hypertrophy by reducing ferroptosis via AMPK up-regulation.
Zhao BB, Wang J, Zhang LL, Li C, Xue HH, Zhao L, Han QH, Shi HT
Molecular and cellular biochemistry 2025 Aug;480(8):4849-4864
Molecular and cellular biochemistry 2025 Aug;480(8):4849-4864
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
He H, Huang C, Huang H, Lan N, Liu S, Luo Y, Zheng L, Liu G, Qin Z, Zhao J
Biomaterials 2025 Aug;319:123210
Biomaterials 2025 Aug;319:123210
Hydroxysafflor yellow A ameliorates myocardial ischemia/reperfusion injury by promoting MDH1-mediated mitochondrial metabolic homeostasis.
Zhao F, Cheng W, Wu D, Gong Z, Ma W, Xu J, Zhang J, Xiang X, Ma R, Zhou W, Zhang X, Wang P, Dai J, Xu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156868
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156868
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism.
Wang M, Chen J, Zhang Z, Wang T, Zhao J, Wang X, Wang J, Zhuang H
Nutrients 2025 Aug 28;17(17)
Nutrients 2025 Aug 28;17(17)
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Li J, Ma C, Cao P, Guo W, Wang P, Yang Y, Ding B, Yin F, Li Z, Wang Y, Li S, Huang C, Wang X, Zhou T, Chang A, Zhao L, Gao S, Zhao T, Wang H, Yu J, Xu J, Feng Y, Hao J
Cell reports. Medicine 2025 Aug 19;6(8):102292
Cell reports. Medicine 2025 Aug 19;6(8):102292
AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria.
Chen L, Liu Y, Zhang J, Song T, Wu J, Ren Z
Cell death & disease 2025 Aug 18;16(1):623
Cell death & disease 2025 Aug 18;16(1):623
Engineered MSCs Break Endothelial-Myofibroblast Crosstalk in Pulmonary Fibrosis: Reconstructing the Vascular Niche.
Fang YF, Zhang C, Han MM, Wang Y, Zhou TJ, Xing L, Wei N, Wang J, Jeong JH, Zhou F, Wang GJ, Jiang HL
Advanced materials (Deerfield Beach, Fla.) 2025 Apr;37(13):e2414601
Advanced materials (Deerfield Beach, Fla.) 2025 Apr;37(13):e2414601
Fine-tuned calcium homeostasis is crucial for murine erythropoiesis.
Zhang S, Zhang Y, Li Y, Zhang Z, Li H, Xu M, Lu Z, Li Y, Zhao B
The FEBS journal 2025 Apr;292(8):1934-1949
The FEBS journal 2025 Apr;292(8):1934-1949
Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer.
Liang X, Tian R, Li T, Wang H, Qin Y, Qian M, Fan J, Wang D, Cui HY, Jiang J
Cell death discovery 2025 Apr 4;11(1):139
Cell death discovery 2025 Apr 4;11(1):139
The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.
Zhu K, Fan J, Cai H, Zhou C, Gong Z, Li Z, Yu J
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434
Progranulin enhances M2 macrophage polarization and renal fibrosis by modulating autophagy in chronic kidney disease.
Tu WC, He YK, Wang DW, Ming SX, Zhao Y
Cellular and molecular life sciences : CMLS 2025 Apr 28;82(1):186
Cellular and molecular life sciences : CMLS 2025 Apr 28;82(1):186
Epimedii Folium and Ligustri Lucidi Fructus synergistically delay renal aging through AMPK/ULK1/Bcl2L13-mediated mitophagy.
Long Y, Li Y, Ma Z, Xie Y, Zhao H, Zhang M, Liu R
Journal of ethnopharmacology 2025 Apr 25;346:119668
Journal of ethnopharmacology 2025 Apr 25;346:119668
Anthocyanins prevent the development and progression of urethane-induced lung cancer by regulating energy metabolism in mice.
Luo H, Gao M, Lu H, Chen Q, Lian X
Food & nutrition research 2024;68
Food & nutrition research 2024;68
GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway.
Zhang Y, Yang Y, Kuang S, Zhang Y, Qin H, Xie J
International journal of clinical practice 2024;2024:6875417
International journal of clinical practice 2024;2024:6875417
Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.
Liu B, Si J, Qi K, Li D, Li T, Tang Y, Ji E, Yang S
PloS one 2024;19(3):e0296792
PloS one 2024;19(3):e0296792
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Sun M, Wang F, Li H, Li M, Wang Y, Wang C, Zhang Y, Zhang D, Li J, Yao S
Journal of inflammation research 2024;17:1349-1364
Journal of inflammation research 2024;17:1349-1364
FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.
Liu S, He Y, Gu Z
Frontiers in oncology 2024;14:1442911
Frontiers in oncology 2024;14:1442911
Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway.
Bai Y, Dai C, Chen N, Zhou X, Li H, Xu Q, Xu Y
Journal of clinical biochemistry and nutrition 2024 Sep;75(2):91-101
Journal of clinical biochemistry and nutrition 2024 Sep;75(2):91-101
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Abdel-Wahab BA, Zafaar D, Habeeb MS, El-Shoura EAM
British journal of pharmacology 2024 Sep;181(17):3215-3231
British journal of pharmacology 2024 Sep;181(17):3215-3231
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism.
Li B, Xiao Q, Zhao H, Zhang J, Yang C, Zou Y, Zhang B, Liu J, Sun H, Liu H
Acta pharmaceutica Sinica. B 2024 Sep;14(9):3949-3963
Acta pharmaceutica Sinica. B 2024 Sep;14(9):3949-3963
LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney disease.
Lv Z, Wang Z, Hu J, Su H, Liu B, Lang Y, Yu Q, Liu Y, Fan X, Yang M, Shen N, Zhang D, Zhang X, Wang R
Cell death & disease 2024 Sep 30;15(9):697
Cell death & disease 2024 Sep 30;15(9):697
Nobiletin alleviates macrophage M2 polarization by activating AMPK-mTOR-mediated autophagy in pulmonary fibrosis mice.
Cheng Y, Mei X, Shao W, Zheng J, Yin X, Zhang Q, Li J, Zhao P
International immunopharmacology 2024 Sep 30;139:112792
International immunopharmacology 2024 Sep 30;139:112792
Exposure to Succinate Leads to Steatosis in Non-Obese Non-Alcoholic Fatty Liver Disease by Inhibiting AMPK/PPARα/FGF21-Dependent Fatty Acid Oxidation.
Yang H, Ran S, Zhou Y, Shi Q, Yu J, Wang W, Sun C, Li D, Hu Y, Pan C, Yuan Q, Zhen Y, Liu Q, Song L
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21052-21064
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21052-21064
Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism.
Zhou J-f, Zhang M-r, Wang Q, Li M-z, Bai J-s, Dai Q, Zhang Y-h, Yan M-x, Li X-h, Chen J, Liu Y-y, Liu C-c, Ye J, Zhou B
Journal of virology 2024 Sep 17;98(9):e0063524
Journal of virology 2024 Sep 17;98(9):e0063524
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Xing H, Wu Z, Jiang K, Yuan G, Guo Z, Yu S, He S, Zhong F
Scientific reports 2024 Sep 10;14(1):21135
Scientific reports 2024 Sep 10;14(1):21135
Autophagy aggravates multi-walled carbon nanotube-induced ferroptosis by suppressing PGC-1 dependent-mitochondrial biogenesis in lung epithelial cells.
Zhu L, Zhu D, Ran J, Li M, Lai Z, Zhou Y, Luo L, Liu X, Mao K, Tian K
Chemico-biological interactions 2024 Sep 1;400:111158
Chemico-biological interactions 2024 Sep 1;400:111158
Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death.
Hu Q, Sun L, Cheng Z, Wang L, Wan X, Xu J, Cheng J, Wang Z, Yuan Y, Wang K, Han T
Cell insight 2024 Oct;3(5):100186
Cell insight 2024 Oct;3(5):100186
Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.
Krause PN, McGeorge G, McPeek JL, Khalid S, Nelin LD, Liu Y, Chen B
Physiological reports 2024 Oct;12(20):e70089
Physiological reports 2024 Oct;12(20):e70089
Potential Anti-Obesity Effect of Hazel Leaf Extract in Mice and Network Pharmacology of Selected Polyphenols.
Zhao J, Alimu A, Li Y, Lin Z, Li J, Wang X, Wang Y, Lv G, Lin H, Lin Z
Pharmaceuticals (Basel, Switzerland) 2024 Oct 9;17(10)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 9;17(10)
Characteristics of Myocardial Structure and Central Carbon Metabolism during the Early and Compensatory Stages of Cardiac Hypertrophy.
Chen Y, Luo YM, Li D, Liu H, Luo X, Zhang X, Ling Y, Ouyang W
Journal of proteome research 2024 Oct 4;23(10):4229-4241
Journal of proteome research 2024 Oct 4;23(10):4229-4241
Er-Dong-Xiao-Ke decoction regulates lipid metabolism via PPARG-mediated UCP2/AMPK signaling to alleviate diabetic meibomian gland dysfunction.
Shi L, Li LJ, Sun XY, Chen YY, Luo D, He LP, Ji HJ, Gao WP, Shen HX
Journal of ethnopharmacology 2024 Oct 28;333:118484
Journal of ethnopharmacology 2024 Oct 28;333:118484
Bioenergetic-active exosomes for cartilage regeneration and homeostasis maintenance.
Liu X, Jiang S, Jiang T, Lan Z, Zhang X, Zhong Z, Wu X, Xu C, Du Y, Zhang S
Science advances 2024 Oct 18;10(42):eadp7872
Science advances 2024 Oct 18;10(42):eadp7872
Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner.
Liu N, Cui X, Guo T, Wei X, Sun Y, Liu J, Zhang Y, Ma W, Yan W, Chen L
Antioxidants (Basel, Switzerland) 2024 Oct 16;13(10)
Antioxidants (Basel, Switzerland) 2024 Oct 16;13(10)
Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells in vitro by activating AMPK/mTOR-mediated autophagy.
Qi F, Deng Y, Huang W, Cai Y, Hong K, Xiang S
European journal of histochemistry : EJH 2024 Oct 15;68(4)
European journal of histochemistry : EJH 2024 Oct 15;68(4)
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z
Journal of advanced research 2024 Nov;65:89-104
Journal of advanced research 2024 Nov;65:89-104
β-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway.
Zhuang H, Ren X, Zhang Y, Li H, Zhou P
Aging cell 2024 Nov;23(11):e14294
Aging cell 2024 Nov;23(11):e14294
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation.
Deng K, Su Y, Liu Z, Hu S, Ren C, Wei W, Fan Y, Zhang Y, Wang F
Cellular and molecular life sciences : CMLS 2024 Nov 6;81(1):445
Cellular and molecular life sciences : CMLS 2024 Nov 6;81(1):445
Pretreatment with growth differentiation factor 15 augments cardioprotection by mesenchymal stem cells in myocardial infarction by improving their survival.
Huang X, Liang X, Han Q, Shen Y, Chen J, Li Z, Qiu J, Gao X, Hong Y, Lin F, Li W, Li X, Zhang Y
Stem cell research & therapy 2024 Nov 10;15(1):412
Stem cell research & therapy 2024 Nov 10;15(1):412
Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis.
Zhu J, Wu Y, Zhang L, Bai B, Han W, Wang H, Mei Q
Free radical biology & medicine 2024 Nov 1;224:272-286
Free radical biology & medicine 2024 Nov 1;224:272-286
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition.
Yang Z, Jiang J, Tan Y, Yang G, Chen M, Huang J, Liu J, Wei X, Wang S, Luo X, Han Z
Journal of physiology and biochemistry 2024 May;80(2):407-420
Journal of physiology and biochemistry 2024 May;80(2):407-420
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway.
Hu F, Hu T, Qiao Y, Huang H, Zhang Z, Huang W, Liu J, Lai S
International journal of molecular medicine 2024 May;53(5)
International journal of molecular medicine 2024 May;53(5)
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway.
Zhao L, Zhang X, Chen Z, Lai Y, Xu J, Zhou R, Ma P, Cai W, Zeng Y, Wu X, Ying H, Yu F
Food & function 2024 May 7;15(9):4954-4969
Food & function 2024 May 7;15(9):4954-4969
Probiotic-fermented tomato with hepatic lipid metabolism modulation effects: analysis of physicochemical properties, bioactivities, and potential bioactive compounds.
Wei B, Zheng W, Peng Z, Xiao M, Huang T, Xie M, Xiong T
Food & function 2024 May 7;15(9):4874-4886
Food & function 2024 May 7;15(9):4874-4886
Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy.
Ding SA, Liu H, Zheng R, Ge Y, Fu Z, Mei J, Tang M
Cell biology and toxicology 2024 May 27;40(1):40
Cell biology and toxicology 2024 May 27;40(1):40
AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy.
Liu M, Wei X, Zheng Z, Xie E, Yu Q, Gao Y, Ma J, Yang L
Molecular medicine (Cambridge, Mass.) 2024 May 17;30(1):63
Molecular medicine (Cambridge, Mass.) 2024 May 17;30(1):63
Cisplatin induces acute kidney injury by downregulating miR-30e-5p that targets Galnt3 to activate the AMPK signaling pathway.
Mao W, Zhang L, Wang Y, Sun S, Wu J, Sun J, Zou X, Chen M, Zhang G
Environmental toxicology 2024 Mar;39(3):1567-1580
Environmental toxicology 2024 Mar;39(3):1567-1580
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.
Yang Y, Qiu W, Xiao J, Sun J, Ren X, Jiang L
Journal of translational medicine 2024 Mar 26;22(1):309
Journal of translational medicine 2024 Mar 26;22(1):309
FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA.
Wang K, Mei Z, Zheng M, Liu X, Li D, Wang H
Heliyon 2024 Mar 15;10(5):e27571
Heliyon 2024 Mar 15;10(5):e27571
Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice.
Yuan Y, Deng S, Yang J, Shou Z, Wei C, Zhang L, Zhu F, Gao F, Liu X, Liu Y, Chen Q, Fan H
Aging 2024 Mar 11;16(6):5336-5353
Aging 2024 Mar 11;16(6):5336-5353
Protective effects of l-cysteine and N-acetyl-l-cysteine on boar sperm quality during hypothermic liquid storage with bovine serum albumin as a protectant.
Yang D, Yu X, Li X, Yu B, Peng H
Theriogenology 2024 Mar 1;216:185-195
Theriogenology 2024 Mar 1;216:185-195
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Kang Z, Zhang Z, Li J, Deng K, Wang F, Fan Y
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
Zhao Q, Chen L, Zhang X, Yang H, Li Y, Li P
Chinese medicine 2024 Jun 15;19(1):86
Chinese medicine 2024 Jun 15;19(1):86
TGF β1 promotes the polarization of M2-type macrophages and activates PI3K/mTOR signaling pathway by inhibiting ISG20 to sensitize ovarian cancer to cisplatin.
Wu J, Jiang L, Wang S, Peng L, Zhang R, Liu Z
International immunopharmacology 2024 Jun 15;134:112235
International immunopharmacology 2024 Jun 15;134:112235
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
Li X, Tang X, Xiang Y, Zhao Z, Li Y, Ding Q, Zhang L, Xu J, Zhao L, Chen Y
American journal of physiology. Gastrointestinal and liver physiology 2024 Jun 1;326(6):G697-G711
American journal of physiology. Gastrointestinal and liver physiology 2024 Jun 1;326(6):G697-G711
Mechanism Research of DHEA Treatment Improving Diminished Ovarian Reserve by Attenuating the AMPK-SIRT1 Signaling and Mitophagy.
Ma Q, Shen M, Wu J, Ye C, Tan Y
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jul;31(7):2059-2072
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jul;31(7):2059-2072
Identification of a novel hypoglycemic small molecule, trans-2, 4-dimethoxystilbene by rectifying gut microbiota and activating hepatic AMPKα-PPARγ pathway through gut-liver axis.
Wang ZJ, Ma P, Xu CY, Xu TS, Zhang L, He P, Hou BY, Yang XY, Du GH, Ji TF, Qiang GF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116760
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116760
Dasabuvir alleviates 5-fluorouracil-induced intestinal injury through anti-senescence and anti-inflammatory.
He S, Wang Z, Xia J, Jia H, Dai Q, Chen C, He F, Wang X, Zhou M
Scientific reports 2024 Jul 8;14(1):15730
Scientific reports 2024 Jul 8;14(1):15730
GPR30 selective agonist G-1 induced insulin resistance in ovariectomized mice on high fat diet and its mechanism.
Lu C, Liu D, Li M, Shi X, Guan J, Song G, Yin Y, Zheng M, Ma F, Liu G
Biochemical and biophysical research communications 2024 Jul 5;716:150026
Biochemical and biophysical research communications 2024 Jul 5;716:150026
Tangeretin Enhances Muscle Endurance and Aerobic Metabolism in Mice via Targeting AdipoR1 to Increase Oxidative Myofibers.
Li J, Li J, Ullah A, Shi X, Zhang X, Cui Z, Lyu Q, Kou G
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16687-16699
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16687-16699
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Jiang T, Sun L, Wang Y, Zhang F, Guo J, Sun L, Jiang Y, Xue J, Duan J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Palmatine improves cognitive dysfunction in Alzheimer's disease model rats through autophagy pathway and regulation of gut microbiota.
Han L, Chen W, Li J, Zhao Y, Zong Y, He Z, Du R
Brain research 2024 Jul 15;1835:148932
Brain research 2024 Jul 15;1835:148932
Low selenium and T-2 toxin may be involved in the pathogenesis of Kashin-Beck disease by affecting AMPK/mTOR/ULK1 pathway mediated autophagy.
Deng H, Lin X, Xiang R, Bao M, Qiao L, Liu H, He H, Wen X, Han J
Ecotoxicology and environmental safety 2024 Jul 1;279:116503
Ecotoxicology and environmental safety 2024 Jul 1;279:116503
High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis.
Wen J, Feng Y, Xue L, Yuan S, Chen Q, Luo A, Wang S, Zhang J
Gut microbes 2024 Jan-Dec;16(1):2412381
Gut microbes 2024 Jan-Dec;16(1):2412381
Real-time monitoring of glucose metabolism and effects of metformin on HepG2 cells using (13)C in-cell NMR spectroscopy.
Teng M, Li Z, Gu Y, Fan Y, Wang D, Liu M, Li Y, Wei G, Huang Y
Biochemical and biophysical research communications 2024 Jan 29;694:149383
Biochemical and biophysical research communications 2024 Jan 29;694:149383
CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.
Jiang HL, Yang HH, Liu YB, Duan JX, Guan XX, Zhang CY, Zhong WJ, Jin L, Li D, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2024 Feb;239(2):e31169
Journal of cellular physiology 2024 Feb;239(2):e31169
Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1.
Cheng Z, Tu J, Wang K, Li F, He Y, Wu W
Brain research bulletin 2024 Feb;207:110886
Brain research bulletin 2024 Feb;207:110886
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Wang Z, Bi M, Zhe X, Wang X, Dai B, Han X, Ren B, Liang H, Liu D
Cell death discovery 2024 Feb 22;10(1):95
Cell death discovery 2024 Feb 22;10(1):95
Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis.
Zhao Y, Liang X, Li T, Shao Z, Cao Z, Zeng Y, Yan X, Chen Q, Zhou H, Li W, Cheng G, Jiang Y, Li X, Zhang Y, Hu B
Free radical research 2024 Dec;58(12):854-867
Free radical research 2024 Dec;58(12):854-867
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Zhang G, Wen F, Li Y, Sun P, Li Y, Hu Z, Wang H, Ma Y, Liang G, Chen L, Yang K, Hu J
Theriogenology 2024 Dec;230:330-340
Theriogenology 2024 Dec;230:330-340
Calpain-1 Up-Regulation Promotes Bleomycin-Induced Pulmonary Fibrosis by Activating Ferroptosis.
Wei S, Liu Y, Ran C, Li Y, Tang B, Lu M, Wang H
The American journal of pathology 2024 Dec;194(12):2272-2289
The American journal of pathology 2024 Dec;194(12):2272-2289
Astragaloside IV and cycloastragenol promote liver regeneration through regulation of hepatic oxidative homeostasis and glucose/lipid metabolism.
Li Y, Yang X, Li X, Wang S, Chen P, Ma T, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156165
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156165
Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.
Zhang Y, Zhao Q, Zhao R, Lu Y, Jiang S, Tang Y
International immunopharmacology 2024 Dec 5;142(Pt A):113154
International immunopharmacology 2024 Dec 5;142(Pt A):113154
Notoginsenoside R1-Protocatechuic aldehyde reduces vascular inflammation and calcification through increasing the release of nitric oxide to inhibit TGFβR1-YAP/TAZ pathway in vascular smooth muscle cells.
Cui X, Zhang L, Lin L, Hu Y, Zhang M, Sun B, Zhang Z, Lu M, Guan X, Hao J, Li Y, Li C
International immunopharmacology 2024 Dec 25;143(Pt 3):113574
International immunopharmacology 2024 Dec 25;143(Pt 3):113574
Adiponectin receptor 1-mediated basolateral amygdala-prelimbic cortex circuit regulates methamphetamine-associated memory.
Chen Z, Tang S, Xiao X, Hong Y, Fu B, Li X, Shao Y, Chen L, Yuan D, Long Y, Wang H, Hong H
Cell reports 2024 Dec 24;43(12):115074
Cell reports 2024 Dec 24;43(12):115074
Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK/NRF2/SLC7A11 axis.
Ma Y, Fei S, Chen X, Gui Y, Zhou B, Xiang T, Liu J, Yue K, Li Q, Jiang W, Sun C, Huang X
Communications biology 2024 Dec 19;7(1):1679
Communications biology 2024 Dec 19;7(1):1679
Apigenin Reduces Lipid Droplet Accumulation in Hepatocytes by Enhancing Chaperone-Mediated Autophagy via AMPK.
Lu J, Zhou H, Hu J, Zhang R, Meng Z, Guan S
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27965-27977
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27965-27977
Chronic microcystin-leucine-arginine exposure induces osteoporosis by breaking the balance of osteoblasts and osteoclasts.
Pan C, Wang K, Hong R, Wang X, Zhang Y, Fan Z, Shi Y, Liu T, Chen H
Environmental research 2024 Dec 15;263(Pt 2):120098
Environmental research 2024 Dec 15;263(Pt 2):120098
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway.
Xia Y, Zhang H, Wu X, Xu Y, Tan Q
Biogerontology 2024 Aug;25(4):649-664
Biogerontology 2024 Aug;25(4):649-664
Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1.
Tao L, Wang J, Wang K, Liu Q, Li H, Xu S, Gu C, Zhu Y
Aging cell 2024 Aug;23(8):e14181
Aging cell 2024 Aug;23(8):e14181
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
Zhu G, Li Y, Gao H, Li X, Fan H, Fan L
Journal of cardiovascular translational research 2024 Aug;17(4):782-794
Journal of cardiovascular translational research 2024 Aug;17(4):782-794
GPRASP2 deficiency contributes to apoptosis in the spiral ganglion cells via the AMPK/DRP1 signaling pathway.
Huang K, Cai J, Lu Y, Wang T, Yue S, Wei Q, Yao J, Chen Z, Cao X
Heliyon 2024 Aug 30;10(16):e36140
Heliyon 2024 Aug 30;10(16):e36140
Capsaicin combined with cisplatin inhibits TGF-β1-induced EMT and TSCC cells migration via the Claudin-1/PI3K/AKT/mTOR signaling pathway.
Li Z, Zhao Q, Liu X, Zhou X, Wang Y, Zhao M, Wu F, Zhao G, Guo X
Cancer cell international 2024 Aug 28;24(1):300
Cancer cell international 2024 Aug 28;24(1):300
Regulatory effect of β-glucan secreted by Rhizobium pusense on triglyceride metabolism and their relationships with the modulation of intestinal microbiota in mice fed a high-fat diet.
Zhang B, Zhao W, Song D, Lyu X
Food & function 2024 Aug 27;15(17):8759-8774
Food & function 2024 Aug 27;15(17):8759-8774
Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth-retarded suckling piglets associated with activation of FGF21-AMPKα pathway.
Bai G, Chen J, Liu Y, Chen J, Yan H, You J, Zou T
Journal of the science of food and agriculture 2024 Apr;104(6):3719-3728
Journal of the science of food and agriculture 2024 Apr;104(6):3719-3728
Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor.
Liu Z, Hua W, Jin S, Wang Y, Pang Y, Wang B, Zhao N, Song Y, Qi J
European journal of pharmacology 2024 Apr 5;968:176381
European journal of pharmacology 2024 Apr 5;968:176381
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Zhao J, Yang T, Yi J, Hu H, Lai Q, Nie L, Liu M, Chu C, Yang J
iScience 2024 Apr 19;27(4):109321
iScience 2024 Apr 19;27(4):109321
Complexes of Soluble Dietary Fiber and Polyphenols from Lotus Root Regulate High-Fat Diet-Induced Hyperlipidemia in Mice.
Zheng Z, Gao W, Zhu Z, Li S, Chen X, Cravotto G, Sui Y, Zhou L
Antioxidants (Basel, Switzerland) 2024 Apr 16;13(4)
Antioxidants (Basel, Switzerland) 2024 Apr 16;13(4)
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
Liu N, Fan Y, Li Y, Zhang Y, Li J, Wang Y, Wang Z, Liu Y, Li Y, Kang Z, Peng Y, Ru Z, Yang M, Feng C, Wang Y, Yang X
Current neuropharmacology 2023;21(12):2550-2562
Current neuropharmacology 2023;21(12):2550-2562
ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM.
Li L, Yang M, Pu X, Tang Y, Fei F, Li Z, Hou H, Chen Q, Wang Q, Wu Y, Zhang Y, Ren C, Gong A
Journal of Cancer 2023;14(9):1579-1591
Journal of Cancer 2023;14(9):1579-1591
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Wang Y, He Q, Rong K, Zhu M, Zhao X, Zheng P, Mi Y
Frontiers in pharmacology 2023;14:1338260
Frontiers in pharmacology 2023;14:1338260
Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure.
Wang J, Zhu X, Wang S, Zhang Y, Hua W, Liu Z, Zheng Y, Lu X
Frontiers in pharmacology 2023;14:1181622
Frontiers in pharmacology 2023;14:1181622
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Zou YY, Tang XB, Chen ZL, Liu B, Zheng L, Song MY, Xiao Q, Zhou ZQ, Peng XY, Tang CF
Frontiers in endocrinology 2023;14:1162485
Frontiers in endocrinology 2023;14:1162485
Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways.
Gao X, Di X, Li J, Kang Y, Xie W, Sun L, Zhang J
Journal of bone and mineral metabolism 2023 Sep;41(5):606-620
Journal of bone and mineral metabolism 2023 Sep;41(5):606-620
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Yu H, Hao Z, Liu X, Wei Z, Tan R, Liu X, Chen Q, Chen Y, Zhou H, Liu Y, Fu Z
Environmental toxicology 2023 Sep;38(9):2100-2110
Environmental toxicology 2023 Sep;38(9):2100-2110
Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway.
Bingbing L, Jieru LI, Jianchao SI, Qi C, Shengchang Y, Ensheng JI
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(5):906-914
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(5):906-914
Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway.
Si J, Liu B, Qi K, Chen X, Li D, Yang S, Ji E
Journal of ethnopharmacology 2023 Oct 28;315:116677
Journal of ethnopharmacology 2023 Oct 28;315:116677
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
Wang H, He D, Li Z, Gao X, Yang S, Cui M, Ye B, Huang B, Fu S, Liu D
Chemico-biological interactions 2023 Oct 1;384:110726
Chemico-biological interactions 2023 Oct 1;384:110726
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
Wang Y, Fu M, Xiao W, Zhao Y, Yuan P, Zhang X, Wu W
Advanced healthcare materials 2023 Nov;12(29):e2301247
Advanced healthcare materials 2023 Nov;12(29):e2301247
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
Gao D, Wang R, Gong Y, Yu X, Niu Q, Yang E, Fan G, Ma J, Chen C, Tao Y, Lu J, Wang Z
Free radical biology & medicine 2023 Nov 1;208:587-601
Free radical biology & medicine 2023 Nov 1;208:587-601
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Wang K, Li Z, Ding Y, Liu Z, Li Y, Liu X, Sun Y, Hong J, Zheng W, Qian L, Xu D
Journal of physiology and biochemistry 2023 May;79(2):341-353
Journal of physiology and biochemistry 2023 May;79(2):341-353
Gallotannin Isolated from Pericarp of Water Caltrop Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.
Lü H, Meng X, Ding X, Jian T, Zuo Y, Liu Y, Ren B, Li W, Chen J
Journal of agricultural and food chemistry 2023 May 10;71(18):7046-7057
Journal of agricultural and food chemistry 2023 May 10;71(18):7046-7057
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Chen Y, Liu Y, Jiang K, Wen Z, Cao X, Wu S
Journal of orthopaedic translation 2023 Mar;39:1-11
Journal of orthopaedic translation 2023 Mar;39:1-11
Regulation of Paracellular Fluxes of Amino Acids by Claudin-8 in Normal Mouse Intestinal MCE301 Cells.
Okamoto E, Matsuda S, Yoshino Y, Morikawa Y, Suenami K, Tabuchi Y, Matsunaga T, Ikari A
Nutrients 2023 Mar 10;15(6)
Nutrients 2023 Mar 10;15(6)
Ferrostatin-1 improves BMSC survival by inhibiting ferroptosis.
Xie Q, Sun Y, Xu H, Chen T, Xiang H, Liu H, Wang R, Tan B, Yi Q, Tian J, Zhu J
Archives of biochemistry and biophysics 2023 Mar 1;736:109535
Archives of biochemistry and biophysics 2023 Mar 1;736:109535
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Cai Z, Li Y, Ma M, Wang L, Wang H, Liu M, Jiang C
Oncology reports 2023 Jul;50(1)
Oncology reports 2023 Jul;50(1)
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Huang P, Zhao H, Pan X, Li J, Pan W, Dai H, Wang J, Xia C, Liu F
Biochemical pharmacology 2023 Jul;213:115592
Biochemical pharmacology 2023 Jul;213:115592
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Cheng X, Han X, Zhou L, Sun Y, Zhou Q, Lin X, Gao Z, Wang J, Zhao W
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Jie Li Z, Bing Luo C, Liang Wang H, Sun J, Qian Yang Q, Lang Zhou Y
International journal of pharmaceutics 2023 Jul 25;642:123190
International journal of pharmaceutics 2023 Jul 25;642:123190
Modulation of the Microbiome-Fat-Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice.
Wei B, Peng Z, Xiao M, Huang T, Yang S, Liu K, Wu M, Zheng W, Xie M, Xiong T
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10361-10374
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10361-10374
Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.
Han S, Zhang H, Liu X, Wen F, Li B, Bie Z, Qiu H, Hu J
Ecotoxicology and environmental safety 2023 Jul 1;259:115063
Ecotoxicology and environmental safety 2023 Jul 1;259:115063
Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis.
Wang J, Huang P, Pan X, Xia C, Zhang H, Zhao H, Yuan Z, Liu J, Meng C, Liu F
Phytotherapy research : PTR 2023 Jan;37(1):211-230
Phytotherapy research : PTR 2023 Jan;37(1):211-230
Recombinant human angiotensin-converting enzyme 2 plays a protective role in mice with sepsis-induced cardiac dysfunction through multiple signaling pathways dependent on converting angiotensin II to angiotensin 1-7.
Wu C, Chen Y, Zhou P, Hu Z
Annals of translational medicine 2023 Jan 15;11(1):13
Annals of translational medicine 2023 Jan 15;11(1):13
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Song Z, Liu N, He Y, Chen J, Li J, Wang F, Wu Z
Inflammation 2023 Feb;46(1):404-417
Inflammation 2023 Feb;46(1):404-417
Quantification and Proteomic Characterization of β-Hydroxybutyrylation Modification in the Hearts of AMPKα2 Knockout Mice.
Ding WJ, Li XH, Tang CM, Yang XC, Sun Y, Song YP, Ling MY, Yan R, Gao HQ, Zhang WH, Yu N, Feng JC, Zhang Z, Xing YQ
Molecular & cellular proteomics : MCP 2023 Feb;22(2):100494
Molecular & cellular proteomics : MCP 2023 Feb;22(2):100494
A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector.
Liang Q, Wan J, Liu H, Jia D, Chen Q, Wang A, Wei T
Autophagy 2023 Feb;19(2):616-631
Autophagy 2023 Feb;19(2):616-631
Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.
Li F, Liu H, Wu X, Song Z, Tang H, Gong M, Liu L, Li F
International journal of molecular sciences 2023 Feb 4;24(4)
International journal of molecular sciences 2023 Feb 4;24(4)
The Degree of Hydrolysis and Peptide Profile Affect the Anti-Fatigue Activities of Whey Protein Hydrolysates in Promoting Energy Metabolism in Exercise Mice.
Zhao C, Gong Y, Zheng L, Zhao M
Journal of agricultural and food chemistry 2023 Feb 15;71(6):3010-3021
Journal of agricultural and food chemistry 2023 Feb 15;71(6):3010-3021
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Chen T, Bao S, Chen J, Zhang J, Wei H, Hu X, Liang Y, Li J, Yan S
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B
Autophagy 2023 Dec;19(12):3132-3150
Autophagy 2023 Dec;19(12):3132-3150
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Ruiz-Mitjana A, Vidal-Sabanés M, Navaridas R, Perramon-Güell A, Yeramian A, Nicholson-Sabaté N, Egea J, Encinas M, Matias-Guiu X, Dolcet X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Increase in Paracellular Leakage of Amino Acids Mediated by Aging-Induced Reduction of Claudin-4 Expression.
Okamoto E, Matsuda S, Yoshino Y, Morikawa Y, Suenami K, Tabuchi Y, Matsunaga T, Hayashi H, Ikari A
The Journal of nutrition 2023 Dec;153(12):3360-3372
The Journal of nutrition 2023 Dec;153(12):3360-3372
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Wan L, Qian Y, Ni W, Lu Y, Li W, Pan Y, Chen W
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Chen M, Zhu JY, Mu WJ, Luo HY, Li Y, Li S, Yan LJ, Li RY, Guo L
Nature communications 2023 Dec 18;14(1):8391
Nature communications 2023 Dec 18;14(1):8391
Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo.
Zhang W, Liu S, Kong L, Wu S, Zhong Z, Yu L, Yang Q, Zhang J, Li J, Zheng G
International journal of biological macromolecules 2023 Dec 1;252:126511
International journal of biological macromolecules 2023 Dec 1;252:126511
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Li P, Dai S, Gao X, Li W
Journal of physiology and biochemistry 2023 Aug;79(3):569-582
Journal of physiology and biochemistry 2023 Aug;79(3):569-582
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway.
Xu J, Zhao L, Zhang X, Ying K, Zhou R, Cai W, Wu X, Jiang H, Xu Q, Miao D, Zeng Y, Yu F
Ecotoxicology and environmental safety 2023 Aug 7;262:115331
Ecotoxicology and environmental safety 2023 Aug 7;262:115331
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Liang Z, Yang Y, Wu X, Lu C, Zhao H, Chen K, Zhao A, Li X, Xu J
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Caffeic Acid Phenethyl Ester (CAPE) Improves Boar Sperm Quality and Antioxidant Capacity in Liquid Preservation (17°C) Linked to AMPK Activity Maintenance.
Lan Q, Xue L, Cao J, Xie Y, Xiao T, Fang S
Frontiers in veterinary science 2022;9:904886
Frontiers in veterinary science 2022;9:904886
Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway.
Zhang Y, Yao H, Li C, Sun W, Chen X, Cao Y, Liu Y, Liu Y, Chen J, Qi J, Zhang Q, Zhang H, Xu A, Zhang J
Oxidative medicine and cellular longevity 2022;2022:6275505
Oxidative medicine and cellular longevity 2022;2022:6275505
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Wang L, Wang J
Oxidative medicine and cellular longevity 2022;2022:1755608
Oxidative medicine and cellular longevity 2022;2022:1755608
Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.
Zhang FK, Ni QZ, Wang K, Cao HJ, Guan DX, Zhang EB, Ma N, Wang YK, Zheng QW, Xu S, Zhu B, Chen TW, Xia J, Qiu XS, Ding XF, Jiang H, Qiu L, Wang X, Chen W, Cheng SQ, Xie D, Li JJ
Cellular and molecular gastroenterology and hepatology 2022;14(1):101-127
Cellular and molecular gastroenterology and hepatology 2022;14(1):101-127
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Zhu Z, Wang X, Song Z, Zuo X, Ma Y, Zhang Z, Ju C, Liang Z, Li K, Hu X, Wang Z
Frontiers in pharmacology 2022;13:991421
Frontiers in pharmacology 2022;13:991421
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
He J, Yang Y, Zhang F, Li Y, Li X, Pu X, He X, Zhang M, Yang X, Yu Q, Qi Y, Li X, Yu J
Frontiers in pharmacology 2022;13:1007274
Frontiers in pharmacology 2022;13:1007274
Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.
Yu C, Liu S, Niu Y, Fu L
The Journal of nutritional biochemistry 2022 Sep;107:109059
The Journal of nutritional biochemistry 2022 Sep;107:109059
Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function.
He L, Zhou X, Wu Z, Feng Y, Liu D, Li T, Yin Y
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Sep;10:137-147
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Sep;10:137-147
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3.
Wang D, Cao L, Zhou X, Wang G, Ma Y, Hao X, Fan H
Journal of hazardous materials 2022 Sep 5;437:129381
Journal of hazardous materials 2022 Sep 5;437:129381
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.
Wu M, Zhao A, Yan X, Gao H, Zhang C, Liu X, Luo Q, Xie F, Liu S, Shi D
eLife 2022 Sep 26;11
eLife 2022 Sep 26;11
A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.
Zhu Y, Sun Y, Rui B, Lin J, Shen J, Xiao H, Liu X, Chai Y, Xu J, Yang Y
ACS applied materials & interfaces 2022 Sep 14;14(36):40674-40687
ACS applied materials & interfaces 2022 Sep 14;14(36):40674-40687
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Xu Z, Sun X, Ding B, Zi M, Ma Y
Transplant immunology 2022 Oct;74:101664
Transplant immunology 2022 Oct;74:101664
Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.
Zheng J, Duan Y, Zheng C, Yu J, Li F, Guo Q, Yin Y
Animals : an open access journal from MDPI 2022 Oct 26;12(21)
Animals : an open access journal from MDPI 2022 Oct 26;12(21)
Copper Depletion Strongly Enhances Ferroptosis via Mitochondrial Perturbation and Reduction in Antioxidative Mechanisms.
Li F, Wu X, Liu H, Liu M, Yue Z, Wu Z, Liu L, Li F
Antioxidants (Basel, Switzerland) 2022 Oct 22;11(11)
Antioxidants (Basel, Switzerland) 2022 Oct 22;11(11)
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Zhao Y, Lin J, Li J, Bwalya C, Xu Y, Niu Y, Zhang Y, Wu J, Xu Y, Chen J, Ye S, Lin L
International journal of molecular sciences 2022 Oct 18;23(20)
International journal of molecular sciences 2022 Oct 18;23(20)
Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition.
Zhou F, Yang L, Yang L, Wang X, Guo N, Sun W, Ma H
Biochemical and biophysical research communications 2022 Nov 19;630:1-7
Biochemical and biophysical research communications 2022 Nov 19;630:1-7
Empagliflozin inhibits macrophage inflammation through AMPK signaling pathway and plays an anti-atherosclerosis role.
Fu J, Xu H, Wu F, Tu Q, Dong X, Xie H, Cao Z
International journal of cardiology 2022 Nov 15;367:56-62
International journal of cardiology 2022 Nov 15;367:56-62
Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency.
Li Z, Yue M, Heng BC, Liu Y, Zhang P, Zhou Y
International journal of oral science 2022 Nov 15;14(1):54
International journal of oral science 2022 Nov 15;14(1):54
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Tang K, Qin W, Wei R, Jiang Y, Fan L, Wang Z, Tan N
Pharmacological research 2022 May;179:106123
Pharmacological research 2022 May;179:106123
Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions.
Lai R, Ji L, Zhang X, Xu Y, Zhong Y, Chen L, Hu H, Wang L
Molecular and cellular endocrinology 2022 May 1;547:111598
Molecular and cellular endocrinology 2022 May 1;547:111598
Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion.
Ren X, Lv J, Wang N, Liu J, Gao C, Wu X, Yu Y, Teng Q, Dong W, Kong H, Kong L
Diabetes research and clinical practice 2022 Mar;185:109788
Diabetes research and clinical practice 2022 Mar;185:109788
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Wang Q, Wang L, Abdullah, Tian W, Song M, Cao Y, Xiao J
Food & function 2022 Mar 21;13(6):3419-3430
Food & function 2022 Mar 21;13(6):3419-3430
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation.
Xie M, Xiong Z, Yin S, Xiong J, Li X, Jin L, Zhang F, Chen H, Lan P, Lian L
Digestive diseases and sciences 2022 Jun;67(6):2232-2243
Digestive diseases and sciences 2022 Jun;67(6):2232-2243
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome.
Xiao N, Wang J, Wang T, Xiong X, Zhou J, Su X, Peng J, Yang C, Li X, Lin G, Lu G, Gong F, Cheng L
eLife 2022 Jun 24;11
eLife 2022 Jun 24;11
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Metformin and MiR-365 synergistically promote the apoptosis of gastric cancer cells via MiR-365-PTEN-AMPK axis.
Huang F, Xiang Y, Li T, Huang Y, Wang J, Zhang HM, Li HH, Dai ZT, Li JP, Li H, Zhou J, Liao XH
Pathology, research and practice 2022 Feb;230:153740
Pathology, research and practice 2022 Feb;230:153740
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167
Food & function 2022 Feb 7;13(3):1153-1167
Mdivi-1 improves postoperative neurocognitive disorders in aged rats undergoing splenectomy by inhibiting dynamin-related protein-1.
Lin N, Jin JW, Lai ZM, Zhang DF, Chen Y, Guo HG, Liu JL
Annals of translational medicine 2022 Dec;10(24):1338
Annals of translational medicine 2022 Dec;10(24):1338
Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.
Xing H, Liang C, Wang C, Xu X, Hu Y, Qiu B
Biochemical and biophysical research communications 2022 Dec 3;632:113-121
Biochemical and biophysical research communications 2022 Dec 3;632:113-121
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL
Nature 2022 Aug;608(7922):413-420
Nature 2022 Aug;608(7922):413-420
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Wang Z, Li C, He X, Xu K, Xue Z, Wang T, Xu Z, Liu X
Food & function 2022 Apr 4;13(7):3946-3956
Food & function 2022 Apr 4;13(7):3946-3956
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Wu M, Cong Y, Wang K, Yu H, Zhang X, Ma M, Duan Z, Pei X
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic β-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux.
Li R, Sun X, Li P, Li W, Zhao L, Zhu L, Zhu S
Frontiers in cell and developmental biology 2021;9:646113
Frontiers in cell and developmental biology 2021;9:646113
Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways.
Zhu X, Chen Y, Lin M, Huang B, Lin J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9950499
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9950499
Effects of Fluorine on Neutrophil Extracellular Trap Formation through Regulating AMPK/p38 Signaling Pathway.
Song Y, Zhang Y, Zhang P, Yu P, Shang X, Lu Y, Li Y, Gao H
Oxidative medicine and cellular longevity 2021;2021:6693921
Oxidative medicine and cellular longevity 2021;2021:6693921
Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway.
Hou Y, Yuan P, Fu Y, Zhang Q, Gao L, Wei Y, Zheng X, Feng W
Drug design, development and therapy 2021;15:949-962
Drug design, development and therapy 2021;15:949-962
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway.
Zhao Y, Ye S, Lin J, Liang F, Chen J, Hu J, Chen K, Fang Y, Chen X, Xiong Y, Lin L, Tan X
Frontiers in pharmacology 2021;12:680351
Frontiers in pharmacology 2021;12:680351
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Ren F, Xu X, Xu J, Mei Y, Zhang J, Wang X, Li F
Environmental toxicology 2021 Sep;36(9):1765-1774
Environmental toxicology 2021 Sep;36(9):1765-1774
Simvastatin-romidepsin combination kills bladder cancer cells synergistically.
Okubo K, Miyai K, Kato K, Asano T, Sato A
Translational oncology 2021 Sep;14(9):101154
Translational oncology 2021 Sep;14(9):101154
Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice.
Bai X, Zhang X, Fang R, Wang J, Ma Y, Liu Z, Dong H, Li Q, Ge J, Yu M, Fei J, Sun R, Huang F
Aging 2021 Sep 20;13(18):22390-22411
Aging 2021 Sep 20;13(18):22390-22411
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.
Zeng Y, Liang H, Guo Y, Feng Y, Yao Q
Journal of cellular physiology 2021 Oct;236(10):7088-7096
Journal of cellular physiology 2021 Oct;236(10):7088-7096
Co-modification with MSC membrane and PDA prevents Fe(3)O(4)-induced pulmonary toxicity in mice via AMPK-ULK1 axis.
Yao H, Yan J, Shao P, Wang Y, Liu T, Jiang J, Liu T
Toxicology letters 2021 Oct 15;351:145-154
Toxicology letters 2021 Oct 15;351:145-154
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Zou Y, Chen Z, Sun C, Yang D, Zhou Z, Peng X, Zheng L, Tang C
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1α axis in the development of benign prostatic hyperplasia.
Li Y, Wang Q, Li J, Shi B, Liu Y, Wang P
The Prostate 2021 Nov;81(15):1135-1148
The Prostate 2021 Nov;81(15):1135-1148
Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.
Chen Z, Zhou Z, Peng X, Sun C, Yang D, Li C, Zhu R, Zhang P, Zheng L, Tang C
The journal of physiological sciences : JPS 2021 Nov 8;71(1):33
The journal of physiological sciences : JPS 2021 Nov 8;71(1):33
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.
Hu Y, Chen H, Zhang L, Lin X, Li X, Zhuang H, Fan H, Meng T, He Z, Huang H, Gong Q, Zhu D, Xu Y, He P, Li L, Feng D
Autophagy 2021 May;17(5):1142-1156
Autophagy 2021 May;17(5):1142-1156
Angiotensin II-mediated improvement of renal mitochondrial function via the AMPK/PGC-1α/NRF-2 pathway is superior to norepinephrine in a rat model of septic shock associated with acute renal injury.
An H, Hu Z, Chen Y, Cheng L, Shi J, Han L
Annals of translational medicine 2021 Mar;9(6):481
Annals of translational medicine 2021 Mar;9(6):481
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
The antitumor role of a newly discovered α-d-glucan from Holotrichia diomphalia Bates as a selective blocker of aldolase A.
Wang J, Li Z, Yang X, Qiao Y, Feng C, Yu S, Jing H, Liu W, Ren L, Duan Q, Li XQ, Cao W
Carbohydrate polymers 2021 Mar 1;255:117532
Carbohydrate polymers 2021 Mar 1;255:117532
Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE(-/-) mice.
Wu H, Feng K, Zhang C, Zhang H, Zhang J, Hua Y, Dong Z, Zhu Y, Yang S, Ma C
Biochemical and biophysical research communications 2021 Jun 11;557:334-341
Biochemical and biophysical research communications 2021 Jun 11;557:334-341
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
Xue H, Cao H, Xing C, Feng J, Zhang L, Zhang C, Hu G, Yang F
Toxicology 2021 Jul;459:152855
Toxicology 2021 Jul;459:152855
SCF(JFK) is functionally linked to obesity and metabolic syndrome.
He L, Yan R, Yang Z, Zhang Y, Liu X, Yang J, Liu X, Liu X, Xia L, Wang Y, Wu J, Wu X, Shan L, Yang X, Liang J, Shang Y, Sun L
EMBO reports 2021 Jul 5;22(7):e52036
EMBO reports 2021 Jul 5;22(7):e52036
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Zhou J, Zhao Y, Guo YJ, Zhao YS, Liu H, Ren J, Li JR, Ji ES
Life sciences 2021 Jul 1;276:119403
Life sciences 2021 Jul 1;276:119403
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Gong X, Li T, Wan R, Sha L
International immunopharmacology 2021 Feb;91:107173
International immunopharmacology 2021 Feb;91:107173
The Dual Histone Deacetylase-Proteasome Inhibitor RTS-V5 Acts Synergistically With Ritonavir to Induce Endoplasmic Reticulum Stress in Bladder Cancer Cells.
Okubo K, REßING N, Schulz WA, Hansen FK, Asano T, Sato A
Anticancer research 2021 Dec;41(12):5987-5996
Anticancer research 2021 Dec;41(12):5987-5996
Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1α signaling pathway in mice and C2C12 myotubes.
Xue Y, Huang Z, Chen X, Jia G, Zhao H, Liu G
Nutrition research (New York, N.Y.) 2021 Aug;92:99-108
Nutrition research (New York, N.Y.) 2021 Aug;92:99-108
Danqi Tablet () Regulates Energy Metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway.
Meng H, Wang QY, Li N, He H, Lu WJ, Wang QX, Sun XQ, Jiao SH, Wang Y, Tu PF
Chinese journal of integrative medicine 2021 Aug;27(8):597-603
Chinese journal of integrative medicine 2021 Aug;27(8):597-603
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway.
Pu JL, Huang ZT, Luo YH, Mou T, Li TT, Li ZT, Wei XF, Wu ZJ
Hepatobiliary & pancreatic diseases international : HBPD INT 2021 Aug;20(4):352-360
Hepatobiliary & pancreatic diseases international : HBPD INT 2021 Aug;20(4):352-360
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Xiaoli F, Yaqing Z, Ruhui L, Xuan L, Aijie C, Yanli Z, Chen H, Lili C, Longquan S
Journal of hazardous materials 2021 Aug 15;416:126158
Journal of hazardous materials 2021 Aug 15;416:126158
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Sun CC, Zhou ZQ, Chen ZL, Zhu RK, Yang D, Peng XY, Zheng L, Tang CF
Biology 2021 Aug 10;10(8)
Biology 2021 Aug 10;10(8)
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
Wang Y, Zhao H, Liu Y, Li J, Nie X, Huang P, Xing M
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice.
Ding X, Jian T, Li J, Lv H, Tong B, Li J, Meng X, Ren B, Chen J
Oxidative medicine and cellular longevity 2020;2020:9734560
Oxidative medicine and cellular longevity 2020;2020:9734560
Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway.
Jiang X, Ruan XL, Xue YX, Yang S, Shi M, Wang LN
Oxidative medicine and cellular longevity 2020;2020:8708236
Oxidative medicine and cellular longevity 2020;2020:8708236
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Zhou B, Qiu Y, Wu N, Chen AD, Zhou H, Chen Q, Kang YM, Li YH, Zhu GQ
Oxidative medicine and cellular longevity 2020;2020:6384803
Oxidative medicine and cellular longevity 2020;2020:6384803
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Xie T, Wang C, Jin Y, Meng Q, Liu Q, Wu J, Sun H
Frontiers in pharmacology 2020;11:1034
Frontiers in pharmacology 2020;11:1034
Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis.
Zhang H, Tian F, Jiang P, Qian S, Dai X, Ma B, Wang M, Dai H, Sha X, Yang Z, Zhu X, Sun X
Frontiers in oncology 2020;10:614067
Frontiers in oncology 2020;10:614067
S -1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway.
Ushijima M, Kunimura K, Suzuki JI
Experimental and therapeutic medicine 2020 Sep;20(3):2815-2821
Experimental and therapeutic medicine 2020 Sep;20(3):2815-2821
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, Kong W, Kong W
Experimental cell research 2020 Sep 1;394(1):112093
Experimental cell research 2020 Sep 1;394(1):112093
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334
Metabolism: clinical and experimental 2020 Oct;111:154334
Gypenoside A protects ischemia/reperfusion injuries by suppressing miR-143-3p level via the activation of AMPK/Foxo1 pathway.
Chang L, Shi R, Wang X, Bao Y
BioFactors (Oxford, England) 2020 May;46(3):432-440
BioFactors (Oxford, England) 2020 May;46(3):432-440
The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization.
Ye W, Wang J, Lin D, Ding Z
International journal of biological macromolecules 2020 Mar 1;146:25-35
International journal of biological macromolecules 2020 Mar 1;146:25-35
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma.
Chu YD, Lin WR, Lin YH, Kuo WH, Tseng CJ, Lim SN, Huang YL, Huang SC, Wu TJ, Lin KH, Yeh CT
Cancers 2020 Jun 22;12(6)
Cancers 2020 Jun 22;12(6)
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells.
Okubo K, Isono M, Miyai K, Asano T, Sato A
Cancer science 2020 Jan;111(1):112-126
Cancer science 2020 Jan;111(1):112-126
UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
Liu X, Ma F, Liu C, Zhu K, Li W, Xu Y, Li G, Niu Z, Liu J, Chen D, Li Z, Fu Y, Qian C
Cell death & disease 2020 Jan 6;11(1):10
Cell death & disease 2020 Jan 6;11(1):10
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
You B, Dun Y, Zhang W, Jiang L, Li H, Xie M, Liu Y, Liu S
The Journal of endocrinology 2020 Feb;244(2):383-393
The Journal of endocrinology 2020 Feb;244(2):383-393
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484
Nature 2020 Dec;588(7838):479-484
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration.
Lv J, Bao S, Liu T, Wei L, Wang D, Ye W, Wang N, Song S, Li J, Chudhary M, Ren X, Kong L
Cell and tissue research 2020 Dec;382(3):477-486
Cell and tissue research 2020 Dec;382(3):477-486
Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression.
Wang L, Li YS, Yu LG, Zhang XK, Zhao L, Gong FL, Yang XX, Guo XL
Biochemical pharmacology 2020 Aug;178:114113
Biochemical pharmacology 2020 Aug;178:114113
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
Wang C, Le Y, Lu D, Zhao M, Dou X, Zhang Q
Journal of hazardous materials 2020 Apr 15;388:121732
Journal of hazardous materials 2020 Apr 15;388:121732
The balance of apoptosis and autophagy via regulation of the AMPK signal pathway in aging rat striatum during regular aerobic exercise.
Liu W, Wang Z, Xia Y, Kuang H, Liu S, Li L, Tang C, Yin D
Experimental gerontology 2019 Sep;124:110647
Experimental gerontology 2019 Sep;124:110647
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells.
Lu J, Meng Z, Cheng B, Liu M, Tao S, Guan S
Experimental and therapeutic medicine 2019 Oct;18(4):2965-2971
Experimental and therapeutic medicine 2019 Oct;18(4):2965-2971
Lopinavir-Ritonavir Combination Induces Endoplasmic Reticulum Stress and Kills Urological Cancer Cells.
Okubo K, Isono M, Asano T, Sato A
Anticancer research 2019 Nov;39(11):5891-5901
Anticancer research 2019 Nov;39(11):5891-5901
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Meng Z, Liu Q, Sun F, Qiao L
Lipids in health and disease 2019 Nov 4;18(1):191
Lipids in health and disease 2019 Nov 4;18(1):191
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy.
Chen C, Jiang L, Zhang M, Pan X, Peng C, Huang W, Jiang Q
Food & function 2019 May 22;10(5):2651-2657
Food & function 2019 May 22;10(5):2651-2657
Effect of CAPE-pNO(2) against type 2 diabetes mellitus via the AMPK/GLUT4/ GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice.
Li S, Huang Q, Zhang L, Qiao X, Zhang Y, Tang F, Li Z
European journal of pharmacology 2019 Jun 15;853:1-10
European journal of pharmacology 2019 Jun 15;853:1-10
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Sun J, Liu Y, Yu J, Wu J, Gao W, Ran L, Jiang R, Guo M, Han D, Liu B, Wang N, Li Y, Huang H, Zeng L, Gao Y, Li X, Wu Y
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway.
Wang H, Zhong P, Sun L
Biology open 2019 Jul 17;8(7)
Biology open 2019 Jul 17;8(7)
The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.
Yang Y, Zhu G, Dong B, Piao J, Chen L, Lin Z
Cancer letters 2019 Jul 1;453:170-183
Cancer letters 2019 Jul 1;453:170-183
Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis.
Ma WQ, Sun XJ, Wang Y, Zhu Y, Han XQ, Liu NF
Molecular and cellular endocrinology 2019 Jan 5;479:39-53
Molecular and cellular endocrinology 2019 Jan 5;479:39-53
Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria.
Han X, Zhang Y, Guo J, You Y, Zhan J, Huang W
Journal of food science 2019 Dec;84(12):3815-3824
Journal of food science 2019 Dec;84(12):3815-3824
Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells.
Bao H, Zhang Q, Liu X, Song Y, Li X, Wang Z, Li C, Peng A, Gong R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):14370-14381
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):14370-14381
PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.
Gu S, Hua H, Guo X, Jia Z, Zhang Y, Maslov LN, Zhang X, Ma H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902
Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.
Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, Zhang H, Chai Y
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy.
Fang J, Zhu Y, Wang H, Cao B, Fei M, Niu W, Zhou Y, Wang X, Li X, Zhou M
Frontiers in neuroscience 2018;12:1006
Frontiers in neuroscience 2018;12:1006
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Du Y, Wang L, Chen S, Liu Y, Zhao Y
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Guo XF, Sinclair AJ, Kaur G, Li D
Prostaglandins, leukotrienes, and essential fatty acids 2018 Sep;136:47-55
Prostaglandins, leukotrienes, and essential fatty acids 2018 Sep;136:47-55
Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Okubo K, Isono M, Asano T, Sato A
Anticancer research 2018 Oct;38(10):5615-5626
Anticancer research 2018 Oct;38(10):5615-5626
Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1.
Yu B, Liu D, Zhang H, Xie D, Nie W, Shi K, Yang P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1390-1395
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1390-1395
Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model.
Lee HW, Lee SM, Lee MH, Son YK, Kim SE, An WS
Marine drugs 2018 Oct 23;16(11)
Marine drugs 2018 Oct 23;16(11)
MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene.
Zeng N, Huang R, Li N, Jiang H, Li R, Wang F, Chen W, Xia M, Wang Q
Molecular and cellular endocrinology 2018 Oct 15;474:260-271
Molecular and cellular endocrinology 2018 Oct 15;474:260-271
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Dai J, Huang Q, Niu K, Wang B, Li Y, Dai C, Chen Z, Tao K, Dai J
Cancer medicine 2018 Nov;7(11):5691-5703
Cancer medicine 2018 Nov;7(11):5691-5703
3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5.
Chen Y, Wei L, Zhang X, Liu X, Chen Y, Zhang S, Zhou L, Li Q, Pan Q, Zhao S, Liu H
Oncology reports 2018 Nov;40(5):2435-2444
Oncology reports 2018 Nov;40(5):2435-2444
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Gao J, Xiong R, Xiong D, Zhao W, Zhang S, Yin T, Zhang X, Jiang G, Yin Z
Medical science monitor : international medical journal of experimental and clinical research 2018 Nov 26;24:8533-8543
Medical science monitor : international medical journal of experimental and clinical research 2018 Nov 26;24:8533-8543
Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration.
Luo X, Wang D, Zhu X, Wang G, You Y, Ning Z, Li Y, Jin S, Huang Y, Hu Y, Chen T, Meng Y, Li X
Cell death & disease 2018 May 1;9(5):576
Cell death & disease 2018 May 1;9(5):576
Nelfinavir and Ritonavir Kill Bladder Cancer Cells Synergistically by Inducing Endoplasmic Reticulum Stress.
Sato A, Asano T, Okubo K, Isono M, Asano T
Oncology research 2018 Mar 5;26(2):323-332
Oncology research 2018 Mar 5;26(2):323-332
AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.
Liu JQ, Zhang L, Yao J, Yao S, Yuan T
Biochemical and biophysical research communications 2018 Mar 4;497(2):564-570
Biochemical and biophysical research communications 2018 Mar 4;497(2):564-570
Delanzomib Interacts with Ritonavir Synergistically to Cause Endoplasmic Reticulum Stress in Renal Cancer Cells.
Isono M, Sato A, Asano T, Okubo K, Asano T
Anticancer research 2018 Jun;38(6):3493-3500
Anticancer research 2018 Jun;38(6):3493-3500
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress.
Cheng G, Li B, Sun X, Cao Z, Zhang G, Zhao Z, Zhao Y, Yu Q, Liu W
Biochemical and biophysical research communications 2018 Jan 29;496(1):1-6
Biochemical and biophysical research communications 2018 Jan 29;496(1):1-6
Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway.
Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, Wang L, Gao D, Tian X, Yao J
Toxicology and applied pharmacology 2018 Jan 15;339:172-180
Toxicology and applied pharmacology 2018 Jan 15;339:172-180
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
Li CF, Sun JX, Gao Y, Shi F, Pan YK, Wang YC, Sun XQ
Cell death & disease 2018 Feb 2;9(2):147
Cell death & disease 2018 Feb 2;9(2):147
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J
International immunopharmacology 2018 Dec;65:256-267
International immunopharmacology 2018 Dec;65:256-267
9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells.
Cao S, Yu S, Cheng L, Yan J, Zhu Y, Deng Y, Qiu F, Kang N
Environmental toxicology and pharmacology 2018 Dec;64:11-17
Environmental toxicology and pharmacology 2018 Dec;64:11-17
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Cheng B, Lu J, Li T, Meng Z, Liu M, Sun M, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480
Pharmacological research 2018 Apr;130:466-480
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Cao M, Fang J, Wang X, Wang Y, Duan K, Ye F, Ouyang W, Tong J
Brain research 2018 Apr 1;1684:21-29
Brain research 2018 Apr 1;1684:21-29
Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control.
Dun Y, Liu S, Zhang W, Xie M, Qiu L
Oxidative medicine and cellular longevity 2017;2017:8024857
Oxidative medicine and cellular longevity 2017;2017:8024857
Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio).
Ran G, Ying L, Li L, Yan Q, Yi W, Ying C, Wu H, Ye X
PloS one 2017;12(7):e0180865
PloS one 2017;12(7):e0180865
SIRT1/PGC-1α Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Zhou Y, Wang S, Li Y, Yu S, Zhao Y
Frontiers in molecular neuroscience 2017;10:443
Frontiers in molecular neuroscience 2017;10:443
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration.
Luo X, Dan Wang, Luo X, Zhu X, Wang G, Ning Z, Li Y, Ma X, Yang R, Jin S, Huang Y, Meng Y, Li X
Redox biology 2017 Oct;13:508-521
Redox biology 2017 Oct;13:508-521
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, Tan N
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Chronic metformin treatment facilitates seizure termination.
Yang Y, Zhu B, Zheng F, Li Y, Zhang Y, Hu Y, Wang X
Biochemical and biophysical research communications 2017 Mar 4;484(2):450-455
Biochemical and biophysical research communications 2017 Mar 4;484(2):450-455
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.
La X, Zhang L, Li Z, Yang P, Wang Y
Oncotarget 2017 Mar 28;8(13):20909-20924
Oncotarget 2017 Mar 28;8(13):20909-20924
AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.
He L, Huang N, Li H, Tian J, Zhou X, Li T, Yao K, Wu G, Yin Y
Journal of agricultural and food chemistry 2017 Mar 22;65(11):2287-2298
Journal of agricultural and food chemistry 2017 Mar 22;65(11):2287-2298
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, Shi D, Dai J, Li J, Ju H, Cao Y, Qin J, Chen S, Teng H, Jiang Q
Scientific reports 2017 Feb 22;7:43245
Scientific reports 2017 Feb 22;7:43245
AMP-activated protein kinase and cAMP response element-binding protein activity are associated with distinct postoperative behavioral changes in rats.
Li D, Ye F, Ouyang W, Wang Y
Journal of anesthesia 2017 Dec;31(6):806-812
Journal of anesthesia 2017 Dec;31(6):806-812
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
Li M, Jin C, Xu M, Zhou L, Li D, Yin Y
Cell communication and signaling : CCS 2017 Dec 16;15(1):52
Cell communication and signaling : CCS 2017 Dec 16;15(1):52
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:33
Cell & bioscience 2016;6:33
The Effect of Hippocampal Cognitive Impairment and XIAP on Glucose and Lipids Metabolism in Rats.
Xia C, Zhu L, Shao W, Mi S, Du S, Ye L, Liu M, Pang Y, Nong L, Jiang C, Zhao H, Qi G
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;38(2):609-18
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;38(2):609-18
Activation of AMPK α2 inhibits airway smooth muscle cells proliferation.
Liu L, Pan Y, Song Y, Su X, Ke R, Yang L, Gao L, Li M
European journal of pharmacology 2016 Nov 15;791:235-243
European journal of pharmacology 2016 Nov 15;791:235-243
Knockdown of AMPKα2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27(Kip1) Signaling Pathway.
Ke R, Liu L, Zhu Y, Li S, Xie X, Li F, Song Y, Yang L, Gao L, Li M
International journal of molecular sciences 2016 May 31;17(6)
International journal of molecular sciences 2016 May 31;17(6)
Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis.
Liu Q, Yuan W, Tong D, Liu G, Lan W, Zhang D, Xiao H, Zhang Y, Huang Z, Yang J, Zhang J, Jiang J
Oncotarget 2016 May 10;7(19):28235-46
Oncotarget 2016 May 10;7(19):28235-46
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
Li L, Xiao L, Hou Y, He Q, Zhu J, Li Y, Wu J, Zhao J, Yu S, Zhao Y
Scientific reports 2016 Jul 25;6:30272
Scientific reports 2016 Jul 25;6:30272
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
Dong K, Wu M, Liu X, Huang Y, Zhang D, Wang Y, Yan LJ, Shi D
Free radical biology & medicine 2016 Dec;101:334-347
Free radical biology & medicine 2016 Dec;101:334-347
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y
International journal of clinical and experimental pathology 2015;8(12):15836-44
International journal of clinical and experimental pathology 2015;8(12):15836-44
AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth.
Zhu K, Chen X, Liu J, Ye H, Zhu L, Wu JY
Protein & cell 2013 Feb;4(2):155-61
Protein & cell 2013 Feb;4(2):155-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10929-2-AP(PRKAA1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AMPK alpha 1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AMPK alpha 1. This antibody recognizes human,mouse,rat antigen. The AMPK alpha 1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 10929-2-AP(PRKAA1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
