66536-1-Ig

antibody from Proteintech Group

Targeting: PRKAA1 AMPKa1

Provider product page for 66536-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [62]
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Product number: 66536-1-Ig - Provider product page
Provider: Proteintech Group
Product name: AMPK Alpha antibody
Antibody type: Monoclonal
Description: KD/KO validated AMPK Alpha antibody (Cat. #66536-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Rat, Mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1H8E1
Vial size: 20ul, 150ul

PRKAA1 protein structure - 66536-1-Ig shown in red.

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International journal of biological sciences 2023;19(13):4340-4359

Exercise prevents fatal stress-induced myocardial injury in obese mice.

Dun Y, Hu Z, You B, Du Y, Zeng L, Zhao Y, Liu Y, Wu S, Cui N, Yang F, Liu S
Frontiers in endocrinology 2023;14:1223423

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Pu Q, Yang F, Zhao R, Jiang S, Tang Y, Han T
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Heliyon 2023 Nov;9(11):e21282

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Zhong S, Chen W, Wang B, Gao C, Liu X, Song Y, Qi H, Liu H, Wu T, Wang R, Chen B
Redox biology 2023 Jul;63:102760

Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro.

Huang Q, Zhang Y, Jiang Y, Huang L, Liu Q, Ouyang D
Chinese journal of natural medicines 2023 Jul;21(7):516-526

Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.

Guo HH, Shen HR, Wang LL, Luo ZG, Zhang JL, Zhang HJ, Gao TL, Han YX, Jiang JD
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Daughter cell fate choice instructed preemptively by mother cells facing nutrient limitation.

Zheng D, Mao Y, Gao Y, He F, Ma J
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Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.

Zhou XH, Cheng ZP, Lu M, Lin WY, Luo LL, Ming ZY, Hu Y
Acta pharmacologica Sinica 2023 Feb;44(2):356-366

Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.

Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
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Different levels of autophagy induced by transient serum starvation regulate metabolism and differentiation of porcine skeletal muscle satellite cells.

Wang Y, Gao J, Fan B, Hu Y, Yang Y, Wu Y, Li F, Ju H
Scientific reports 2023 Aug 12;13(1):13153

Fatty Acid Excess Dysregulates CARF to Initiate the Development of Hepatic Steatosis.

Hasan KM, Parveen M, Pena A, Bautista F, Rivera JC, Huerta RR, Martinez E, Espinoza-Derout J, Sinha-Hikim AP, Friedman TC
Cells 2023 Apr 1;12(7)

Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.

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Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-[Formula: see text]B Signaling Pathway.

Huang ZW, Tan P, Yi XK, Chen H, Sun B, Shi H, Mou ZQ, Cheng YL, Li TX, Li Q, Fu WG
The American journal of Chinese medicine 2022;50(8):2185-2197

Metformin Improves the Prognosis of Adult Mice with Sepsis-Associated Encephalopathy Better than That of Aged Mice.

Song G, Liang H, Song H, Ding X, Wang D, Zhang X, Sun T
Journal of immunology research 2022;2022:3218452

Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.

Ye Z, Ma J, Liu Y, Xu B, Dai X, Fu M, Tian T, Sui X, Mo F, Gao S, Zhao D, Zhang D
Frontiers in pharmacology 2022;13:950535

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Peng Y, Liao K, Tan F, Liang Y, Sun X, Cui Z, Ye B, Chen Z, Tang S, Chen J
Experimental eye research 2022 Sep;222:109158

Apelin-13 attenuates depressive-like behaviors induced by chronic unpredictable mild stress via activating AMPK/PGC-1α/FNDC5/BDNF pathway.

Hu S, He L, Chen B, You Y
Peptides 2022 Oct;156:170847

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Food chemistry 2022 Oct 15;391:133284

CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.

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Molecular carcinogenesis 2022 Nov;61(11):1043-1055

Dietary N(ε)-(carboxymethyl) lysine affects cardiac glucose metabolism and myocardial remodeling in mice.

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World journal of diabetes 2022 Nov 15;13(11):972-985

Transcriptomics combined with metabolomics analysis of the mechanism of agmatine in the treatment of septic liver injury.

Huang L, Gan L, Pan J, Zhong L, Wang Q, Luo S, Tian J, Liang H
Annals of translational medicine 2022 May;10(10):578

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International journal of molecular sciences 2022 May 17;23(10)

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Thoracic cancer 2022 Jan;13(2):190-201

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Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.

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Redox biology 2022 Aug;54:102390

Maternal L-carnitine supplementation promotes brown adipose tissue thermogenesis of newborn goats after cold exposure.

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Cells 2022 Aug 30;11(17)

Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology.

Chen Y, Li Q, Ren S, Chen T, Zhai B, Cheng J, Shi X, Song L, Fan Y, Guo D
Journal of Zhejiang University. Science. B 2022 Aug 15;23(8):682-698

An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer's Disease.

Li YQ, Chen Y, Jiang SQ, Shi YY, Jiang XL, Wu SS, Zhou P, Wang HY, Li P, Li F
Frontiers in cell and developmental biology 2021;9:652310

Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.

Hu C, Cao Y, Li P, Tang X, Yang M, Gu S, Xiong K, Li T, Xiao T
Journal of oncology 2021;2021:8281718

Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.

Zhang S, Zhang R, Qiao P, Ma X, Lu R, Wang F, Li C, E L, Liu H
Stem cells international 2021;2021:6616240

Stimulation of AMPK Prevents Diabetes-Induced Photoreceptor Cell Degeneration.

Song S, Bao S, Zhang C, Zhang J, Lv J, Li X, Chudhary M, Ren X, Kong L
Oxidative medicine and cellular longevity 2021;2021:5587340

Integrated application of metabolomics and RNA-seq reveals thermogenic regulation in goat brown adipose tissues.

Wang Y, Chen X, Fan W, Zhang X, Zhan S, Zhong T, Guo J, Cao J, Li L, Zhang H, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Sep;35(9):e21868

Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.

Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558

Stanniocalcin-1 Protected Astrocytes from Hypoxic Damage Through the AMPK Pathway.

Sun B, He S, Liu B, Xu G, Guoji E, Feng L, Xu L, Chen D, Zhao W, Chen J, Gao Y, Zhang E
Neurochemical research 2021 Nov;46(11):2948-2957

WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1.

Zheng Z, Li Y, Fan S, An J, Luo X, Liang M, Zhu F, Huang K
Cell death & disease 2021 Mar 3;12(3):228

Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis.

Liu S, Xu A, Gao Y, Xie Y, Liu Z, Sun M, Mao H, Wang X
Journal of nanobiotechnology 2021 Mar 25;19(1):85

Paeoniflorin suppresses allergic and inflammatory responses by promoting autophagy in rats with urticaria.

Guo J, Peng L, Zeng J, Zhang M, Xu F, Zhang X, Wei Q
Experimental and therapeutic medicine 2021 Jun;21(6):590

Different Proportions of Branched-Chain Amino Acids Modulate Lipid Metabolism in a Finishing Pig Model.

Zhang L, Li F, Guo Q, Duan Y, Wang W, Yang Y, Yin Y, Gong S, Han M, Yin Y
Journal of agricultural and food chemistry 2021 Jun 30;69(25):7037-7048

A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice.

Li X, Yang L, Li J, Lin L, Zheng G
Food & function 2021 Jul 5;12(13):5862-5875

In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma.

Chen H, Sa G, Li L, He S, Wu T
European journal of pharmacology 2021 Jan 15;891:173757

Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.

Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380

Regulating the immunosuppressive tumor microenvironment to enhance breast cancer immunotherapy using pH-responsive hybrid membrane-coated nanoparticles.

Gong C, Yu X, Zhang W, Han L, Wang R, Wang Y, Gao S, Yuan Y
Journal of nanobiotechnology 2021 Feb 25;19(1):58

Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway.

Shu X, Cao KY, Liu HQ, Yu L, Sun LX, Yang ZH, Wu CA, Ran YL
Stem cell research & therapy 2021 Feb 12;12(1):119

Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner.

Chen X, Zou D, Chen X, Wu H, Xu D
Journal of physiology and biochemistry 2021 Aug;77(3):405-417

Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.

Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, Chen Z, Wang Y, Zou Q, Wang L
European journal of nutrition 2021 Apr;60(3):1655-1668

The Histone Demethylase JMJD1C Regulates CAMKK2-AMPK Signaling to Participate in Cardiac Hypertrophy.

Yu S, Li Y, Zhao H, Wang Q, Chen P
Frontiers in physiology 2020;11:539

Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.

Song Q, He Z, Li B, Liu J, Liu L, Liao W, Xiong Y, Song C, Yang S, Liu Y
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610

Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway.

Luo J, Tang C, Chen X, Ren Z, Qu H, Chen R, Tong Z
International journal of environmental research and public health 2020 Mar 19;17(6)

QiDiTangShen Granules Activate Renal Nutrient-Sensing Associated Autophagy in db/db Mice.

Wang X, Zhao L, Ajay AK, Jiao B, Zhang X, Wang C, Gao X, Yuan Z, Liu H, Liu WJ
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GABA attenuates ETEC-induced intestinal epithelial cell apoptosis involving GABA(A)R signaling and the AMPK-autophagy pathway.

Xia Y, Chen S, Zhao Y, Chen S, Huang R, Zhu G, Yin Y, Ren W, Deng J
Food & function 2019 Nov 1;10(11):7509-7522

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