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Learn66888-1-Ig
antibody from Proteintech Group
Targeting: MTOR
FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [678]
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- Product number
- 66888-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- mTOR antibody
- Antibody type
- Monoclonal
- Description
- mTOR antibody (Cat. #66888-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1G11A3
- Vial size
- 20ul, 150ul
Submitted references A Novel Autophagy Inhibitor p-Hydroxylcinnamaldehyde Suppresses Esophageal Squamous Cell Carcinoma by Targeting LDHA Phosphorylation-Mediated Metabolic Reprogramming.
The mTOR Inhibitor Rapamycin Attenuates Ozone-Induced Airway Inflammation and Emphysema In Mice.
Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion.
Protopanaxatriol ameliorates diabetic retinopathy by regulating mTOR/G6PD mediated pentose phosphate pathway.
A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting.
Mo-Rubbing abdominal improves metabolic homeostasis in type 2 diabetes mellitus mice via a jejunum-specific GLP1-dependent mechanism.
Serine Supplementation Attenuates High-Selenium-Induced Insulin Resistance via Feedback Inhibition of PHGDH in Mice.
Eupalinolide B ameliorates liver fibrosis by targeting PKCα to suppress the AKT/mTOR axis in hepatic stellate cells.
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT.
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.
A Brain-Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF-β1/PI3K-AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses.
PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma.
An integrated network pharmacology and proteomics approach reveals the anti-fibrotic effect of Fushen Granule on peritoneal fibrosis.
Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing.
Parthenolide Attenuates Skeletal Muscle Atrophy Through Regulation of Protein Homeostasis and Inhibition of Inflammation.
Integrating multi-omics approaches to elucidate the mechanism of XiaoPi Decoction in treating hyperplasia of mammary glands via AMPK signaling pathway activation.
Therapeutic potential of 20-Hydroxyecdysone in pulmonary arterial hypertension: involvement of Mas receptor and PI3K-Akt pathway.
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Mechanism of isoleucyl-tRNA synthetase 2 regulating proliferation and apoptosis of cervical cancer cells.
Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival.
Overexpression of As3mt Attenuates Sodium Arsenite Induced Ferritinophagy and Hepatic Lipid Accumulation in Mice.
The Mechanism of Combined Exposure of Polystyrene Microplastics and Cadmium Inducing Hepatic Injury through the Modulation of PI3K/AKT/mTOR-Mediated Autophagy.
RNA-binding Protein NMD3 Promotes Osteosarcoma Cell Proliferation Via Regulating mTOR Signaling Pathway, Exerting Adverse Impacts on Patient Prognosis.
Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pathogenesis of polycystic ovary syndrome.
Androsin alleviates colorectal cancer by inhibiting the PI3K/Akt-centered signaling pathway.
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
ACE2 impairs epidermal regeneration by inhibiting TNC expression and PI3K/AKT/mTOR signaling.
Resveratrol triggers autophagy-dependent apoptosis via suppressing the PI3K/AKT/mTOR pathway in Chlamydia psittaci-infected cells.
Atractylenolide I ameliorates acute-on-chronic liver failure (ACLF) by promoting autophagy and preserving mitochondrial function through mTOR inhibition.
Pterostilbene inhibits ferritinophagy-mediated ferroptosis via the NRF2/NCOA4/FTH1 axis and alleviates intervertebral disc degeneration through nanoliposomal delivery.
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair.
Ketogenic diet modulates AMPK-mTOR pathway in breast cancer.
Design, synthesis, and biological evaluation of selective cytotoxicity-derived Miliusol derivatives inducing profound TNBC regression in vivo.
Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis.
IMPDH2 facilitates CD4+ T cell activation through AKT/mTOR pathway by upregulating SRPK1 in myasthenia gravis.
Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation.
Ubiquitin-mediated immunoglobulin-binding protein 1 degradation promotes autophagy and sperm capacitation in vitro.
Jiawei Qingxin Zishen Decoction mitigates granulosa cell apoptosis and enhances ovarian reserve through Netrin/UNC5B signaling pathway.
Multi-omics analysis reveals the mechanism of Cistanche deserticola against alcoholic liver disease via bile salt hydrolase and SCD1.
Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation.
Integrated Phosphoproteomics Identifies TGFβ-Dependent Phosphorylation Events Linking Kinase Signaling to Autophagy in Palatogenesis.
A Molecular and Functional Investigation of the Anabolic Effect of an Essential Amino Acids' Blend Which Is Active In Vitro in Supporting Muscle Function.
KIN17 facilitates the initiation and progression of renal tumor progression through the PI3K-AKT-mTOR pathway.
NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin.
BCAR3 Hypomethylation as a Potential Diagnostic Marker for Thyroid Cancer and Its Mechanism via Promoting EMT and AKT/mTOR Pathway.
Integrated microbiota and metabolomic analysis demonstrates the growth-promoting effects of Lactobacillus plantarum in Nile tilapia (Oreochromis nilotica).
FMDV VP3 Induces IL-10 Expression in Porcine Macrophages via PI3K Interaction and PI3K/AKT-mTOR Pathway Activation.
Construction and clinical validation of a machine-learning-based consensus prognostic signature (MLPS) for osteosarcoma via multi-cohort data integration.
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy.
Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress.
L-tetrahydropalmatine attenuates methamphetamine-induced pulmonary vascular remodeling via CaSR-BMP2/mTOR signaling.
OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis.
A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
DLGAP5 regulates malignancy and lenvatinib sensitivity of hepatocellular carcinoma through AKT/mTOR/NF-κB pathway.
Liver-muscle metabolic crosstalk: xanthosine as a key effector of broiler myogenesis.
Neuron-Derived Sema3B Facilitates Microglial Hematoma Clearance After Intracerebral Hemorrhage.
Lipophagy Dynamics in Hyperlipidemia Model ICR Mice Across Different High-Fat-Diet Feeding Durations.
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Identification of immune-related targets of N6-methyladenosine regulators in hepatocellular carcinoma via RNA-seq analysis.
Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation.
ANGPTL8 accelerates bone loss in diabetic mice by promoting osteoclastic differentiation and inhibiting osteoblastic differentiation through AMPK pathway-mediated metabolic reprogramming.
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.
Adiponectin Receptor 1-vascular endothelial growth factor axis mediates resistance to epidermal growth factor receptor-targeted therapy in nasopharyngeal carcinoma.
miR-17-5p inhibits classical swine fever virus replication by targeting the PKD2-regulated AMPK/mTOR autophagy pathway.
Anmei decoction alleviates myocardial injury in sleep-deprived rats by PI3K/Akt/mTOR/HIF-1 pathway.
Monosodium Glutamate Exposure and Liver Damage: Modulatory Effects of L-Carnitine on Inflammation and Autophagy.
Marek's disease virus hijacks host nucleotide metabolism via UL23-mediated c-Myc activation.
Fighting periodontitis with a pH-triggered nanocoating: A sustained-release strategy for simvastatin delivery.
Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy pathways: macroautophagy and chaperone-mediated autophagy.
Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.
Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Induce ROS-Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2.
Supramolecular dynamic hydrogels loaded with bevacizumab nanoparticles promote hyaline cartilage regeneration by inhibiting angiogenesis.
miR-512-3p/RPS6KA2 Axis Regulates Cisplatin Resistance in Ovarian Cancer via Autophagy and Ferroptosis.
The Punicalagin Compound Mitigates Bronchial Epithelial Cell Senescence Induced by Cigarette Smoke Extract through the PAR2/mTOR Pathway.
Vimentin Regulates Alternative Polyadenylation and mTOR Signaling via ARVCF to Promote B Cell Lymphoma Progression.
Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network.
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling.
Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy.
Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury.
The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis.
Long Non-Coding RNA lncTAF15:1-1 Promotes CCL5 Secretion and Cell Migration of Monocyte-Derived Dendritic Cells via PI3K/AKT/mTOR Pathway in Systemic Lupus Erythematosus.
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Longikaurin A, a natural ent-kaurane, suppresses proliferation, invasion and tumorigenicity in oral squamous cell carcinoma cell by via inhibiting PI3K/Akt pathway in vitro and in vivo.
SREBP1-SCD1 enhanced MUFAs Biosynthesis drives Nutrient Deprived Pancreatic cancer cell Ferroptosis Resistance.
Integrating Single-Cell and Bulk RNA Sequencing Reveals the Malignant Phenotype of CBX4 in Prostate Cancer.
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.
Extracellular vesicles from prostate tumors reshape the pre-metastatic bone environment in an mTOR/RAB1A-dependent manner.
Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511.
Mycoplasma genitalium protein of adhesion inhibits human urethral epithelial cells apoptosis via CypA/PI3K/AKT/mTOR-dependent autophagy.
Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway: in vivo and in vitro studies.
Atractylenolide-I restore intestinal barrier function by targeting the S100A9/AMPK/mTOR signaling pathway.
Pseudouridine synthase 1 promotes progression of hepatocellular carcinoma via mTOR and MYC signaling pathways.
Macrophage-derived exosome piR-50971 exacerbates sepsis-induced myocardial injury by inhibiting autophagy through the upregulation of N6-Methyladenosine modification of mTOR.
Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathway.
L-cysteine mitigates busulfan-induced testicular injury through modulation of CBS/H(2)S axis.
Insight into the mechanisms of milk protein synthesis via peptides derived from Micropterus salmoides.
Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.
Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.
Involvement of the PINK1/Parkin signaling pathway in 4-vinylcyclohexene diepoxide-induced ovary toxicity in rats.
Modulating Macrophage-Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration.
Suppressed autophagy of thymic cells promotes apoptosis and thymic atrophy in COPD.
Investigating the role of 1,8-Cineole in mitigating ferroptosis in a HFSD/STZ diabetes mellitus type 2-induced model: A GEO data analysis approach.
mTOR-autophagy axis regulation by intermittent fasting promotes skeletal muscle growth and differentiation.
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.
Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis.
Pharmacological effects and mechanism of Maxing Shigan Decoction in the treatment of influenza A viral pneumonia.
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow.
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Adipose-derived stem cell exosomes promote neurological recovery after subarachnoid hemorrhage via AMPK/mTOR-mediated TFEB activation.
Orthosteric-allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer.
Study on Antitumor Secondary Metabolites from Euphorbia ebracteolata Hayata: Structural Characterization, Network Pharmacology, Molecular Docking and In Vitro.
Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways.
IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways.
Effect of activated autophagy on an animal model of vestibular migraine-like attacks.
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
Chemokines and PI3K/AKT signaling pathway mediate the spontaneously ruptured hepatocellular carcinoma through the regulation of the cell cycle.
YY1/INSIG1 enhances atherosclerosis progression by regulating AMPK-mTOR signaling.
High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.
Isovaleric acid ameliorates chronic restraint stress and resists inflammation by inhibiting NF-κB activation in mice.
Network Pharmacology and Molecular Docking Elucidate the Mechanism of Phillyrin in Colorectal Cancer.
Lactate Dehydrogenase C4 Accelerates Triple-Negative Breast Cancer Progression by Promoting Acetyl-CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation.
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway.
Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy.
Icariside II attenuates renal fibrosis through mTOR signaling modulation: an integrated approach combining network pharmacology, molecular dynamics, and in vitro validation.
SENP5 Attenuates LPS-Induced Acute Lung Injury by Inhibiting Apoptosis of Lung Epithelial Cells Through SLC7A5/mTOR Signaling Pathway.
Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway.
Novel magnolol-sulforaphane hybrids as potent antitumor agents: synthesis and biological characterization.
Paeoniflorin inhibits glioblastoma proliferation and promotes autophagy through the AKT/mTOR pathway.
Lysosomal homeostasis regulates myocardial ischemia-reperfusion injury through autophagy pathway.
Biomimetic ferritin nanocages for synergistic co-delivery of metformin and rapamycin restore neurodevelopmental homeostasis in autism spectrum disorders.
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.
Bispecific aptamers target thyrotropin receptor (TSHR) and insulin growth factor-1 receptor (IGF-1R) for the improvement of orbital fibroblasts activation in the treatment of thyroid-associated ophthalmopathy.
Autophagy-targeted intervention synergized with pegaspargase: an innovative therapeutic paradigm for pancreatic cancer.
PPA1 promotes oxidative phosphorylation and malignant progression of colorectal cancer under glucose restriction via AMPK/ULK1/FUNDC1-mediated mitophagy.
KAL suppresses cholangiocarcinoma growth via downregulating miR-21 and modulating the PTEN/AKT signaling pathway.
Integrating serum pharmacochemistry, network pharmacology, and metabolomics to explore the protective mechanism of Hua-Feng-Dan in ischemic stroke.
LRP12 promotes gastric cancer progression through AKT/mTOR signaling and M2 macrophage-mediated immunosuppression.
Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism.
miR-199a functions downstream of MeCP2 in neurons of MECP2 duplication syndrome models.
Astragalin rescues Cadmium-induced cognitive decline by revering glial metabolic reprogramming and neuroinflammation via the mTOR/HIF-1α axis.
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Exosomal lncRNA MIR210HG derived from hypoxic TAMs promotes the metastasis of triple negative breast cancer.
Gallic Acid Alleviates Cerebral Ischemia-reperfusion Injury in Mice by Mediating Microglial Polarization Through the NLRP3/mTOR Axis.
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy.
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.
Oleracein E Rejuvenates Senescent Hippocampal NSCs by Inhibiting the ERK1/2-mTOR Axis to Improve Cognitive Dysfunction in Vascular Dementia.
NSUN2-mediated m5C modification of circFAM190B promotes lung cancer progression by inhibiting cellular autophagy.
Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation.
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m(6)A modification in triple-negative breast cancer.
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
Estradiol and vitamin D exert a synergistic effect on preventing osteoporosis via the miR-351-5p/IRS1 axis and mTOR/NFκB signaling pathway.
Lysionotin promoted apoptosis of hepatocellular carcinoma cells via inducing autophagy.
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata.
Modified weiling decoction inhibited excessive autophagy via AKT/mTOR/ULK1 pathway to alleviate T2DM: Integrating network pharmacology and experimental validation.
Creatine promotes osteogenic differentiation of dental pulp stem cells via the AMPK-ULK1-autophagy axis.
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Knockdown of SESN2 Exacerbates Cerebral Ischemia-Reperfusion Injury Through Enhancing Glycolysis via the mTOR/HIF-1α Pathway.
Aerobic exercise improves energy and glucose homeostasis through hypothalamic Mitofusion 2-rescued endoplasmic reticulum stress in diet-induced obese mice.
Long-term leucine supplementation increases body weight in goats by controlling appetite and muscle protein synthesis under protein-restricted conditions.
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione mediates the effect of ROS-enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer.
USP5 Promotes Head and Neck Squamous Cell Carcinoma Progression via mTOR Signaling Pathway.
CircMRP4 orchestrates podocytes injury via the miR-499-5p/RRAGB/mTORC1 axis in diabetic kidney disease.
Extracellular vesicle-packaged PKM2 from endometriotic stromal cells promotes endometrial collagen I deposition by inhibiting autophagy in endometriosis.
Citrulline regulates macrophage metabolism and inflammation to counter aging in mice.
Nuciferine Restores Autophagy via the PI3K-AKT-mTOR Pathway to Alleviate Renal Fibrosis in Diabetic Kidney Disease.
miR-21 regulates autophagy and apoptosis of ectopic endometrial stromal cells of adenomyosis via PI3K/ AKT/ mTOR pathway.
Lactoferrin influences atherosclerotic progression by modulating macrophagic AMPK/mTOR signaling-dependent autophagy.
Role of octamer transcription factor 4 in proliferation, migration, drug sensitivity, and stemness maintenance of pancreatic cancer cells.
CDX1 improves nicotine induced cardiac fibroblasts activation and cardiomyocyte hypertrophy by alleviating autophagic flux impairment through modulation of LAPTM4B.
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
MT1H inhibits the growth of gastric cancer by regulating SLC6A19/TTC39B/ADM2 and activating p53-dependent autophagy.
Lactobacillus plantarum SMUM211204 Exopolysaccharides Have Tumor-Suppressive Effects on Colorectal Cancer by Regulating Autophagy via the mTOR Pathway.
Mark3 a Prognostic Marker for the Endometrial Cancer.
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Leucyl-tRNA synthetase regulates casein synthesis in dairy cows via the mTORC1-LAT1 pathway.
Charge-reversed small extracellular vesicles from human adipose-derived mesenchymal stromal cells attenuate renal fibrosis postacute kidney injury by inhibiting epithelial-mesenchymal transition progression in SD rat model.
The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy.
WITHDRAWN: Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signaling pathway: In vivo and in vitro studies.
Triptonide facilitates autophagy-mediated apoptosis in esophageal squamous cell carcinoma by targeting the AMPK-mTOR-ULK1 axis.
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Independent and synergistic effects of extreme heat and NO(2) pollution on diabetic nephropathy in a type II diabetes mouse model.
Novel ALK inhibitors containing DAAP fragments: Rational drug design and anti-tumor activity research.
Podophyllum hexandrum Royle mitigates perimenopausal symptoms in an OVX rat model by activating the PI3K/AKT/mTOR pathway and enhancing estrogen receptor expression.
Deciphering the polypharmacology of Dingzhi Xiaowan against comorbid depression: Integrated metabolomics of brain tissue and network pharmacology analysis in chronic restraint stress (CRS)-LPS model.
Comprehensive multi-omics analysis of histone acetylation modulators identifies ASH1L as a novel aggressive marker for osteosarcoma.
Effects of Long-Term Blue Light Exposure on Body Fat Synthesis and Body Weight Gain in Mice and the Inhibitory Effect of Tranexamic Acid.
Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis.
Anti-sarcopenic effects of active vitamin D through modulation of anabolic and catabolic signaling pathways in human skeletal muscle: A randomized controlled trial.
Procyanidin C1 ameliorates aging-related skin fibrosis through targeting EGFR to inhibit TGFβ/SMAD pathway.
Synergic effect of the combination of isoliquiritigenin and arsenic trioxide in HepG2 liver cancer cells.
2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling.
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice.
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.
TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway.
The mechanism of Bletilla striata inhibiting glioma proliferation through the PI3K/AKT/mTOR signaling pathway based on network Pharmacology analysis.
Defective Hippocampal Primary Ciliary Function and Aberrant LKB1/AMPK Signaling Pathway Are Associated With the Inhibition of Autophagic Activity in Offspring Born to Mothers of Advanced Maternal Age.
O-GlcNAcylation of progranulin promotes hepatocellular carcinoma proliferation.
PCSK9 promotes vascular neointimal hyperplasia through non-lipid regulation of vascular smooth muscle cell proliferation, migration, and autophagy.
Niraparib perturbs autophagosome-lysosome fusion in pancreatic ductal adenocarcinoma and exhibits anticancer potential against gemcitabine-resistant PDAC.
IL-17A's role in exacerbating radiation-induced lung injury: Autophagy impairment via the PP2A-mTOR pathway.
Trametinib and M17, a novel small molecule inhibitor of AKT, display a synergistic antitumor effect in triple negative breast cancer cells through the AKT/mTOR and MEK/ERK pathways.
Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13.
GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy.
MYBL2 promotes proliferation of clear cell renal cell carcinoma by regulating TOP2A and activating AKT/mTOR signaling pathway.
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation.
HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.
DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism.
Sulforaphane regulation autophagy-mediated pyroptosis in autoimmune hepatitis via AMPK/mTOR pathway.
Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models.
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice.
Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis.
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1.
Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept.
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis.
GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway.
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma.
Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway.
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring.
Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis.
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Macrophage-mimicking nanotherapy for attenuation of acute pancreatitis.
MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis.
The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.
Repressing cytokine storm-like response in macrophages by targeting the eIF2α-integrated stress response pathway.
TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer.
SJB2-043, a USP1 Inhibitor, Suppresses A549 Cell Proliferation, Migration, and EMT via Modulation of PI3K/AKT/mTOR, MAPK, and Wnt Signaling Pathways.
Molecular Observations on the Regulation of hIAPP Aggregation Process and Enhancement of Autophagy by the Short Peptide LPFYPN and Its Modified Peptides of Coix Seed Prolamins.
RhoB regulates prostate cancer cell proliferation and docetaxel sensitivity via the PI3K-AKT signaling pathway.
THSWD upregulates the LTF/AMPK/mTOR/Becn1 axis and promotes lysosomal autophagy in hepatocellular carcinoma cells by regulating gut flora and metabolic reprogramming.
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Network pharmacology, molecular docking and biological verification to explore the potential anti-prostate cancer mechanisms of Tripterygium wilfordii Hook. F.
Ginsenoside Rg1 Alleviates Hydrogen Peroxide-Induced Autophagy and Apoptosis in Ovarian Granulosa Cells.
High-Glucose Microenvironment Accelerates Malignant Progression Via O-GlcNAcylation in Oral Squamous Cell Carcinoma.
Comprehensive analysis of the leukocyte immunoglobulin-like receptor family in clear cell renal cell carcinoma.
Trichinella spiralis excretory-secretory proteins induced autophagy via activating AMPK/mTOR pathway and protected gut epithelial barrier.
α-hederin decreases the glycolysis level in intestinal epithelial cells via SNX10-mediated DEPDC5 degradation.
Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.
Obesity-induced gut microbiota transplantation promotes the occurrence and development of hepatocellular carcinoma.
Phosvitin-Derived Peptide Pt5-1c Is a Pro-Angiogenic Agent Capable of Enhancing Wound Healing.
HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells.
Sestrin 2 Regulates Milk Protein Synthesis through a LAT1/mTOR Pathway.
Quercetin Regulates Autophagy to Inhibit PRRSV Replication Through the PI3K/Akt/mTOR Signaling Pathway.
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
SMURF2 Inhibits Autophagy and Growth in Ovarian Cancer by Regulating the RACK1/AKT/mTOR Pathway.
Epigallocatechin-3-Gallate Attenuates Benign Prostatic Hyperplasia Development via Regulating Firmicutes to Inhibit Gastric Secretion of Insulin-Like Growth Factor-1.
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
NUTF2 Promotes Proliferation of Oral Squamous Cell Carcinoma Through PI3K/AKT Signaling Pathway.
Clostridium butyricum ameliorates post-gastrectomy insulin resistance by regulating the mTORC1 signaling pathway through the gut-liver axis.
1,3-Dichloro-2-propanol Causes Lipid Droplet Accumulation by Inhibiting Autophagy via REV-ERBα in Hepatocytes.
AP1S3 affects lipid metabolism in breast cancer cells by regulating the PI3K/AKT/mTOR pathway.
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.
Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4(QTY)-Fc as a molecular trap.
Irisolidone enhances osteoblast differentiation via the AMPK-ULK1-autophagy Axis to accelerate osteoporotic fracture repair.
Activation of mTOR/HK2 signaling mitigates effects of PYCR2 depletion in colorectal cells.
Isoliquiritigenin, an Extract from Licorice, Attenuates Dexamethasone-Induced Muscle Atrophy via Akt/mTOR Pathway.
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
Phlecarinatones H-N: Abietane-type diterpenoids from Phlegmariurus carinatus with proliferative inhibitory effect on U251 glioblastoma cells.
Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy.
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Tricin Delays Aging and Enhances Muscle Function via Activating AMPK-Mediated Autophagy in Diverse Model Organisms.
Comprehensive analysis illustrating the role of HOXB8 in head and neck squamous cell carcinoma: evidence from multi-omics analysis and experiments validation.
Baicalin Relieves Glaesserella parasuis-Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets.
Carbon dot-based treatment for bacterial pneumonia by promoting a PI3K-mediated M1 polarization of macrophages.
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
SNX10 Is Involved in Ovarian Cancer Cell Metastasis by Repolarizing Tumor-Associated Macrophages Through mTOR1/Lysosomes Pathway.
KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids.
lncRNA NR_146969 promotes the progression of lung adenocarcinoma.
Methylmercury Chloride Exposure Affects Oocyte Maturation Through AMPK/mTOR-Mediated Mitochondrial Autophagy.
Chryxanthone A, an extracted substance from endophytic fungal Aspergillus versicolor, produces anti-oxidant neuroprotection possibly via the action on mTOR/CREB axis.
Network Analysis and Basic Experiments on the Inhibition of Renal Cancer Proliferation and Migration by Alpinetin through PI3K/AKT/ mTOR Pathway.
HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling.
IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway.
CD52 knockdown inhibits aerobic glycolysis and malignant behavior of NSCLC cells through AKT signaling pathway.
miR-769-3p inhibits cellular proliferation of KSHV-infected SH-SY5Y cells through targeting mTOR.
Microbiota-derived tryptophan metabolism and AMPK/mTOR pathway mediate antidepressant-like effect of Shugan Hewei Decoction.
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Enhancing angiogenesis in peri-implant soft tissue with bioactive silk fibroin microgroove coatings on zirconia surfaces.
IDN5706 Inhibits Synovial Inflammation via Inducing M2 Polarization of Synovial Macrophages in Osteoarthritis Rats.
TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation.
Potential of semen coicis in enhancing the anti-tumor effects of PD-1 inhibitor on A549 cell lines by blocking the PI3K-AKT-mTOR pathway.
Panax notoginseng saponins dually modulates autophagy in gastric precancerous lesions complicated with myocardial ischemia-reperfusion injury model through the PI3K/AKT/mTOR pathway.
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.
Autophagy Deficiency Induced by SAT1 Potentiates Tumor Progression in Triple-Negative Breast Cancer.
Selenomethionine Promotes Milk Protein and Fat Synthesis and Proliferation of Mammary Epithelial Cells through the GPR37-mTOR-S6K1 Signaling.
Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.
Clarithromycin attenuates airway epithelial-mesenchymal transition in ovalbumin-induced asthmatic mice through modulation of Kv1.3 channels and PI3K/Akt signaling.
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis.
GQ262 Attenuates Pathological Cardiac Remodeling by Downregulating the Akt/mTOR Signaling Pathway.
Signaling proteins in HSC fate determination are unequally segregated during asymmetric cell division.
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Mechanisms of Yiai Fuzheng formula in the treatment of triple-negative breast cancer based on UPLC-Q-Orbitrap-HRMS, network pharmacology, and experimental validation.
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
FAT10 induces immune suppression by upregulating PD-L1 expression in hepatocellular carcinoma.
SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.
Dihydroberberine alleviates Th17/Treg imbalance in premature ovarian insufficiency mice via inhibiting Rheb/mTOR signaling.
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice.
Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway.
Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma.
SCYL1-mediated regulation of the mTORC1 signaling pathway inhibits autophagy and promotes gastric cancer metastasis.
Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer.
USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1.
Propyl acetate protects intestinal barrier during parenteral nutrition in mice and Caco-2 cells.
Protective effect of folic acid on MNNG-induced proliferation of esophageal epithelial cells via the PI3K/AKT/mTOR signaling pathway.
Neutralization of TLR2 in combination with either TNF-α or IL-1β antibody reduces the severity of septic arthritis through STAT3/mTOR signalling in lymphocytes.
Taurine Inhibits Lung Metastasis in Triple-Negative Breast Cancer by Modulating Macrophage Polarization Through PTEN-PI3K/Akt/mTOR Pathway.
Momordica charantia Extract Ameliorates Melanoma Cell Proliferation and Invasion into Mouse Lungs by Suppressing PAX3 Expression.
Piezo1 Modulates Neuronal Autophagy and Apoptosis in Cerebral Ischemia-Reperfusion Injury Through the AMPK-mTOR Signaling Pathway.
Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.
EYA3 promotes the tumorigenesis of gastric cancer through activation of the mTORC1 signaling pathway and inhibition of autophagy.
Succinylation modification-mediated upregulation of Sp1 promotes hepatocellular carcinoma cell proliferation.
Folic Acid Attenuates N-Methyl-N'-Nitro-N-NitrosoguanidineInduced Gastric Mucosal Injury in Rats.
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity.
Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy.
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis.
SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice.
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits.
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.
Rapamycin improves the survival of epilepsy model cells by blocking phosphorylation of mTOR base on computer simulations and cellular experiments.
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
SULF1 regulates malignant progression of colorectal cancer by modulating ARSH via FAK/PI3K/AKT/mTOR signaling.
RNA sequencing screening and gene function analysis uncover G protein-coupled receptor 183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells.
Investigating the potential role of α-SNAP in preventing chemotherapy-induced ovarian dysfunction: Insights from cellular and animal models.
Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma.
Treg and neutrophil extracellular trap interaction contributes to the development of immunosuppression in sepsis.
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
TGF β1 promotes the polarization of M2-type macrophages and activates PI3K/mTOR signaling pathway by inhibiting ISG20 to sensitize ovarian cancer to cisplatin.
SIAH2 is specifically expressed during cervical carcinogenesis, and closely relates to the abnormal proliferation of cervical epithelial cells.
Electrical Pulse Stimulation Protects C2C12 Myotubes against Hydrogen Peroxide-Induced Cytotoxicity via Nrf2/Antioxidant Pathway.
The autophagy-mediated mechanism via TSC1/mTOR signaling pathway in thiram-induced tibial dyschondroplasia of broilers.
The therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism.
Metformin mitigates adipogenesis of fibro-adipogenic progenitors after rotator cuff tears via activating mTOR/ULK1-mediated autophagy.
PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis.
Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway.
LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.
Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways.
Hydrogen Sulfide Promotes Platelet Autophagy via PDGFR-α/PI3K/Akt Signaling in Cirrhotic Thrombocytopenia.
KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway.
Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.
Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster-positive hepatocellular carcinoma patients who have undergone living donor liver transplantation.
Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training.
Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice.
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin.
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Chrysophanol induces apoptosis and ferroptosis of gastric cancer cells by targeted regulation of mTOR.
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Tumor-associated macrophage-derived exosomal miR-513b-5p is a target of jianpi yangzheng decoction for inhibiting gastric cancer.
PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis.
METTL3-Mediated m(6)A Modification of FMRP Drives Hepatocellular Carcinoma Progression and Indicates Poor Prognosis.
TGN-020 ameliorates motor dysfunction post-spinal cord injury via enhancing astrocyte autophagy and mitigating inflammation by activating AQP4/PPAR-γ/mTOR pathway.
High-level L-Gln compromises intestinal amino acid utilization efficiency and inhibits protein synthesis by GCN2/eIF2α/ATF4 signaling pathway in piglets fed low-crude protein diets.
MLN4924 Suppresses head and neck squamous cell carcinoma progression by inactivating the mTOR signaling pathway via the NEDD8/CUL4/TSC2 axis.
Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis.
Gnetupendin A protects against ischemic stroke through activating the PI3K/AKT/mTOR-dependent autophagy pathway.
LAMTOR1/mTORC1 promotes CD276 to induce immunosuppression via PI3K/Akt/MMP signaling pathway in Clostridium perfringens-induced necrotic enteritis of laying hens.
Identification and analysis of microplastic aggregation in CAR-T cells.
Chinese formula Guben-Jiannao Ye alleviates the dysfunction of circadian and sleep rhythms in APP/PS1 mice implicated in activation of the PI3K/AKT/mTOR signaling pathway.
Imperatorin promotes melanin degradation in keratinocytes through facilitating autophagy via the PI3K/Akt signaling pathway.
The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation.
Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway.
EIF2S2 transcriptionally upregulates HIF1α to promote gastric cancer progression via activating PI3K/AKT/mTOR pathway.
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
mTOR Inhibitor Everolimus Modulates Tumor Growth in Small-Cell Carcinoma of the Ovary, Hypercalcemic Type and Augments the Drug Sensitivity of Cancer Cells to Cisplatin.
Roles of gut microbiome-associated metabolites in pulmonary fibrosis by integrated analysis.
Osteoblast-derived exosomal miR-140-3p targets ACER2 and increases the progression of prostate cancer via the AKT/mTOR pathway-mediated inhibition of autophagy.
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.
The vitamin D receptor is essential for the replication of pseudorabies virus.
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke: Insights from Network Pharmacology and in vivo Experiments.
SCD1 promotes the stemness of gastric cancer stem cells by inhibiting ferroptosis through the SQLE/cholesterol/mTOR signalling pathway.
Silk fibroin microgrooved zirconia surfaces improve connective tissue sealing through mediating glycolysis of fibroblasts.
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression.
FANCD2 expression affects platinum response and further characteristics of high grade serous ovarian cancer in cells with different genetic backgrounds.
A Lipid-Sensitive Spider Peptide Toxin Exhibits Selective Anti-Leukemia Efficacy through Multimodal Mechanisms.
Mito-LND and (E)-Akt inhibitor-IV: novel compounds inducing endoplasmic reticulum stress and ROS accumulation against hepatocellular carcinoma.
Sestrin2 knockout exacerbates high-fat diet induced metabolic disorders and complications in female mice.
Ac-HSP20 regulates autophagy and promotes the encystation of Acanthamoeba castellanii by inhibiting the PI3K/AKT/mTOR signaling pathway.
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma.
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis.
Arsenic disturbs neural tube closure involving AMPK/PKB-mTORC1-mediated autophagy in mice.
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury.
Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1.
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy.
Network pharmacology and experimental verification reveal the mechanism of safranal against glioblastoma (GBM).
S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation.
Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.
Role of UDP-glucose ceramide glucosyltransferase in venous malformation.
Knockdown of NF-κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway.
Hirudin inhibits glioma growth through mTOR-regulated autophagy.
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model.
Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats.
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells.
Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells.
Combined Epimedii Folium and Ligustri Lucidi Fructus with dexamethasone alleviate the proliferation of airway smooth muscle cells by regulating apoptosis/autophagy.
Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study.
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis.
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.
G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy.
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway.
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
SLC25A32 promotes malignant progression of glioblastoma by activating PI3K-AKT signaling pathway.
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through the AMPK/mTOR/ULK1 pathway.
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Astragaloside IV Blunts Epithelial-Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy.
Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level.
SNRPD1 inhibition suppresses the proliferation of hepatocellular carcinoma and promotes autophagy through the PI3K/AKT/mTOR/4EBP1 pathway.
Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice.
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress.
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Activation of moderate autophagy promotes survival of fat graft.
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization.
Protocol for high-sensitivity western blot on murine hematopoietic stem cells.
Proteomic analysis reveals the molecular mechanism of Astragaloside in the treatment of non-small cell lung cancer by inducing apoptosis.
Milk Exosomes from Gestational Diabetes Mellitus (GDM) and Healthy Parturient Exhibit Differential miRNAs Profiles and Distinct Regulatory Bioactivity on Hepatocyte Proliferation.
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Different levels of autophagy induced by transient serum starvation regulate metabolism and differentiation of porcine skeletal muscle satellite cells.
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis.
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway.
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway.
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma.
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity.
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Rapamycin Attenuates Anxiety and Depressive Behavior Induced by Helicobacter pylori in Association with Reduced Circulating Levels of Ghrelin.
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway.
The diagnostic and prognostic significance of small nuclear ribonucleoprotein Sm D1 aberrantly high expression in hepatocellular carcinoma.
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn's Disease.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway.
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling.
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
SLC7A5 is a lung adenocarcinoma-specific prognostic biomarker and participates in forming immunosuppressive tumor microenvironment.
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR pathway.
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy.
Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells.
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Anti-fatigue effects of fermented soybean protein peptides in mice.
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism.
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
YB1 associates with oncogenetic roles and poor prognosis in nasopharyngeal carcinoma.
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level.
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's disease by regulating the metabolism of astrocytes.
Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Dickkopf1 (Dkk1) Alleviates Vascular Calcification by Regulating the Degradation of Phospholipase D1 (PLD1).
MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis.
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.
Plasma exosomal miR-199a-3p downregulates cell proliferation and migration in Hirschsprung's disease by targeting mTOR.
Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
CD44-fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition.
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
miR-145-5p affects autophagy by targeting CaMKIIδ in atherosclerosis.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway.
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway.
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Latcripin-7A from Lentinula edodes C(91-3) induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.
Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner.
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Comparative Proteomics of Rat Olfactory Bulb Reveal Insights into Susceptibility and Resiliency to Chronic-stress-induced Depression or Anxiety.
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea.
2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.
Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis.
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway.
Social context-dependent singing alters molecular markers of synaptic plasticity signaling in finch basal ganglia Area X.
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes.
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10.
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids.
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs.
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1α signaling pathway.
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway.
Hypothermic oxygenated machine perfusion alleviates liver injury in donation after circulatory death through activating autophagy in mice.
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Wei S, Wang J, Zhang Z, Fu Y, Zhao L, Bi Y, Li X, Dai S, Zhang C, Zhu W, Min L, Shan B, Zhao L
Research (Washington, D.C.) 2026;9:1070
Research (Washington, D.C.) 2026;9:1070
The mTOR Inhibitor Rapamycin Attenuates Ozone-Induced Airway Inflammation and Emphysema In Mice.
Tian X, Han L, Huang Y, Zhou Y, Zhang X, Zhang M
Journal of inflammation research 2026;19:545564
Journal of inflammation research 2026;19:545564
Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion.
Zhou YF, Yang SB, Zhang F, Sun XD, Chang BH, Li YN, Wu JH, Jin HJ, Huang M, Chen SC, Yang H, Zhu DY, Menon BK, Hu B
Theranostics 2026;16(7):3577-3598
Theranostics 2026;16(7):3577-3598
Protopanaxatriol ameliorates diabetic retinopathy by regulating mTOR/G6PD mediated pentose phosphate pathway.
Guan M, Yuan Z, Xie J, Cui J, Zang S, Huang J, Wang C
Journal of natural medicines 2026 May;80(3):603-624
Journal of natural medicines 2026 May;80(3):603-624
A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting.
Pei WB, Lei ZY, Xie FQ, Chen P, Su YC, Qin YS, Li JQ, Shen QW, Ma MM, Gao CY, Zhu JC, Xu YJ, Zhang KY, Zhang WQ, Zhang YD, Hu TH, Xu BB
Acta pharmacologica Sinica 2026 May;47(5):1249-1269
Acta pharmacologica Sinica 2026 May;47(5):1249-1269
Mo-Rubbing abdominal improves metabolic homeostasis in type 2 diabetes mellitus mice via a jejunum-specific GLP1-dependent mechanism.
Zhang Z, Gan L, Camille C, He X, Li L, Chen Y, Xu H, Hu J, Wei Q, Liu W, Wu Y
Diabetes, obesity & metabolism 2026 May;28(5):3819-3838
Diabetes, obesity & metabolism 2026 May;28(5):3819-3838
Serine Supplementation Attenuates High-Selenium-Induced Insulin Resistance via Feedback Inhibition of PHGDH in Mice.
Wang J, Wang Q, Han F, Xiang X, Huang J, Fang C, Liu Y, Huang Z
Biological trace element research 2026 May;204(5):3309-3326
Biological trace element research 2026 May;204(5):3309-3326
Eupalinolide B ameliorates liver fibrosis by targeting PKCα to suppress the AKT/mTOR axis in hepatic stellate cells.
Wang A, Dong H, Cui Y, Xiong Y, Jin L, Zhang Q, Zhu W, Ye J, Lin M, Luo W, Liang G, Sun J
Journal of ethnopharmacology 2026 May 23;363:121421
Journal of ethnopharmacology 2026 May 23;363:121421
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT.
Ma X, Lei P, Ren B, Xie S, Zhang Y, Wang Y, Ma W
Archives of pharmacal research 2026 Mar;49(3):357-374
Archives of pharmacal research 2026 Mar;49(3):357-374
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Wang J, Liu WW, Huang QL, Ning HJ, Wang JY, Han XH
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.
Zhang M, Wu J, Xu J, Hu X, Shi H, Huang W, Song L, Zhu J, Tan H, Yu R
International journal of biological macromolecules 2026 Mar;352:151196
International journal of biological macromolecules 2026 Mar;352:151196
A Brain-Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF-β1/PI3K-AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses.
Han Z, Li X, Zhu Y, Wang Z, Hou Y, Tao H, Ma M, Xie X, Zhang H
Journal of cellular and molecular medicine 2026 Mar;30(5):e71065
Journal of cellular and molecular medicine 2026 Mar;30(5):e71065
PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma.
Liu Y, Cheng Z, Zhang J, Zhang Y, Zhao T, Sun L, Wen G, Han T, Wang J
Autophagy 2026 Mar;22(3):468-483
Autophagy 2026 Mar;22(3):468-483
An integrated network pharmacology and proteomics approach reveals the anti-fibrotic effect of Fushen Granule on peritoneal fibrosis.
Yang K, Li J, Wang L, Yu H, Liu X, Gao Z, Wang Z, Zhang L, Yang H
BMC complementary medicine and therapies 2026 Mar 9;26(1)
BMC complementary medicine and therapies 2026 Mar 9;26(1)
Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing.
Deng X, Ren K, Min T, Ma Y, Peng Y, Wang S, Zhang B, Xie X, Nan Y, Tong S, Liu Y, Zhang Y, Li K, Wang W, Hao N, Zhang G, Dang C, Sun T, Zhu K, Zhang H
Journal of advanced research 2026 Mar 6;
Journal of advanced research 2026 Mar 6;
Parthenolide Attenuates Skeletal Muscle Atrophy Through Regulation of Protein Homeostasis and Inhibition of Inflammation.
Bai Y, Li W, Lu Y, Lai H, Ye L, Li K, Wang C, Ding Y, Li W, Chen Y, Gan K, Chen Z, He D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71660
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71660
Integrating multi-omics approaches to elucidate the mechanism of XiaoPi Decoction in treating hyperplasia of mammary glands via AMPK signaling pathway activation.
Chen L, Hu M, Ding XQ, Chen YG, Zeng QY, Zhang Z, Wang X, Liu HT
Journal of ethnopharmacology 2026 Mar 25;359:121060
Journal of ethnopharmacology 2026 Mar 25;359:121060
Therapeutic potential of 20-Hydroxyecdysone in pulmonary arterial hypertension: involvement of Mas receptor and PI3K-Akt pathway.
Lu T, Jia W, Wang Y, Ma Y, Song C, Du F, Gao H, Jin X, Li H, Liu C, Jin H, Lin Y
Cellular & molecular biology letters 2026 Mar 24;31(1)
Cellular & molecular biology letters 2026 Mar 24;31(1)
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916
iScience 2026 Mar 20;29(3):114916
Mechanism of isoleucyl-tRNA synthetase 2 regulating proliferation and apoptosis of cervical cancer cells.
Bi Y, Ye Y, Wu X, Cao H, Ma Q
Scientific reports 2026 Mar 2;16(1)
Scientific reports 2026 Mar 2;16(1)
Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival.
Chen L, Duan B, Jiang Q, Wang Y, Chen Y, Zhang L, Guo A
eLife 2026 Mar 18;14
eLife 2026 Mar 18;14
Overexpression of As3mt Attenuates Sodium Arsenite Induced Ferritinophagy and Hepatic Lipid Accumulation in Mice.
Bao JC, Yang Y, Wang Y, Xie FS
Biological trace element research 2026 Mar 17;
Biological trace element research 2026 Mar 17;
The Mechanism of Combined Exposure of Polystyrene Microplastics and Cadmium Inducing Hepatic Injury through the Modulation of PI3K/AKT/mTOR-Mediated Autophagy.
Li S, Zhang Q, Hao Y, Liu X, Li Y, Yan L, Pan G, Sun W
Chemical research in toxicology 2026 Mar 16;39(3):293-304
Chemical research in toxicology 2026 Mar 16;39(3):293-304
RNA-binding Protein NMD3 Promotes Osteosarcoma Cell Proliferation Via Regulating mTOR Signaling Pathway, Exerting Adverse Impacts on Patient Prognosis.
Zhang Z, Liu L, Liu J, Chai Y, Zhang X
Applied biochemistry and biotechnology 2026 Mar 16;
Applied biochemistry and biotechnology 2026 Mar 16;
Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pathogenesis of polycystic ovary syndrome.
Liu K, Hong Y, Gao Q, Huang J, Liu L, Li Y, Liang Y, Zhang S, He X, Nie X
Cellular and molecular life sciences : CMLS 2026 Mar 11;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 11;83(1)
Androsin alleviates colorectal cancer by inhibiting the PI3K/Akt-centered signaling pathway.
Zhang Y, Luo H, Ma P, Leng Y, Tan Y, Zhuo S, Tan C, Xu D
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2026 Mar 1;30(2):155-168
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2026 Mar 1;30(2):155-168
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Niu Z, Fan Y, Chen J, Ji L, Tong Y, Yao L, Ding S, Xu H, Chen J, Zhang Q, Zhao C, Chen J, Bi Q, Xia C
Materials today. Bio 2026 Jun;38:103038
Materials today. Bio 2026 Jun;38:103038
ACE2 impairs epidermal regeneration by inhibiting TNC expression and PI3K/AKT/mTOR signaling.
Guo Y, Bai R, Liang B, Liu W, Wen Z, Wang Z, Zhang Y, Du J, Song Y, Ma X, Yu Z
Pathology, research and practice 2026 Jun;282:156468
Pathology, research and practice 2026 Jun;282:156468
Resveratrol triggers autophagy-dependent apoptosis via suppressing the PI3K/AKT/mTOR pathway in Chlamydia psittaci-infected cells.
Zeng X, Li Y, Wang X, Luo X, Wang C, Li Z, Bai Q, Chen S, Chen L
Microbial pathogenesis 2026 Jun;215:108442
Microbial pathogenesis 2026 Jun;215:108442
Atractylenolide I ameliorates acute-on-chronic liver failure (ACLF) by promoting autophagy and preserving mitochondrial function through mTOR inhibition.
Tang D, Tuo F, Chen J, Ding L, Wu YN, Wang R
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168197
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168197
Pterostilbene inhibits ferritinophagy-mediated ferroptosis via the NRF2/NCOA4/FTH1 axis and alleviates intervertebral disc degeneration through nanoliposomal delivery.
Song Z, Yan M, Lv X, Zhang S, Kou H, Han H, Wang Z, Chen Y, Shi L, Shao Z, Hu B, Chen S, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158051
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158051
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Liu Y, Yang X, Qin M, Chen W, Liu C, Jiang W, Wang Y, Tan S, Sun H, Chen J, Sun H, He S
Journal of ethnopharmacology 2026 Jun 28;365:121554
Journal of ethnopharmacology 2026 Jun 28;365:121554
A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair.
Sun X, Xie S, Fang Y, Zhang D, Wang W, Sun Z, Lu J, Yue X, Kong W, Fu D, Xu X, Dai K, Wang J, Wei J, Sun X
Bioactive materials 2026 Jul;61:692-711
Bioactive materials 2026 Jul;61:692-711
Ketogenic diet modulates AMPK-mTOR pathway in breast cancer.
Luo Y, Li J, Yang Y, Yan L, Huang Z, Chen L, Zhao L, Wang J, Yang Y, Liu X, Yang X
The Journal of nutritional biochemistry 2026 Jul;153:110312
The Journal of nutritional biochemistry 2026 Jul;153:110312
Design, synthesis, and biological evaluation of selective cytotoxicity-derived Miliusol derivatives inducing profound TNBC regression in vivo.
Cheng X, Chen W, Hao W, Guo Y, Zhang J, Song C, He Z, Wu H, Yao D
Bioorganic & medicinal chemistry 2026 Jul;138:118680
Bioorganic & medicinal chemistry 2026 Jul;138:118680
Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis.
Pan R, Zhang Y, Wang H, Guan J, Chen Z, Xiao L, Ru N, Zhao J, Cheng Y, Feng S, Zheng X
Translational oncology 2026 Jan;63:102569
Translational oncology 2026 Jan;63:102569
IMPDH2 facilitates CD4+ T cell activation through AKT/mTOR pathway by upregulating SRPK1 in myasthenia gravis.
Ren Y, Wu T, Liu Z, Li L, Li Y, Xin G, Peng S, Niu J, Chen B, Cai H, Tian Q, Wang L, Zhang H
Clinical immunology (Orlando, Fla.) 2026 Jan;282:110634
Clinical immunology (Orlando, Fla.) 2026 Jan;282:110634
Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation.
Zhao N, Zhou X, Li Z, Liang L, Bao J, Chen X, Shu P, Zhong J
Journal of photochemistry and photobiology. B, Biology 2026 Jan;274:113343
Journal of photochemistry and photobiology. B, Biology 2026 Jan;274:113343
Ubiquitin-mediated immunoglobulin-binding protein 1 degradation promotes autophagy and sperm capacitation in vitro.
Qu X, Lv Y, Zhang Y, Cao L, Zhang J, Chen X, Jin Y
Andrology 2026 Jan;14(1):109-121
Andrology 2026 Jan;14(1):109-121
Jiawei Qingxin Zishen Decoction mitigates granulosa cell apoptosis and enhances ovarian reserve through Netrin/UNC5B signaling pathway.
Shen T, Yu Q, Zhang J, Wang J, Wang J, Zhou T, Wang J, Zhao X
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120686
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120686
Multi-omics analysis reveals the mechanism of Cistanche deserticola against alcoholic liver disease via bile salt hydrolase and SCD1.
Yuan S, Gao P, Lei J, Sun J, Fang X, Tu P, Lu Y, Jiang Y
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120626
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120626
Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation.
Fang Y, Mou C, Yu X, Zhang J, Zhu W, Zhou C, Jiang B, Chen Y
Hereditas 2026 Jan 27;163(1):31
Hereditas 2026 Jan 27;163(1):31
Integrated Phosphoproteomics Identifies TGFβ-Dependent Phosphorylation Events Linking Kinase Signaling to Autophagy in Palatogenesis.
Peng X, Chen J, Zheng X, Zhao X, Wang Y, Wang X, Du J
Proteomes 2026 Jan 23;14(1)
Proteomes 2026 Jan 23;14(1)
A Molecular and Functional Investigation of the Anabolic Effect of an Essential Amino Acids' Blend Which Is Active In Vitro in Supporting Muscle Function.
d'Adduzio L, Fanzaga M, Musco MS, Sindaco M, D'Incecco P, Boschin G, Bollati C, Lammi C
Nutrients 2026 Jan 20;18(2)
Nutrients 2026 Jan 20;18(2)
KIN17 facilitates the initiation and progression of renal tumor progression through the PI3K-AKT-mTOR pathway.
Wen Y, Lyu L, Zhang H, Zhang Y, Yang S, Wang Q, Song Y, Wen J
Scientific reports 2026 Jan 19;16(1):5721
Scientific reports 2026 Jan 19;16(1):5721
NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin.
Wang Y, Yang X, Dong Y, Yang X, Hou Y, Fu Q, Yan J, Du Y, Zhang Q, Zhou Y, Wu A, Chang S, Xu J, Zhang C, Hu X, Meng H, Sun W, Liu D
iScience 2026 Jan 16;29(1):114488
iScience 2026 Jan 16;29(1):114488
BCAR3 Hypomethylation as a Potential Diagnostic Marker for Thyroid Cancer and Its Mechanism via Promoting EMT and AKT/mTOR Pathway.
Yu W, Mao Y, Yin Y, Yang J, Zhang Y, Huang X, Zhang Y, Jiang C, Yang R
Cancers 2026 Jan 15;18(2)
Cancers 2026 Jan 15;18(2)
Integrated microbiota and metabolomic analysis demonstrates the growth-promoting effects of Lactobacillus plantarum in Nile tilapia (Oreochromis nilotica).
Li L, Wang Y, Li Y, Wang T, Wang Z, Zhou N, Qiao F, Du ZY, Zhang ML
Animal microbiome 2026 Jan 14;8(1):14
Animal microbiome 2026 Jan 14;8(1):14
FMDV VP3 Induces IL-10 Expression in Porcine Macrophages via PI3K Interaction and PI3K/AKT-mTOR Pathway Activation.
Li Y, Guo Z, Zhang Y, Luo L, He C, Xia Q, Zhang J, Zhang Z, Li Y
Viruses 2026 Jan 1;18(1)
Viruses 2026 Jan 1;18(1)
Construction and clinical validation of a machine-learning-based consensus prognostic signature (MLPS) for osteosarcoma via multi-cohort data integration.
Chen L, Wu H, Ren R, Zhang Y, Zhu Z, Chen X, Wang L, Gan X, Kang H, Pu H, Xiong W
International immunopharmacology 2026 Jan 1;168(Pt 1):115831
International immunopharmacology 2026 Jan 1;168(Pt 1):115831
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy.
Zheng R, Liu Y, Zhou S, Liu G, Liu X, Yang Y, Zhang Y
Oncology reports 2026 Feb;55(2)
Oncology reports 2026 Feb;55(2)
Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress.
Qiu QQ, Zhang N, Xu YY, Qin JW, Yu GF, Song XR
Molecular medicine reports 2026 Feb;33(2)
Molecular medicine reports 2026 Feb;33(2)
L-tetrahydropalmatine attenuates methamphetamine-induced pulmonary vascular remodeling via CaSR-BMP2/mTOR signaling.
Chen L, Wang X, Zhu X, Hu WT, Yang D, Wang Y
Bioorganic chemistry 2026 Feb;169:109418
Bioorganic chemistry 2026 Feb;169:109418
OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis.
Pan Z, Kong L, Shi F, Ying K, Xie H, Wu X, Lin G, Yao J, Chen Z, Wang Y, Chen G, Zhu Q
Cellular signalling 2026 Feb;138:112217
Cellular signalling 2026 Feb;138:112217
A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
Shan M, Xiao M, Zhang L, Wang S, Wu J, Cao K, Li Y, Zhang G, Xie J, Lu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
DLGAP5 regulates malignancy and lenvatinib sensitivity of hepatocellular carcinoma through AKT/mTOR/NF-κB pathway.
He B, Deng M, Guan R, Mei J, Zou H, Tang Y, Yang Z, Zheng Z, Lin W, Li S, Guo R, Zhao R, Wei W
European journal of medical research 2026 Feb 9;
European journal of medical research 2026 Feb 9;
Liver-muscle metabolic crosstalk: xanthosine as a key effector of broiler myogenesis.
Chen Y, Ding C, Ren M, Li Z, Liu S, Sun H, Yu S, Niu Q, Li X, Li B, Li L, Yang X, Sun Q
Journal of animal science and biotechnology 2026 Feb 8;17(1):24
Journal of animal science and biotechnology 2026 Feb 8;17(1):24
Neuron-Derived Sema3B Facilitates Microglial Hematoma Clearance After Intracerebral Hemorrhage.
Huang B, Chen A, Zhou T, Xu Y, Sun Y, He Q
Antioxidants (Basel, Switzerland) 2026 Feb 8;15(2)
Antioxidants (Basel, Switzerland) 2026 Feb 8;15(2)
Lipophagy Dynamics in Hyperlipidemia Model ICR Mice Across Different High-Fat-Diet Feeding Durations.
Xue S, Guo X, Wang Q, Chen X, Yang J, Zhou Y, Zhang Y, Niu W
International journal of molecular sciences 2026 Feb 5;27(3)
International journal of molecular sciences 2026 Feb 5;27(3)
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Zhao K, Zhang C, Deng C, Zhu W
International journal of molecular sciences 2026 Feb 28;27(5)
International journal of molecular sciences 2026 Feb 28;27(5)
Identification of immune-related targets of N6-methyladenosine regulators in hepatocellular carcinoma via RNA-seq analysis.
Zhao Y, Zhang D, Zheng H, Chen X, Xu L
Translational cancer research 2026 Feb 28;15(2):90
Translational cancer research 2026 Feb 28;15(2):90
Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation.
Cao D, Jia J, Yin Y, Lu W
International journal of molecular sciences 2026 Feb 26;27(5)
International journal of molecular sciences 2026 Feb 26;27(5)
ANGPTL8 accelerates bone loss in diabetic mice by promoting osteoclastic differentiation and inhibiting osteoblastic differentiation through AMPK pathway-mediated metabolic reprogramming.
Tuo P, Mu W, Bai X, Wang S, Hu L, Xu Y, Mao R, Liu Y, Yuan Y, Zhang Q, Guo X, Ma S, Wang X
Cellular and molecular life sciences : CMLS 2026 Feb 23;83(1)
Cellular and molecular life sciences : CMLS 2026 Feb 23;83(1)
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
Li Q, Bao Q, Wei C, Xie Y, Zhao S, Yan H, Wu F, Li W, Liu X, Gao H
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.
Han M, Guan Q, Yan F, Wang M, Xi D, Ning Q
Cell communication and signaling : CCS 2026 Feb 2;24(1)
Cell communication and signaling : CCS 2026 Feb 2;24(1)
Adiponectin Receptor 1-vascular endothelial growth factor axis mediates resistance to epidermal growth factor receptor-targeted therapy in nasopharyngeal carcinoma.
Cheng Z, Peng X, Wu S, Li W, Liu X, Zhang G
Anti-cancer drugs 2026 Feb 1;37(2):146-156
Anti-cancer drugs 2026 Feb 1;37(2):146-156
miR-17-5p inhibits classical swine fever virus replication by targeting the PKD2-regulated AMPK/mTOR autophagy pathway.
Wang X, Yang S, Xie L, Qi S, Gao L, Li Y, Li Q, Bi J, Liu J, Li Y, Yin G
Virulence 2026 Dec;17(1):2629657
Virulence 2026 Dec;17(1):2629657
Anmei decoction alleviates myocardial injury in sleep-deprived rats by PI3K/Akt/mTOR/HIF-1 pathway.
Xu B, Zhu M, Sun K, Feng QQ, Zhang Z, Xia J, Xie GJ, Liu Y, Chen LL, Wang P
Journal of ethnopharmacology 2026 Aug 10;367:121697
Journal of ethnopharmacology 2026 Aug 10;367:121697
Monosodium Glutamate Exposure and Liver Damage: Modulatory Effects of L-Carnitine on Inflammation and Autophagy.
Kalkan KT, Pektas F
Journal of applied toxicology : JAT 2026 Apr;46(4):1361-1371
Journal of applied toxicology : JAT 2026 Apr;46(4):1361-1371
Marek's disease virus hijacks host nucleotide metabolism via UL23-mediated c-Myc activation.
Wang Q, Shao H, Qian K, Ye J, Qin A
Veterinary microbiology 2026 Apr;315:110958
Veterinary microbiology 2026 Apr;315:110958
Fighting periodontitis with a pH-triggered nanocoating: A sustained-release strategy for simvastatin delivery.
Du S, Zheng Y, Chen Y, Guo Y, Kang X, Wang L
Colloids and surfaces. B, Biointerfaces 2026 Apr;260:115375
Colloids and surfaces. B, Biointerfaces 2026 Apr;260:115375
Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy pathways: macroautophagy and chaperone-mediated autophagy.
Li Z, Yang X, Mao J, Zeng P, Qi Y, Shi Y, Guo J, Zhou J, Wang D, Liu J, Hou L
Autophagy 2026 Apr;22(4):744-762
Autophagy 2026 Apr;22(4):744-762
Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.
Liu H, Zhu C, Yao X, Liu Y, Zhu J, Li Y, Xu H, Peng C, Shan G, Chen L, Zhou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18922
Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Induce ROS-Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2.
Miglionico R, Viceconte F, Armentano MF, Mariconda A, Nigro I, Longo P, Bisaccia F
Chemical biology & drug design 2026 Apr;107(4):e70283
Chemical biology & drug design 2026 Apr;107(4):e70283
Supramolecular dynamic hydrogels loaded with bevacizumab nanoparticles promote hyaline cartilage regeneration by inhibiting angiogenesis.
Li A, Jiao Z, Liu P, Lin M, Chen J, Liang R, Huang J, Yue Y, Cao F, You H, Zeng H, Zhang K, Lin J
Acta biomaterialia 2026 Apr 20;
Acta biomaterialia 2026 Apr 20;
miR-512-3p/RPS6KA2 Axis Regulates Cisplatin Resistance in Ovarian Cancer via Autophagy and Ferroptosis.
Wu J, Chen H, Wang S, Peng L, Hu X, Liu Z
Oncology research 2025;34(1):26
Oncology research 2025;34(1):26
The Punicalagin Compound Mitigates Bronchial Epithelial Cell Senescence Induced by Cigarette Smoke Extract through the PAR2/mTOR Pathway.
Xu J, Li X, Zeng X, Bao H, Liu X
Current medicinal chemistry 2025;32(38):8701-8719
Current medicinal chemistry 2025;32(38):8701-8719
Vimentin Regulates Alternative Polyadenylation and mTOR Signaling via ARVCF to Promote B Cell Lymphoma Progression.
Shao L, Xing Q, Xiong Y, Jin K, Li Q, Dong C, Ye Q
Human mutation 2025;2025:1463685
Human mutation 2025;2025:1463685
Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network.
Wang J, Qi X, Zhao W, Hao Z, Wang K, Li Y, Wang Y, Zhang Y
PloS one 2025;20(8):e0329847
PloS one 2025;20(8):e0329847
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Wang Y, Liao Q, Mei X, Xu H, Luo L, Huang R, Tang Y, Zhou C
PloS one 2025;20(6):e0326687
PloS one 2025;20(6):e0326687
Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling.
Li M, Hu X, Hu X, Gao F, Cui Y, Wei X, Qin Y, An X, Zhao Y, Gao Y
PloS one 2025;20(4):e0320509
PloS one 2025;20(4):e0320509
Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Tong W, Qin N, Lu T, Liu L, Liu R, Chen J, Luo N
PloS one 2025;20(4):e0302766
PloS one 2025;20(4):e0302766
Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy.
Ma J, Ding L, Zang X, Yang Y, Zhang W, Li X, Zhao D, Zhang Z, Wang Z, Zhao L, Tong X
Journal of inflammation research 2025;18:8447-8475
Journal of inflammation research 2025;18:8447-8475
Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury.
Jiang W, Zhang J, Zhang Y, Huang Z
International journal of general medicine 2025;18:1917-1931
International journal of general medicine 2025;18:1917-1931
The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis.
Guo C, Xu P, Luo W, Zhang J, Sun X, Hoang H, Ma D, Wu D, Zhong J, Miao C
Journal of inflammation research 2025;18:1147-1165
Journal of inflammation research 2025;18:1147-1165
Long Non-Coding RNA lncTAF15:1-1 Promotes CCL5 Secretion and Cell Migration of Monocyte-Derived Dendritic Cells via PI3K/AKT/mTOR Pathway in Systemic Lupus Erythematosus.
Xiang M, Sun Z, Ge Y, Zhang Z, Zheng C, Gao Z, Wang J, Xu J, Liang J, Wang Y
Journal of inflammation research 2025;18:10389-10402
Journal of inflammation research 2025;18:10389-10402
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Huang L, Li Q, Wu J, He Y, Huang J, Xie S, Yang C, Ruan Q, Zhou Z, Deng M
Frontiers in aging neuroscience 2025;17:1568002
Frontiers in aging neuroscience 2025;17:1568002
Longikaurin A, a natural ent-kaurane, suppresses proliferation, invasion and tumorigenicity in oral squamous cell carcinoma cell by via inhibiting PI3K/Akt pathway in vitro and in vivo.
Luo Y, Wang Z, Li Y, Zhang L
Journal of Cancer 2025;16(3):708-719
Journal of Cancer 2025;16(3):708-719
SREBP1-SCD1 enhanced MUFAs Biosynthesis drives Nutrient Deprived Pancreatic cancer cell Ferroptosis Resistance.
Zhang Z, Cai X, Gong Y, Gong A, Liao X, Gao J, Wang D
Journal of Cancer 2025;16(13):3960-3971
Journal of Cancer 2025;16(13):3960-3971
Integrating Single-Cell and Bulk RNA Sequencing Reveals the Malignant Phenotype of CBX4 in Prostate Cancer.
Liu Z, Liu Y, Fu Z, Huang H, Wang R, Wang Z, Peng S, Wang J, Fang Z, Liu L, Chen R, Wang Y
Journal of Cancer 2025;16(11):3525-3536
Journal of Cancer 2025;16(11):3525-3536
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Zhang C, Hu B, Wang C, Hou S, Lin N
Frontiers in immunology 2025;16:1662351
Frontiers in immunology 2025;16:1662351
Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.
Liu Y, Xu W, Wang K, You Z, Chen X, Ti H, Liang X, Cao L, Cai H, Liu J, Yang Z
Frontiers in pharmacology 2025;16:1612043
Frontiers in pharmacology 2025;16:1612043
Extracellular vesicles from prostate tumors reshape the pre-metastatic bone environment in an mTOR/RAB1A-dependent manner.
Lv T, Guo Y, Zhang Y, Cao J, Li X, Wang D, Zhang X, He D, Guo X, Yang C, Wang Z
Frontiers in immunology 2025;16:1605494
Frontiers in immunology 2025;16:1605494
Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511.
Deng X, Hu C, Li L, Yang G, Li C, Zhang W, Cheng G
Frontiers in pharmacology 2025;16:1586657
Frontiers in pharmacology 2025;16:1586657
Mycoplasma genitalium protein of adhesion inhibits human urethral epithelial cells apoptosis via CypA/PI3K/AKT/mTOR-dependent autophagy.
Chen L, Luo D, Xiao H, Zeng Z, Luo H, Gao S, Tang X, Huang Z, Zeng Y
Frontiers in microbiology 2025;16:1570659
Frontiers in microbiology 2025;16:1570659
Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway: in vivo and in vitro studies.
Wang Y, Wang X, Qian Y, Sun M, Yang H, Su L, Yan S
Frontiers in pharmacology 2025;16:1550458
Frontiers in pharmacology 2025;16:1550458
Atractylenolide-I restore intestinal barrier function by targeting the S100A9/AMPK/mTOR signaling pathway.
Chen C, Sun B, Chen K, Bao H, Tao Y, Zhou J, Yuan X, He L, Lu Z, Chen K, Li Y, Yu C, Chen Y, Zhang Y
Frontiers in pharmacology 2025;16:1530109
Frontiers in pharmacology 2025;16:1530109
Pseudouridine synthase 1 promotes progression of hepatocellular carcinoma via mTOR and MYC signaling pathways.
Chen L, Tan Y, Li W, Huang L, Li K, Feng Z, Peng C, Mei Y
Frontiers in oncology 2025;15:1576651
Frontiers in oncology 2025;15:1576651
Macrophage-derived exosome piR-50971 exacerbates sepsis-induced myocardial injury by inhibiting autophagy through the upregulation of N6-Methyladenosine modification of mTOR.
Wang J, Zhang J, Zhong S, Chen X, Liu HY, Lu C, Zhu H, Chen Y, Wang J, Yu J, Zhang X, Liu Y, Gao M
Burns & trauma 2025;13:tkaf045
Burns & trauma 2025;13:tkaf045
Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathway.
Song J, Qiao J, Chen M, Li J, Wang J, Yu D, Zheng H, Shi L
PeerJ 2025;13:e19085
PeerJ 2025;13:e19085
L-cysteine mitigates busulfan-induced testicular injury through modulation of CBS/H(2)S axis.
Liu S, Wei B, Wei H, Xu A, Sheng L, Sun X, Dong Y, Yang H
Frontiers in cell and developmental biology 2025;13:1679330
Frontiers in cell and developmental biology 2025;13:1679330
Insight into the mechanisms of milk protein synthesis via peptides derived from Micropterus salmoides.
Liu B, Wu X, Zhang X, Hao G, Li X, Cai Y, Lv D, Li P, Yan Y, Zan L, Pan F
International journal of biological macromolecules 2025 Sep;322(Pt 4):147039
International journal of biological macromolecules 2025 Sep;322(Pt 4):147039
Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.
Kong Y, Wang Q, Wang J, Qiu X, Yang Y, Liu J, Yang F, Qi R
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Sep;22:363-374
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Sep;22:363-374
Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.
Li H, Zhang M, Ma J, Li W, Liu X, Li Y, Ma J, Yang D, Tie Y, Bai H, Wang S
Biological trace element research 2025 Sep;203(9):4659-4670
Biological trace element research 2025 Sep;203(9):4659-4670
Involvement of the PINK1/Parkin signaling pathway in 4-vinylcyclohexene diepoxide-induced ovary toxicity in rats.
Che Y, Wang X, Li Q, Peng X, Liu Z, Xu W, Jiang M, Wang T, Gao J, Wang W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115572
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115572
Modulating Macrophage-Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration.
Kong X, Hu R, Zhang P, Li Q, Song K, Gu H, Zheng J, Liu S, Liu L, Jin L, Cheng L, Li C, Wei Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e07178
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e07178
Suppressed autophagy of thymic cells promotes apoptosis and thymic atrophy in COPD.
He S, Yang Z, Xie L
Heart & lung : the journal of critical care 2025 Sep-Oct;73:180-189
Heart & lung : the journal of critical care 2025 Sep-Oct;73:180-189
Investigating the role of 1,8-Cineole in mitigating ferroptosis in a HFSD/STZ diabetes mellitus type 2-induced model: A GEO data analysis approach.
Yang H, Chen Y, Wu G, Ren P, Chen T, Liu J, Zhang B, Ma X, Jiang F, Li Y, Tao L, Shen X
European journal of pharmacology 2025 Sep 5;1002:177846
European journal of pharmacology 2025 Sep 5;1002:177846
mTOR-autophagy axis regulation by intermittent fasting promotes skeletal muscle growth and differentiation.
Xinyan C, Yajie W, Shangfan H, Yuefei Y, Junwei L, Jiaqiao Z, Huiming J
Nutrition & metabolism 2025 Sep 30;22(1):109
Nutrition & metabolism 2025 Sep 30;22(1):109
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.
Rao Z, Chen Z, Bao Y, Lu Z, Tang Y, Zhu J, Ma J, Dong S, Shi J, Sheng S, Chen Y, Wang J, Mukondiwa AV, Li Z, Wang X, Huang Z, Li C, Ding W, Chen M, Han Z, Wang C, Pan X, Wang X, Zhu H, Lin L, Huang Z, Lu W, Li X, Luo Y
Signal transduction and targeted therapy 2025 Sep 26;10(1):315
Signal transduction and targeted therapy 2025 Sep 26;10(1):315
Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis.
Fan X, Gao J, Liu S, Hua J, Shao D, Jia L, Shen Y, Wang Z, Jin Z, Wang J
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120357
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120357
Pharmacological effects and mechanism of Maxing Shigan Decoction in the treatment of influenza A viral pneumonia.
Huang J, Shi J, Fu J, Liu Z, Feng Z, Wang K, Chen C, Ning Y, Lu F, Li L
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120275
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120275
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow.
Yang B, Su J, Wu J, Wang Z, Hu J, Yang M, Lin Y, Jin M, Bai X, Yu B, Zhang X
Nature communications 2025 Sep 25;16(1):8409
Nature communications 2025 Sep 25;16(1):8409
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Sun L, Wang Y, Zhang K, Chen X, Shi H
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
Adipose-derived stem cell exosomes promote neurological recovery after subarachnoid hemorrhage via AMPK/mTOR-mediated TFEB activation.
Liu M, Li S, Wu L, Liu M, Zeng C, Shen J, Cai Z, Yin J, Wu G
Neurological research 2025 Sep 22;:1-12
Neurological research 2025 Sep 22;:1-12
Orthosteric-allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer.
Xiong L, Tang 唐磊 L, Zhao W, Wang R, Cheng C, Wang D, Xu Y, Tang 汤磊 L, Fan Y
Journal of advanced research 2025 Sep 22;
Journal of advanced research 2025 Sep 22;
Study on Antitumor Secondary Metabolites from Euphorbia ebracteolata Hayata: Structural Characterization, Network Pharmacology, Molecular Docking and In Vitro.
Xu NW, Yang YH, Ding L, Cai BX, Li MM, Wang JT, Zheng H, Yu Y
ACS omega 2025 Sep 16;10(36):41479-41491
ACS omega 2025 Sep 16;10(36):41479-41491
Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways.
Zhang F, Xu J, Yuan Q, Xie Y, Zhang L, Zhang J, Xu Z, Liu M
Molecular neurobiology 2025 Oct;62(10):12394-12412
Molecular neurobiology 2025 Oct;62(10):12394-12412
IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.
Guo N, Xia Y, He N, Zhang L, Liu J
Inflammation 2025 Oct;48(5):3282-3299
Inflammation 2025 Oct;48(5):3282-3299
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways.
Wang Y, Liu Y
Hearing research 2025 Oct;466:109386
Hearing research 2025 Oct;466:109386
Effect of activated autophagy on an animal model of vestibular migraine-like attacks.
Li H, Huang Y, Chen Q, Zhai Q, Zhang C, Yu Q, Chen S, Ying C, Pan Y
Experimental neurology 2025 Oct;392:115366
Experimental neurology 2025 Oct;392:115366
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
Yaxian L, Xiaodong W, Futao M, Huizhen W, Chuansheng W, Mengdi M, Bo Y, Yida L, Xin X, Ziqing F, Mingdian L, Yuxian S, Yongxiang L
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188
Chemokines and PI3K/AKT signaling pathway mediate the spontaneously ruptured hepatocellular carcinoma through the regulation of the cell cycle.
Zhang Y, Zhou YL, Xu N, Meng T, Wang ZZ, Pan FM, Zhu LX
Hepatobiliary & pancreatic diseases international : HBPD INT 2025 Oct;24(5):511-526
Hepatobiliary & pancreatic diseases international : HBPD INT 2025 Oct;24(5):511-526
YY1/INSIG1 enhances atherosclerosis progression by regulating AMPK-mTOR signaling.
Yang M, Zhang J, Xu Z, Yang L, Tang S
Molecular immunology 2025 Oct;186:26-38
Molecular immunology 2025 Oct;186:26-38
High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.
Son JS, Chae SA, Chun YH, Wang H, Jiang Z, Du M
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70027
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70027
Isovaleric acid ameliorates chronic restraint stress and resists inflammation by inhibiting NF-κB activation in mice.
Guo C, Shi X, Luo B, Yang Y, Huang J, Xu J, Zheng R, Jiang S, Chai J
The Journal of nutritional biochemistry 2025 Oct;144:109955
The Journal of nutritional biochemistry 2025 Oct;144:109955
Network Pharmacology and Molecular Docking Elucidate the Mechanism of Phillyrin in Colorectal Cancer.
Hu ZJ, Lv GJ, Dong WS, Zheng F, Yan PH, Yu SL, He DN, Liu BY, Gao YY, Su DY, Guo YY, Bai YH, Zhu HY
Food science & nutrition 2025 Oct;13(10):e71069
Food science & nutrition 2025 Oct;13(10):e71069
Lactate Dehydrogenase C4 Accelerates Triple-Negative Breast Cancer Progression by Promoting Acetyl-CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation.
Cui Z, Zheng C, Lin Y, Xiao Z, Li Y, Peng W, He S, Li A, Wu X, Chen Y, Sun Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e11849
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e11849
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Zhu MY, Guo YJ, Zhu YQ, Wang HZ, Wang HD, Chen HY, Jiang YX, Li H, Hui H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway.
Yan S, Liu J, Zhang T, Li J, Zeng J, Li M, Aslam MS, Shen J, Tong T, You Z, Liu S, Li P, Li J, Gong K, Wei S, Hao C, Meng X
Molecular brain 2025 Oct 8;18(1):77
Molecular brain 2025 Oct 8;18(1):77
Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy.
Ying L, Zhu Y, Zhang L, Ji M, Wang M, Dong L, Yun Z, Chen Y, Zhou J, Huang C, Zhang S, Yang X, Yang H, Huang G, Qin S, Xie J, Liu L
Cell death & disease 2025 Oct 6;16(1):706
Cell death & disease 2025 Oct 6;16(1):706
Icariside II attenuates renal fibrosis through mTOR signaling modulation: an integrated approach combining network pharmacology, molecular dynamics, and in vitro validation.
Ding P, Pan JC, Tian WJ, Yang YJ, Feng YH, Gao G, Wu CL, Xin ZC
Translational andrology and urology 2025 Oct 31;14(10):3159-3180
Translational andrology and urology 2025 Oct 31;14(10):3159-3180
SENP5 Attenuates LPS-Induced Acute Lung Injury by Inhibiting Apoptosis of Lung Epithelial Cells Through SLC7A5/mTOR Signaling Pathway.
He Y, Zhang H, Gu J, Ju M, Zhang C
Frontiers in bioscience (Landmark edition) 2025 Oct 29;30(10):45811
Frontiers in bioscience (Landmark edition) 2025 Oct 29;30(10):45811
Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway.
Li Q, Hong H, Xu G, Xia M, Wang T, Zhou Z, Huang J, Fu Q, Cui Z
Journal of integrative neuroscience 2025 Oct 29;24(10):43900
Journal of integrative neuroscience 2025 Oct 29;24(10):43900
Novel magnolol-sulforaphane hybrids as potent antitumor agents: synthesis and biological characterization.
Peng Y, Liu B, Guo Y, Chen J, Chen H, Liu X, Huang J, Luo D, Hong Y, Wu D, Chen Z, Lin X, Tao C
RSC medicinal chemistry 2025 Oct 29;16(12):6380-96
RSC medicinal chemistry 2025 Oct 29;16(12):6380-96
Paeoniflorin inhibits glioblastoma proliferation and promotes autophagy through the AKT/mTOR pathway.
Li H, Ouyang J, Zhang Y, Zhang Z, Sun M, Liu R, Qian C
Scientific reports 2025 Oct 29;15(1):37897
Scientific reports 2025 Oct 29;15(1):37897
Lysosomal homeostasis regulates myocardial ischemia-reperfusion injury through autophagy pathway.
Li Y, Liu Y, Wu H, Zhang S, Liu D, Huang X, Zhou G, Zhang D, Yang X, Zhou T, Xiong Y
Scientific reports 2025 Oct 22;15(1):36952
Scientific reports 2025 Oct 22;15(1):36952
Biomimetic ferritin nanocages for synergistic co-delivery of metformin and rapamycin restore neurodevelopmental homeostasis in autism spectrum disorders.
Shen Y, Yu L, Wang L, Jin J, Yu C, Fan Y, Lang Y, Xu H, Jones BC, Liu Y, Wu J, Gao S, Chen F, Feng S
Journal of nanobiotechnology 2025 Oct 14;23(1):670
Journal of nanobiotechnology 2025 Oct 14;23(1):670
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Zou X, Li S, Huang S, Niu R, Liu G, Wang Z
International journal of oncology 2025 Nov;67(5)
International journal of oncology 2025 Nov;67(5)
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.
Huang C, Chen X, Wu D, Chen J, Wang J, Li S, Hu J, Yan Z, Zhu Y, Zhang Y
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928
Bispecific aptamers target thyrotropin receptor (TSHR) and insulin growth factor-1 receptor (IGF-1R) for the improvement of orbital fibroblasts activation in the treatment of thyroid-associated ophthalmopathy.
Xie B, Zhang F, Yin J, Ouyang S, Cao J, Tan Y, Xiong W
International journal of biological macromolecules 2025 Nov;330(Pt 1):147867
International journal of biological macromolecules 2025 Nov;330(Pt 1):147867
Autophagy-targeted intervention synergized with pegaspargase: an innovative therapeutic paradigm for pancreatic cancer.
Zhou D, Ding Z, Yin T, Huang M, Zhang X, Cao H, Wang C
Cancer cell international 2025 Nov 28;25(1):428
Cancer cell international 2025 Nov 28;25(1):428
PPA1 promotes oxidative phosphorylation and malignant progression of colorectal cancer under glucose restriction via AMPK/ULK1/FUNDC1-mediated mitophagy.
Chen Y, Deng Q, Chen Z, Yang L, Li X, Fu Z
Cell death discovery 2025 Nov 28;11(1):549
Cell death discovery 2025 Nov 28;11(1):549
KAL suppresses cholangiocarcinoma growth via downregulating miR-21 and modulating the PTEN/AKT signaling pathway.
Huang J, Chi Z, Lin X, Yan L
Scientific reports 2025 Nov 25;15(1):45326
Scientific reports 2025 Nov 25;15(1):45326
Integrating serum pharmacochemistry, network pharmacology, and metabolomics to explore the protective mechanism of Hua-Feng-Dan in ischemic stroke.
Yuan X, He X, Shu Q, Gao Y, Chen Y, Xu J, Zhang Y, Cao G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157251
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157251
LRP12 promotes gastric cancer progression through AKT/mTOR signaling and M2 macrophage-mediated immunosuppression.
Wang Y, Yin X, Wang M, Zhu M, Xue Y
Scientific reports 2025 Nov 23;15(1):45183
Scientific reports 2025 Nov 23;15(1):45183
Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism.
Miao Z, Long J, Huang B, Yan D, Wang A
iScience 2025 Nov 21;28(11):113892
iScience 2025 Nov 21;28(11):113892
miR-199a functions downstream of MeCP2 in neurons of MECP2 duplication syndrome models.
Akaba Y, Takahashi S, Adachi S, Nishimura M, Suzuki K, Nakashima H, Nakashima K, Kira R, Chong PF, Sakai Y, Hayashi Y, Kushima I, Mori D, Arioka Y, Okumura H, Nakayama A, Mizuno S, Yamamoto T, Osakada F, Ozaki N, Tsujimura K
iScience 2025 Nov 21;28(11):113789
iScience 2025 Nov 21;28(11):113789
Astragalin rescues Cadmium-induced cognitive decline by revering glial metabolic reprogramming and neuroinflammation via the mTOR/HIF-1α axis.
Huang Q, Wang J, Cao MM, Ma HY, Qin XY, Hu Y, Lan R
Neuroscience 2025 Nov 19;588:31-39
Neuroscience 2025 Nov 19;588:31-39
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Zhang Y, Fan T
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Exosomal lncRNA MIR210HG derived from hypoxic TAMs promotes the metastasis of triple negative breast cancer.
Feng L, Wang Y, Wang X, Li B, Liu Y, Zhang W, Ji J, Shao L, Guo X
International immunopharmacology 2025 Nov 14;165:115416
International immunopharmacology 2025 Nov 14;165:115416
Gallic Acid Alleviates Cerebral Ischemia-reperfusion Injury in Mice by Mediating Microglial Polarization Through the NLRP3/mTOR Axis.
Hua W, Xu H, Chen R, Zhang H, Zhang Y, Zhang X, Zhang Y, Liu J, Zhang L, Yang P
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Nov 10;20(1):101
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Nov 10;20(1):101
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy.
Huang T, Tang Y, Su Q, Su C, Wang J, Fu L, Tang Y
Cell death & disease 2025 Nov 10;16(1):815
Cell death & disease 2025 Nov 10;16(1):815
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.
Duan WL, Wang XJ, Gu LH, Guo A, Ding YY, Lin P, Zhang BG
Cell death discovery 2025 Nov 10;11(1):520
Cell death discovery 2025 Nov 10;11(1):520
Oleracein E Rejuvenates Senescent Hippocampal NSCs by Inhibiting the ERK1/2-mTOR Axis to Improve Cognitive Dysfunction in Vascular Dementia.
Lang H, Zeng J, Wen Y, Xu J, Xiao R, Shi Y, Lu Q, Xia X, Hu G
The European journal of neuroscience 2025 May;61(9):e70137
The European journal of neuroscience 2025 May;61(9):e70137
NSUN2-mediated m5C modification of circFAM190B promotes lung cancer progression by inhibiting cellular autophagy.
Chen S, Cai D, Zhao Q, Wu J, Zhou X, Xu H, Li X, Zhang R, Peng W, Li G, Nan A
International journal of biological macromolecules 2025 May;306(Pt 3):141528
International journal of biological macromolecules 2025 May;306(Pt 3):141528
Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation.
Cao MM, Guo Z, Wang J, Ma HY, Qin XY, Hu Y, Lan R
Free radical biology & medicine 2025 May;232:340-352
Free radical biology & medicine 2025 May;232:340-352
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
Su J, Fan X, Zou Y, Fu G, Feng S, Wang X, Yu Y, Li L, Bian Z, Huang R, Qin L, Chen J, Zeng Q, Yan K, Gao C, Lian Z, Li X, Li Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2409154
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2409154
Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m(6)A modification in triple-negative breast cancer.
Yu Y, Hu J, Wang W, Lei H, Xi Z, Zhang P, Zhao E, Lu C, Chen H, Liu C, Li L
Science advances 2025 May 9;11(19):eadr3173
Science advances 2025 May 9;11(19):eadr3173
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
Duan C, Zhao Y, Xiao Y, Hou Y, Gong W, Zhang H, Wang Y, Nie X
Journal of hazardous materials 2025 May 5;488:137420
Journal of hazardous materials 2025 May 5;488:137420
Estradiol and vitamin D exert a synergistic effect on preventing osteoporosis via the miR-351-5p/IRS1 axis and mTOR/NFκB signaling pathway.
Dai X, Liu C, Bi W, Zheng G, Lv K, Xia Z
Scientific reports 2025 May 28;15(1):18678
Scientific reports 2025 May 28;15(1):18678
Lysionotin promoted apoptosis of hepatocellular carcinoma cells via inducing autophagy.
Wang X, Zhong W, Wang Q, Song P, Lin X, Li B, Yin Y, Yang C, Li M
Discover oncology 2025 May 16;16(1):788
Discover oncology 2025 May 16;16(1):788
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Zhang HJ, Zhao Q, Zhang M, Yang LL, Abiti J, Han MM, Gao YP, Lu JT, Wang JN, Ji MY, Zhang X, Wang W, Qiu LL, Wang XY, Wang TY, Jia YL
ACS synthetic biology 2025 May 16;14(5):1802-1812
ACS synthetic biology 2025 May 16;14(5):1802-1812
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata.
Xu W, Li XJ, Zhong YS, He JQ, Xie W, Kang YK, Ying HZ, Yu CH
Carbohydrate polymers 2025 May 15;356:123381
Carbohydrate polymers 2025 May 15;356:123381
Modified weiling decoction inhibited excessive autophagy via AKT/mTOR/ULK1 pathway to alleviate T2DM: Integrating network pharmacology and experimental validation.
Gao W, Wang M, Xu W, Ma R, Wang X, Sun T, Li P, Li F, He Y, Xie X, Pang X, Zhou Y, Pang G
Journal of ethnopharmacology 2025 May 12;347:119753
Journal of ethnopharmacology 2025 May 12;347:119753
Creatine promotes osteogenic differentiation of dental pulp stem cells via the AMPK-ULK1-autophagy axis.
Liu L, Chu Z, Han X, Wu J, Cai K, Wang J, Guo Z, Gao S, Li G, Tang C
Connective tissue research 2025 Mar;66(2):73-86
Connective tissue research 2025 Mar;66(2):73-86
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Tang J, Lu L, Yuan J, Feng L
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Knockdown of SESN2 Exacerbates Cerebral Ischemia-Reperfusion Injury Through Enhancing Glycolysis via the mTOR/HIF-1α Pathway.
Wang Z, Huang Y, Zhang Y, Zhu H, Amin MR, Chen R, Gu L, Xiong X
CNS neuroscience & therapeutics 2025 Mar;31(3):e70314
CNS neuroscience & therapeutics 2025 Mar;31(3):e70314
Aerobic exercise improves energy and glucose homeostasis through hypothalamic Mitofusion 2-rescued endoplasmic reticulum stress in diet-induced obese mice.
Zhang S, Chen Y, Yang R, Ye L, Chen H, Jiang L, Bai D, Wu D
Diabetes, obesity & metabolism 2025 Mar;27(3):1251-1264
Diabetes, obesity & metabolism 2025 Mar;27(3):1251-1264
Long-term leucine supplementation increases body weight in goats by controlling appetite and muscle protein synthesis under protein-restricted conditions.
Lv X, Jiang A, Hua J, Liu Z, Yan Q, Tang S, Kang J, Tan Z, Wu J, Zhou C
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Mar;20:404-418
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Mar;20:404-418
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione mediates the effect of ROS-enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer.
Chen L, Chen M, Xie Y, Zhang Y, Mo S, He Y, Liang T, Liao Y, Huang R, Huang G, Han C, Pham TTH
FEBS open bio 2025 Mar;15(3):474-489
FEBS open bio 2025 Mar;15(3):474-489
USP5 Promotes Head and Neck Squamous Cell Carcinoma Progression via mTOR Signaling Pathway.
Xiong N, Wang Y, Jiang J
Cancer medicine 2025 Mar;14(5):e70752
Cancer medicine 2025 Mar;14(5):e70752
CircMRP4 orchestrates podocytes injury via the miR-499-5p/RRAGB/mTORC1 axis in diabetic kidney disease.
Deng S, Huang L, Shao Y, Xie Y, Yuan S, Tang L
Cellular signalling 2025 Mar;127:111611
Cellular signalling 2025 Mar;127:111611
Extracellular vesicle-packaged PKM2 from endometriotic stromal cells promotes endometrial collagen I deposition by inhibiting autophagy in endometriosis.
Zhu Y, Gao L, Zhang J, Li M, Zhou J, Zhou J
Cellular signalling 2025 Mar;127:111523
Cellular signalling 2025 Mar;127:111523
Citrulline regulates macrophage metabolism and inflammation to counter aging in mice.
Xie Z, Lin M, Xing B, Wang H, Zhang H, Cai Z, Mei X, Zhu ZJ
Science advances 2025 Mar 7;11(10):eads4957
Science advances 2025 Mar 7;11(10):eads4957
Nuciferine Restores Autophagy via the PI3K-AKT-mTOR Pathway to Alleviate Renal Fibrosis in Diabetic Kidney Disease.
Li T, Chen H, Guo Y, Huang M, Liu P, Aikemu A, Mohammadtursun N, Pan X, Yang X
Journal of agricultural and food chemistry 2025 Mar 5;73(9):5223-5235
Journal of agricultural and food chemistry 2025 Mar 5;73(9):5223-5235
miR-21 regulates autophagy and apoptosis of ectopic endometrial stromal cells of adenomyosis via PI3K/ AKT/ mTOR pathway.
Jia JJ, Lai HJ, Sun BW, Lu J, Zeng YY
Scientific reports 2025 Mar 4;15(1):7639
Scientific reports 2025 Mar 4;15(1):7639
Lactoferrin influences atherosclerotic progression by modulating macrophagic AMPK/mTOR signaling-dependent autophagy.
Xia B, Liang J, Lu Y, Ding J, Peng J, Li F, Dai J, Liu Y, Wang J, Wan C, Luo P
Scientific reports 2025 Mar 27;15(1):10585
Scientific reports 2025 Mar 27;15(1):10585
Role of octamer transcription factor 4 in proliferation, migration, drug sensitivity, and stemness maintenance of pancreatic cancer cells.
Shi XY, Wang XL, Zhao J, Yang SH, Zhang CH
World journal of clinical oncology 2025 Mar 24;16(3):100723
World journal of clinical oncology 2025 Mar 24;16(3):100723
CDX1 improves nicotine induced cardiac fibroblasts activation and cardiomyocyte hypertrophy by alleviating autophagic flux impairment through modulation of LAPTM4B.
Li YY, Meng FL, Zhou SY, Du JM, Li WJ, Liu QY, Wu L, Zhao MM, Jin Y, Zhang QY, Li Y, Su GH
Scientific reports 2025 Mar 22;15(1):9985
Scientific reports 2025 Mar 22;15(1):9985
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
Peng C, Lei P, Qi H, Zhu Q, Huang C, Fu J, Zhao C
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
MT1H inhibits the growth of gastric cancer by regulating SLC6A19/TTC39B/ADM2 and activating p53-dependent autophagy.
Xing Y, Li G, Li G, Xu J, Zhang T, Li M, Gao C, Fu M, Zheng P, Chu X
Scientific reports 2025 Mar 18;15(1):9339
Scientific reports 2025 Mar 18;15(1):9339
Lactobacillus plantarum SMUM211204 Exopolysaccharides Have Tumor-Suppressive Effects on Colorectal Cancer by Regulating Autophagy via the mTOR Pathway.
Wang Z, Chen H, Xiong S, Chen X, Gao X, Huang P, Zou J, Cao H
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5931-5946
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5931-5946
Mark3 a Prognostic Marker for the Endometrial Cancer.
Wang Y, Guo L
Current oncology (Toronto, Ont.) 2025 Mar 10;32(3)
Current oncology (Toronto, Ont.) 2025 Mar 10;32(3)
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Ma Z, Xu Y, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Yang X, Cao X
Neuroscience bulletin 2025 Jun;41(6):951-969
Neuroscience bulletin 2025 Jun;41(6):951-969
Leucyl-tRNA synthetase regulates casein synthesis in dairy cows via the mTORC1-LAT1 pathway.
Ke Y, Du X, Chen B, Chen X, Song C, Fang X, Wang Y, Zhang C
Animal bioscience 2025 Jun;38(6):1259-1271
Animal bioscience 2025 Jun;38(6):1259-1271
Charge-reversed small extracellular vesicles from human adipose-derived mesenchymal stromal cells attenuate renal fibrosis postacute kidney injury by inhibiting epithelial-mesenchymal transition progression in SD rat model.
Ping W, Xu X, Jiang Y, Yang R, Xu L
Cytotherapy 2025 Jun;27(6):753-765
Cytotherapy 2025 Jun;27(6):753-765
The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.
Zhang R, Li N, Yu K, Wang Q, Fan M, Zhang X, Liu X
Pharmacological research 2025 Jun;216:107763
Pharmacological research 2025 Jun;216:107763
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Wu Y, Duan Z, Qu L, Liu Y, Ma X, Fan D
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy.
Qin Y, Wang X, Zhao M, Liu Y, Hou H, Wang T, Pei Y, Zhang J, Shen Z, Wu F, Zheng L, Li J, Ni Z, Shi J
Acta biochimica et biophysica Sinica 2025 Jun 25;58(2):383-395
Acta biochimica et biophysica Sinica 2025 Jun 25;58(2):383-395
WITHDRAWN: Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signaling pathway: In vivo and in vitro studies.
Wang Y, Wang X, Qian Y, Sun M, Yang H, Su L, Yan S
The Journal of nutritional biochemistry 2025 Jun 24;:110013
The Journal of nutritional biochemistry 2025 Jun 24;:110013
Triptonide facilitates autophagy-mediated apoptosis in esophageal squamous cell carcinoma by targeting the AMPK-mTOR-ULK1 axis.
Ju J, Xu N, Li B, Shi D, Cai J, Zheng Q, Ye L, Zhang S, Wang C
Acta biochimica et biophysica Sinica 2025 Jun 20;57(10):1611-1624
Acta biochimica et biophysica Sinica 2025 Jun 20;57(10):1611-1624
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Son SM, Siddiqi FH, Lopez A, Ansari R, Tyrkalska SD, Park SJ, Kunath T, Metzakopian E, Fleming A, Rubinsztein DC
Neuron 2025 Jun 18;113(12):1908-1924.e13
Neuron 2025 Jun 18;113(12):1908-1924.e13
Independent and synergistic effects of extreme heat and NO(2) pollution on diabetic nephropathy in a type II diabetes mouse model.
Qiao Z, Feng X, Sun W, Wang F, Lu C
Environmental pollution (Barking, Essex : 1987) 2025 Jun 15;375:126321
Environmental pollution (Barking, Essex : 1987) 2025 Jun 15;375:126321
Novel ALK inhibitors containing DAAP fragments: Rational drug design and anti-tumor activity research.
Wang R, Li X, Long L, Li M, Chen H, Zhang H, Ruan W, Zhang H, Zheng P, Xu S
Bioorganic chemistry 2025 Jun 15;160:108416
Bioorganic chemistry 2025 Jun 15;160:108416
Podophyllum hexandrum Royle mitigates perimenopausal symptoms in an OVX rat model by activating the PI3K/AKT/mTOR pathway and enhancing estrogen receptor expression.
Tan CC, Cao SJ, Chao WH, Zhang B, Deng XY, Wang LN, Kang N, Qiu F
Journal of ethnopharmacology 2025 Jun 12;349:119968
Journal of ethnopharmacology 2025 Jun 12;349:119968
Deciphering the polypharmacology of Dingzhi Xiaowan against comorbid depression: Integrated metabolomics of brain tissue and network pharmacology analysis in chronic restraint stress (CRS)-LPS model.
Chu H, Sun N, Tang Q, Yu X, Li L, Chang H
Journal of ethnopharmacology 2025 Jun 12;349:119960
Journal of ethnopharmacology 2025 Jun 12;349:119960
Comprehensive multi-omics analysis of histone acetylation modulators identifies ASH1L as a novel aggressive marker for osteosarcoma.
Ni C, Sun Q, Yin H
Discover oncology 2025 Jun 12;16(1):1070
Discover oncology 2025 Jun 12;16(1):1070
Effects of Long-Term Blue Light Exposure on Body Fat Synthesis and Body Weight Gain in Mice and the Inhibitory Effect of Tranexamic Acid.
Hiramoto K, Oikawa H
International journal of molecular sciences 2025 Jun 10;26(12)
International journal of molecular sciences 2025 Jun 10;26(12)
Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis.
Chen J, Li M, Mao J, Wang X, Guo B, Chen X, Kalvakolanu DV, Hong J, Yang M, Liu J, Luo Q, Yang J, Sun X, Tian Y, Zhang L
Biochemical pharmacology 2025 Jul;237:116926
Biochemical pharmacology 2025 Jul;237:116926
Anti-sarcopenic effects of active vitamin D through modulation of anabolic and catabolic signaling pathways in human skeletal muscle: A randomized controlled trial.
Kawahara T, Inazu T, Mizuno S, Tominaga N, Toda M, Toyama N, Kawahara C, Suzuki G, DPVD Research Group
Metabolism: clinical and experimental 2025 Jul;168:156240
Metabolism: clinical and experimental 2025 Jul;168:156240
Procyanidin C1 ameliorates aging-related skin fibrosis through targeting EGFR to inhibit TGFβ/SMAD pathway.
Wang JH, Li M, Xie PF, Si JY, Feng ZJ, Tang CF, Li JM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156787
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156787
Synergic effect of the combination of isoliquiritigenin and arsenic trioxide in HepG2 liver cancer cells.
Li J, Gu J, Pan S, Deng N, Khan M, Li L, Wu X, Li Y
Cellular signalling 2025 Jul;131:111752
Cellular signalling 2025 Jul;131:111752
2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling.
Luo M, Mo J, Huang C, Mao Y, Wang H, Wang X
Chemical biology & drug design 2025 Jul;106(1):e70161
Chemical biology & drug design 2025 Jul;106(1):e70161
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice.
Liu S, Sun H, Du Z, Lu S, Wang C, Zhang Y, Luo Z, Wang L, Fan Z, Wei P, Yan Y, Zhang J, Yin S, Liu T, He Q, Guo X, Ding K, Zhou J, Hua H, Yu C, Xu W, Shan J, Li Y, Xu Y, Shen X, Cao G, Zhou W
Nature communications 2025 Jul 30;16(1):6983
Nature communications 2025 Jul 30;16(1):6983
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Wang Y, Wang C, Zhu Y, Chen K, Yu Y, Li R, Huang S, Tao T, Jiang Y
Journal of ethnopharmacology 2025 Jul 24;351:120042
Journal of ethnopharmacology 2025 Jul 24;351:120042
Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.
Zang S, Chen H, Han Y, Cui D, Yu J
Scientific reports 2025 Jul 11;15(1):25065
Scientific reports 2025 Jul 11;15(1):25065
TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway.
Yang Q, Feng J, Xu H, Kang T, Wei Q, Jiang H
Scientific reports 2025 Jul 10;15(1):24797
Scientific reports 2025 Jul 10;15(1):24797
The mechanism of Bletilla striata inhibiting glioma proliferation through the PI3K/AKT/mTOR signaling pathway based on network Pharmacology analysis.
Ren F, Wang Y, He C, Zheng X, Zhou C, Zhong X
Scientific reports 2025 Jul 1;15(1):20415
Scientific reports 2025 Jul 1;15(1):20415
Defective Hippocampal Primary Ciliary Function and Aberrant LKB1/AMPK Signaling Pathway Are Associated With the Inhibition of Autophagic Activity in Offspring Born to Mothers of Advanced Maternal Age.
Han Z, Yang X, Gui J, Luo H, Huang D, Chen H, Cheng L, Yuan P, Jiang L
Developmental neurobiology 2025 Jan;85(1):e22954
Developmental neurobiology 2025 Jan;85(1):e22954
O-GlcNAcylation of progranulin promotes hepatocellular carcinoma proliferation.
Liang Y, Chen L, Huang Z, Li Y, Weng H, Guo L
Biochemical and biophysical research communications 2025 Jan;742:151150
Biochemical and biophysical research communications 2025 Jan;742:151150
PCSK9 promotes vascular neointimal hyperplasia through non-lipid regulation of vascular smooth muscle cell proliferation, migration, and autophagy.
Zhang Q, Miao M, Cao S, Liu D, Cao Z, Bai X, Yin Y, Jin S, Dong L, Zheng M
Biochemical and biophysical research communications 2025 Jan;742:151081
Biochemical and biophysical research communications 2025 Jan;742:151081
Niraparib perturbs autophagosome-lysosome fusion in pancreatic ductal adenocarcinoma and exhibits anticancer potential against gemcitabine-resistant PDAC.
Yao Z, Zhang H, Huang K, Huang G, Xi P, Jiang L, Qin D, Chen F, Li S, Wei R
Translational oncology 2025 Jan;51:102206
Translational oncology 2025 Jan;51:102206
IL-17A's role in exacerbating radiation-induced lung injury: Autophagy impairment via the PP2A-mTOR pathway.
Liu L, Yi G, Li X, Chen C, Chen K, He H, Li J, Cai F, Peng Y, Yang Z, Zhang X
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119864
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119864
Trametinib and M17, a novel small molecule inhibitor of AKT, display a synergistic antitumor effect in triple negative breast cancer cells through the AKT/mTOR and MEK/ERK pathways.
Han H, Yang M, Wen Z, Mei F, Chen Q, Ma Y, Lai X, Zhang Y, Fang R, Yin T, Sun S, Wang X, Qi J, Lin H, Yang Y
Bioorganic chemistry 2025 Jan;154:107981
Bioorganic chemistry 2025 Jan;154:107981
Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13.
Tan C, Zhou H, Xiong Q, Xian X, Liu Q, Zhang Z, Xu J, Yao H
Respiratory research 2025 Jan 6;26(1):3
Respiratory research 2025 Jan 6;26(1):3
GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy.
Liu J, Feng C, Zhao R, Song H, Huang L, Jiang N, Yang X, Liu L, Duan C, Wan L, Gao Q, Sun L, Hou X, Liu M, Zhang Y, Zhang X, Zhang D, Wang Y, Li Y, Ma X, Zhong H, Min M, Wei C, Cao Y, Yang X
Journal for immunotherapy of cancer 2025 Jan 6;13(1)
Journal for immunotherapy of cancer 2025 Jan 6;13(1)
MYBL2 promotes proliferation of clear cell renal cell carcinoma by regulating TOP2A and activating AKT/mTOR signaling pathway.
Huang Y, Xi X, Ye Z, Zhang C, Jiang Y, Yu F, Huang G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70330
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70330
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Ren X, Zhou N, Li D, Li L, Wang Y, Li L, Ma Y, Gao X, Zhao Y, Sun Y, Wang Y
Journal of ethnopharmacology 2025 Jan 31;340:119278
Journal of ethnopharmacology 2025 Jan 31;340:119278
Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation.
Mu SQ, Lin JJ, Wang Y, Yang LY, Wang S, Wang ZY, Zhao AQ, Luo WJ, Dong ZQ, Cao YG, Jiang ZA, Wang SF, Cao SH, Meng L, Li Y, Yang SY, Sun SG
Communications biology 2025 Jan 30;8(1):146
Communications biology 2025 Jan 30;8(1):146
HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.
Qi H, Gao Y, Zhang Z, Zhang X, Tian D, Jiang Y, Zhang L, Zeng N, Yang R
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917
DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism.
Wu X, Li Y, Wang W, Xu J, Zhao B, Sun W, Ge D, Xiong L, Dou X, Zou X, Wang L, Chen M
Scientific reports 2025 Jan 28;15(1):3542
Scientific reports 2025 Jan 28;15(1):3542
Sulforaphane regulation autophagy-mediated pyroptosis in autoimmune hepatitis via AMPK/mTOR pathway.
Yang W, Zeng S, Shao R, Jin R, Huang J, Wang X, Liu E, Zhou T, Li F, Chen Y, Chen D
International immunopharmacology 2025 Jan 27;146:113826
International immunopharmacology 2025 Jan 27;146:113826
Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models.
Yang J, Yuan J, Wen YQ, Wu L, Liao JJ, Qi HB
World journal of stem cells 2025 Jan 26;17(1):98349
World journal of stem cells 2025 Jan 26;17(1):98349
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice.
Pramanik R, Chattopadhyay S, Bishayi B
Immunologic research 2025 Jan 20;73(1):38
Immunologic research 2025 Jan 20;73(1):38
Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis.
Xia B, Lu YL, Peng J, Liang JW, Li FQ, Ding JY, Wan CW, Le CY, Dai JL, Jie-Wang, Guo B, Huang J
Scientific reports 2025 Jan 2;15(1):603
Scientific reports 2025 Jan 2;15(1):603
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1.
Jin S, Zhou Y, Lv J, Lu Y, Zhang Y, Li M, Feng N
Molecular medicine (Cambridge, Mass.) 2025 Jan 16;31(1):14
Molecular medicine (Cambridge, Mass.) 2025 Jan 16;31(1):14
Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept.
Li J, Zhang Y, Wei M, He J, Ma H, Chen Z, Duan J, Liu C
Ecotoxicology and environmental safety 2025 Jan 15;290:117617
Ecotoxicology and environmental safety 2025 Jan 15;290:117617
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis.
Wang L, Ouyang D, Li L, Cao Y, Wang Y, Gu N, Zhang Z, Li Z, Tang S, Tang H, Zhang Y, Sun X, Yan J
Journal of neuroinflammation 2025 Jan 13;22(1):6
Journal of neuroinflammation 2025 Jan 13;22(1):6
GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway.
Luo C, Xiao Z, Yang W
Scientific reports 2025 Jan 13;15(1):1787
Scientific reports 2025 Jan 13;15(1):1787
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
Xu J, Wang G, Hou Y, Sun K, Zheng Z, Guo Z, Hou L, Zhang X, Ruan Z, Ye Y, Guo F
International immunopharmacology 2025 Jan 10;144:113681
International immunopharmacology 2025 Jan 10;144:113681
N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma.
Fang R, Jia Z, Xin Y, Zhao K, Qin W, Lu H, Zhou Y, Yang Y, Fang H
Cell death discovery 2025 Jan 10;11(1):3
Cell death discovery 2025 Jan 10;11(1):3
Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway.
Yang M, Zheng S, Zeng W, Zhan C, Yang Y, Yang F
Journal of toxicology and environmental health. Part A 2025 Jan 10;:1-9
Journal of toxicology and environmental health. Part A 2025 Jan 10;:1-9
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring.
Cheng X, Xue Y, Wang H, Ma Z, Hu N, Zhang C, Gao Y, Fan R, Hu L, Li J, Zhang D, Huang J, Fang S, Xiao R, He Y, Luo T, Zheng L
Ecotoxicology and environmental safety 2025 Jan 1;289:117632
Ecotoxicology and environmental safety 2025 Jan 1;289:117632
Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis.
Liu C, Huang X, Kong J, Li X, Wang Y, Zhang F, Duan J
Ecotoxicology and environmental safety 2025 Jan 1;289:117441
Ecotoxicology and environmental safety 2025 Jan 1;289:117441
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Zhang Y, Xie W, Zong X, Fang Y, Ren J, Jing Z, Wei Y, Lu S, Zhu Q, Liu P
FASEB bioAdvances 2025 Feb;7(2):e1488
FASEB bioAdvances 2025 Feb;7(2):e1488
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Gan X, Luo X, Chen J, Fang W, Nie M, Lu H, Liu Y, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H
Cancer gene therapy 2025 Feb;32(2):240-253
Cancer gene therapy 2025 Feb;32(2):240-253
Macrophage-mimicking nanotherapy for attenuation of acute pancreatitis.
Shi F, Ergashev A, Pan Z, Sun H, Kong L, Jin Y, Zhang T, Liu Z, Xie H, Wang J, Li H, Wang Y, Zheng L, Shen J, Herrmann A, Chen G, Kong H
Materials today. Bio 2025 Feb;30:101406
Materials today. Bio 2025 Feb;30:101406
MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis.
Zhang Z, Chen S, Jun S, Xu X, Hong Y, Yang X, Zou L, Song YQ, Chen Y, Tu J
Autophagy 2025 Feb;21(2):424-446
Autophagy 2025 Feb;21(2):424-446
The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.
Deng Z, Guo J, Zhu Z, Qing Q, Wan D, Lei P, Liu Q, Huang B
Toxicology research 2025 Feb;14(1):tfae202
Toxicology research 2025 Feb;14(1):tfae202
Repressing cytokine storm-like response in macrophages by targeting the eIF2α-integrated stress response pathway.
Wang X, Dai C, Cheng W, Wang J, Cui X, Pan G, Chen Y, Han Y, Guo X, Jiang F
International immunopharmacology 2025 Feb 6;147:113965
International immunopharmacology 2025 Feb 6;147:113965
TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer.
Chen C, Chen Z, Zhao J, Wen X, Yao H, Weng Z, Xiong H, Zheng Z, Wu J
Cell death discovery 2025 Feb 5;11(1):47
Cell death discovery 2025 Feb 5;11(1):47
SJB2-043, a USP1 Inhibitor, Suppresses A549 Cell Proliferation, Migration, and EMT via Modulation of PI3K/AKT/mTOR, MAPK, and Wnt Signaling Pathways.
Wu L, Yu M, Liang H, Lin L, Li H, Chen G, Muhetaer H, Li J, Wu B, Jia X, Dang Y, Zheng G, Li C
Current issues in molecular biology 2025 Feb 27;47(3)
Current issues in molecular biology 2025 Feb 27;47(3)
Molecular Observations on the Regulation of hIAPP Aggregation Process and Enhancement of Autophagy by the Short Peptide LPFYPN and Its Modified Peptides of Coix Seed Prolamins.
Zhang S, Sun J, Yu S, Fu T, Feng Y, Li Z, Zhang D, Wang C
Journal of agricultural and food chemistry 2025 Feb 26;73(8):4659-4672
Journal of agricultural and food chemistry 2025 Feb 26;73(8):4659-4672
RhoB regulates prostate cancer cell proliferation and docetaxel sensitivity via the PI3K-AKT signaling pathway.
Sheng T, Su H, Yao L, Qu Z, Liu H, Shao W, Zhang X
BMC cancer 2025 Feb 26;25(1):354
BMC cancer 2025 Feb 26;25(1):354
THSWD upregulates the LTF/AMPK/mTOR/Becn1 axis and promotes lysosomal autophagy in hepatocellular carcinoma cells by regulating gut flora and metabolic reprogramming.
Zhu Z, Zuo S, Zhu Z, Wang C, Du Y, Chen F
International immunopharmacology 2025 Feb 20;148:114091
International immunopharmacology 2025 Feb 20;148:114091
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Xia H, Tai XJ, Cheng W, Wu Y, He D, Wang LF, Liu H, Zhang SY, Sun YT, Liu HZ, Liu DD, Zhao HZ, Ji FY, Li XH
Scientific reports 2025 Feb 19;15(1):6081
Scientific reports 2025 Feb 19;15(1):6081
Network pharmacology, molecular docking and biological verification to explore the potential anti-prostate cancer mechanisms of Tripterygium wilfordii Hook. F.
Sang Y, Hu Y, Zhang Y, Chen L, Lu Y, Gao L, Lu Y, Cao X, Zhang Y, Chen G
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119071
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119071
Ginsenoside Rg1 Alleviates Hydrogen Peroxide-Induced Autophagy and Apoptosis in Ovarian Granulosa Cells.
Li X, Weng SQ, Li QH, Ji M, Zhou Y, Xiao Q, Luo T, Liu ZX
Cell biochemistry and biophysics 2025 Dec;83(4):4781-4792
Cell biochemistry and biophysics 2025 Dec;83(4):4781-4792
High-Glucose Microenvironment Accelerates Malignant Progression Via O-GlcNAcylation in Oral Squamous Cell Carcinoma.
Zhu Z, Ren W, Yan X, Li S, Zheng J, Zhi K, Gao L
International dental journal 2025 Dec;75(6):103897
International dental journal 2025 Dec;75(6):103897
Comprehensive analysis of the leukocyte immunoglobulin-like receptor family in clear cell renal cell carcinoma.
He W, Cong Z, Niu C, Sun X, Yao Z, Zhang Y, Jiang X, Niu Z, Fu Q
Annals of medicine 2025 Dec;57(1):2546684
Annals of medicine 2025 Dec;57(1):2546684
Trichinella spiralis excretory-secretory proteins induced autophagy via activating AMPK/mTOR pathway and protected gut epithelial barrier.
Zhang XZ, Zhang Y, Zhang R, Wu JY, Cong PK, Long SR, Liu RD, Wang ZQ, Cui J
PLoS neglected tropical diseases 2025 Dec;19(12):e0013863
PLoS neglected tropical diseases 2025 Dec;19(12):e0013863
α-hederin decreases the glycolysis level in intestinal epithelial cells via SNX10-mediated DEPDC5 degradation.
Feng H, Wang J, Tao L, Li L, Fan M, Yu C, Sun D, Cheng H, Shen W
Journal of pharmaceutical analysis 2025 Dec;15(12):101301
Journal of pharmaceutical analysis 2025 Dec;15(12):101301
Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.
Zhang H, Huang X, Chen R, Lin W, Li L, Peng X, Yang X, Chen X, Guo T, Weng J, Li J, Yuan Q, Tan H, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e09998
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e09998
Obesity-induced gut microbiota transplantation promotes the occurrence and development of hepatocellular carcinoma.
Wu J, Zheng W, Ding X, Jin Q, Ding M
Future science OA 2025 Dec;11(1):2599729
Future science OA 2025 Dec;11(1):2599729
Phosvitin-Derived Peptide Pt5-1c Is a Pro-Angiogenic Agent Capable of Enhancing Wound Healing.
Xuan C, Li M, Zhang P, Wang Y, Li H, Gao Z, Zhang S, Wu F
Biomolecules 2025 Dec 31;16(1)
Biomolecules 2025 Dec 31;16(1)
HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells.
Wei Y, Cheng T, Liu H, Ma Y, Liu H, Du Y, Deng S
Scientific reports 2025 Dec 24;16(1):3909
Scientific reports 2025 Dec 24;16(1):3909
Sestrin 2 Regulates Milk Protein Synthesis through a LAT1/mTOR Pathway.
Ke Y, Chen B, Wang X, Jiang X, Liu T, Pan Y, Li Y, Song C, Chen X, Fang X, Wang Y, Zhang C
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31783-31793
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31783-31793
Quercetin Regulates Autophagy to Inhibit PRRSV Replication Through the PI3K/Akt/mTOR Signaling Pathway.
Yang Y, Li X, Shi H, Yu J, Gao C, Liu Y, Feng W, Peng L, Fu B, Yi P
Viruses 2025 Dec 17;17(12)
Viruses 2025 Dec 17;17(12)
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
Hao J, Zheng J, Liu C, Lu J, Tan M, Li J, Mao J, Yu Y, Wang H, Zhang Y, Shen H
International immunopharmacology 2025 Dec 10;167:115594
International immunopharmacology 2025 Dec 10;167:115594
SMURF2 Inhibits Autophagy and Growth in Ovarian Cancer by Regulating the RACK1/AKT/mTOR Pathway.
Wu L, Xiao Z, Zhang S, Guo L, Liu X, Zhang L, Xu J, Lv M, Wang J
American journal of reproductive immunology (New York, N.Y. : 1989) 2025 Aug;94(2):e70140
American journal of reproductive immunology (New York, N.Y. : 1989) 2025 Aug;94(2):e70140
Epigallocatechin-3-Gallate Attenuates Benign Prostatic Hyperplasia Development via Regulating Firmicutes to Inhibit Gastric Secretion of Insulin-Like Growth Factor-1.
Yang T, Shao Y, Wang Z, Liu C, Gu M
Cell biology international 2025 Aug;49(8):952-964
Cell biology international 2025 Aug;49(8):952-964
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
He H, Huang C, Huang H, Lan N, Liu S, Luo Y, Zheng L, Liu G, Qin Z, Zhao J
Biomaterials 2025 Aug;319:123210
Biomaterials 2025 Aug;319:123210
NUTF2 Promotes Proliferation of Oral Squamous Cell Carcinoma Through PI3K/AKT Signaling Pathway.
Chen Z, Zhao Z, Xu T, Zou F, Yang Y, Lu P, Chen Y, Zhu Z, He Y, Wu Y, Ding X, Song X
Oral diseases 2025 Aug;31(8):2441-2455
Oral diseases 2025 Aug;31(8):2441-2455
Clostridium butyricum ameliorates post-gastrectomy insulin resistance by regulating the mTORC1 signaling pathway through the gut-liver axis.
He Z, Xiong H, Cai Y, Chen W, Shi M, Liu L, Wu K, Deng X, Deng X, Chen T
Microbiological research 2025 Aug;297:128154
Microbiological research 2025 Aug;297:128154
1,3-Dichloro-2-propanol Causes Lipid Droplet Accumulation by Inhibiting Autophagy via REV-ERBα in Hepatocytes.
Chen Y, Peng H, Wang Z, Zhang D, Lang L, Lu J, Guan S
Journal of agricultural and food chemistry 2025 Aug 6;73(31):19789-19801
Journal of agricultural and food chemistry 2025 Aug 6;73(31):19789-19801
AP1S3 affects lipid metabolism in breast cancer cells by regulating the PI3K/AKT/mTOR pathway.
Wu Z, Wang S, Yang Q, Gong Y, Hu J
Biochemical and biophysical research communications 2025 Aug 30;776:152200
Biochemical and biophysical research communications 2025 Aug 30;776:152200
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.
Xiong L, Shu J, Gao H, Qin Y, Zhang Y, Chang X, Dong Q, Chen H
Acta odontologica Scandinavica 2025 Aug 21;84:479-490
Acta odontologica Scandinavica 2025 Aug 21;84:479-490
Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4(QTY)-Fc as a molecular trap.
Sun C, Hao S, Wang L, Meng R, Wang H, Li W, Deng J, Yin Q, Chen X, Xiang T, Liu Z, Zheng H, Luo Z, Cai K, Wang B, Zhang S, Qing R
Cell chemical biology 2025 Aug 21;32(8):1058-1074.e6
Cell chemical biology 2025 Aug 21;32(8):1058-1074.e6
Irisolidone enhances osteoblast differentiation via the AMPK-ULK1-autophagy Axis to accelerate osteoporotic fracture repair.
Lao Z, Liu Z, Ji W, Chen X, Yang W, Qian Y
Biochemical pharmacology 2025 Aug 13;242(Pt 1):117234
Biochemical pharmacology 2025 Aug 13;242(Pt 1):117234
Activation of mTOR/HK2 signaling mitigates effects of PYCR2 depletion in colorectal cells.
Chen L, Yuan Y, Zhang N, Huang Q, Zhou Y
Tissue & cell 2025 Apr;93:102729
Tissue & cell 2025 Apr;93:102729
Isoliquiritigenin, an Extract from Licorice, Attenuates Dexamethasone-Induced Muscle Atrophy via Akt/mTOR Pathway.
Jiao X, Zhang Y, Wang Z, Chang H, Li Y, Wang B, Gan Y, Gu D
Molecular nutrition & food research 2025 Apr;69(7):e70000
Molecular nutrition & food research 2025 Apr;69(7):e70000
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
Wang G, Dai S, Chen J, Zhang K, Huang C, Zhang J, Xie K, Lin F, Wang H, Gao Y, Yin L, Jiang K, Miao Y, Lu Z
Cell death and differentiation 2025 Apr;32(4):702-713
Cell death and differentiation 2025 Apr;32(4):702-713
Phlecarinatones H-N: Abietane-type diterpenoids from Phlegmariurus carinatus with proliferative inhibitory effect on U251 glioblastoma cells.
Wang H, Wang Q, Chen YH, Chen X, Zheng DK, Xie Z, Feng DM, Liu L, Li J, Liu Y
Phytochemistry 2025 Apr;232:114356
Phytochemistry 2025 Apr;232:114356
Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy.
Wang Y, Ding L, Wang Y, Li H, Wu M, Li S, Xu Q, Chen Y, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156483
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156483
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Zhang P, Liu Z, Ma G, Wang J, Shao J, Ma C, Wang L, Ma C
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Tricin Delays Aging and Enhances Muscle Function via Activating AMPK-Mediated Autophagy in Diverse Model Organisms.
Zhu YF, Zhou XY, Lan C, Wen YP, Fu HJ, Li ZC, Li YP, Li SY, Huang FH, Wang L, Yu L, Qin DL, Wu AG, Wu JM, Zhou XG
Journal of agricultural and food chemistry 2025 Apr 30;73(17):10246-10264
Journal of agricultural and food chemistry 2025 Apr 30;73(17):10246-10264
Comprehensive analysis illustrating the role of HOXB8 in head and neck squamous cell carcinoma: evidence from multi-omics analysis and experiments validation.
Zhang JW, Gao XL, Wang J, Fan XL, Liang QW
BMC cancer 2025 Apr 30;25(1):804
BMC cancer 2025 Apr 30;25(1):804
Baicalin Relieves Glaesserella parasuis-Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets.
Fu S, Dong Q, Fu Y, Luo R, Li J, Sun Y, Liu S, Qiu Y, Guo L, Hu J
Biomolecules 2025 Apr 29;15(5)
Biomolecules 2025 Apr 29;15(5)
Carbon dot-based treatment for bacterial pneumonia by promoting a PI3K-mediated M1 polarization of macrophages.
Jiang X, Wang J, Gan L, Wu Z, Wu T, Li F, Xu X, Lei L, Li N
Journal of nanobiotechnology 2025 Apr 26;23(1):315
Journal of nanobiotechnology 2025 Apr 26;23(1):315
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
Ma L, Sun H, Xiang N, Xu Q
Scientific reports 2025 Apr 25;15(1):14516
Scientific reports 2025 Apr 25;15(1):14516
SNX10 Is Involved in Ovarian Cancer Cell Metastasis by Repolarizing Tumor-Associated Macrophages Through mTOR1/Lysosomes Pathway.
Chai R, Zheng K, Xu T, Wang H, Cheng X, Lu C, Kang Y
Biomedicines 2025 Apr 23;13(5)
Biomedicines 2025 Apr 23;13(5)
KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids.
Berlind JE, Lai JD, Lie C, Vicente J, Lam K, Guo S, Chang J, Yu V, Ichida JK
Neuron 2025 Apr 16;113(8):1169-1189.e7
Neuron 2025 Apr 16;113(8):1169-1189.e7
lncRNA NR_146969 promotes the progression of lung adenocarcinoma.
Chen Y, Wang J, Gu L, Chen H, Gai Z, Hu R, Qing B, Yuan Y, Xia Z
Experimental cell research 2025 Apr 15;447(2):114535
Experimental cell research 2025 Apr 15;447(2):114535
Methylmercury Chloride Exposure Affects Oocyte Maturation Through AMPK/mTOR-Mediated Mitochondrial Autophagy.
Hou S, Wang C, Ma X, Zhao J, Wang J, Fang Y, Liu H, Ding H, Guo J, Lu W
International journal of molecular sciences 2025 Apr 11;26(8)
International journal of molecular sciences 2025 Apr 11;26(8)
Chryxanthone A, an extracted substance from endophytic fungal Aspergillus versicolor, produces anti-oxidant neuroprotection possibly via the action on mTOR/CREB axis.
Zhang X, Hong Y, Hu C, Zhai Y, Pan N, Ding L, Han W, Cui W
Gene 2025 Apr 10;944:149298
Gene 2025 Apr 10;944:149298
Network Analysis and Basic Experiments on the Inhibition of Renal Cancer Proliferation and Migration by Alpinetin through PI3K/AKT/ mTOR Pathway.
Guo Y, Jiang L, Luo S, Hu D, Zhao X, Zhao G, Tang W
Current molecular medicine 2024;24(1):134-144
Current molecular medicine 2024;24(1):134-144
HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling.
Zhang Y, Pan R, Li K, Cheang LH, Zhao J, Zhong Z, Li S, Wang J, Zhang X, Cheng Y, Zheng X, He R, Wang H
International journal of biological sciences 2024;20(13):5162-5190
International journal of biological sciences 2024;20(13):5162-5190
IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway.
Guo N, Xia Y, He N, Cheng H, Zhang L, Liu J
Journal of inflammation research 2024;17:10255-10272
Journal of inflammation research 2024;17:10255-10272
CD52 knockdown inhibits aerobic glycolysis and malignant behavior of NSCLC cells through AKT signaling pathway.
Cai Y, Zhao J, Luo C, Fang M, Yi Y, Chen Y, Huang P, Liao L, Huang L
Journal of Cancer 2024;15(11):3394-3405
Journal of Cancer 2024;15(11):3394-3405
miR-769-3p inhibits cellular proliferation of KSHV-infected SH-SY5Y cells through targeting mTOR.
Cao D, Wu Z, Yang R, Yao L, Huang J, Ding Y, Ruzi A, Pan Z, Pan Y, Li D, Gu W, Zhang J
Journal of Cancer 2024;15(11):3338-3349
Journal of Cancer 2024;15(11):3338-3349
Microbiota-derived tryptophan metabolism and AMPK/mTOR pathway mediate antidepressant-like effect of Shugan Hewei Decoction.
Yue Y, Ke Y, Zheng J, Wang Z, Liu H, Liu S
Frontiers in pharmacology 2024;15:1466336
Frontiers in pharmacology 2024;15:1466336
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Cai W, Xiao Y, Yan J, Peng H, Tu C
Frontiers in cell and developmental biology 2024;12:1489774
Frontiers in cell and developmental biology 2024;12:1489774
Enhancing angiogenesis in peri-implant soft tissue with bioactive silk fibroin microgroove coatings on zirconia surfaces.
Wang Z, Tuerxun P, Ng T, Yan Y, Zhao K, Jian Y, Jia X
Regenerative biomaterials 2024;11:rbae068
Regenerative biomaterials 2024;11:rbae068
IDN5706 Inhibits Synovial Inflammation via Inducing M2 Polarization of Synovial Macrophages in Osteoarthritis Rats.
Zhang J, Cheng F, Rong G, Tang Z, Gui B
Pharmacology 2024;109(3):156-168
Pharmacology 2024;109(3):156-168
TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.
Wang L, Wu Z, Wang Y, Chen C, Li Y, Dong H, Yao T, Jin G, Wang Z
Cell biochemistry and biophysics 2024 Sep;82(3):2717-2726
Cell biochemistry and biophysics 2024 Sep;82(3):2717-2726
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Zhang W, Yu L, Xu C, Tang T, Cao J, Chen L, Pang X, Ren W
Cell biology international 2024 Sep;48(9):1285-1300
Cell biology international 2024 Sep;48(9):1285-1300
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Gu J, Jin J, Ren X, Zhang X, Li J, Wang X, Zhang S, Yin X, Zhang Q, Wang Z
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Diabetes & metabolism journal 2024 Sep;48(5):885-900
PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation.
Yoshioka Y, Huang Y, Jin X, Ngo KX, Kumaki T, Jin M, Toyoda S, Takayama S, Inotsume M, Fujita K, Homma H, Ando T, Tanaka H, Okazawa H
The EMBO journal 2024 Sep;43(18):3968-3999
The EMBO journal 2024 Sep;43(18):3968-3999
Potential of semen coicis in enhancing the anti-tumor effects of PD-1 inhibitor on A549 cell lines by blocking the PI3K-AKT-mTOR pathway.
Fu ZY, Huang Y, Lian LS, Huang HT, Zhan SF, Cai Y, Li JX, Liu XH
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Sep;26(9):2250-2261
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Sep;26(9):2250-2261
Panax notoginseng saponins dually modulates autophagy in gastric precancerous lesions complicated with myocardial ischemia-reperfusion injury model through the PI3K/AKT/mTOR pathway.
Wang X, Zhang R, Zeng N, Li H, Hua B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117268
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117268
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.
Li X, Wang G, Li N, Wang X, Fan W, Zhang Z, Li W, Liu J, Huang J, Liu X, Zhou Q, Hou S
Immunology 2024 Sep;173(1):141-151
Immunology 2024 Sep;173(1):141-151
Autophagy Deficiency Induced by SAT1 Potentiates Tumor Progression in Triple-Negative Breast Cancer.
Tian W, Zhu L, Luo Y, Tang Y, Tan Q, Zou Y, Chen K, Deng X, Tang H, Li H, Cai M, Xie X, Ye F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2309903
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2309903
Selenomethionine Promotes Milk Protein and Fat Synthesis and Proliferation of Mammary Epithelial Cells through the GPR37-mTOR-S6K1 Signaling.
Zhang J, Xie L, Li H, Li S, Gao X, Zhang M
Journal of agricultural and food chemistry 2024 Sep 4;72(35):19505-19516
Journal of agricultural and food chemistry 2024 Sep 4;72(35):19505-19516
Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.
Qin Y, Li W, Liu J, Wang F, Zhou W, Xiao L, Zhou P, Wu F, Chen X, Xu S, Liu L, Xiao X, Zhang D
International immunopharmacology 2024 Sep 30;139:112719
International immunopharmacology 2024 Sep 30;139:112719
Clarithromycin attenuates airway epithelial-mesenchymal transition in ovalbumin-induced asthmatic mice through modulation of Kv1.3 channels and PI3K/Akt signaling.
Sun B, Shen K, Zhao R, Li Y, Lin J
International immunopharmacology 2024 Sep 30;139:112624
International immunopharmacology 2024 Sep 30;139:112624
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis.
Zhao S, Hao S, Zhou J, Chen X, Zhang T, Qi Z, Zhang T, Jalal S, Zhai C, Yin L, Bo Y, Teng H, Wang Y, Gao D, Zhang H, Huang L
Cellular & molecular biology letters 2024 Sep 27;29(1):125
Cellular & molecular biology letters 2024 Sep 27;29(1):125
GQ262 Attenuates Pathological Cardiac Remodeling by Downregulating the Akt/mTOR Signaling Pathway.
Ma H, Ge Y, Di C, Wang X, Qin B, Wang A, Hu W, Lai Z, Xiong X, Qi R
International journal of molecular sciences 2024 Sep 25;25(19)
International journal of molecular sciences 2024 Sep 25;25(19)
Signaling proteins in HSC fate determination are unequally segregated during asymmetric cell division.
Ugale A, Shunmugam D, Pimpale LG, Rebhan E, Baccarini M
The Journal of cell biology 2024 Sep 2;223(9)
The Journal of cell biology 2024 Sep 2;223(9)
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Liu Z, Zhang Z, Tang R, Liu J, Yang Y
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Mechanisms of Yiai Fuzheng formula in the treatment of triple-negative breast cancer based on UPLC-Q-Orbitrap-HRMS, network pharmacology, and experimental validation.
Li R, Ke H, Liu P, Yang Q, Li Y, Ke L, Wang X, Wu C, Zhang Y
Heliyon 2024 Sep 15;10(17):e36579
Heliyon 2024 Sep 15;10(17):e36579
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
Jiang X, Liu K, Luo P, Li Z, Xiao F, Jiang H, Wu S, Tang M, Yuan F, Li X, Shu Y, Peng B, Chen S, Ni S, Guo F
Nature communications 2024 Sep 11;15(1):7948
Nature communications 2024 Sep 11;15(1):7948
FAT10 induces immune suppression by upregulating PD-L1 expression in hepatocellular carcinoma.
Wang Q, Tan W, Zhang Z, Chen Q, Xie Z, Yang L, Tang C, Zhuang H, Wang B, Jiang J, Ma X, Wang W, Hua Y, Shang C, Chen Y
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1529-1545
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1529-1545
SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.
Pan S, Yuan T, Xia Y, Yu W, Li H, Rao T, Ye Z, Li L, Zhou X, Cheng F
Biomedicines 2024 Oct 8;12(10)
Biomedicines 2024 Oct 8;12(10)
Dihydroberberine alleviates Th17/Treg imbalance in premature ovarian insufficiency mice via inhibiting Rheb/mTOR signaling.
Deng D, Wu Y, Wu K, Zeng N, Li W
Molecular medicine (Cambridge, Mass.) 2024 Oct 29;30(1):194
Molecular medicine (Cambridge, Mass.) 2024 Oct 29;30(1):194
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice.
Zheng S, Zhu J, Wang C, Wu Y, Sun S, Guo H, Chang Y, Ma R, Li G
Cell communication and signaling : CCS 2024 Oct 24;22(1):516
Cell communication and signaling : CCS 2024 Oct 24;22(1):516
Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway.
Zhao J, Gao G, Ding J, Liu W, Wang T, Zhao L, Xu J, Zhang Z, Zhang X, Xie Z
Journal of agricultural and food chemistry 2024 Oct 2;72(39):21548-21559
Journal of agricultural and food chemistry 2024 Oct 2;72(39):21548-21559
Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma.
He L, Zhang X, Shi F, Zhang H, Chen Y, Sun K, Yang H, Shi J, Lin Z, Lu Q, Wang S, Liu L, Liu X, Meng Q, Huang J, Xu P, Bai X, Liang T
Cell reports. Medicine 2024 Oct 15;5(10):101731
Cell reports. Medicine 2024 Oct 15;5(10):101731
SCYL1-mediated regulation of the mTORC1 signaling pathway inhibits autophagy and promotes gastric cancer metastasis.
Zhao Z, Liu J, Gao X, Chen Z, Hu Y, Chen J, Zang W, Xue W
Journal of cancer research and clinical oncology 2024 Oct 12;150(10):456
Journal of cancer research and clinical oncology 2024 Oct 12;150(10):456
Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer.
Zheng Y, Li L, Shen Z, Wang L, Niu X, Wei Y, Sun S, Zhao J
Journal of experimental & clinical cancer research : CR 2024 Oct 10;43(1):284
Journal of experimental & clinical cancer research : CR 2024 Oct 10;43(1):284
USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1.
Geng L, Liu F, Yang L, Liu Y, Wu G
Experimental cell research 2024 Oct 1;442(2):114284
Experimental cell research 2024 Oct 1;442(2):114284
Propyl acetate protects intestinal barrier during parenteral nutrition in mice and Caco-2 cells.
Wang J, Du J, Gou X, Huang Y, He J, Lu X, Xie M
JPEN. Journal of parenteral and enteral nutrition 2024 Nov;48(8):917-926
JPEN. Journal of parenteral and enteral nutrition 2024 Nov;48(8):917-926
Protective effect of folic acid on MNNG-induced proliferation of esophageal epithelial cells via the PI3K/AKT/mTOR signaling pathway.
Cheng S, Chen J, Li Q, Nie Y, Ni T, Peng C, Luo X, Yasin P, Zhang S, Tang J, Liu Z
The Journal of nutritional biochemistry 2024 Nov;133:109702
The Journal of nutritional biochemistry 2024 Nov;133:109702
Neutralization of TLR2 in combination with either TNF-α or IL-1β antibody reduces the severity of septic arthritis through STAT3/mTOR signalling in lymphocytes.
Ghosh R, Bishayi B
Cellular immunology 2024 Nov-Dec;405-406:104878
Cellular immunology 2024 Nov-Dec;405-406:104878
Taurine Inhibits Lung Metastasis in Triple-Negative Breast Cancer by Modulating Macrophage Polarization Through PTEN-PI3K/Akt/mTOR Pathway.
Lin Y, Huang Y, Zheng Y, Chen W, Zhang Y, Yang Y, Huang W
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Nov-Dec 01;47(9):369-377
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Nov-Dec 01;47(9):369-377
Momordica charantia Extract Ameliorates Melanoma Cell Proliferation and Invasion into Mouse Lungs by Suppressing PAX3 Expression.
Hiramoto K, Oikawa H
International journal of molecular sciences 2024 Nov 28;25(23)
International journal of molecular sciences 2024 Nov 28;25(23)
Piezo1 Modulates Neuronal Autophagy and Apoptosis in Cerebral Ischemia-Reperfusion Injury Through the AMPK-mTOR Signaling Pathway.
Yue Y, Chen P, Ren C
Neurochemical research 2024 Nov 25;50(1):32
Neurochemical research 2024 Nov 25;50(1):32
Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.
Chen Y, Xu W, Jin H, Zhang M, Liu S, Liu Y, Zhang H
ACS nano 2024 Nov 19;18(46):31846-31868
ACS nano 2024 Nov 19;18(46):31846-31868
EYA3 promotes the tumorigenesis of gastric cancer through activation of the mTORC1 signaling pathway and inhibition of autophagy.
Xu Z, Liu J, Yang M, Huang K
Scientific reports 2024 Nov 16;14(1):28355
Scientific reports 2024 Nov 16;14(1):28355
Succinylation modification-mediated upregulation of Sp1 promotes hepatocellular carcinoma cell proliferation.
Han Y, Deng X, Chen H, Chen J, Xu W, Liu L
Discover oncology 2024 Nov 15;15(1):660
Discover oncology 2024 Nov 15;15(1):660
Folic Acid Attenuates N-Methyl-N'-Nitro-N-NitrosoguanidineInduced Gastric Mucosal Injury in Rats.
Peng C, Wang L, Liang Y, Che L, Sun R, Yu J, Gong J, Wang D, Cheng S, Yang Q, Jing T, Liu Z
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024 Nov 1;35(11):839-848
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024 Nov 1;35(11):839-848
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Liu L, Xiao W, Yang Z, Wang Q, Yi J
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity.
Yin HT, Hui-Lu, Yang JH, Li Q, Li M, Zhao QQ, Wen ZP
Biochemical pharmacology 2024 May;223:116113
Biochemical pharmacology 2024 May;223:116113
Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy.
Liu X, Jiang L, Zeng H, Gao L, Guo S, Chen C, Liu X, Zhang M, Ma L, Li Y, Qi X, Wu Y
Autophagy 2024 May;20(5):1072-1097
Autophagy 2024 May;20(5):1072-1097
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Kundu A, Ghosh P, Bishayi B
International immunopharmacology 2024 May 30;133:112153
International immunopharmacology 2024 May 30;133:112153
αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis.
Guo X, He L, Xu W, Wang W, Feng X, Fu Y, Zhang X, Ding RB, Qi X, Bao J, Luo S
Marine drugs 2024 May 29;22(6)
Marine drugs 2024 May 29;22(6)
SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice.
Guo L, Yuan H, Zhu H, Zhou J, Wan Z, Zhou Y
BMC cardiovascular disorders 2024 May 28;24(1):275
BMC cardiovascular disorders 2024 May 28;24(1):275
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Wang FR, Peng ML, Zhu QF, Yu LL, Zhang LJ, Xu SY, Wang Q, Li J, He X, Liao SG, Ao JL, Xu GB
Journal of ethnopharmacology 2024 May 10;325:117830
Journal of ethnopharmacology 2024 May 10;325:117830
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Ou X, Tan Y, Xie J, Yuan J, Deng X, Shao R, Song C, Cao X, Xie X, He R, Li Y, Tang H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Zhou ZX, Ma XF, Xiong WH, Ren Z, Jiang M, Deng NH, Zhou BB, Liu HT, Zhou K, Hu HJ, Tang HF, Zheng H, Jiang ZS
Atherosclerosis 2024 Mar;390:117430
Atherosclerosis 2024 Mar;390:117430
Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits.
Zhou J, Li C, Lu M, Jiang G, Chen S, Li H, Lu K
PLoS biology 2024 Mar;22(3):e3002537
PLoS biology 2024 Mar;22(3):e3002537
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
Liu ZD, Shi YH, Xu QC, Zhao GY, Zhu YQ, Li FX, Ma MJ, Ye JY, Huang XT, Wang XY, Xu X, Wang JQ, Zhao W, Yin XY
Cancer letters 2024 Mar 31;585:216640
Cancer letters 2024 Mar 31;585:216640
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Xu J, Xue D, Li Y, Zhou J, Chen H, Fan L
Heliyon 2024 Mar 30;10(6):e27629
Heliyon 2024 Mar 30;10(6):e27629
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
Zhang S, Cai X, Khan GJ, Cheng J, He J, Zhai K, Mao Y
Journal of ethnopharmacology 2024 Mar 25;322:117572
Journal of ethnopharmacology 2024 Mar 25;322:117572
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Xu T, Zhao H, Li J, Fang X, Wu H, Hu W
JOR spine 2024 Jun;7(2):e1325
JOR spine 2024 Jun;7(2):e1325
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.
Wang H, Liu X, Yan X, Du Y, Pu F, Ren J, Qu X
Biomaterials 2024 Jun;307:122523
Biomaterials 2024 Jun;307:122523
Rapamycin improves the survival of epilepsy model cells by blocking phosphorylation of mTOR base on computer simulations and cellular experiments.
Li K, Cao JF, Gong Y, Xiong L, Wu M, Qi Y, Ying X, Liu D, Ma X, Zhang X
Neurochemistry international 2024 Jun;176:105746
Neurochemistry international 2024 Jun;176:105746
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Zhao ZX, Li S, Liu LX
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
SULF1 regulates malignant progression of colorectal cancer by modulating ARSH via FAK/PI3K/AKT/mTOR signaling.
Zhu W, Wu C, Liu Z, Zhao S, Cheng X, Huang J
Cancer cell international 2024 Jun 6;24(1):201
Cancer cell international 2024 Jun 6;24(1):201
RNA sequencing screening and gene function analysis uncover G protein-coupled receptor 183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells.
Zhou Y, Fan S, Xu M, Zhang M, Gao X
The British journal of nutrition 2024 Jun 4;:1-13
The British journal of nutrition 2024 Jun 4;:1-13
Investigating the potential role of α-SNAP in preventing chemotherapy-induced ovarian dysfunction: Insights from cellular and animal models.
Qin Y, Wen C, Hu B, Wu H
Heliyon 2024 Jun 30;10(12):e32802
Heliyon 2024 Jun 30;10(12):e32802
Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma.
Bai Y, You Y, Chen D, Chen Y, Yin Z, Liao S, You B, Lu D, Sun Y, Wu L, Wu Y
iScience 2024 Jun 21;27(6):109997
iScience 2024 Jun 21;27(6):109997
Treg and neutrophil extracellular trap interaction contributes to the development of immunosuppression in sepsis.
Shi Y, Wu D, Wang Y, Shao Y, Zeng F, Zhou D, Zhang H, Miao C
JCI insight 2024 Jun 18;9(14)
JCI insight 2024 Jun 18;9(14)
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
Zhao Q, Chen L, Zhang X, Yang H, Li Y, Li P
Chinese medicine 2024 Jun 15;19(1):86
Chinese medicine 2024 Jun 15;19(1):86
TGF β1 promotes the polarization of M2-type macrophages and activates PI3K/mTOR signaling pathway by inhibiting ISG20 to sensitize ovarian cancer to cisplatin.
Wu J, Jiang L, Wang S, Peng L, Zhang R, Liu Z
International immunopharmacology 2024 Jun 15;134:112235
International immunopharmacology 2024 Jun 15;134:112235
SIAH2 is specifically expressed during cervical carcinogenesis, and closely relates to the abnormal proliferation of cervical epithelial cells.
Jing LP, Li M, Xia XY, Zheng X, Chen JY, He J, Zhuang XW
Heliyon 2024 Jun 15;10(11):e31487
Heliyon 2024 Jun 15;10(11):e31487
Electrical Pulse Stimulation Protects C2C12 Myotubes against Hydrogen Peroxide-Induced Cytotoxicity via Nrf2/Antioxidant Pathway.
Pribil Pardun S, Bhat A, Anderson CP, Allen MF, Bruening W, Jacob J, Pendyala VV, Yu L, Bruett T, Zimmerman MC, Park SY, Zucker IH, Gao L
Antioxidants (Basel, Switzerland) 2024 Jun 12;13(6)
Antioxidants (Basel, Switzerland) 2024 Jun 12;13(6)
The autophagy-mediated mechanism via TSC1/mTOR signaling pathway in thiram-induced tibial dyschondroplasia of broilers.
Quan C, Zhou S, Zhang Y, Kulyar MF, Gong S, Nawaz S, Ahmed AE, Mo Q, Li J
The Science of the total environment 2024 Jun 10;928:172305
The Science of the total environment 2024 Jun 10;928:172305
The therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism.
Wang X, Wang F, Dong P, Zhou L
Radiology and oncology 2024 Jun 1;58(2):221-233
Radiology and oncology 2024 Jun 1;58(2):221-233
Metformin mitigates adipogenesis of fibro-adipogenic progenitors after rotator cuff tears via activating mTOR/ULK1-mediated autophagy.
Zhou H, Lin X, Feng S, Zhu S, Zhou H, Chen H, Youwu H, Wang Z, Wang R, Shao X, Wang J
American journal of physiology. Cell physiology 2024 Jun 1;326(6):C1590-C1603
American journal of physiology. Cell physiology 2024 Jun 1;326(6):C1590-C1603
PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis.
Zhang J, Tian Y, Xu X, Wang B, Huang Z, Song K, Lou S, Kang J, Zhang N, Li J, Weng J, Liang Y, Ma W
Autophagy 2024 Jul;20(7):1616-1638
Autophagy 2024 Jul;20(7):1616-1638
Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
Huang R, Liu L, Shen K, Duan C, Fan Z
Journal of integrative neuroscience 2024 Jul 5;23(7):124
Journal of integrative neuroscience 2024 Jul 5;23(7):124
Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway.
Duan H, Li H, Liu T, Chen Y, Luo M, Shi Y, Zhou J, Rashed MMA, Zhai K, Li L, Wei Z
ACS omega 2024 Jul 30;9(30):32920-32930
ACS omega 2024 Jul 30;9(30):32920-32930
LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.
Wu HH, Du JM, Liu P, Meng FL, Li YY, Li WJ, Wang SX, Du NL, Zheng Y, Zhang L, Wang HY, Liu YR, Song CH, Ni X, Li Y, Su GH
International immunopharmacology 2024 Jul 30;136:112338
International immunopharmacology 2024 Jul 30;136:112338
Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways.
Fu S, Li J, You J, Liu S, Dong Q, Fu Y, Luo R, Sun Y, Tian X, Liu W, Zhang J, Ding Y, Zhang Y, Wang W, Guo L, Qiu Y
Veterinary research 2024 Jul 29;55(1):95
Veterinary research 2024 Jul 29;55(1):95
Hydrogen Sulfide Promotes Platelet Autophagy via PDGFR-α/PI3K/Akt Signaling in Cirrhotic Thrombocytopenia.
Yang HX, Li YJ, He YL, Jin KK, Lyu LN, Ding HG
Journal of clinical and translational hepatology 2024 Jul 28;12(7):625-633
Journal of clinical and translational hepatology 2024 Jul 28;12(7):625-633
KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway.
Yu L, Liu Y, Xia J, Feng S, Chen F
Behavioural brain research 2024 Jul 26;470:115069
Behavioural brain research 2024 Jul 26;470:115069
Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.
Tang L, Xu S, Wei R, Fan G, Zhou J, Wei X, Xu X
Molecular medicine (Cambridge, Mass.) 2024 Jul 25;30(1):108
Molecular medicine (Cambridge, Mass.) 2024 Jul 25;30(1):108
Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster-positive hepatocellular carcinoma patients who have undergone living donor liver transplantation.
Toshida K, Itoh S, Toshima T, Yoshiya S, Goto R, Mita A, Harada N, Kohashi K, Oda Y, Yoshizumi T
Annals of gastroenterological surgery 2024 Jan;8(1):163-171
Annals of gastroenterological surgery 2024 Jan;8(1):163-171
Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training.
Bou T, Ding W, Ren X, Liu H, Gong W, Jia Z, Zhang X, Dugarjaviin M, Bai D
Equine veterinary journal 2024 Jan;56(1):178-192
Equine veterinary journal 2024 Jan;56(1):178-192
Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice.
Huang Y, Han M, Shi Q, Li X, Mo J, Liu Y, Chu Z, Li W
Experimental neurology 2024 Jan;371:114583
Experimental neurology 2024 Jan;371:114583
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Wang T, Chen S, Wang Z, Li S, Fei X, Wang T, Zhang M
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin.
Chen Z, Guo Q, Huang S, Li L, Wu F, Liu Z, Li Z, Chen T, Song G, Xu S, Chen J, Hou Y
Genes & diseases 2024 Jan;11(1):397-412
Genes & diseases 2024 Jan;11(1):397-412
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Wei L, Li X, Yao Y, Wang S, Ai X, Liu S
Chemical biology & drug design 2024 Jan;103(1):e14421
Chemical biology & drug design 2024 Jan;103(1):e14421
Chrysophanol induces apoptosis and ferroptosis of gastric cancer cells by targeted regulation of mTOR.
Xi S, Ding W, Weng D, Zeng Y, Gao K, Wu Q, Huang G, Li Y, Yue H
Chemical biology & drug design 2024 Jan;103(1):e14417
Chemical biology & drug design 2024 Jan;103(1):e14417
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Tian X, Wei J
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234741
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234741
Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
Xie L, Li R, Zhang J, Li H, Gao X, Zhang M
Journal of agricultural and food chemistry 2024 Jan 31;72(4):2135-2144
Journal of agricultural and food chemistry 2024 Jan 31;72(4):2135-2144
FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Zhou Z, Zhang B, Deng Y, Deng S, Li J, Wei W, Wang Y, Wang J, Feng Z, Che M, Yang X, Meng J, Li Y, Hu Y, Sun Y, Wen L, Huang F, Sheng Y, Wan C, Yang K
Journal of experimental & clinical cancer research : CR 2024 Jan 29;43(1):34
Journal of experimental & clinical cancer research : CR 2024 Jan 29;43(1):34
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Li Y, Li L, Xiong W, Duan X, Xi H
Theriogenology 2024 Jan 15;214:192-200
Theriogenology 2024 Jan 15;214:192-200
Tumor-associated macrophage-derived exosomal miR-513b-5p is a target of jianpi yangzheng decoction for inhibiting gastric cancer.
Zhang R, Chen X, Miao C, Chen Y, Li Y, Shen J, Yuan M, Chen M, Cheng J, Liu S, Sun Q, Wu J
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117013
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117013
PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
Wang L, Yan F, Shi Y, Su X, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2024 Feb;94:105711
Toxicology in vitro : an international journal published in association with BIBRA 2024 Feb;94:105711
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
Lin S, Chen Z, Wu Z, Fei F, Xu Z, Tong Y, Sun W, Wang P
Neurochemical research 2024 Feb;49(2):477-491
Neurochemical research 2024 Feb;49(2):477-491
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
Yu H, Li X, Li Y, Wang T, Wang M, Mao P
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
Son SM, Park SJ, Breusegem SY, Larrieu D, Rubinsztein DC
Nature cell biology 2024 Feb;26(2):235-249
Nature cell biology 2024 Feb;26(2):235-249
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Ghosh R, Bishayi B
Microbial pathogenesis 2024 Feb;187:106518
Microbial pathogenesis 2024 Feb;187:106518
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
Xia ZY, Liu L, Kuok CF, Wang XL, Shi D, Ma Q, Cheng XY, Wang GL, Li MJ, Zheng QS, Liu XN, Li DF, Li BH
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Adzraku SY, Cao C, Zhou Q, Yuan K, Hao X, Li Y, Yuan S, Huang Y, Xu K, Qiao J, Ju W, Zeng L
Cell death & disease 2024 Feb 21;15(2):159
Cell death & disease 2024 Feb 21;15(2):159
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J
Free radical biology & medicine 2024 Feb 20;212:133-148
Free radical biology & medicine 2024 Feb 20;212:133-148
mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.
Ali Y, Gomez-Sanchez CE, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez EP
Endocrinology 2024 Feb 20;165(4)
Endocrinology 2024 Feb 20;165(4)
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.
Zhan X, Li J, Zeng R, Lei L, Feng A, Yang Z
Experimental cell research 2024 Feb 1;435(1):113925
Experimental cell research 2024 Feb 1;435(1):113925
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells.
Kořánová T, Dvořáček L, Grebeňová D, Kuželová K
Pharmacological reports : PR 2024 Dec;76(6):1390-1402
Pharmacological reports : PR 2024 Dec;76(6):1390-1402
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis.
Wei W, Qu ZL, Lei L, Zhang P
Current medical science 2024 Dec;44(6):1280-1292
Current medical science 2024 Dec;44(6):1280-1292
METTL3-Mediated m(6)A Modification of FMRP Drives Hepatocellular Carcinoma Progression and Indicates Poor Prognosis.
Fu S, Sun D, Wang Z, Zhu P, Ding W, Huang J, Guo X, Yang Y, Gu F
Cancer biotherapy & radiopharmaceuticals 2024 Dec;39(10):745-754
Cancer biotherapy & radiopharmaceuticals 2024 Dec;39(10):745-754
TGN-020 ameliorates motor dysfunction post-spinal cord injury via enhancing astrocyte autophagy and mitigating inflammation by activating AQP4/PPAR-γ/mTOR pathway.
Kong J, Zhang Q, Zheng H, Tang D, Fang L, An S, Li J, Fan Z
Experimental neurology 2024 Dec;382:114975
Experimental neurology 2024 Dec;382:114975
High-level L-Gln compromises intestinal amino acid utilization efficiency and inhibits protein synthesis by GCN2/eIF2α/ATF4 signaling pathway in piglets fed low-crude protein diets.
Li J, Chen Y, Yang Y, Yang Y, Wu Z
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Dec;19:480-487
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Dec;19:480-487
MLN4924 Suppresses head and neck squamous cell carcinoma progression by inactivating the mTOR signaling pathway via the NEDD8/CUL4/TSC2 axis.
Jiang Y, Le F, Huang S, Chen X, Deng Z
The international journal of biochemistry & cell biology 2024 Dec;177:106696
The international journal of biochemistry & cell biology 2024 Dec;177:106696
Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis.
Yin J, Ding L, Yao S, Huang J, Xiao Y, Wang Y, Zhang B, Rehmutulla M, Gu L, Tong Q, Zhang Y
Bioorganic chemistry 2024 Dec;153:107820
Bioorganic chemistry 2024 Dec;153:107820
Gnetupendin A protects against ischemic stroke through activating the PI3K/AKT/mTOR-dependent autophagy pathway.
Mu D, Liu J, Mi Y, Wang D, Xu L, Yang Y, Liu Y, Liang D, Hou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156233
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156233
LAMTOR1/mTORC1 promotes CD276 to induce immunosuppression via PI3K/Akt/MMP signaling pathway in Clostridium perfringens-induced necrotic enteritis of laying hens.
Dong Q, Sun Y, Li J, Tian X, Liu S, Fu Y, Luo R, Guo L, Zong B, Lu Q, Ye C, Fu S, Qiu Y
Poultry science 2024 Dec;103(12):104216
Poultry science 2024 Dec;103(12):104216
Identification and analysis of microplastic aggregation in CAR-T cells.
Yin Z, Huang Y, Zhu Y, Zhong Q, Shen H, Mahati S, Huang J, Li G, Ou R, Liu Z, Zhang Q, Liu S
Journal of hazardous materials 2024 Dec 5;480:136351
Journal of hazardous materials 2024 Dec 5;480:136351
Chinese formula Guben-Jiannao Ye alleviates the dysfunction of circadian and sleep rhythms in APP/PS1 mice implicated in activation of the PI3K/AKT/mTOR signaling pathway.
Mao JQ, Cheng L, Zhang YD, Xie GJ, Wang P
Journal of ethnopharmacology 2024 Dec 5;335:118696
Journal of ethnopharmacology 2024 Dec 5;335:118696
Imperatorin promotes melanin degradation in keratinocytes through facilitating autophagy via the PI3K/Akt signaling pathway.
Huang P, Yang Z, Wang H, Wang C, Luo M, Zhou R, Pan Y
Archives of dermatological research 2024 Dec 5;317(1):70
Archives of dermatological research 2024 Dec 5;317(1):70
The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation.
Zhao Y, Qi Y, Xia J, Duan M, Hao C, Yao W
International immunopharmacology 2024 Dec 5;142(Pt B):113186
International immunopharmacology 2024 Dec 5;142(Pt B):113186
Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
Huang Y, Yue S, Yan Z, Liu Y, Qiao J, Zhang M, Dong Y, Zheng J
International immunopharmacology 2024 Dec 5;142(Pt A):113071
International immunopharmacology 2024 Dec 5;142(Pt A):113071
TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway.
Yang S, Shang H, Zhang Y, Qiu J, Guo Z, Ma Y, Lan Y, Cui S, Tong H, Li G
Cellular and molecular neurobiology 2024 Dec 4;45(1):1
Cellular and molecular neurobiology 2024 Dec 4;45(1):1
EIF2S2 transcriptionally upregulates HIF1α to promote gastric cancer progression via activating PI3K/AKT/mTOR pathway.
Wang Z, Zhang Y, Xue Y, Huang W, Zhang H
Carcinogenesis 2024 Dec 30;45(12):916-927
Carcinogenesis 2024 Dec 30;45(12):916-927
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
Sun J, Li Y, Meng M, Zeng X, Wang Q, Li W, Luo Y, Chen H, Dong Q
International immunopharmacology 2024 Dec 25;143(Pt 1):113300
International immunopharmacology 2024 Dec 25;143(Pt 1):113300
mTOR Inhibitor Everolimus Modulates Tumor Growth in Small-Cell Carcinoma of the Ovary, Hypercalcemic Type and Augments the Drug Sensitivity of Cancer Cells to Cisplatin.
Zheng K, Gao Y, Xu J, Kang M, Chai R, Jin G, Kang Y
Biomedicines 2024 Dec 24;13(1)
Biomedicines 2024 Dec 24;13(1)
Roles of gut microbiome-associated metabolites in pulmonary fibrosis by integrated analysis.
Li J, Wu W, Kong X, Yang X, Li K, Jiang Z, Zhang C, Zou J, Liang Y
NPJ biofilms and microbiomes 2024 Dec 19;10(1):154
NPJ biofilms and microbiomes 2024 Dec 19;10(1):154
Osteoblast-derived exosomal miR-140-3p targets ACER2 and increases the progression of prostate cancer via the AKT/mTOR pathway-mediated inhibition of autophagy.
Liu Y, Chen S, Guo K, Ma S, Wang X, Liu Q, Yan R, Huang Y, Li T, He S, Hui J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 15;38(23):e70206
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 15;38(23):e70206
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.
Jiang D, Qi Z, Xu ZY, Li YR
Biomolecules & biomedicine 2024 Dec 11;25(1):189-209
Biomolecules & biomedicine 2024 Dec 11;25(1):189-209
The vitamin D receptor is essential for the replication of pseudorabies virus.
Zeng L, Wang S-Y, Du M-H, Chu B-B, Ming S-L
mBio 2024 Dec 11;15(12):e0213724
mBio 2024 Dec 11;15(12):e0213724
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke: Insights from Network Pharmacology and in vivo Experiments.
Li ZH, Pu XQ, Li SS, Dong XK, Zhang GQ, Wang Y, Liu JM
Chinese journal of integrative medicine 2024 Aug;30(8):713-720
Chinese journal of integrative medicine 2024 Aug;30(8):713-720
SCD1 promotes the stemness of gastric cancer stem cells by inhibiting ferroptosis through the SQLE/cholesterol/mTOR signalling pathway.
Mao X, Wang L, Chen Z, Huang H, Chen J, Su J, Li Z, Shen G, Ren Y, Li Z, Wang W, Ou J, Guo W, Hu Y
International journal of biological macromolecules 2024 Aug;275(Pt 2):133698
International journal of biological macromolecules 2024 Aug;275(Pt 2):133698
Silk fibroin microgrooved zirconia surfaces improve connective tissue sealing through mediating glycolysis of fibroblasts.
Yan Y, Yan Q, Cai K, Wang Z, Li Q, Zhao K, Jian Y, Jia X
Materials today. Bio 2024 Aug;27:101158
Materials today. Bio 2024 Aug;27:101158
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, D'Orazi G, Cirone M
Autophagy 2024 Aug;20(8):1854-1867
Autophagy 2024 Aug;20(8):1854-1867
FANCD2 expression affects platinum response and further characteristics of high grade serous ovarian cancer in cells with different genetic backgrounds.
Taylor SJ, Hollis RL, Gourley C, Herrington CS, Langdon SP, Arends MJ
Experimental and molecular pathology 2024 Aug;138:104916
Experimental and molecular pathology 2024 Aug;138:104916
A Lipid-Sensitive Spider Peptide Toxin Exhibits Selective Anti-Leukemia Efficacy through Multimodal Mechanisms.
Zhang P, Luo W, Zhang Z, Lv M, Sang L, Wen Y, Wang L, Ding C, Wu K, Li F, Nie Y, Zhu J, Liu X, Yi Y, Ding X, Zeng Y, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2404937
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2404937
Mito-LND and (E)-Akt inhibitor-IV: novel compounds inducing endoplasmic reticulum stress and ROS accumulation against hepatocellular carcinoma.
Liao S, Wang Q, Chen S, Huang Q, Zhou L, Liu H, He S, Zhou Z
Journal of translational medicine 2024 Aug 28;22(1):792
Journal of translational medicine 2024 Aug 28;22(1):792
Sestrin2 knockout exacerbates high-fat diet induced metabolic disorders and complications in female mice.
Zhang L, Kan C, Shi J, Qiu H, Zhang J, Ding W, Xu L, Zhang K, Guo Z, Hou N, Sun X, Han F
Nutrition & metabolism 2024 Aug 2;21(1):60
Nutrition & metabolism 2024 Aug 2;21(1):60
Ac-HSP20 regulates autophagy and promotes the encystation of Acanthamoeba castellanii by inhibiting the PI3K/AKT/mTOR signaling pathway.
Guo S, Liu D, Wan X, Guo D, Zheng M, Zheng W, Feng X
Parasites & vectors 2024 Aug 19;17(1):347
Parasites & vectors 2024 Aug 19;17(1):347
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma.
Dong L, Luo L, Wang Z, Lian S, Wang M, Wu X, Fan J, Zeng Y, Li S, Lv S, Yang Y, Chen R, Shen E, Yang W, Li C, Wang K
Free radical biology & medicine 2024 Aug 1;220:111-124
Free radical biology & medicine 2024 Aug 1;220:111-124
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis.
Zhao Y, Jiang J, Zhou P, Deng K, Liu Z, Yang M, Yang X, Li J, Li R, Xia J
Biochemical pharmacology 2024 Apr;222:116120
Biochemical pharmacology 2024 Apr;222:116120
Arsenic disturbs neural tube closure involving AMPK/PKB-mTORC1-mediated autophagy in mice.
Li X, Li G, Cui S, Hou Y, Li Z, Yan Z, Huang T, Zhao T, Su H, Zhou B, Zhang J, Ao R, Zhao H, Qiu Y, Liu Z, Xie J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114538
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114538
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
Shi G, Zeng L, Shi J, Chen Y
International heart journal 2023;64(3):462-469
International heart journal 2023;64(3):462-469
TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury.
Zhong WJ, Liu T, Yang HH, Duan JX, Yang JT, Guan XX, Xiong JB, Zhang YF, Zhang CY, Zhou Y, Guan CX
International journal of biological sciences 2023;19(1):242-257
International journal of biological sciences 2023;19(1):242-257
Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.
Zheng W, Guo Y, Zhang G, Bai J, Song Y, Song X, Zhu Q, Bao X, Wu G, Zhang C
PloS one 2023;18(6):e0287133
PloS one 2023;18(6):e0287133
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1.
Li F, Wang L, Wang Y, Shen H, Kou Q, Shen C, Xu X, Zhang Y, Zhang J
Journal of Cancer 2023;14(15):2820-2832
Journal of Cancer 2023;14(15):2820-2832
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Wang Y, He Q, Rong K, Zhu M, Zhao X, Zheng P, Mi Y
Frontiers in pharmacology 2023;14:1338260
Frontiers in pharmacology 2023;14:1338260
Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy.
Hu BA, Li YL, Han HT, Lu B, Jia X, Han L, Ma WX, Zhu P, Wang ZH, Zhang W, Zhong M, Zhang L
Frontiers in pharmacology 2023;14:1112123
Frontiers in pharmacology 2023;14:1112123
Network pharmacology and experimental verification reveal the mechanism of safranal against glioblastoma (GBM).
Yang X, Lu D, Sun Y, Wei T, Man D, Chen A, Luo T, Zhao F, Liu X, Cheng B, Wang X, Zhao P, Wang D, Li X
Frontiers in oncology 2023;13:1255164
Frontiers in oncology 2023;13:1255164
S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation.
Lv D, Xu Z, Cheng P, Hu Z, Dong Y, Rong Y, Xu H, Wang Z, Cao X, Deng W, Tang B
Burns & trauma 2023;11:tkad024
Burns & trauma 2023;11:tkad024
Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.
Shahabi F, Abdoli S, Bazi Z, Shamsabadi F, Yamchi A, Shahbazi M
Frontiers in bioengineering and biotechnology 2023;11:1268048
Frontiers in bioengineering and biotechnology 2023;11:1268048
Role of UDP-glucose ceramide glucosyltransferase in venous malformation.
Chen S, Wang Y, Kong L, Ji Y, Cui J, Shen W
Frontiers in cell and developmental biology 2023;11:1178045
Frontiers in cell and developmental biology 2023;11:1178045
Knockdown of NF-κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway.
Xu X, Hou D, Wang Y, Zhang J, Hei Y, Wang B, Tian S, Zhang Y, Wang F
Molecular biology reports 2023 Sep;50(9):7501-7513
Molecular biology reports 2023 Sep;50(9):7501-7513
Hirudin inhibits glioma growth through mTOR-regulated autophagy.
Ma Y, Wu S, Zhao F, Li H, Li Q, Zhang J, Li H, Yuan Z
Journal of cellular and molecular medicine 2023 Sep;27(18):2701-2713
Journal of cellular and molecular medicine 2023 Sep;27(18):2701-2713
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
Hu S, Yang M, Xiao K, Yang Z, Cai L, Xie Y, Wang L, Wei R
Experimental and therapeutic medicine 2023 Sep;26(3):457
Experimental and therapeutic medicine 2023 Sep;26(3):457
Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
Yang XM, Wang XQ, Hu LP, Feng MX, Zhou YQ, Li DX, Li J, Miao XC, Zhang YL, Yao LL, Nie HZ, Huang S, Xia Q, Zhang XL, Jiang SH, Zhang ZG
Gastroenterology 2023 Sep;165(3):629-646
Gastroenterology 2023 Sep;165(3):629-646
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model.
Dai W, Yang H, Xu B, He T, Liu L, Ma X, Ma J, Yang G, Si R, Pei X, Du X, Fu X
Journal of ovarian research 2023 Sep 30;16(1):198
Journal of ovarian research 2023 Sep 30;16(1):198
Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats.
Jin SW, Han YL, Pan XL, Zhang HX
Heliyon 2023 Oct;9(10):e21005
Heliyon 2023 Oct;9(10):e21005
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Li X, Wang G, Zhou X, Zhao H, Chen X, Cui Q, Li M, Gao X, Wei X, Ye L, Li D, Hong P
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells.
Zheng Y, Shi D, Chen L, Yang Y, Yao M
Aging 2023 Oct 9;15(19):10593-10606
Aging 2023 Oct 9;15(19):10593-10606
Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells.
He L, Chen J, Deng P, Huang S, Liu P, Wang C, Huang X, Li Y, Chen B, Shi D, Xiao Y, Chen X, Ouyang Y, Song L, Lin C
Molecular cell 2023 Oct 5;83(19):3502-3519.e11
Molecular cell 2023 Oct 5;83(19):3502-3519.e11
Combined Epimedii Folium and Ligustri Lucidi Fructus with dexamethasone alleviate the proliferation of airway smooth muscle cells by regulating apoptosis/autophagy.
Long Y, Wang H, Ma Z, Li Y, Ma Z, Yu P, Tang X, Liu R
Journal of ethnopharmacology 2023 Oct 5;314:116547
Journal of ethnopharmacology 2023 Oct 5;314:116547
Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.
Gao Y, Lu LJ, Zhang ZZ, Yang X, Du J, Wen K, Huang H, Wang XP, Sun XL
Journal of ethnopharmacology 2023 Oct 28;315:116678
Journal of ethnopharmacology 2023 Oct 28;315:116678
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Zhao S, Li Y, Li G, Ye J, Wang R, Zhang X, Li F, Gao C, Li J, Jiang J, Mi Y
European journal of pharmacology 2023 Oct 15;957:176004
European journal of pharmacology 2023 Oct 15;957:176004
Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study.
Qiu K, Xia Q, Chen H, Ye Q, Mao H, Tian M, Gan Y, Huang Q, Wang H, Duan S
Heliyon 2023 Nov;9(11):e21851
Heliyon 2023 Nov;9(11):e21851
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Yan Y, Yu S, Fan Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277
Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
Huang X, Liu X, Lin J
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2361-2380
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2361-2380
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Liu H, Xi Q, Tan S, Qu Y, Meng Q, Zhang Y, Cheng Y, Wu G
International immunopharmacology 2023 Nov;124(Pt B):111001
International immunopharmacology 2023 Nov;124(Pt B):111001
Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis.
Jiang P, Zhao L, Hu R, Zhai Z, Guo J, Zhang K
International immunopharmacology 2023 Nov;124(Pt B):110914
International immunopharmacology 2023 Nov;124(Pt B):110914
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Lin L, Li X, Wu AJ, Xiu JB, Gan YZ, Yang XM, Ai ZH
iScience 2023 Nov 17;26(11):108226
iScience 2023 Nov 17;26(11):108226
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Li J, Zhang M, Pei Y, Yang Q, Zheng L, Wang G, Sun Y, Yang W, Liu L
Journal of ethnopharmacology 2023 Nov 15;316:116723
Journal of ethnopharmacology 2023 Nov 15;316:116723
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
Li P, Fang X, Hao G, Li X, Cai Y, Yan Y, Zan L, Yang R, Liu B
Metabolites 2023 Nov 14;13(11)
Metabolites 2023 Nov 14;13(11)
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Wang K, Li Z, Ding Y, Liu Z, Li Y, Liu X, Sun Y, Hong J, Zheng W, Qian L, Xu D
Journal of physiology and biochemistry 2023 May;79(2):341-353
Journal of physiology and biochemistry 2023 May;79(2):341-353
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Ji X, Hong J, Yang W, Yao M, Wang J, Jiang G, Wang Y, Li C, Lin J, Mou H, Li C, Li S, Chen Y, Shi M, Wang W, Lu F, Wu H, Zhao X, Qi Y, Yan S
Redox biology 2023 May;61:102635
Redox biology 2023 May;61:102635
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
Liu W, Chen Y, Song X, Xue Y, Zhang Y
International ophthalmology 2023 May;43(5):1523-1536
International ophthalmology 2023 May;43(5):1523-1536
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Sun X, Huang LY, Pan HX, Li LJ, Wang L, Pei GQ, Wang Y, Zhang Q, Cheng HX, He CQ, Wei Q
Neural regeneration research 2023 May;18(5):1067-1075
Neural regeneration research 2023 May;18(5):1067-1075
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Wang Z, Tan M, Su W, Huang W, Zhang J, Jia F, Cao G, Liu X, Song H, Ran H, Nie G, Wang H
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.
Lu S, Liu Y, Tian S, He Y, Dong W
Experimental cell research 2023 May 1;426(1):113564
Experimental cell research 2023 May 1;426(1):113564
G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
Li S, Liao Z, Yin H, Liu O, Hua W, Wu X, Zhang Y, Gao Y, Yang C
Cell proliferation 2023 Mar;56(3):e13368
Cell proliferation 2023 Mar;56(3):e13368
BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy.
Liu W, Zhu SO, Guo YL, Tu LF, Zhen YQ, Zhao RY, Ou-Yang L, Kurihara H, He RR, Liu B
Acta pharmacologica Sinica 2023 Mar;44(3):524-537
Acta pharmacologica Sinica 2023 Mar;44(3):524-537
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Liu W, Lin T, Gong L
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2023 Mar;39(2):128-138
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2023 Mar;39(2):128-138
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Chen D, Jiang X, Zou H
Journal of orthopaedic translation 2023 Mar;39:163-176
Journal of orthopaedic translation 2023 Mar;39:163-176
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Zhou H, Yun X, Shu Y, Xu K
Oncology letters 2023 Mar;25(3):101
Oncology letters 2023 Mar;25(3):101
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Yang J, Hasenbilige, Bao S, Luo S, Jiang L, Li Q, Kong Y, Cao J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
Zhong WJ, Zhang J, Duan JX, Zhang CY, Ma SC, Li YS, Yang NS, Yang HH, Xiong JB, Guan CX, Jiang ZX, You ZJ, Zhou Y
Journal of translational medicine 2023 Mar 6;21(1):179
Journal of translational medicine 2023 Mar 6;21(1):179
A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.
Chen J, Feng D, Lu Y, Zhang Y, Jiang H, Yuan M, Xu Y, Zou J, Zhu Y, Zhang J, Ge C, Wang Y
Cancers 2023 Mar 5;15(5)
Cancers 2023 Mar 5;15(5)
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Jin L, Mi T, Wu X, Wang Z, Zhang Z, Liu J, Wang Z, Wang J, Li M, Ren C, Guo P, He D
Cancers 2023 Mar 28;15(7)
Cancers 2023 Mar 28;15(7)
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
Wei P, He Q, Liu T, Zhang J, Shi K, Zhang J, Liu S
Journal of ethnopharmacology 2023 Mar 25;304:116095
Journal of ethnopharmacology 2023 Mar 25;304:116095
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Cai J, Ye Z, Hu Y, Ye L, Gao L, Wang Y, Sun Q, Tong S, Zhang S, Wu L, Yang J, Chen Q
Cell death & disease 2023 Mar 25;14(3):211
Cell death & disease 2023 Mar 25;14(3):211
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Liu X, Xi H, Han S, Zhang H, Hu J
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Ge XF, Li SS, Liu YH, Lu MQ, Su HN, Yang X, Sun XW
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway.
Zhang T, Zhang Y, Yang Z, Jiang Y, Sun L, Huang D, Tian M, Shen Y, Deng J, Hou J, Ma Y
Pathogens and global health 2023 Jun;117(4):409-416
Pathogens and global health 2023 Jun;117(4):409-416
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)
Cancers 2023 Jun 27;15(13)
SLC25A32 promotes malignant progression of glioblastoma by activating PI3K-AKT signaling pathway.
Xue Z, Wang J, Wang Z, Liu J, Zhao J, Liu X, Zhang Y, Liu G, Zhao Z, Li W, Zhang Q, Li X, Huang B, Wang X
BMC cancer 2023 Jun 26;23(1):589
BMC cancer 2023 Jun 26;23(1):589
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
Guo M, Zhu C, Fu R, Ma X, Duan Z, Fan D
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through the AMPK/mTOR/ULK1 pathway.
Yang C, Deng Z, Zeng Q, Chang X, Wu X, Li G
Biochemical and biophysical research communications 2023 Jun 18;661:34-41
Biochemical and biophysical research communications 2023 Jun 18;661:34-41
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Li X, Wang W, Hou Y, Li G, Yi H, Cui S, Zhang J, He X, Zhao H, Yang Z, Qiu Y, Liu Z, Xie J
Ecotoxicology and environmental safety 2023 Jun 1;257:114914
Ecotoxicology and environmental safety 2023 Jun 1;257:114914
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Zhou W, Wang C, Zhang B, Gou S
European journal of pharmacology 2023 Jul 5;950:175751
European journal of pharmacology 2023 Jul 5;950:175751
Astragaloside IV Blunts Epithelial-Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy.
Li D, Liu Y, Zhan Q, Zeng Y, Peng Z, He Q, Tan Q, Cao W, Wang S, Wang J
Cells 2023 Jul 4;12(13)
Cells 2023 Jul 4;12(13)
Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level.
Psatha K, Kollipara L, Drakos E, Deligianni E, Brintakis K, Patsouris E, Sickmann A, Rassidakis GZ, Aivaliotis M
Cancers 2023 Jul 31;15(15)
Cancers 2023 Jul 31;15(15)
SNRPD1 inhibition suppresses the proliferation of hepatocellular carcinoma and promotes autophagy through the PI3K/AKT/mTOR/4EBP1 pathway.
Wang H, Chen M, Yang C, Hu H, Jiang Y, Yang F, Lv L
Archives of biochemistry and biophysics 2023 Jul 15;743:109661
Archives of biochemistry and biophysics 2023 Jul 15;743:109661
Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice.
Li X, Huang L, Kong L, Su Y, Zhou H, Ji P, Sun R, Wang C, Li W, Li W
Molecular medicine reports 2023 Jan;27(1)
Molecular medicine reports 2023 Jan;27(1)
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Song R, Ma S, Xu J, Ren X, Guo P, Liu H, Li P, Yin F, Liu M, Wang Q, Yu L, Liu J, Duan B, Rahman NA, Wołczyński S, Li G, Li X
Molecular cancer 2023 Jan 23;22(1):16
Molecular cancer 2023 Jan 23;22(1):16
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.
Zhou Z, Zhang G, Li T, Ai J, Li W, Zeng S, Ye M, Liu Q, Xiao J, Li Y, Tan G, Zhang X
Cancers 2023 Jan 18;15(3)
Cancers 2023 Jan 18;15(3)
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Xu M, Zhou Y, Fan S, Zhang M, Gao X
Amino acids 2023 Feb;55(2):243-252
Amino acids 2023 Feb;55(2):243-252
Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress.
Zhang J, Zha Y, Jiao Y, Li Y, Zhang S
Toxicology 2023 Feb;485:153426
Toxicology 2023 Feb;485:153426
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
Zhuge R, Li Z, He C, Ma W, Yan J, Xue Q, Wang R, Liu Y, Lu R, Du H, Yin F, Guo L
Environmental toxicology 2023 Feb;38(2):289-299
Environmental toxicology 2023 Feb;38(2):289-299
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Zhang H, Xie X, Shi J, Zhao Q, Luo D, Hao J, Zhou Y, Han G, Pang X
Phytotherapy research : PTR 2023 Feb;37(2):410-423
Phytotherapy research : PTR 2023 Feb;37(2):410-423
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Deng Y, Ma J, Zhao S, Yang M, Sun Y, Zhang Q
Translational oncology 2023 Feb;28:101614
Translational oncology 2023 Feb;28:101614
Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.
Ke C, Zhao S, Wang L, Zhang M, Gao X
Biochemical and biophysical research communications 2023 Feb 5;643:88-95
Biochemical and biophysical research communications 2023 Feb 5;643:88-95
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Lu R, Wei Z, Wang Z, Xu S, Sun K, Cheng P, Huang X, You H, Guo F, Liang S, Chen AM
iScience 2023 Feb 17;26(2):105936
iScience 2023 Feb 17;26(2):105936
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Li Y, Zang J, Wang X, Feng X, Qiu F
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Chen T, Bao S, Chen J, Zhang J, Wei H, Hu X, Liang Y, Li J, Yan S
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Xu Y, Wang Y, Xiao H, Li Y
Journal of periodontal research 2023 Dec;58(6):1248-1260
Journal of periodontal research 2023 Dec;58(6):1248-1260
Activation of moderate autophagy promotes survival of fat graft.
Pei SJ, Zhu YZ, Yang JM, Zhang MC, Shi CL, Ding Y, Yi YY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23289
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23289
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B
Autophagy 2023 Dec;19(12):3132-3150
Autophagy 2023 Dec;19(12):3132-3150
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Ruiz-Mitjana A, Vidal-Sabanés M, Navaridas R, Perramon-Güell A, Yeramian A, Nicholson-Sabaté N, Egea J, Encinas M, Matias-Guiu X, Dolcet X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Huang Y, Luo W, Chen S, Su H, Zhu W, Wei Y, Qiu Y, Long Y, Shi Y, Wei J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization.
Yao Y, Chen C, Wang J, Xuan H, Chen X, Li Z, Yang F, Wang B, Lin S, Li S, Tang D, Gong L, Gao W
Journal of experimental & clinical cancer research : CR 2023 Dec 5;42(1):330
Journal of experimental & clinical cancer research : CR 2023 Dec 5;42(1):330
Protocol for high-sensitivity western blot on murine hematopoietic stem cells.
Li C, Guan J, Li Y, Tian X, Zhao Y, Liu W, Tian H, Tian H, Yang Y, Zhao M
STAR protocols 2023 Dec 15;4(4):102578
STAR protocols 2023 Dec 15;4(4):102578
Proteomic analysis reveals the molecular mechanism of Astragaloside in the treatment of non-small cell lung cancer by inducing apoptosis.
Liu J, Sun Y, Chen W, Deng L, Chen M, Dong J
BMC complementary medicine and therapies 2023 Dec 15;23(1):461
BMC complementary medicine and therapies 2023 Dec 15;23(1):461
Milk Exosomes from Gestational Diabetes Mellitus (GDM) and Healthy Parturient Exhibit Differential miRNAs Profiles and Distinct Regulatory Bioactivity on Hepatocyte Proliferation.
Zheng Z, Mo J, Lin F, Wang J, Chen J, Luo H, Liu Y, Su C, Gu X, Xiong F, Zha L
Molecular nutrition & food research 2023 Aug;67(16):e2300005
Molecular nutrition & food research 2023 Aug;67(16):e2300005
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
He P, He Y, Ma J, Liu Y, Liu C, Baoping Y, Dong W
Phytotherapy research : PTR 2023 Aug;37(8):3467-3480
Phytotherapy research : PTR 2023 Aug;37(8):3467-3480
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
Li N, Chen L, Zhao X, Gu C, Chang Y, Feng S
Cell death discovery 2023 Aug 24;9(1):309
Cell death discovery 2023 Aug 24;9(1):309
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X
Cell & bioscience 2023 Aug 21;13(1):154
Cell & bioscience 2023 Aug 21;13(1):154
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.
Li MX, Wu XT, Jing WQ, Hou WK, Hu S, Yan W
Cell death & disease 2023 Aug 2;14(8):492
Cell death & disease 2023 Aug 2;14(8):492
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Yan C, Xiong J, Zhou Z, Li Q, Gao C, Zhang M, Yu L, Li J, Hu MM, Zhang CS, Cai C, Zhang H, Zhang J
eLife 2023 Aug 17;12
eLife 2023 Aug 17;12
Different levels of autophagy induced by transient serum starvation regulate metabolism and differentiation of porcine skeletal muscle satellite cells.
Wang Y, Gao J, Fan B, Hu Y, Yang Y, Wu Y, Li F, Ju H
Scientific reports 2023 Aug 12;13(1):13153
Scientific reports 2023 Aug 12;13(1):13153
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Zhang PP, Zhuo BY, Duan ZW, Li X, Huang SL, Cao Q, Zhao T, Wei SL, Hu XH, Zhang Y
Journal of ethnopharmacology 2023 Aug 10;312:116523
Journal of ethnopharmacology 2023 Aug 10;312:116523
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis.
Zhang M, Zhang B, Wang X, Song J, Tong M, Dong Z, Xu J, Liu M, Jiang Y, Wang N, Wang Y, Du Z, Liu Y, Zhang R, Xu C
Science China. Life sciences 2023 Apr;66(4):783-799
Science China. Life sciences 2023 Apr;66(4):783-799
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway.
Wu W, Chen X, Liu X, Bao HJ, Li QH, Xian JY, Lu BF, Zhao Y, Chen S
Molecular carcinogenesis 2023 Apr;62(4):413-426
Molecular carcinogenesis 2023 Apr;62(4):413-426
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Liang X, Yang Y, Huang C, Ye Z, Lai W, Luo J, Li X, Yi X, Fan JB, Wang Y, Wang Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Zhang L, Xue K, Fan P, Chen C, Hu J, Huang J, Lu W, Xu J, Xu S, Ran J, Zhu S, Gan S
Experimental eye research 2023 Apr;229:109416
Experimental eye research 2023 Apr;229:109416
CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway.
Zhu Y, Zuo L, Xiong H, Li S, Chen R, Liu H
Cell cycle (Georgetown, Tex.) 2023 Apr;22(8):919-938
Cell cycle (Georgetown, Tex.) 2023 Apr;22(8):919-938
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Wang J, Wang D, Feng L, Li X, Gong Y, Wang Z, Tan N, Han J
Phytochemistry 2023 Apr;208:113603
Phytochemistry 2023 Apr;208:113603
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
Lin G, Qi H, Guo X, Wang W, Zhang M, Gao X
The Journal of nutritional biochemistry 2023 Apr;114:109274
The Journal of nutritional biochemistry 2023 Apr;114:109274
Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma.
Liu L, Shi D, Xia ZY, Wang BW, Wang XL, Wang XT, Wang GL, Li MJ, Zheng QS, Li D, Li BH
Journal of natural products 2023 Apr 28;86(4):966-978
Journal of natural products 2023 Apr 28;86(4):966-978
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Wang Y, Yuan Y, Wang C, Wang B, Zou W, Zhang N, Chen X
Frontiers in nutrition 2022;9:858261
Frontiers in nutrition 2022;9:858261
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
Osuru HP, Lavallee M, Thiele RH
Frontiers in cardiovascular medicine 2022;9:711421
Frontiers in cardiovascular medicine 2022;9:711421
Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity.
Tu Z, Li J, Long X, Wu L, Zhu X, Huang K
Oxidative medicine and cellular longevity 2022;2022:9408886
Oxidative medicine and cellular longevity 2022;2022:9408886
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Mu X, Shen Z, Lin Y, Xiao J, Xia K, Xu C, Chen B, Shi R, Zhu A, Sun X, Tao T, Song X, Xuan Q
Oxidative medicine and cellular longevity 2022;2022:8693259
Oxidative medicine and cellular longevity 2022;2022:8693259
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Rapamycin Attenuates Anxiety and Depressive Behavior Induced by Helicobacter pylori in Association with Reduced Circulating Levels of Ghrelin.
Tian J, Wang Z, Ren Y, Jiang Y, Zhao Y, Li M, Zhang Z
Neural plasticity 2022;2022:2847672
Neural plasticity 2022;2022:2847672
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Zuo X, Shi X, Zhang X, Chen Z, Yang Z, Pan X, Lai R, Zhao Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
Lin L, Wang X, Zhao W, Chen Y
Genetics research 2022;2022:1500768
Genetics research 2022;2022:1500768
CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
Zhang Z, Xu P, Hu Z, Fu Z, Deng T, Deng X, Peng L, Xie Y, Long L, Zheng D, Shen P, Zhang M, Gong B, Zhu Z, Lin J, Chen R, Liu Z, Yang H, Li R, Fang W
International journal of biological sciences 2022;18(10):4171-4186
International journal of biological sciences 2022;18(10):4171-4186
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Hao M, Ding C, Sun S, Peng X, Liu W
Journal of inflammation research 2022;15:4921-4938
Journal of inflammation research 2022;15:4921-4938
Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway.
Zhu N, Chen X, Zhao J, Fang L, Yao Y, Zhou F, Tao L, Xu Q
Journal of Cancer 2022;13(11):3177-3188
Journal of Cancer 2022;13(11):3177-3188
The diagnostic and prognostic significance of small nuclear ribonucleoprotein Sm D1 aberrantly high expression in hepatocellular carcinoma.
Wang H, Xu F, Lu L, Yang F, Huang X, Lv L, Hu H, Jiang Y
Journal of Cancer 2022;13(1):184-201
Journal of Cancer 2022;13(1):184-201
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Fan XX, Sun WY, Li Y, Tang Q, Li LN, Yu X, Wang SY, Fan AR, Xu XQ, Chang HS
Frontiers in pharmacology 2022;13:968124
Frontiers in pharmacology 2022;13:968124
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
Cheng Z, Luo X, Zhu Z, Huang Y, Yan X
Frontiers in pharmacology 2022;13:906933
Frontiers in pharmacology 2022;13:906933
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Xin M, Gao Q, Xiang X, Xu J, Jiao Y, Li X, Zhang X, Jia X
Frontiers in pharmacology 2022;13:890974
Frontiers in pharmacology 2022;13:890974
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn's Disease.
Liu J, Zhang L, Wang Z, Chen S, Feng S, He Y, Zhang S
Frontiers in pharmacology 2022;13:844685
Frontiers in pharmacology 2022;13:844685
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Glathar AR, Oyelakin A, Gluck C, Bard J, Sinha S
Frontiers in oncology 2022;12:879054
Frontiers in oncology 2022;12:879054
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway.
Li Y, Liu H, Liu X, Xiao B, Zhang M, Luo Y, Li M, Yang J
Frontiers in oncology 2022;12:851300
Frontiers in oncology 2022;12:851300
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
Shen G, Wang H, Zhu N, Lu Q, Liu J, Xu Q, Huang D
Frontiers in cell and developmental biology 2022;10:893888
Frontiers in cell and developmental biology 2022;10:893888
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
Wang YN, Ye Y, Zhou D, Guo ZW, Xiong Z, Gong XX, Jiang SW, Chen H
Frontiers in cell and developmental biology 2022;10:852561
Frontiers in cell and developmental biology 2022;10:852561
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Yuan D, Guo T, Qian H, Ge H, Zhao Y, Huang A, Wang X, Cao X, Zhu D, He C, Yu H
Drug development research 2022 Sep;83(6):1383-1393
Drug development research 2022 Sep;83(6):1383-1393
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Chen L, Kang Y, Jiang Y, You J, Huang C, Xu X, Chen F
Pathology, research and practice 2022 Sep;237:154031
Pathology, research and practice 2022 Sep;237:154031
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Zhang C, Li Z, Li L, Li S, Yang L, Chen L, Zhang X, Yang S, Guo Y
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling.
Zhao G, Li S, Wang Q, Wu W, Fu X, Zhu C, Wang W, Wang X
Cell death discovery 2022 Sep 26;8(1):398
Cell death discovery 2022 Sep 26;8(1):398
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
Li H, Li K, Shu D, Shen M, Tan Z, Zhang W, Pu D, Tan W, Tang Z, Jin A, Liu S
Life (Basel, Switzerland) 2022 Sep 20;12(10)
Life (Basel, Switzerland) 2022 Sep 20;12(10)
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
Li B, Ge N, Pan Z, Hou C, Xie K, Wang D, Liu J, Wan J, Deng F, Li M, Luo S
BMC medical genomics 2022 Sep 13;15(1):194
BMC medical genomics 2022 Sep 13;15(1):194
SLC7A5 is a lung adenocarcinoma-specific prognostic biomarker and participates in forming immunosuppressive tumor microenvironment.
Liu Y, Ma G, Liu J, Zheng H, Huang G, Song Q, Pang Z, Du J
Heliyon 2022 Oct;8(10):e10866
Heliyon 2022 Oct;8(10):e10866
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Yin L, Feng S, Sun Y, Jiang Y, Tang C, Sun D
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR pathway.
Li N, Li M, Xiu L, Liao W, Ren Y, Liu H, Chen S, Chen F, Yu X, Fan A, Huo M, He J, Zhong G
Journal of ethnopharmacology 2022 Oct 5;296:115443
Journal of ethnopharmacology 2022 Oct 5;296:115443
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy.
Huang L, Chen Y, Liu R, Li B, Fei X, Li X, Liu G, Li Y, Xu B, Fang W
Aging and disease 2022 Oct 1;13(5):1546-1561
Aging and disease 2022 Oct 1;13(5):1546-1561
Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.
Zhai Y, Sun J, Sun C, Zhao H, Li X, Yao J, Su J, Xu X, Xu X, Hu J, Daglia M, Han B, Kai G
Phytotherapy research : PTR 2022 Nov;36(11):4263-4277
Phytotherapy research : PTR 2022 Nov;36(11):4263-4277
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fan Y, Wu H, Xiong L, Luo F, Li Q, Wang D, Zhong T
Fitoterapia 2022 Nov;163:105314
Fitoterapia 2022 Nov;163:105314
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
Zhu Y, Yang Y, Bu H, Huang H, Chen H, Ran J, Qin L, Ni Y, Yao M, Song T, Li M, Yang Y, Guo T, Chao N, Liu Z, Li W, Zhang L
Cancer science 2022 Nov;113(11):3722-3734
Cancer science 2022 Nov;113(11):3722-3734
A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.
Chen W, Zhu L, Wang L, Zeng J, Wen M, Xu X, Zou L, Huang F, Huang Q, Qin D, Mei Q, Yang J, Wang Q, Wu J
International journal of molecular sciences 2022 Nov 14;23(22)
International journal of molecular sciences 2022 Nov 14;23(22)
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells.
Ali Y, Gomez-Sanchez EP, Gomez-Sanchez CE
Endocrinology 2022 Nov 14;164(1)
Endocrinology 2022 Nov 14;164(1)
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Cao Y, Li Y, Fu SC, Shen J, Zhang H, Jiang C, Shu-Hang Yung P
Journal of orthopaedic translation 2022 May;34:102-112
Journal of orthopaedic translation 2022 May;34:102-112
Anti-fatigue effects of fermented soybean protein peptides in mice.
Fang L, Zhang RX, Wei Y, Ling K, Lu L, Wang J, Pan XC, Cai MY
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Yang J, Li J, Guo H, Zhang Y, Guo Z, Liu Y, Huo T
International journal of molecular sciences 2022 May 19;23(10)
International journal of molecular sciences 2022 May 19;23(10)
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism.
Liu D, Bi X, Yang Y
Bioengineered 2022 Mar;13(3):7485-7499
Bioengineered 2022 Mar;13(3):7485-7499
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
Lu Y, Zhong W, Liu Y, Chen W, Zhang J, Zeng Z, Huang H, Qiao Y, Wan X, Meng X, Cai S, Dong H
International immunopharmacology 2022 Mar;104:108504
International immunopharmacology 2022 Mar;104:108504
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
Miao Y, Geng Y, Yang L, Zheng Y, Dai Y, Wei Z
The Journal of nutritional biochemistry 2022 Mar;101:108923
The Journal of nutritional biochemistry 2022 Mar;101:108923
YB1 associates with oncogenetic roles and poor prognosis in nasopharyngeal carcinoma.
Zhan Y, Chen X, Zheng H, Luo J, Yang Y, Ning Y, Wang H, Zhang Y, Zhou M, Wang W, Fan S
Scientific reports 2022 Mar 8;12(1):3699
Scientific reports 2022 Mar 8;12(1):3699
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Xu P, Li X, Tang C, Wang T, Xu J
Experimental cell research 2022 Mar 1;412(1):113018
Experimental cell research 2022 Mar 1;412(1):113018
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Zhong Y, Sun D, Yao Y, Liu Q, Guo T, Wang X, Peng X
Chemico-biological interactions 2022 Mar 1;355:109850
Chemico-biological interactions 2022 Mar 1;355:109850
IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.
Shi XY, Zhang XL, Shi QY, Qiu X, Wu XB, Zheng BL, Jiang HX, Qin SY
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 Jun;24(6):1073-1085
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 Jun;24(6):1073-1085
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
Yan JN, Zhang HY, Li JR, Chen Y, Jiang YC, Shen JB, Ke KF, Gu XS
Neural regeneration research 2022 Jun;17(6):1357-1363
Neural regeneration research 2022 Jun;17(6):1357-1363
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
Chen C, Guo Y, Huang Q, Wang B, Wang W, Niu J, Lou J, Xu J, Ren T, Huang Y, Guo W
Cancer letters 2022 Jun 28;536:215660
Cancer letters 2022 Jun 28;536:215660
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, Di Renzo L, D'Orazi G, Cirone M
Cell death discovery 2022 Jun 25;8(1):295
Cell death discovery 2022 Jun 25;8(1):295
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
Li X, Wang J, Lin W, Yuan Q, Lu Y, Wang H, Chen Y, Chen L, Dai P, Long H, Li X
Molecular cancer 2022 Jun 23;21(1):135
Molecular cancer 2022 Jun 23;21(1):135
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Yan S, Chen J, Zhu L, Guo T, Qin D, Hu Z, Han S, Zhou Y, Akan OD, Wang J, Luo F, Lin Q
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6429-6443
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6429-6443
SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level.
Nie K, Cai M
Digestive diseases and sciences 2022 Jul;67(7):2948-2956
Digestive diseases and sciences 2022 Jul;67(7):2948-2956
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
Huang X, Huang Y, Lv Z, Wang T, Feng H, Wang H, Du S, Wu S, Shen D, Wang C, Li H, Wang B, Ma X, Zhang X
International journal of oncology 2022 Jul;61(1)
International journal of oncology 2022 Jul;61(1)
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Niu Z, Lin J, Hao C, Xu X, Wang C, Dai K, Deng X, Deng M, Guo Y, Yao W
International journal of environmental research and public health 2022 Jul 18;19(14)
International journal of environmental research and public health 2022 Jul 18;19(14)
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Jin D, Liu F, Yu M, Zhao Y, Yan G, Xue J, Sun Y, Zhao D, Li X, Qi W, Wang X
Journal of ethnopharmacology 2022 Jul 15;293:115246
Journal of ethnopharmacology 2022 Jul 15;293:115246
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Liu R, Cai D, Li X, Liu B, Chen J, Jiang X, Li H, Li Z, Teerds K, Sun J, Bai W, Jin Y
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's disease by regulating the metabolism of astrocytes.
Wang C, Zheng D, Weng F, Jin Y, He L
Psychopharmacology 2022 Jan;239(1):215-227
Psychopharmacology 2022 Jan;239(1):215-227
Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring.
Yang Q, Mao Y, Wang J, Yu H, Zhang X, Pei X, Duan Z, Xiao C, Ma M
Human & experimental toxicology 2022 Jan-Dec;41:9603271221129852
Human & experimental toxicology 2022 Jan-Dec;41:9603271221129852
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Xi H, Ren F, Li Y, Xian M, Wang L, Hu J
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.
Wen C, Lin L, Zou R, Lin F, Liu Y
Cell cycle (Georgetown, Tex.) 2022 Feb;21(3):289-303
Cell cycle (Georgetown, Tex.) 2022 Feb;21(3):289-303
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
Ouyang S, Zeng Z, Liu Z, Zhang Z, Sun J, Wang X, Ma M, Ye X, Yu J, Kang W
Cell death discovery 2022 Feb 2;8(1):45
Cell death discovery 2022 Feb 2;8(1):45
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
Xu Z, Li X, Ding Z, Zhang Y, Peng Z, Yang X, Cao W, Du R
The FEBS journal 2022 Dec;289(23):7545-7560
The FEBS journal 2022 Dec;289(23):7545-7560
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Liu L, Li X, Bu W, Jin N, Meng Y, Wang Y, Wang D, Xu X, Zhou D, Sun H
Materials today. Bio 2022 Dec;16:100344
Materials today. Bio 2022 Dec;16:100344
Dickkopf1 (Dkk1) Alleviates Vascular Calcification by Regulating the Degradation of Phospholipase D1 (PLD1).
Li X, Liu XL, Li X, Zhao YC, Wang QQ, Zhong HY, Liu DD, Yuan C, Zheng TF, Zhang M
Journal of cardiovascular translational research 2022 Dec;15(6):1327-1339
Journal of cardiovascular translational research 2022 Dec;15(6):1327-1339
MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis.
Han F, Shen L, Ma H, Wang L, Guo H, Wu X
International immunopharmacology 2022 Dec;113(Pt A):109279
International immunopharmacology 2022 Dec;113(Pt A):109279
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Sun Y, Li H, Liu L, Bai X, Wu L, Shan J, Sun X, Wang Q, Guo Y
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.
Liao WL, Liu YF, Ying TH, Shieh JC, Hung YT, Lee HJ, Shen CY, Cheng CW
International journal of molecular sciences 2022 Dec 26;24(1)
International journal of molecular sciences 2022 Dec 26;24(1)
Plasma exosomal miR-199a-3p downregulates cell proliferation and migration in Hirschsprung's disease by targeting mTOR.
Daiyue Y, Yang Y, Zhaorong H, Yi L, Chen W, Caiyun L, Yuqian S, Liucheng Y, Kai W
Pediatric surgery international 2022 Dec 19;39(1):54
Pediatric surgery international 2022 Dec 19;39(1):54
Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
Kong X, Shu X, Wang J, Liu D, Ni Y, Zhao W, Wang L, Gao Z, Chen J, Yang B, Guo X, Wang Z
Development (Cambridge, England) 2022 Dec 15;149(24)
Development (Cambridge, England) 2022 Dec 15;149(24)
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Tao T, Chen Y, Chen J, Lian C, Xu S, Zhang M, Fang C
Experimental dermatology 2022 Aug;31(8):1154-1164
Experimental dermatology 2022 Aug;31(8):1154-1164
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Wang K, Li Z, Sun Y, Liu X, Ma W, Ding Y, Hong J, Qian L, Xu D
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
CD44-fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition.
Wang C, Wang Y, Zuo N, Fang S, Shi J
Blood advances 2022 Aug 9;6(15):4617-4633
Blood advances 2022 Aug 9;6(15):4617-4633
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Jia X, Xin M, Xu J, Xiang X, Li X, Jiao Y, Wang L, Jiang J, Pang F, Zhang X, Zhang J
Cell death & disease 2022 Aug 30;13(8):750
Cell death & disease 2022 Aug 30;13(8):750
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Liu M, Yue Z, Zhang B, Li F, Liu L, Li F
Metabolites 2022 Aug 25;12(9)
Metabolites 2022 Aug 25;12(9)
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Zhao X, Sun W, Guo B, Cui L
Stem cell research & therapy 2022 Aug 13;13(1):417
Stem cell research & therapy 2022 Aug 13;13(1):417
miR-145-5p affects autophagy by targeting CaMKIIδ in atherosclerosis.
Zhang X, Zai L, Tao Z, Wu D, Lin M, Wan J
International journal of cardiology 2022 Aug 1;360:68-75
International journal of cardiology 2022 Aug 1;360:68-75
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2022 Apr;18(4):860-876
Autophagy 2022 Apr;18(4):860-876
LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway.
Tan Y, Chen Q, Pan S, An W, Xu H, Xing Y, Zhang J
BMC cancer 2022 Apr 30;22(1):474
BMC cancer 2022 Apr 30;22(1):474
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Cheng F, Dun Y, Cheng J, Ripley-Gonzalez JW, Jiang W, You B, Liu S
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway.
Wang JZ, Zhu H, You P, Liu H, Wang WK, Fan X, Yang Y, Xu K, Zhu Y, Li Q, Wu P, Peng C, Wong CC, Li K, Shi Y, Zhang N, Wang X, Zeng R, Huang Y, Yang L, Wang Z, Hui J
The Journal of clinical investigation 2022 Apr 15;132(8)
The Journal of clinical investigation 2022 Apr 15;132(8)
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Wu M, Cong Y, Wang K, Yu H, Zhang X, Ma M, Duan Z, Pei X
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
Deng C, Hu F, Zhao Z, Zhou Y, Liu Y, Zhang T, Li S, Zheng W, Zhang W, Wang T, Ma X
Frontiers in cell and developmental biology 2021;9:797005
Frontiers in cell and developmental biology 2021;9:797005
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Luo Q, Li X, Gan G, Yang M, Chen X, Chen F
Frontiers in cell and developmental biology 2021;9:764263
Frontiers in cell and developmental biology 2021;9:764263
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Hua L, Zhou Y, Hou C, Chen J, Wang Y, Zhang S, Zhou H, He S, Jia E
Frontiers in cardiovascular medicine 2021;8:700630
Frontiers in cardiovascular medicine 2021;8:700630
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Yao M, Zhang J, Li Z, Bai X, Ma J, Li Y
Frontiers in medicine 2021;8:630962
Frontiers in medicine 2021;8:630962
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Qiao D, Jin J, Xing J, Zhang Y, Jia N, Ren X, Lin Z, Jin N, Chen L, Piao Y
The American journal of Chinese medicine 2021;49(2):525-541
The American journal of Chinese medicine 2021;49(2):525-541
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Hu C, Cao Y, Li P, Tang X, Yang M, Gu S, Xiong K, Li T, Xiao T
Journal of oncology 2021;2021:8281718
Journal of oncology 2021;2021:8281718
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
Yang R, Wen J, Yang T, Dai C, Zhao Y
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5570831
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5570831
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
Du P, Luo K, Li G, Zhu J, Xiao Q, Li Y, Zhang X
International journal of medical sciences 2021;18(15):3588-3598
International journal of medical sciences 2021;18(15):3588-3598
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Deng L, Wu X, Zhu X, Yu Z, Liu Z, Wang J, Zheng Y
American journal of translational research 2021;13(1):57-72
American journal of translational research 2021;13(1):57-72
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Ren F, Xu X, Xu J, Mei Y, Zhang J, Wang X, Li F
Environmental toxicology 2021 Sep;36(9):1765-1774
Environmental toxicology 2021 Sep;36(9):1765-1774
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Xian M, Cai J, Zheng K, Liu Q, Liu Y, Lin H, Liang S, Wang S
Food & function 2021 Sep 7;12(17):8056-8067
Food & function 2021 Sep 7;12(17):8056-8067
Latcripin-7A from Lentinula edodes C(91-3) induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.
Din SRU, Nisar MA, Ramzan MN, Saleem MZ, Ghayas H, Ahmad B, Batool S, Kifayat K, Guo X, Huang M, Zhong M
European journal of pharmacology 2021 Sep 15;907:174305
European journal of pharmacology 2021 Sep 15;907:174305
Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner.
Yang L, Cao N, Miao Y, Dai Y, Wei Z
Molecular nutrition & food research 2021 Oct;65(19):e2100367
Molecular nutrition & food research 2021 Oct;65(19):e2100367
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Lu C, Liu X, Li J, Huang Y, Huang X, Dai G, Wu L
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Comparative Proteomics of Rat Olfactory Bulb Reveal Insights into Susceptibility and Resiliency to Chronic-stress-induced Depression or Anxiety.
Liu D, Cai X, Wang L, Yi F, Liao W, Huang R, Fang C, Chen J, Zhou J
Neuroscience 2021 Oct 1;473:29-43
Neuroscience 2021 Oct 1;473:29-43
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
Xing Y, Wang L, Xu G, Guo S, Zhang M, Cheng G, Liu Y, Liu J
Research in veterinary science 2021 Nov;140:18-25
Research in veterinary science 2021 Nov;140:18-25
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622
Cancer cell international 2021 Nov 25;21(1):622
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea.
Deng Z, Chen M, Liu Y, Xu S, Ouyang Y, Shi W, Jian D, Wang B, Liu F, Li J, Shi Q, Peng Q, Sha K, Xiao W, Liu T, Zhang Y, Zhang H, Wang Q, Sun L, Xie H, Li J
EMBO molecular medicine 2021 May 7;13(5):e13560
EMBO molecular medicine 2021 May 7;13(5):e13560
2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.
Wu X, Li J, Wang S, Jiang L, Sun X, Liu X, Yao X, Zhang C, Wang N, Yang G
Journal of agricultural and food chemistry 2021 May 5;69(17):5206-5215
Journal of agricultural and food chemistry 2021 May 5;69(17):5206-5215
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Qi R, Sun J, Qiu X, Zhang Y, Wang J, Wang Q, Huang J, Ge L, Liu Z
Scientific reports 2021 May 27;11(1):11237
Scientific reports 2021 May 27;11(1):11237
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.
Ye D, Xu H, Xia H, Zhang C, Tang Q, Bi F
Journal of experimental & clinical cancer research : CR 2021 May 18;40(1):173
Journal of experimental & clinical cancer research : CR 2021 May 18;40(1):173
Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.
Zhu Y, Su Y, Zhang J, Zhang Y, Li Y, Han Y, Dong X, Li W, Li W
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Ma Y, Yang X, Han H, Wen Z, Yang M, Zhang Y, Fu J, Wang X, Yin T, Lu G, Qi J, Lin H, Wang X, Yang Y
Bioorganic chemistry 2021 Jun;111:104872
Bioorganic chemistry 2021 Jun;111:104872
CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis.
Zhang S, Lu Y, Jiang HY, Cheng ZM, Wei ZJ, Wei YH, Liu T, Xia BJ, Zhao XY, Huang Y, Zou X, Liu R, Zhou S
Cell death & disease 2021 Jun 9;12(6):597
Cell death & disease 2021 Jun 9;12(6):597
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Liu YP, Yuan XY, Li XY, Wang Y, Sun ZB, Deng WH, Lei YD, Huang L, Jiang TY, Zhang ZH
Journal of applied toxicology : JAT 2021 Jun 6;
Journal of applied toxicology : JAT 2021 Jun 6;
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.
Liu C, Zhou X, Pan Y, Liu Y, Zhang Y
BMC cancer 2021 Jun 22;21(1):722
BMC cancer 2021 Jun 22;21(1):722
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
Liu H, Bian W, Yang D, Yang M, Luo H
Life sciences 2021 Jan 1;264:118667
Life sciences 2021 Jan 1;264:118667
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Liu Z, Ma T, Duan J, Liu X, Liu L
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Zheng J, Zhu X, He Y, Hou S, Liu T, Zhi K, Hou T, Gao L
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Liu S, Chen L, Chen H, Xu K, Peng X, Zhang M
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway.
Shu X, Cao KY, Liu HQ, Yu L, Sun LX, Yang ZH, Wu CA, Ran YL
Stem cell research & therapy 2021 Feb 12;12(1):119
Stem cell research & therapy 2021 Feb 12;12(1):119
Social context-dependent singing alters molecular markers of synaptic plasticity signaling in finch basal ganglia Area X.
So LY, Miller JE
Behavioural brain research 2021 Feb 1;398:112955
Behavioural brain research 2021 Feb 1;398:112955
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes.
Kim HJ, Han YH, Kim JY, Lee MO
Hepatology communications 2021 Dec;5(12):2121-2138
Hepatology communications 2021 Dec;5(12):2121-2138
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Guo H, Peng J, Hu J, Chang S, Liu H, Luo H, Chen X, Tang H, Chen Y
Journal of bone oncology 2021 Dec;31:100393
Journal of bone oncology 2021 Dec;31:100393
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10.
Qu G, He T, Dai A, Zhao Y, Guan D, Li S, Shi H, Gan W, Zhang A
Experimental and therapeutic medicine 2021 Dec;22(6):1469
Experimental and therapeutic medicine 2021 Dec;22(6):1469
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Chen X, Tang H, Liang Y, Wu P, Xie L, Ding Y, Yang P, Long B, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
Zhao P, Cai Z, Tian Y, Li J, Li K, Li M, Bai Y, Li J
International immunopharmacology 2021 Dec;101(Pt B):108360
International immunopharmacology 2021 Dec;101(Pt B):108360
The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids.
Xia F, Xiang S, Chen Z, Song L, Li Y, Liao Z, Ge B, Zhou B
Archives of biochemistry and biophysics 2021 Dec 15;714:109080
Archives of biochemistry and biophysics 2021 Dec 15;714:109080
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Man S, Wu Z, Sun R, Guan Q, Li Z, Zuo D, Zhang W, Wu Y
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Xiaoli F, Yaqing Z, Ruhui L, Xuan L, Aijie C, Yanli Z, Chen H, Lili C, Longquan S
Journal of hazardous materials 2021 Aug 15;416:126158
Journal of hazardous materials 2021 Aug 15;416:126158
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Ji Q, Qiao X, Liu Y, Wang D
Histology and histopathology 2021 Apr;36(4):475-484
Histology and histopathology 2021 Apr;36(4):475-484
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z
BMC cancer 2021 Apr 12;21(1):396
BMC cancer 2021 Apr 12;21(1):396
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs.
Zha A, Cui Z, Qi M, Liao S, Chen L, Liao P, Tan B
Current drug metabolism 2020;21(8):614-625
Current drug metabolism 2020;21(8):614-625
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
Li R, Liu W, Ou L, Gao F, Li M, Wang L, Wei P, Miao F
BioMed research international 2020;2020:1562915
BioMed research international 2020;2020:1562915
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Lv S, Yuan P, Dong J, Lu C, Li M, Qu F, Zhu Y, Yuan Z, Zhang J
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J
Nature communications 2020 Nov 30;11(1):6088
Nature communications 2020 Nov 30;11(1):6088
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Cooper LM, Hanson A, Kavanagh JA, Waddell DS
Cellular signalling 2020 Jun;70:109576
Cellular signalling 2020 Jun;70:109576
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Zheng Y, Nie P, Xu S
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Wu G, Long Y, Lu Y, Feng Y, Yang X, Xu X, Yao D
Oncology reports 2020 Jul;44(1):69-76
Oncology reports 2020 Jul;44(1):69-76
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Meng Q, Xue H
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Chen M, Zhu LL, Su JL, Li GL, Wang J, Zhang YN
Human & experimental toxicology 2020 Feb;39(2):173-181
Human & experimental toxicology 2020 Feb;39(2):173-181
Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1α signaling pathway.
Ren C, Pan R, Hou L, Wu H, Sun J, Zhang W, Tian X, Chen H
Molecular medicine reports 2020 Apr;21(4):1739-1748
Molecular medicine reports 2020 Apr;21(4):1739-1748
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Zhang C, Wang B, Wang X, Sheng X, Cui Y
Cancer cell international 2019;19:339
Cancer cell international 2019;19:339
Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway.
Ran Z, Zhang Y, Wen X, Ma J
Molecular medicine reports 2019 Feb;19(2):1024-1031
Molecular medicine reports 2019 Feb;19(2):1024-1031
Hypothermic oxygenated machine perfusion alleviates liver injury in donation after circulatory death through activating autophagy in mice.
Zeng X, Wang S, Li S, Yang Y, Fang Z, Huang H, Wang Y, Fan X, Ye Q
Artificial organs 2019 Dec;43(12):E320-E332
Artificial organs 2019 Dec;43(12):E320-E332
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Liu X, Tan X, Liu P, Wu Y, Qian S, Zhang X
Oncology research 2018 Aug 23;26(7):1123-1131
Oncology research 2018 Aug 23;26(7):1123-1131
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