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Learn66888-1-Ig
antibody from Proteintech Group
Targeting: MTOR
FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [293]
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- Product number
- 66888-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- mTOR antibody
- Antibody type
- Monoclonal
- Description
- mTOR antibody (Cat. #66888-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1G11A3
- Vial size
- 20ul, 150ul
Submitted references Potential of semen coicis in enhancing the anti-tumor effects of PD-1 inhibitor on A549 cell lines by blocking the PI3K-AKT-mTOR pathway.
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity.
Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy.
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits.
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.
Rapamycin improves the survival of epilepsy model cells by blocking phosphorylation of mTOR base on computer simulations and cellular experiments.
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma.
TGF β1 promotes the polarization of M2-type macrophages and activates PI3K/mTOR signaling pathway by inhibiting ISG20 to sensitize ovarian cancer to cisplatin.
The autophagy-mediated mechanism via TSC1/mTOR signaling pathway in thiram-induced tibial dyschondroplasia of broilers.
The therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism.
Metformin mitigates adipogenesis of fibro-adipogenic progenitors after rotator cuff tears via activating mTOR/ULK1-mediated autophagy.
PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis.
Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster-positive hepatocellular carcinoma patients who have undergone living donor liver transplantation.
Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training.
Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice.
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin.
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Chrysophanol induces apoptosis and ferroptosis of gastric cancer cells by targeted regulation of mTOR.
Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Tumor-associated macrophage-derived exosomal miR-513b-5p is a target of jianpi yangzheng decoction for inhibiting gastric cancer.
PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression.
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis.
Arsenic disturbs neural tube closure involving AMPK/PKB-mTORC1-mediated autophagy in mice.
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury.
Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1.
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy.
Network pharmacology and experimental verification reveal the mechanism of safranal against glioblastoma (GBM).
S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation.
Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.
Role of UDP-glucose ceramide glucosyltransferase in venous malformation.
Knockdown of NF-κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway.
Hirudin inhibits glioma growth through mTOR-regulated autophagy.
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model.
Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats.
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells.
Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells.
Combined Epimedii Folium and Ligustri Lucidi Fructus with dexamethasone alleviate the proliferation of airway smooth muscle cells by regulating apoptosis/autophagy.
Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study.
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis.
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.
G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy.
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway.
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
SLC25A32 promotes malignant progression of glioblastoma by activating PI3K-AKT signaling pathway.
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through the AMPK/mTOR/ULK1 pathway.
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Astragaloside IV Blunts Epithelial-Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy.
Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level.
SNRPD1 inhibition suppresses the proliferation of hepatocellular carcinoma and promotes autophagy through the PI3K/AKT/mTOR/4EBP1 pathway.
Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice.
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress.
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Activation of moderate autophagy promotes survival of fat graft.
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization.
Protocol for high-sensitivity western blot on murine hematopoietic stem cells.
Proteomic analysis reveals the molecular mechanism of Astragaloside in the treatment of non-small cell lung cancer by inducing apoptosis.
Milk Exosomes from Gestational Diabetes Mellitus (GDM) and Healthy Parturient Exhibit Differential miRNAs Profiles and Distinct Regulatory Bioactivity on Hepatocyte Proliferation.
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Different levels of autophagy induced by transient serum starvation regulate metabolism and differentiation of porcine skeletal muscle satellite cells.
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis.
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway.
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway.
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma.
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity.
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Rapamycin Attenuates Anxiety and Depressive Behavior Induced by Helicobacter pylori in Association with Reduced Circulating Levels of Ghrelin.
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway.
The diagnostic and prognostic significance of small nuclear ribonucleoprotein Sm D1 aberrantly high expression in hepatocellular carcinoma.
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn's Disease.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway.
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling.
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
SLC7A5 is a lung adenocarcinoma-specific prognostic biomarker and participates in forming immunosuppressive tumor microenvironment.
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR pathway.
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy.
Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells.
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Anti-fatigue effects of fermented soybean protein peptides in mice.
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism.
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
YB1 associates with oncogenetic roles and poor prognosis in nasopharyngeal carcinoma.
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level.
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's disease by regulating the metabolism of astrocytes.
Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Dickkopf1 (Dkk1) Alleviates Vascular Calcification by Regulating the Degradation of Phospholipase D1 (PLD1).
MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis.
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.
Plasma exosomal miR-199a-3p downregulates cell proliferation and migration in Hirschsprung's disease by targeting mTOR.
Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
CD44-fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition.
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
miR-145-5p affects autophagy by targeting CaMKIIδ in atherosclerosis.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway.
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway.
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Latcripin-7A from Lentinula edodes C(91-3) induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.
Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner.
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Comparative Proteomics of Rat Olfactory Bulb Reveal Insights into Susceptibility and Resiliency to Chronic-stress-induced Depression or Anxiety.
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea.
2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.
Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis.
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway.
Social context-dependent singing alters molecular markers of synaptic plasticity signaling in finch basal ganglia Area X.
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes.
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10.
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids.
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs.
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway.
Hypothermic oxygenated machine perfusion alleviates liver injury in donation after circulatory death through activating autophagy in mice.
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Fu ZY, Huang Y, Lian LS, Huang HT, Zhan SF, Cai Y, Li JX, Liu XH
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Sep;26(9):2250-2261
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Sep;26(9):2250-2261
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Liu L, Xiao W, Yang Z, Wang Q, Yi J
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity.
Yin HT, Hui-Lu, Yang JH, Li Q, Li M, Zhao QQ, Wen ZP
Biochemical pharmacology 2024 May;223:116113
Biochemical pharmacology 2024 May;223:116113
Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy.
Liu X, Jiang L, Zeng H, Gao L, Guo S, Chen C, Liu X, Zhang M, Ma L, Li Y, Qi X, Wu Y
Autophagy 2024 May;20(5):1072-1097
Autophagy 2024 May;20(5):1072-1097
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Kundu A, Ghosh P, Bishayi B
International immunopharmacology 2024 May 30;133:112153
International immunopharmacology 2024 May 30;133:112153
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Wang FR, Peng ML, Zhu QF, Yu LL, Zhang LJ, Xu SY, Wang Q, Li J, He X, Liao SG, Ao JL, Xu GB
Journal of ethnopharmacology 2024 May 10;325:117830
Journal of ethnopharmacology 2024 May 10;325:117830
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Ou X, Tan Y, Xie J, Yuan J, Deng X, Shao R, Song C, Cao X, Xie X, He R, Li Y, Tang H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Zhou ZX, Ma XF, Xiong WH, Ren Z, Jiang M, Deng NH, Zhou BB, Liu HT, Zhou K, Hu HJ, Tang HF, Zheng H, Jiang ZS
Atherosclerosis 2024 Mar;390:117430
Atherosclerosis 2024 Mar;390:117430
Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits.
Zhou J, Li C, Lu M, Jiang G, Chen S, Li H, Lu K
PLoS biology 2024 Mar;22(3):e3002537
PLoS biology 2024 Mar;22(3):e3002537
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
Liu ZD, Shi YH, Xu QC, Zhao GY, Zhu YQ, Li FX, Ma MJ, Ye JY, Huang XT, Wang XY, Xu X, Wang JQ, Zhao W, Yin XY
Cancer letters 2024 Mar 31;585:216640
Cancer letters 2024 Mar 31;585:216640
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Xu J, Xue D, Li Y, Zhou J, Chen H, Fan L
Heliyon 2024 Mar 30;10(6):e27629
Heliyon 2024 Mar 30;10(6):e27629
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
Zhang S, Cai X, Khan GJ, Cheng J, He J, Zhai K, Mao Y
Journal of ethnopharmacology 2024 Mar 25;322:117572
Journal of ethnopharmacology 2024 Mar 25;322:117572
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Xu T, Zhao H, Li J, Fang X, Wu H, Hu W
JOR spine 2024 Jun;7(2):e1325
JOR spine 2024 Jun;7(2):e1325
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.
Wang H, Liu X, Yan X, Du Y, Pu F, Ren J, Qu X
Biomaterials 2024 Jun;307:122523
Biomaterials 2024 Jun;307:122523
Rapamycin improves the survival of epilepsy model cells by blocking phosphorylation of mTOR base on computer simulations and cellular experiments.
Li K, Cao JF, Gong Y, Xiong L, Wu M, Qi Y, Ying X, Liu D, Ma X, Zhang X
Neurochemistry international 2024 Jun;176:105746
Neurochemistry international 2024 Jun;176:105746
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Zhao ZX, Li S, Liu LX
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma.
Bai Y, You Y, Chen D, Chen Y, Yin Z, Liao S, You B, Lu D, Sun Y, Wu L, Wu Y
iScience 2024 Jun 21;27(6):109997
iScience 2024 Jun 21;27(6):109997
TGF β1 promotes the polarization of M2-type macrophages and activates PI3K/mTOR signaling pathway by inhibiting ISG20 to sensitize ovarian cancer to cisplatin.
Wu J, Jiang L, Wang S, Peng L, Zhang R, Liu Z
International immunopharmacology 2024 Jun 15;134:112235
International immunopharmacology 2024 Jun 15;134:112235
The autophagy-mediated mechanism via TSC1/mTOR signaling pathway in thiram-induced tibial dyschondroplasia of broilers.
Quan C, Zhou S, Zhang Y, Kulyar MF, Gong S, Nawaz S, Ahmed AE, Mo Q, Li J
The Science of the total environment 2024 Jun 10;928:172305
The Science of the total environment 2024 Jun 10;928:172305
The therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism.
Wang X, Wang F, Dong P, Zhou L
Radiology and oncology 2024 Jun 1;58(2):221-233
Radiology and oncology 2024 Jun 1;58(2):221-233
Metformin mitigates adipogenesis of fibro-adipogenic progenitors after rotator cuff tears via activating mTOR/ULK1-mediated autophagy.
Zhou H, Lin X, Feng S, Zhu S, Zhou H, Chen H, Youwu H, Wang Z, Wang R, Shao X, Wang J
American journal of physiology. Cell physiology 2024 Jun 1;326(6):C1590-C1603
American journal of physiology. Cell physiology 2024 Jun 1;326(6):C1590-C1603
PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis.
Zhang J, Tian Y, Xu X, Wang B, Huang Z, Song K, Lou S, Kang J, Zhang N, Li J, Weng J, Liang Y, Ma W
Autophagy 2024 Jul;20(7):1616-1638
Autophagy 2024 Jul;20(7):1616-1638
Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster-positive hepatocellular carcinoma patients who have undergone living donor liver transplantation.
Toshida K, Itoh S, Toshima T, Yoshiya S, Goto R, Mita A, Harada N, Kohashi K, Oda Y, Yoshizumi T
Annals of gastroenterological surgery 2024 Jan;8(1):163-171
Annals of gastroenterological surgery 2024 Jan;8(1):163-171
Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training.
Bou T, Ding W, Ren X, Liu H, Gong W, Jia Z, Zhang X, Dugarjaviin M, Bai D
Equine veterinary journal 2024 Jan;56(1):178-192
Equine veterinary journal 2024 Jan;56(1):178-192
Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice.
Huang Y, Han M, Shi Q, Li X, Mo J, Liu Y, Chu Z, Li W
Experimental neurology 2024 Jan;371:114583
Experimental neurology 2024 Jan;371:114583
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Wang T, Chen S, Wang Z, Li S, Fei X, Wang T, Zhang M
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin.
Chen Z, Guo Q, Huang S, Li L, Wu F, Liu Z, Li Z, Chen T, Song G, Xu S, Chen J, Hou Y
Genes & diseases 2024 Jan;11(1):397-412
Genes & diseases 2024 Jan;11(1):397-412
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Wei L, Li X, Yao Y, Wang S, Ai X, Liu S
Chemical biology & drug design 2024 Jan;103(1):e14421
Chemical biology & drug design 2024 Jan;103(1):e14421
Chrysophanol induces apoptosis and ferroptosis of gastric cancer cells by targeted regulation of mTOR.
Xi S, Ding W, Weng D, Zeng Y, Gao K, Wu Q, Huang G, Li Y, Yue H
Chemical biology & drug design 2024 Jan;103(1):e14417
Chemical biology & drug design 2024 Jan;103(1):e14417
Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
Xie L, Li R, Zhang J, Li H, Gao X, Zhang M
Journal of agricultural and food chemistry 2024 Jan 31;72(4):2135-2144
Journal of agricultural and food chemistry 2024 Jan 31;72(4):2135-2144
FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Zhou Z, Zhang B, Deng Y, Deng S, Li J, Wei W, Wang Y, Wang J, Feng Z, Che M, Yang X, Meng J, Li Y, Hu Y, Sun Y, Wen L, Huang F, Sheng Y, Wan C, Yang K
Journal of experimental & clinical cancer research : CR 2024 Jan 29;43(1):34
Journal of experimental & clinical cancer research : CR 2024 Jan 29;43(1):34
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Li Y, Li L, Xiong W, Duan X, Xi H
Theriogenology 2024 Jan 15;214:192-200
Theriogenology 2024 Jan 15;214:192-200
Tumor-associated macrophage-derived exosomal miR-513b-5p is a target of jianpi yangzheng decoction for inhibiting gastric cancer.
Zhang R, Chen X, Miao C, Chen Y, Li Y, Shen J, Yuan M, Chen M, Cheng J, Liu S, Sun Q, Wu J
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117013
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117013
PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
Wang L, Yan F, Shi Y, Su X, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2024 Feb;94:105711
Toxicology in vitro : an international journal published in association with BIBRA 2024 Feb;94:105711
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
Lin S, Chen Z, Wu Z, Fei F, Xu Z, Tong Y, Sun W, Wang P
Neurochemical research 2024 Feb;49(2):477-491
Neurochemical research 2024 Feb;49(2):477-491
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
Yu H, Li X, Li Y, Wang T, Wang M, Mao P
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
Son SM, Park SJ, Breusegem SY, Larrieu D, Rubinsztein DC
Nature cell biology 2024 Feb;26(2):235-249
Nature cell biology 2024 Feb;26(2):235-249
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Ghosh R, Bishayi B
Microbial pathogenesis 2024 Feb;187:106518
Microbial pathogenesis 2024 Feb;187:106518
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
Xia ZY, Liu L, Kuok CF, Wang XL, Shi D, Ma Q, Cheng XY, Wang GL, Li MJ, Zheng QS, Liu XN, Li DF, Li BH
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J
Free radical biology & medicine 2024 Feb 20;212:133-148
Free radical biology & medicine 2024 Feb 20;212:133-148
mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.
Ali Y, Gomez-Sanchez CE, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez EP
Endocrinology 2024 Feb 20;165(4)
Endocrinology 2024 Feb 20;165(4)
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.
Zhan X, Li J, Zeng R, Lei L, Feng A, Yang Z
Experimental cell research 2024 Feb 1;435(1):113925
Experimental cell research 2024 Feb 1;435(1):113925
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, D'Orazi G, Cirone M
Autophagy 2024 Aug;20(8):1854-1867
Autophagy 2024 Aug;20(8):1854-1867
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis.
Zhao Y, Jiang J, Zhou P, Deng K, Liu Z, Yang M, Yang X, Li J, Li R, Xia J
Biochemical pharmacology 2024 Apr;222:116120
Biochemical pharmacology 2024 Apr;222:116120
Arsenic disturbs neural tube closure involving AMPK/PKB-mTORC1-mediated autophagy in mice.
Li X, Li G, Cui S, Hou Y, Li Z, Yan Z, Huang T, Zhao T, Su H, Zhou B, Zhang J, Ao R, Zhao H, Qiu Y, Liu Z, Xie J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114538
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114538
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
Shi G, Zeng L, Shi J, Chen Y
International heart journal 2023;64(3):462-469
International heart journal 2023;64(3):462-469
TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury.
Zhong WJ, Liu T, Yang HH, Duan JX, Yang JT, Guan XX, Xiong JB, Zhang YF, Zhang CY, Zhou Y, Guan CX
International journal of biological sciences 2023;19(1):242-257
International journal of biological sciences 2023;19(1):242-257
Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.
Zheng W, Guo Y, Zhang G, Bai J, Song Y, Song X, Zhu Q, Bao X, Wu G, Zhang C
PloS one 2023;18(6):e0287133
PloS one 2023;18(6):e0287133
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1.
Li F, Wang L, Wang Y, Shen H, Kou Q, Shen C, Xu X, Zhang Y, Zhang J
Journal of Cancer 2023;14(15):2820-2832
Journal of Cancer 2023;14(15):2820-2832
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Wang Y, He Q, Rong K, Zhu M, Zhao X, Zheng P, Mi Y
Frontiers in pharmacology 2023;14:1338260
Frontiers in pharmacology 2023;14:1338260
Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy.
Hu BA, Li YL, Han HT, Lu B, Jia X, Han L, Ma WX, Zhu P, Wang ZH, Zhang W, Zhong M, Zhang L
Frontiers in pharmacology 2023;14:1112123
Frontiers in pharmacology 2023;14:1112123
Network pharmacology and experimental verification reveal the mechanism of safranal against glioblastoma (GBM).
Yang X, Lu D, Sun Y, Wei T, Man D, Chen A, Luo T, Zhao F, Liu X, Cheng B, Wang X, Zhao P, Wang D, Li X
Frontiers in oncology 2023;13:1255164
Frontiers in oncology 2023;13:1255164
S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation.
Lv D, Xu Z, Cheng P, Hu Z, Dong Y, Rong Y, Xu H, Wang Z, Cao X, Deng W, Tang B
Burns & trauma 2023;11:tkad024
Burns & trauma 2023;11:tkad024
Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering.
Shahabi F, Abdoli S, Bazi Z, Shamsabadi F, Yamchi A, Shahbazi M
Frontiers in bioengineering and biotechnology 2023;11:1268048
Frontiers in bioengineering and biotechnology 2023;11:1268048
Role of UDP-glucose ceramide glucosyltransferase in venous malformation.
Chen S, Wang Y, Kong L, Ji Y, Cui J, Shen W
Frontiers in cell and developmental biology 2023;11:1178045
Frontiers in cell and developmental biology 2023;11:1178045
Knockdown of NF-κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway.
Xu X, Hou D, Wang Y, Zhang J, Hei Y, Wang B, Tian S, Zhang Y, Wang F
Molecular biology reports 2023 Sep;50(9):7501-7513
Molecular biology reports 2023 Sep;50(9):7501-7513
Hirudin inhibits glioma growth through mTOR-regulated autophagy.
Ma Y, Wu S, Zhao F, Li H, Li Q, Zhang J, Li H, Yuan Z
Journal of cellular and molecular medicine 2023 Sep;27(18):2701-2713
Journal of cellular and molecular medicine 2023 Sep;27(18):2701-2713
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
Hu S, Yang M, Xiao K, Yang Z, Cai L, Xie Y, Wang L, Wei R
Experimental and therapeutic medicine 2023 Sep;26(3):457
Experimental and therapeutic medicine 2023 Sep;26(3):457
Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
Yang XM, Wang XQ, Hu LP, Feng MX, Zhou YQ, Li DX, Li J, Miao XC, Zhang YL, Yao LL, Nie HZ, Huang S, Xia Q, Zhang XL, Jiang SH, Zhang ZG
Gastroenterology 2023 Sep;165(3):629-646
Gastroenterology 2023 Sep;165(3):629-646
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model.
Dai W, Yang H, Xu B, He T, Liu L, Ma X, Ma J, Yang G, Si R, Pei X, Du X, Fu X
Journal of ovarian research 2023 Sep 30;16(1):198
Journal of ovarian research 2023 Sep 30;16(1):198
Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats.
Jin SW, Han YL, Pan XL, Zhang HX
Heliyon 2023 Oct;9(10):e21005
Heliyon 2023 Oct;9(10):e21005
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Li X, Wang G, Zhou X, Zhao H, Chen X, Cui Q, Li M, Gao X, Wei X, Ye L, Li D, Hong P
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells.
Zheng Y, Shi D, Chen L, Yang Y, Yao M
Aging 2023 Oct 9;15(19):10593-10606
Aging 2023 Oct 9;15(19):10593-10606
Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells.
He L, Chen J, Deng P, Huang S, Liu P, Wang C, Huang X, Li Y, Chen B, Shi D, Xiao Y, Chen X, Ouyang Y, Song L, Lin C
Molecular cell 2023 Oct 5;83(19):3502-3519.e11
Molecular cell 2023 Oct 5;83(19):3502-3519.e11
Combined Epimedii Folium and Ligustri Lucidi Fructus with dexamethasone alleviate the proliferation of airway smooth muscle cells by regulating apoptosis/autophagy.
Long Y, Wang H, Ma Z, Li Y, Ma Z, Yu P, Tang X, Liu R
Journal of ethnopharmacology 2023 Oct 5;314:116547
Journal of ethnopharmacology 2023 Oct 5;314:116547
Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.
Gao Y, Lu LJ, Zhang ZZ, Yang X, Du J, Wen K, Huang H, Wang XP, Sun XL
Journal of ethnopharmacology 2023 Oct 28;315:116678
Journal of ethnopharmacology 2023 Oct 28;315:116678
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Zhao S, Li Y, Li G, Ye J, Wang R, Zhang X, Li F, Gao C, Li J, Jiang J, Mi Y
European journal of pharmacology 2023 Oct 15;957:176004
European journal of pharmacology 2023 Oct 15;957:176004
Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study.
Qiu K, Xia Q, Chen H, Ye Q, Mao H, Tian M, Gan Y, Huang Q, Wang H, Duan S
Heliyon 2023 Nov;9(11):e21851
Heliyon 2023 Nov;9(11):e21851
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Yan Y, Yu S, Fan Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277
Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
Huang X, Liu X, Lin J
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2361-2380
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2361-2380
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Liu H, Xi Q, Tan S, Qu Y, Meng Q, Zhang Y, Cheng Y, Wu G
International immunopharmacology 2023 Nov;124(Pt B):111001
International immunopharmacology 2023 Nov;124(Pt B):111001
Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis.
Jiang P, Zhao L, Hu R, Zhai Z, Guo J, Zhang K
International immunopharmacology 2023 Nov;124(Pt B):110914
International immunopharmacology 2023 Nov;124(Pt B):110914
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Lin L, Li X, Wu AJ, Xiu JB, Gan YZ, Yang XM, Ai ZH
iScience 2023 Nov 17;26(11):108226
iScience 2023 Nov 17;26(11):108226
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Li J, Zhang M, Pei Y, Yang Q, Zheng L, Wang G, Sun Y, Yang W, Liu L
Journal of ethnopharmacology 2023 Nov 15;316:116723
Journal of ethnopharmacology 2023 Nov 15;316:116723
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
Li P, Fang X, Hao G, Li X, Cai Y, Yan Y, Zan L, Yang R, Liu B
Metabolites 2023 Nov 14;13(11)
Metabolites 2023 Nov 14;13(11)
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Wang K, Li Z, Ding Y, Liu Z, Li Y, Liu X, Sun Y, Hong J, Zheng W, Qian L, Xu D
Journal of physiology and biochemistry 2023 May;79(2):341-353
Journal of physiology and biochemistry 2023 May;79(2):341-353
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Ji X, Hong J, Yang W, Yao M, Wang J, Jiang G, Wang Y, Li C, Lin J, Mou H, Li C, Li S, Chen Y, Shi M, Wang W, Lu F, Wu H, Zhao X, Qi Y, Yan S
Redox biology 2023 May;61:102635
Redox biology 2023 May;61:102635
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
Liu W, Chen Y, Song X, Xue Y, Zhang Y
International ophthalmology 2023 May;43(5):1523-1536
International ophthalmology 2023 May;43(5):1523-1536
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Sun X, Huang LY, Pan HX, Li LJ, Wang L, Pei GQ, Wang Y, Zhang Q, Cheng HX, He CQ, Wei Q
Neural regeneration research 2023 May;18(5):1067-1075
Neural regeneration research 2023 May;18(5):1067-1075
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Wang Z, Tan M, Su W, Huang W, Zhang J, Jia F, Cao G, Liu X, Song H, Ran H, Nie G, Wang H
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.
Lu S, Liu Y, Tian S, He Y, Dong W
Experimental cell research 2023 May 1;426(1):113564
Experimental cell research 2023 May 1;426(1):113564
G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
Li S, Liao Z, Yin H, Liu O, Hua W, Wu X, Zhang Y, Gao Y, Yang C
Cell proliferation 2023 Mar;56(3):e13368
Cell proliferation 2023 Mar;56(3):e13368
BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy.
Liu W, Zhu SO, Guo YL, Tu LF, Zhen YQ, Zhao RY, Ou-Yang L, Kurihara H, He RR, Liu B
Acta pharmacologica Sinica 2023 Mar;44(3):524-537
Acta pharmacologica Sinica 2023 Mar;44(3):524-537
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Liu W, Lin T, Gong L
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2023 Mar;39(2):128-138
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2023 Mar;39(2):128-138
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Chen D, Jiang X, Zou H
Journal of orthopaedic translation 2023 Mar;39:163-176
Journal of orthopaedic translation 2023 Mar;39:163-176
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Zhou H, Yun X, Shu Y, Xu K
Oncology letters 2023 Mar;25(3):101
Oncology letters 2023 Mar;25(3):101
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Yang J, Hasenbilige, Bao S, Luo S, Jiang L, Li Q, Kong Y, Cao J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
Zhong WJ, Zhang J, Duan JX, Zhang CY, Ma SC, Li YS, Yang NS, Yang HH, Xiong JB, Guan CX, Jiang ZX, You ZJ, Zhou Y
Journal of translational medicine 2023 Mar 6;21(1):179
Journal of translational medicine 2023 Mar 6;21(1):179
A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.
Chen J, Feng D, Lu Y, Zhang Y, Jiang H, Yuan M, Xu Y, Zou J, Zhu Y, Zhang J, Ge C, Wang Y
Cancers 2023 Mar 5;15(5)
Cancers 2023 Mar 5;15(5)
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Jin L, Mi T, Wu X, Wang Z, Zhang Z, Liu J, Wang Z, Wang J, Li M, Ren C, Guo P, He D
Cancers 2023 Mar 28;15(7)
Cancers 2023 Mar 28;15(7)
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
Wei P, He Q, Liu T, Zhang J, Shi K, Zhang J, Liu S
Journal of ethnopharmacology 2023 Mar 25;304:116095
Journal of ethnopharmacology 2023 Mar 25;304:116095
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Cai J, Ye Z, Hu Y, Ye L, Gao L, Wang Y, Sun Q, Tong S, Zhang S, Wu L, Yang J, Chen Q
Cell death & disease 2023 Mar 25;14(3):211
Cell death & disease 2023 Mar 25;14(3):211
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Liu X, Xi H, Han S, Zhang H, Hu J
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Ge XF, Li SS, Liu YH, Lu MQ, Su HN, Yang X, Sun XW
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway.
Zhang T, Zhang Y, Yang Z, Jiang Y, Sun L, Huang D, Tian M, Shen Y, Deng J, Hou J, Ma Y
Pathogens and global health 2023 Jun;117(4):409-416
Pathogens and global health 2023 Jun;117(4):409-416
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)
Cancers 2023 Jun 27;15(13)
SLC25A32 promotes malignant progression of glioblastoma by activating PI3K-AKT signaling pathway.
Xue Z, Wang J, Wang Z, Liu J, Zhao J, Liu X, Zhang Y, Liu G, Zhao Z, Li W, Zhang Q, Li X, Huang B, Wang X
BMC cancer 2023 Jun 26;23(1):589
BMC cancer 2023 Jun 26;23(1):589
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
Guo M, Zhu C, Fu R, Ma X, Duan Z, Fan D
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through the AMPK/mTOR/ULK1 pathway.
Yang C, Deng Z, Zeng Q, Chang X, Wu X, Li G
Biochemical and biophysical research communications 2023 Jun 18;661:34-41
Biochemical and biophysical research communications 2023 Jun 18;661:34-41
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Li X, Wang W, Hou Y, Li G, Yi H, Cui S, Zhang J, He X, Zhao H, Yang Z, Qiu Y, Liu Z, Xie J
Ecotoxicology and environmental safety 2023 Jun 1;257:114914
Ecotoxicology and environmental safety 2023 Jun 1;257:114914
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Zhou W, Wang C, Zhang B, Gou S
European journal of pharmacology 2023 Jul 5;950:175751
European journal of pharmacology 2023 Jul 5;950:175751
Astragaloside IV Blunts Epithelial-Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy.
Li D, Liu Y, Zhan Q, Zeng Y, Peng Z, He Q, Tan Q, Cao W, Wang S, Wang J
Cells 2023 Jul 4;12(13)
Cells 2023 Jul 4;12(13)
Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level.
Psatha K, Kollipara L, Drakos E, Deligianni E, Brintakis K, Patsouris E, Sickmann A, Rassidakis GZ, Aivaliotis M
Cancers 2023 Jul 31;15(15)
Cancers 2023 Jul 31;15(15)
SNRPD1 inhibition suppresses the proliferation of hepatocellular carcinoma and promotes autophagy through the PI3K/AKT/mTOR/4EBP1 pathway.
Wang H, Chen M, Yang C, Hu H, Jiang Y, Yang F, Lv L
Archives of biochemistry and biophysics 2023 Jul 15;743:109661
Archives of biochemistry and biophysics 2023 Jul 15;743:109661
Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice.
Li X, Huang L, Kong L, Su Y, Zhou H, Ji P, Sun R, Wang C, Li W, Li W
Molecular medicine reports 2023 Jan;27(1)
Molecular medicine reports 2023 Jan;27(1)
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Song R, Ma S, Xu J, Ren X, Guo P, Liu H, Li P, Yin F, Liu M, Wang Q, Yu L, Liu J, Duan B, Rahman NA, Wołczyński S, Li G, Li X
Molecular cancer 2023 Jan 23;22(1):16
Molecular cancer 2023 Jan 23;22(1):16
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.
Zhou Z, Zhang G, Li T, Ai J, Li W, Zeng S, Ye M, Liu Q, Xiao J, Li Y, Tan G, Zhang X
Cancers 2023 Jan 18;15(3)
Cancers 2023 Jan 18;15(3)
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Xu M, Zhou Y, Fan S, Zhang M, Gao X
Amino acids 2023 Feb;55(2):243-252
Amino acids 2023 Feb;55(2):243-252
Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress.
Zhang J, Zha Y, Jiao Y, Li Y, Zhang S
Toxicology 2023 Feb;485:153426
Toxicology 2023 Feb;485:153426
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
Zhuge R, Li Z, He C, Ma W, Yan J, Xue Q, Wang R, Liu Y, Lu R, Du H, Yin F, Guo L
Environmental toxicology 2023 Feb;38(2):289-299
Environmental toxicology 2023 Feb;38(2):289-299
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Zhang H, Xie X, Shi J, Zhao Q, Luo D, Hao J, Zhou Y, Han G, Pang X
Phytotherapy research : PTR 2023 Feb;37(2):410-423
Phytotherapy research : PTR 2023 Feb;37(2):410-423
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Deng Y, Ma J, Zhao S, Yang M, Sun Y, Zhang Q
Translational oncology 2023 Feb;28:101614
Translational oncology 2023 Feb;28:101614
Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.
Ke C, Zhao S, Wang L, Zhang M, Gao X
Biochemical and biophysical research communications 2023 Feb 5;643:88-95
Biochemical and biophysical research communications 2023 Feb 5;643:88-95
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Lu R, Wei Z, Wang Z, Xu S, Sun K, Cheng P, Huang X, You H, Guo F, Liang S, Chen AM
iScience 2023 Feb 17;26(2):105936
iScience 2023 Feb 17;26(2):105936
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Li Y, Zang J, Wang X, Feng X, Qiu F
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Chen T, Bao S, Chen J, Zhang J, Wei H, Hu X, Liang Y, Li J, Yan S
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Xu Y, Wang Y, Xiao H, Li Y
Journal of periodontal research 2023 Dec;58(6):1248-1260
Journal of periodontal research 2023 Dec;58(6):1248-1260
Activation of moderate autophagy promotes survival of fat graft.
Pei SJ, Zhu YZ, Yang JM, Zhang MC, Shi CL, Ding Y, Yi YY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23289
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23289
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B
Autophagy 2023 Dec;19(12):3132-3150
Autophagy 2023 Dec;19(12):3132-3150
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Ruiz-Mitjana A, Vidal-Sabanés M, Navaridas R, Perramon-Güell A, Yeramian A, Nicholson-Sabaté N, Egea J, Encinas M, Matias-Guiu X, Dolcet X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Huang Y, Luo W, Chen S, Su H, Zhu W, Wei Y, Qiu Y, Long Y, Shi Y, Wei J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization.
Yao Y, Chen C, Wang J, Xuan H, Chen X, Li Z, Yang F, Wang B, Lin S, Li S, Tang D, Gong L, Gao W
Journal of experimental & clinical cancer research : CR 2023 Dec 5;42(1):330
Journal of experimental & clinical cancer research : CR 2023 Dec 5;42(1):330
Protocol for high-sensitivity western blot on murine hematopoietic stem cells.
Li C, Guan J, Li Y, Tian X, Zhao Y, Liu W, Tian H, Tian H, Yang Y, Zhao M
STAR protocols 2023 Dec 15;4(4):102578
STAR protocols 2023 Dec 15;4(4):102578
Proteomic analysis reveals the molecular mechanism of Astragaloside in the treatment of non-small cell lung cancer by inducing apoptosis.
Liu J, Sun Y, Chen W, Deng L, Chen M, Dong J
BMC complementary medicine and therapies 2023 Dec 15;23(1):461
BMC complementary medicine and therapies 2023 Dec 15;23(1):461
Milk Exosomes from Gestational Diabetes Mellitus (GDM) and Healthy Parturient Exhibit Differential miRNAs Profiles and Distinct Regulatory Bioactivity on Hepatocyte Proliferation.
Zheng Z, Mo J, Lin F, Wang J, Chen J, Luo H, Liu Y, Su C, Gu X, Xiong F, Zha L
Molecular nutrition & food research 2023 Aug;67(16):e2300005
Molecular nutrition & food research 2023 Aug;67(16):e2300005
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
He P, He Y, Ma J, Liu Y, Liu C, Baoping Y, Dong W
Phytotherapy research : PTR 2023 Aug;37(8):3467-3480
Phytotherapy research : PTR 2023 Aug;37(8):3467-3480
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
Li N, Chen L, Zhao X, Gu C, Chang Y, Feng S
Cell death discovery 2023 Aug 24;9(1):309
Cell death discovery 2023 Aug 24;9(1):309
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X
Cell & bioscience 2023 Aug 21;13(1):154
Cell & bioscience 2023 Aug 21;13(1):154
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.
Li MX, Wu XT, Jing WQ, Hou WK, Hu S, Yan W
Cell death & disease 2023 Aug 2;14(8):492
Cell death & disease 2023 Aug 2;14(8):492
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Yan C, Xiong J, Zhou Z, Li Q, Gao C, Zhang M, Yu L, Li J, Hu MM, Zhang CS, Cai C, Zhang H, Zhang J
eLife 2023 Aug 17;12
eLife 2023 Aug 17;12
Different levels of autophagy induced by transient serum starvation regulate metabolism and differentiation of porcine skeletal muscle satellite cells.
Wang Y, Gao J, Fan B, Hu Y, Yang Y, Wu Y, Li F, Ju H
Scientific reports 2023 Aug 12;13(1):13153
Scientific reports 2023 Aug 12;13(1):13153
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Zhang PP, Zhuo BY, Duan ZW, Li X, Huang SL, Cao Q, Zhao T, Wei SL, Hu XH, Zhang Y
Journal of ethnopharmacology 2023 Aug 10;312:116523
Journal of ethnopharmacology 2023 Aug 10;312:116523
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis.
Zhang M, Zhang B, Wang X, Song J, Tong M, Dong Z, Xu J, Liu M, Jiang Y, Wang N, Wang Y, Du Z, Liu Y, Zhang R, Xu C
Science China. Life sciences 2023 Apr;66(4):783-799
Science China. Life sciences 2023 Apr;66(4):783-799
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway.
Wu W, Chen X, Liu X, Bao HJ, Li QH, Xian JY, Lu BF, Zhao Y, Chen S
Molecular carcinogenesis 2023 Apr;62(4):413-426
Molecular carcinogenesis 2023 Apr;62(4):413-426
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Liang X, Yang Y, Huang C, Ye Z, Lai W, Luo J, Li X, Yi X, Fan JB, Wang Y, Wang Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Zhang L, Xue K, Fan P, Chen C, Hu J, Huang J, Lu W, Xu J, Xu S, Ran J, Zhu S, Gan S
Experimental eye research 2023 Apr;229:109416
Experimental eye research 2023 Apr;229:109416
CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway.
Zhu Y, Zuo L, Xiong H, Li S, Chen R, Liu H
Cell cycle (Georgetown, Tex.) 2023 Apr;22(8):919-938
Cell cycle (Georgetown, Tex.) 2023 Apr;22(8):919-938
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Wang J, Wang D, Feng L, Li X, Gong Y, Wang Z, Tan N, Han J
Phytochemistry 2023 Apr;208:113603
Phytochemistry 2023 Apr;208:113603
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
Lin G, Qi H, Guo X, Wang W, Zhang M, Gao X
The Journal of nutritional biochemistry 2023 Apr;114:109274
The Journal of nutritional biochemistry 2023 Apr;114:109274
Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma.
Liu L, Shi D, Xia ZY, Wang BW, Wang XL, Wang XT, Wang GL, Li MJ, Zheng QS, Li D, Li BH
Journal of natural products 2023 Apr 28;86(4):966-978
Journal of natural products 2023 Apr 28;86(4):966-978
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Wang Y, Yuan Y, Wang C, Wang B, Zou W, Zhang N, Chen X
Frontiers in nutrition 2022;9:858261
Frontiers in nutrition 2022;9:858261
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
Osuru HP, Lavallee M, Thiele RH
Frontiers in cardiovascular medicine 2022;9:711421
Frontiers in cardiovascular medicine 2022;9:711421
Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity.
Tu Z, Li J, Long X, Wu L, Zhu X, Huang K
Oxidative medicine and cellular longevity 2022;2022:9408886
Oxidative medicine and cellular longevity 2022;2022:9408886
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Mu X, Shen Z, Lin Y, Xiao J, Xia K, Xu C, Chen B, Shi R, Zhu A, Sun X, Tao T, Song X, Xuan Q
Oxidative medicine and cellular longevity 2022;2022:8693259
Oxidative medicine and cellular longevity 2022;2022:8693259
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Rapamycin Attenuates Anxiety and Depressive Behavior Induced by Helicobacter pylori in Association with Reduced Circulating Levels of Ghrelin.
Tian J, Wang Z, Ren Y, Jiang Y, Zhao Y, Li M, Zhang Z
Neural plasticity 2022;2022:2847672
Neural plasticity 2022;2022:2847672
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Zuo X, Shi X, Zhang X, Chen Z, Yang Z, Pan X, Lai R, Zhao Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
Lin L, Wang X, Zhao W, Chen Y
Genetics research 2022;2022:1500768
Genetics research 2022;2022:1500768
CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
Zhang Z, Xu P, Hu Z, Fu Z, Deng T, Deng X, Peng L, Xie Y, Long L, Zheng D, Shen P, Zhang M, Gong B, Zhu Z, Lin J, Chen R, Liu Z, Yang H, Li R, Fang W
International journal of biological sciences 2022;18(10):4171-4186
International journal of biological sciences 2022;18(10):4171-4186
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Hao M, Ding C, Sun S, Peng X, Liu W
Journal of inflammation research 2022;15:4921-4938
Journal of inflammation research 2022;15:4921-4938
Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway.
Zhu N, Chen X, Zhao J, Fang L, Yao Y, Zhou F, Tao L, Xu Q
Journal of Cancer 2022;13(11):3177-3188
Journal of Cancer 2022;13(11):3177-3188
The diagnostic and prognostic significance of small nuclear ribonucleoprotein Sm D1 aberrantly high expression in hepatocellular carcinoma.
Wang H, Xu F, Lu L, Yang F, Huang X, Lv L, Hu H, Jiang Y
Journal of Cancer 2022;13(1):184-201
Journal of Cancer 2022;13(1):184-201
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Fan XX, Sun WY, Li Y, Tang Q, Li LN, Yu X, Wang SY, Fan AR, Xu XQ, Chang HS
Frontiers in pharmacology 2022;13:968124
Frontiers in pharmacology 2022;13:968124
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
Cheng Z, Luo X, Zhu Z, Huang Y, Yan X
Frontiers in pharmacology 2022;13:906933
Frontiers in pharmacology 2022;13:906933
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Xin M, Gao Q, Xiang X, Xu J, Jiao Y, Li X, Zhang X, Jia X
Frontiers in pharmacology 2022;13:890974
Frontiers in pharmacology 2022;13:890974
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn's Disease.
Liu J, Zhang L, Wang Z, Chen S, Feng S, He Y, Zhang S
Frontiers in pharmacology 2022;13:844685
Frontiers in pharmacology 2022;13:844685
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Glathar AR, Oyelakin A, Gluck C, Bard J, Sinha S
Frontiers in oncology 2022;12:879054
Frontiers in oncology 2022;12:879054
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway.
Li Y, Liu H, Liu X, Xiao B, Zhang M, Luo Y, Li M, Yang J
Frontiers in oncology 2022;12:851300
Frontiers in oncology 2022;12:851300
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
Shen G, Wang H, Zhu N, Lu Q, Liu J, Xu Q, Huang D
Frontiers in cell and developmental biology 2022;10:893888
Frontiers in cell and developmental biology 2022;10:893888
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
Wang YN, Ye Y, Zhou D, Guo ZW, Xiong Z, Gong XX, Jiang SW, Chen H
Frontiers in cell and developmental biology 2022;10:852561
Frontiers in cell and developmental biology 2022;10:852561
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Yuan D, Guo T, Qian H, Ge H, Zhao Y, Huang A, Wang X, Cao X, Zhu D, He C, Yu H
Drug development research 2022 Sep;83(6):1383-1393
Drug development research 2022 Sep;83(6):1383-1393
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Chen L, Kang Y, Jiang Y, You J, Huang C, Xu X, Chen F
Pathology, research and practice 2022 Sep;237:154031
Pathology, research and practice 2022 Sep;237:154031
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Zhang C, Li Z, Li L, Li S, Yang L, Chen L, Zhang X, Yang S, Guo Y
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling.
Zhao G, Li S, Wang Q, Wu W, Fu X, Zhu C, Wang W, Wang X
Cell death discovery 2022 Sep 26;8(1):398
Cell death discovery 2022 Sep 26;8(1):398
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
Li H, Li K, Shu D, Shen M, Tan Z, Zhang W, Pu D, Tan W, Tang Z, Jin A, Liu S
Life (Basel, Switzerland) 2022 Sep 20;12(10)
Life (Basel, Switzerland) 2022 Sep 20;12(10)
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
Li B, Ge N, Pan Z, Hou C, Xie K, Wang D, Liu J, Wan J, Deng F, Li M, Luo S
BMC medical genomics 2022 Sep 13;15(1):194
BMC medical genomics 2022 Sep 13;15(1):194
SLC7A5 is a lung adenocarcinoma-specific prognostic biomarker and participates in forming immunosuppressive tumor microenvironment.
Liu Y, Ma G, Liu J, Zheng H, Huang G, Song Q, Pang Z, Du J
Heliyon 2022 Oct;8(10):e10866
Heliyon 2022 Oct;8(10):e10866
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Yin L, Feng S, Sun Y, Jiang Y, Tang C, Sun D
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR pathway.
Li N, Li M, Xiu L, Liao W, Ren Y, Liu H, Chen S, Chen F, Yu X, Fan A, Huo M, He J, Zhong G
Journal of ethnopharmacology 2022 Oct 5;296:115443
Journal of ethnopharmacology 2022 Oct 5;296:115443
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy.
Huang L, Chen Y, Liu R, Li B, Fei X, Li X, Liu G, Li Y, Xu B, Fang W
Aging and disease 2022 Oct 1;13(5):1546-1561
Aging and disease 2022 Oct 1;13(5):1546-1561
Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.
Zhai Y, Sun J, Sun C, Zhao H, Li X, Yao J, Su J, Xu X, Xu X, Hu J, Daglia M, Han B, Kai G
Phytotherapy research : PTR 2022 Nov;36(11):4263-4277
Phytotherapy research : PTR 2022 Nov;36(11):4263-4277
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fan Y, Wu H, Xiong L, Luo F, Li Q, Wang D, Zhong T
Fitoterapia 2022 Nov;163:105314
Fitoterapia 2022 Nov;163:105314
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
Zhu Y, Yang Y, Bu H, Huang H, Chen H, Ran J, Qin L, Ni Y, Yao M, Song T, Li M, Yang Y, Guo T, Chao N, Liu Z, Li W, Zhang L
Cancer science 2022 Nov;113(11):3722-3734
Cancer science 2022 Nov;113(11):3722-3734
A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.
Chen W, Zhu L, Wang L, Zeng J, Wen M, Xu X, Zou L, Huang F, Huang Q, Qin D, Mei Q, Yang J, Wang Q, Wu J
International journal of molecular sciences 2022 Nov 14;23(22)
International journal of molecular sciences 2022 Nov 14;23(22)
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells.
Ali Y, Gomez-Sanchez EP, Gomez-Sanchez CE
Endocrinology 2022 Nov 14;164(1)
Endocrinology 2022 Nov 14;164(1)
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Cao Y, Li Y, Fu SC, Shen J, Zhang H, Jiang C, Shu-Hang Yung P
Journal of orthopaedic translation 2022 May;34:102-112
Journal of orthopaedic translation 2022 May;34:102-112
Anti-fatigue effects of fermented soybean protein peptides in mice.
Fang L, Zhang RX, Wei Y, Ling K, Lu L, Wang J, Pan XC, Cai MY
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Yang J, Li J, Guo H, Zhang Y, Guo Z, Liu Y, Huo T
International journal of molecular sciences 2022 May 19;23(10)
International journal of molecular sciences 2022 May 19;23(10)
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism.
Liu D, Bi X, Yang Y
Bioengineered 2022 Mar;13(3):7485-7499
Bioengineered 2022 Mar;13(3):7485-7499
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
Lu Y, Zhong W, Liu Y, Chen W, Zhang J, Zeng Z, Huang H, Qiao Y, Wan X, Meng X, Cai S, Dong H
International immunopharmacology 2022 Mar;104:108504
International immunopharmacology 2022 Mar;104:108504
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
Miao Y, Geng Y, Yang L, Zheng Y, Dai Y, Wei Z
The Journal of nutritional biochemistry 2022 Mar;101:108923
The Journal of nutritional biochemistry 2022 Mar;101:108923
YB1 associates with oncogenetic roles and poor prognosis in nasopharyngeal carcinoma.
Zhan Y, Chen X, Zheng H, Luo J, Yang Y, Ning Y, Wang H, Zhang Y, Zhou M, Wang W, Fan S
Scientific reports 2022 Mar 8;12(1):3699
Scientific reports 2022 Mar 8;12(1):3699
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Xu P, Li X, Tang C, Wang T, Xu J
Experimental cell research 2022 Mar 1;412(1):113018
Experimental cell research 2022 Mar 1;412(1):113018
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Zhong Y, Sun D, Yao Y, Liu Q, Guo T, Wang X, Peng X
Chemico-biological interactions 2022 Mar 1;355:109850
Chemico-biological interactions 2022 Mar 1;355:109850
IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.
Shi XY, Zhang XL, Shi QY, Qiu X, Wu XB, Zheng BL, Jiang HX, Qin SY
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 Jun;24(6):1073-1085
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 Jun;24(6):1073-1085
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
Yan JN, Zhang HY, Li JR, Chen Y, Jiang YC, Shen JB, Ke KF, Gu XS
Neural regeneration research 2022 Jun;17(6):1357-1363
Neural regeneration research 2022 Jun;17(6):1357-1363
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
Chen C, Guo Y, Huang Q, Wang B, Wang W, Niu J, Lou J, Xu J, Ren T, Huang Y, Guo W
Cancer letters 2022 Jun 28;536:215660
Cancer letters 2022 Jun 28;536:215660
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, Di Renzo L, D'Orazi G, Cirone M
Cell death discovery 2022 Jun 25;8(1):295
Cell death discovery 2022 Jun 25;8(1):295
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
Li X, Wang J, Lin W, Yuan Q, Lu Y, Wang H, Chen Y, Chen L, Dai P, Long H, Li X
Molecular cancer 2022 Jun 23;21(1):135
Molecular cancer 2022 Jun 23;21(1):135
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Yan S, Chen J, Zhu L, Guo T, Qin D, Hu Z, Han S, Zhou Y, Akan OD, Wang J, Luo F, Lin Q
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6429-6443
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6429-6443
SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level.
Nie K, Cai M
Digestive diseases and sciences 2022 Jul;67(7):2948-2956
Digestive diseases and sciences 2022 Jul;67(7):2948-2956
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
Huang X, Huang Y, Lv Z, Wang T, Feng H, Wang H, Du S, Wu S, Shen D, Wang C, Li H, Wang B, Ma X, Zhang X
International journal of oncology 2022 Jul;61(1)
International journal of oncology 2022 Jul;61(1)
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Niu Z, Lin J, Hao C, Xu X, Wang C, Dai K, Deng X, Deng M, Guo Y, Yao W
International journal of environmental research and public health 2022 Jul 18;19(14)
International journal of environmental research and public health 2022 Jul 18;19(14)
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Jin D, Liu F, Yu M, Zhao Y, Yan G, Xue J, Sun Y, Zhao D, Li X, Qi W, Wang X
Journal of ethnopharmacology 2022 Jul 15;293:115246
Journal of ethnopharmacology 2022 Jul 15;293:115246
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Liu R, Cai D, Li X, Liu B, Chen J, Jiang X, Li H, Li Z, Teerds K, Sun J, Bai W, Jin Y
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's disease by regulating the metabolism of astrocytes.
Wang C, Zheng D, Weng F, Jin Y, He L
Psychopharmacology 2022 Jan;239(1):215-227
Psychopharmacology 2022 Jan;239(1):215-227
Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring.
Yang Q, Mao Y, Wang J, Yu H, Zhang X, Pei X, Duan Z, Xiao C, Ma M
Human & experimental toxicology 2022 Jan-Dec;41:9603271221129852
Human & experimental toxicology 2022 Jan-Dec;41:9603271221129852
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Xi H, Ren F, Li Y, Xian M, Wang L, Hu J
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.
Wen C, Lin L, Zou R, Lin F, Liu Y
Cell cycle (Georgetown, Tex.) 2022 Feb;21(3):289-303
Cell cycle (Georgetown, Tex.) 2022 Feb;21(3):289-303
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
Ouyang S, Zeng Z, Liu Z, Zhang Z, Sun J, Wang X, Ma M, Ye X, Yu J, Kang W
Cell death discovery 2022 Feb 2;8(1):45
Cell death discovery 2022 Feb 2;8(1):45
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
Xu Z, Li X, Ding Z, Zhang Y, Peng Z, Yang X, Cao W, Du R
The FEBS journal 2022 Dec;289(23):7545-7560
The FEBS journal 2022 Dec;289(23):7545-7560
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Liu L, Li X, Bu W, Jin N, Meng Y, Wang Y, Wang D, Xu X, Zhou D, Sun H
Materials today. Bio 2022 Dec;16:100344
Materials today. Bio 2022 Dec;16:100344
Dickkopf1 (Dkk1) Alleviates Vascular Calcification by Regulating the Degradation of Phospholipase D1 (PLD1).
Li X, Liu XL, Li X, Zhao YC, Wang QQ, Zhong HY, Liu DD, Yuan C, Zheng TF, Zhang M
Journal of cardiovascular translational research 2022 Dec;15(6):1327-1339
Journal of cardiovascular translational research 2022 Dec;15(6):1327-1339
MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis.
Han F, Shen L, Ma H, Wang L, Guo H, Wu X
International immunopharmacology 2022 Dec;113(Pt A):109279
International immunopharmacology 2022 Dec;113(Pt A):109279
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Sun Y, Li H, Liu L, Bai X, Wu L, Shan J, Sun X, Wang Q, Guo Y
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.
Liao WL, Liu YF, Ying TH, Shieh JC, Hung YT, Lee HJ, Shen CY, Cheng CW
International journal of molecular sciences 2022 Dec 26;24(1)
International journal of molecular sciences 2022 Dec 26;24(1)
Plasma exosomal miR-199a-3p downregulates cell proliferation and migration in Hirschsprung's disease by targeting mTOR.
Daiyue Y, Yang Y, Zhaorong H, Yi L, Chen W, Caiyun L, Yuqian S, Liucheng Y, Kai W
Pediatric surgery international 2022 Dec 19;39(1):54
Pediatric surgery international 2022 Dec 19;39(1):54
Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
Kong X, Shu X, Wang J, Liu D, Ni Y, Zhao W, Wang L, Gao Z, Chen J, Yang B, Guo X, Wang Z
Development (Cambridge, England) 2022 Dec 15;149(24)
Development (Cambridge, England) 2022 Dec 15;149(24)
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Tao T, Chen Y, Chen J, Lian C, Xu S, Zhang M, Fang C
Experimental dermatology 2022 Aug;31(8):1154-1164
Experimental dermatology 2022 Aug;31(8):1154-1164
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Wang K, Li Z, Sun Y, Liu X, Ma W, Ding Y, Hong J, Qian L, Xu D
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
CD44-fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition.
Wang C, Wang Y, Zuo N, Fang S, Shi J
Blood advances 2022 Aug 9;6(15):4617-4633
Blood advances 2022 Aug 9;6(15):4617-4633
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Jia X, Xin M, Xu J, Xiang X, Li X, Jiao Y, Wang L, Jiang J, Pang F, Zhang X, Zhang J
Cell death & disease 2022 Aug 30;13(8):750
Cell death & disease 2022 Aug 30;13(8):750
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Liu M, Yue Z, Zhang B, Li F, Liu L, Li F
Metabolites 2022 Aug 25;12(9)
Metabolites 2022 Aug 25;12(9)
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Zhao X, Sun W, Guo B, Cui L
Stem cell research & therapy 2022 Aug 13;13(1):417
Stem cell research & therapy 2022 Aug 13;13(1):417
miR-145-5p affects autophagy by targeting CaMKIIδ in atherosclerosis.
Zhang X, Zai L, Tao Z, Wu D, Lin M, Wan J
International journal of cardiology 2022 Aug 1;360:68-75
International journal of cardiology 2022 Aug 1;360:68-75
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2022 Apr;18(4):860-876
Autophagy 2022 Apr;18(4):860-876
LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway.
Tan Y, Chen Q, Pan S, An W, Xu H, Xing Y, Zhang J
BMC cancer 2022 Apr 30;22(1):474
BMC cancer 2022 Apr 30;22(1):474
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Cheng F, Dun Y, Cheng J, Ripley-Gonzalez JW, Jiang W, You B, Liu S
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway.
Wang JZ, Zhu H, You P, Liu H, Wang WK, Fan X, Yang Y, Xu K, Zhu Y, Li Q, Wu P, Peng C, Wong CC, Li K, Shi Y, Zhang N, Wang X, Zeng R, Huang Y, Yang L, Wang Z, Hui J
The Journal of clinical investigation 2022 Apr 15;132(8)
The Journal of clinical investigation 2022 Apr 15;132(8)
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Wu M, Cong Y, Wang K, Yu H, Zhang X, Ma M, Duan Z, Pei X
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
Deng C, Hu F, Zhao Z, Zhou Y, Liu Y, Zhang T, Li S, Zheng W, Zhang W, Wang T, Ma X
Frontiers in cell and developmental biology 2021;9:797005
Frontiers in cell and developmental biology 2021;9:797005
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Luo Q, Li X, Gan G, Yang M, Chen X, Chen F
Frontiers in cell and developmental biology 2021;9:764263
Frontiers in cell and developmental biology 2021;9:764263
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Hua L, Zhou Y, Hou C, Chen J, Wang Y, Zhang S, Zhou H, He S, Jia E
Frontiers in cardiovascular medicine 2021;8:700630
Frontiers in cardiovascular medicine 2021;8:700630
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Yao M, Zhang J, Li Z, Bai X, Ma J, Li Y
Frontiers in medicine 2021;8:630962
Frontiers in medicine 2021;8:630962
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Qiao D, Jin J, Xing J, Zhang Y, Jia N, Ren X, Lin Z, Jin N, Chen L, Piao Y
The American journal of Chinese medicine 2021;49(2):525-541
The American journal of Chinese medicine 2021;49(2):525-541
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Hu C, Cao Y, Li P, Tang X, Yang M, Gu S, Xiong K, Li T, Xiao T
Journal of oncology 2021;2021:8281718
Journal of oncology 2021;2021:8281718
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
Yang R, Wen J, Yang T, Dai C, Zhao Y
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5570831
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5570831
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
Du P, Luo K, Li G, Zhu J, Xiao Q, Li Y, Zhang X
International journal of medical sciences 2021;18(15):3588-3598
International journal of medical sciences 2021;18(15):3588-3598
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Deng L, Wu X, Zhu X, Yu Z, Liu Z, Wang J, Zheng Y
American journal of translational research 2021;13(1):57-72
American journal of translational research 2021;13(1):57-72
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Ren F, Xu X, Xu J, Mei Y, Zhang J, Wang X, Li F
Environmental toxicology 2021 Sep;36(9):1765-1774
Environmental toxicology 2021 Sep;36(9):1765-1774
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Xian M, Cai J, Zheng K, Liu Q, Liu Y, Lin H, Liang S, Wang S
Food & function 2021 Sep 7;12(17):8056-8067
Food & function 2021 Sep 7;12(17):8056-8067
Latcripin-7A from Lentinula edodes C(91-3) induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.
Din SRU, Nisar MA, Ramzan MN, Saleem MZ, Ghayas H, Ahmad B, Batool S, Kifayat K, Guo X, Huang M, Zhong M
European journal of pharmacology 2021 Sep 15;907:174305
European journal of pharmacology 2021 Sep 15;907:174305
Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner.
Yang L, Cao N, Miao Y, Dai Y, Wei Z
Molecular nutrition & food research 2021 Oct;65(19):e2100367
Molecular nutrition & food research 2021 Oct;65(19):e2100367
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Lu C, Liu X, Li J, Huang Y, Huang X, Dai G, Wu L
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Comparative Proteomics of Rat Olfactory Bulb Reveal Insights into Susceptibility and Resiliency to Chronic-stress-induced Depression or Anxiety.
Liu D, Cai X, Wang L, Yi F, Liao W, Huang R, Fang C, Chen J, Zhou J
Neuroscience 2021 Oct 1;473:29-43
Neuroscience 2021 Oct 1;473:29-43
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
Xing Y, Wang L, Xu G, Guo S, Zhang M, Cheng G, Liu Y, Liu J
Research in veterinary science 2021 Nov;140:18-25
Research in veterinary science 2021 Nov;140:18-25
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622
Cancer cell international 2021 Nov 25;21(1):622
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea.
Deng Z, Chen M, Liu Y, Xu S, Ouyang Y, Shi W, Jian D, Wang B, Liu F, Li J, Shi Q, Peng Q, Sha K, Xiao W, Liu T, Zhang Y, Zhang H, Wang Q, Sun L, Xie H, Li J
EMBO molecular medicine 2021 May 7;13(5):e13560
EMBO molecular medicine 2021 May 7;13(5):e13560
2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.
Wu X, Li J, Wang S, Jiang L, Sun X, Liu X, Yao X, Zhang C, Wang N, Yang G
Journal of agricultural and food chemistry 2021 May 5;69(17):5206-5215
Journal of agricultural and food chemistry 2021 May 5;69(17):5206-5215
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Qi R, Sun J, Qiu X, Zhang Y, Wang J, Wang Q, Huang J, Ge L, Liu Z
Scientific reports 2021 May 27;11(1):11237
Scientific reports 2021 May 27;11(1):11237
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.
Ye D, Xu H, Xia H, Zhang C, Tang Q, Bi F
Journal of experimental & clinical cancer research : CR 2021 May 18;40(1):173
Journal of experimental & clinical cancer research : CR 2021 May 18;40(1):173
Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.
Zhu Y, Su Y, Zhang J, Zhang Y, Li Y, Han Y, Dong X, Li W, Li W
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Ma Y, Yang X, Han H, Wen Z, Yang M, Zhang Y, Fu J, Wang X, Yin T, Lu G, Qi J, Lin H, Wang X, Yang Y
Bioorganic chemistry 2021 Jun;111:104872
Bioorganic chemistry 2021 Jun;111:104872
CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis.
Zhang S, Lu Y, Jiang HY, Cheng ZM, Wei ZJ, Wei YH, Liu T, Xia BJ, Zhao XY, Huang Y, Zou X, Liu R, Zhou S
Cell death & disease 2021 Jun 9;12(6):597
Cell death & disease 2021 Jun 9;12(6):597
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Liu YP, Yuan XY, Li XY, Wang Y, Sun ZB, Deng WH, Lei YD, Huang L, Jiang TY, Zhang ZH
Journal of applied toxicology : JAT 2021 Jun 6;
Journal of applied toxicology : JAT 2021 Jun 6;
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.
Liu C, Zhou X, Pan Y, Liu Y, Zhang Y
BMC cancer 2021 Jun 22;21(1):722
BMC cancer 2021 Jun 22;21(1):722
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
Liu H, Bian W, Yang D, Yang M, Luo H
Life sciences 2021 Jan 1;264:118667
Life sciences 2021 Jan 1;264:118667
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Liu Z, Ma T, Duan J, Liu X, Liu L
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Zheng J, Zhu X, He Y, Hou S, Liu T, Zhi K, Hou T, Gao L
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Liu S, Chen L, Chen H, Xu K, Peng X, Zhang M
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway.
Shu X, Cao KY, Liu HQ, Yu L, Sun LX, Yang ZH, Wu CA, Ran YL
Stem cell research & therapy 2021 Feb 12;12(1):119
Stem cell research & therapy 2021 Feb 12;12(1):119
Social context-dependent singing alters molecular markers of synaptic plasticity signaling in finch basal ganglia Area X.
So LY, Miller JE
Behavioural brain research 2021 Feb 1;398:112955
Behavioural brain research 2021 Feb 1;398:112955
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes.
Kim HJ, Han YH, Kim JY, Lee MO
Hepatology communications 2021 Dec;5(12):2121-2138
Hepatology communications 2021 Dec;5(12):2121-2138
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Guo H, Peng J, Hu J, Chang S, Liu H, Luo H, Chen X, Tang H, Chen Y
Journal of bone oncology 2021 Dec;31:100393
Journal of bone oncology 2021 Dec;31:100393
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10.
Qu G, He T, Dai A, Zhao Y, Guan D, Li S, Shi H, Gan W, Zhang A
Experimental and therapeutic medicine 2021 Dec;22(6):1469
Experimental and therapeutic medicine 2021 Dec;22(6):1469
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Chen X, Tang H, Liang Y, Wu P, Xie L, Ding Y, Yang P, Long B, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
Zhao P, Cai Z, Tian Y, Li J, Li K, Li M, Bai Y, Li J
International immunopharmacology 2021 Dec;101(Pt B):108360
International immunopharmacology 2021 Dec;101(Pt B):108360
The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids.
Xia F, Xiang S, Chen Z, Song L, Li Y, Liao Z, Ge B, Zhou B
Archives of biochemistry and biophysics 2021 Dec 15;714:109080
Archives of biochemistry and biophysics 2021 Dec 15;714:109080
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Man S, Wu Z, Sun R, Guan Q, Li Z, Zuo D, Zhang W, Wu Y
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Xiaoli F, Yaqing Z, Ruhui L, Xuan L, Aijie C, Yanli Z, Chen H, Lili C, Longquan S
Journal of hazardous materials 2021 Aug 15;416:126158
Journal of hazardous materials 2021 Aug 15;416:126158
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Ji Q, Qiao X, Liu Y, Wang D
Histology and histopathology 2021 Apr;36(4):475-484
Histology and histopathology 2021 Apr;36(4):475-484
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z
BMC cancer 2021 Apr 12;21(1):396
BMC cancer 2021 Apr 12;21(1):396
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs.
Zha A, Cui Z, Qi M, Liao S, Chen L, Liao P, Tan B
Current drug metabolism 2020;21(8):614-625
Current drug metabolism 2020;21(8):614-625
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
Li R, Liu W, Ou L, Gao F, Li M, Wang L, Wei P, Miao F
BioMed research international 2020;2020:1562915
BioMed research international 2020;2020:1562915
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Lv S, Yuan P, Dong J, Lu C, Li M, Qu F, Zhu Y, Yuan Z, Zhang J
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J
Nature communications 2020 Nov 30;11(1):6088
Nature communications 2020 Nov 30;11(1):6088
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Cooper LM, Hanson A, Kavanagh JA, Waddell DS
Cellular signalling 2020 Jun;70:109576
Cellular signalling 2020 Jun;70:109576
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Zheng Y, Nie P, Xu S
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Wu G, Long Y, Lu Y, Feng Y, Yang X, Xu X, Yao D
Oncology reports 2020 Jul;44(1):69-76
Oncology reports 2020 Jul;44(1):69-76
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Meng Q, Xue H
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Chen M, Zhu LL, Su JL, Li GL, Wang J, Zhang YN
Human & experimental toxicology 2020 Feb;39(2):173-181
Human & experimental toxicology 2020 Feb;39(2):173-181
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Zhang C, Wang B, Wang X, Sheng X, Cui Y
Cancer cell international 2019;19:339
Cancer cell international 2019;19:339
Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway.
Ran Z, Zhang Y, Wen X, Ma J
Molecular medicine reports 2019 Feb;19(2):1024-1031
Molecular medicine reports 2019 Feb;19(2):1024-1031
Hypothermic oxygenated machine perfusion alleviates liver injury in donation after circulatory death through activating autophagy in mice.
Zeng X, Wang S, Li S, Yang Y, Fang Z, Huang H, Wang Y, Fan X, Ye Q
Artificial organs 2019 Dec;43(12):E320-E332
Artificial organs 2019 Dec;43(12):E320-E332
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Liu X, Tan X, Liu P, Wu Y, Qian S, Zhang X
Oncology research 2018 Aug 23;26(7):1123-1131
Oncology research 2018 Aug 23;26(7):1123-1131
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