DCABH-5115

antibody from Creative Diagnostics

Targeting: HSD17B10 17b-HSD10, ABAD, CAMR, ERAB, HADH2, MHBD, MRPP2, MRXS10, SDR5C1

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DCABH-5115

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-5115, RRID:AB_2478796

Product name

Rabbit Anti-Human HSD17B10 polyclonal antibody

Antibody type

Polyclonal

Description

Mutations in several genes associated with early onset Alzheimer's result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB) /L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer's disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer's disease.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.