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Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB7711 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-1 RI Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse IL-1 RI in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-1 RI, rhIL-1 R3, recombinant mouse (rm) IL-18 R, rmIL-1 RII, recombinant rat IL-1 R6, or rhIL-1 R8 is observed.
- Reactivity
- Mouse
- Host
- Hamster
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- JAMA147
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice.
Ojaniemi M, Liljeroos M, Harju K, Sormunen R, Vuolteenaho R, Hallman M
Immunology letters 2006 Feb 15;102(2):158-68
Immunology letters 2006 Feb 15;102(2):158-68
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by IL-1 alpha/IL-1F1 and Neutral-ization by Mouse IL-1 RI Antibody. Recombinant Mouse IL-1 alpha/IL-1F1 (Catalog # 400-ML) stimulates proliferation in the the D10.G4.1 mouse helper T cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-1 alpha/IL-1F1 (50 pg/mL) is neutralized (green line) by increasing concentrations of Mouse IL-1 RI Monoclonal Antibody (Catalog # MAB7711). The ND50 is typically 0.05-0.15 µg/mL in the presence of concanavalin A (1.25 µg/mL).
