67166-1-Ig

antibody from Proteintech Group

Targeting: ACLY ACL, ATPCL, CLATP

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

67166-1-Ig

Provider

Proteintech Group

Product name

ACLY antibody

Antibody type

Monoclonal

Description

ACLY antibody (Cat. #67166-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgM

Antibody clone number

1E10D5

Vial size

20ul, 150ul

References

Submitted references

Mitochondrial ACSS1 links acetate metabolism to pyrimidine biosynthesis in nutrient-stressed B-cell lymphomas.

Basappa J, Goldman AR, Lobello C, Wang S, Rushmore D, Melnikov O, Sen NV, Mallikarjuna VS, Jain P, Edalati M, Nelson DS, Cai KQ, Lu P, Nejati R, Borghaei H, Gupta PK, Nath K, Wellen KE, Wasik MA
Cancer letters 2026 Jul 1;649:218488

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GATA3-NLRP1 Axis Inhibits Hepatocellular Carcinoma Progression Through the Hedgehog Signaling.

Sun D, Sun X, Zhang J, Wang X, Liu L, Xie J, Song H
Cell biology international 2026 Jan;50(1):e70116

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Suppressive Genetic Interactions Between Haploinsufficient Mitochondrial Genes Encoded in the 22q11.2 Microdeletion Locus Define Brain and Cardiac Phenotypes.

Wynne M, Zlatic SA, Park AS, Crocker A, Mendez-Vazquez H, Liporace E, Gokhale A, Tower-Gilchrist C, Robinette M, Purcell RH, Bassell GJ, Werner E, Kwong JQ, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 9;

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A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.

Zhang Z, Chen M, Xu Y, Wang Z, Liu Z, He C, Zhang F, Feng X, Ni X, Chen Y, Wang J, Liang X, Xie Z, Li J, Banach M, Pelisek J, Huo Y, Hu Y, Evans PC, Wang L, Tian XY, Xiao J, Shang Y, Zheng Y, Xian X, Weng J, Xu S
Theranostics 2025;15(10):4325-4344

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Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.

Zhang X, Zhu B, Yan J, Chen X, Wu D, Wang Z, Guan X, Huang Y, Zhao Y, Yang Y, Guo Y
Regenerative biomaterials 2025;12:rbaf056

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A Novel Glucomannan from Dendrobium officinale Inhibits Obesity and Improves Insulin Sensitivity through Regulating Adipogenesis and Lipid Metabolism.

Chen J, Zhang M, Yang Y, Peng H, Zhang J, Shou Y, Tang Y, Du X, Guo C, Wang X
Journal of agricultural and food chemistry 2025 Oct 29;73(43):27751-27770

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Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism.

Zhao QY, Liu WJ, Wang JG, Li H, Lv JL, Wang Y, Wang C
Journal of cancer research and clinical oncology 2025 Mar 28;151(3):126

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ACLY inhibitor reduced Porphyromonas gingivalis-induced pyroptosis by suppressing microtubules acetylation in macrophages.

Mao H, Guo F, Wang C, Jiang K, Li H, Lei L
International immunopharmacology 2025 Mar 26;150:114249

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Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD.

Qin W, Ding Y, Zhang W, Sun L, Weng J, Zheng X, Luo S
Journal of lipid research 2025 Feb;66(2):100740

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Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism.

Wu R, Li N, Huang W, Yang Y, Zang R, Song H, Shi J, Zhu S, Liu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156367

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SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.

Li B, Zhou K, Yin A, Liu Y, Wang X, Cui Y, Liu F, Liu Q, Zheng H, Mu Z, Chen K, Wu Y, Chang Y, Bao J
Nature communications 2025 Dec 26;17(1):835

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Effects of cadherin mediated contact normalization on oncogenic Src kinase mediated gene expression and protein phosphorylation.

Nicoletto RE, Holdcraft CJ, Yin AC, Retzbach EP, Sheehan SA, Greenspan AA, Laugier CM, Trama J, Zhao C, Zheng H, Goldberg GS
Scientific reports 2024 Oct 13;14(1):23942

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Transcriptional Regulation of De Novo Lipogenesis by SIX1 in Liver Cancer Cells.

Li L, Zhang X, Xu G, Xue R, Li S, Wu S, Yang Y, Lin Y, Lin J, Liu G, Gao S, Zhang Y, Ye Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2404229

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The Different Mechanisms of Lipid Accumulation in Hepatocytes Induced by Oleic Acid/Palmitic Acid and High-Fat Diet.

Zhang M, Bai X, Du Q, Xu J, Wang D, Chen L, Dong K, Chen Z, Yang J
Molecules (Basel, Switzerland) 2023 Sep 20;28(18)

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TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.

Lin L, Li X, Wu AJ, Xiu JB, Gan YZ, Yang XM, Ai ZH
iScience 2023 Nov 17;26(11):108226

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17β-Estradiol (E(2)) Upregulates the ERα/SIRT1/PGC-1α Signaling Pathway and Protects Mitochondrial Function to Prevent Bilateral Oophorectomy (OVX)-Induced Nonalcoholic Fatty Liver Disease (NAFLD).

Tian Y, Hong X, Xie Y, Guo Z, Yu Q
Antioxidants (Basel, Switzerland) 2023 Dec 12;12(12)

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ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer.

Zhou F, Ai W, Zhang Y, Hu Q, Gan M, Wang JB, Han T
Cell death & disease 2022 Oct 14;13(10):870

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The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism.

Hu Y, Zai H, Jiang W, Ou Z, Yao Y, Zhu Q
Mediators of inflammation 2021;2021:5754592