RA0018

antibody from Oursmab

Targeting: APCS MGC88159, PTX2, SAP

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0018

Provider

Oursmab

Product name

Dezamizumab (Biosimilar Reference Antibody) (APCS)

Antibody type

Monoclonal

Description

Dezamizumab (GSK 2398852) is a fully humanized recombinant monoclonal IgG1 antibody specifically targeting the serum amyloid P component (SAP). It was developed as a potential therapy for systemic amyloidosis, a group of diseases characterized by the deposition of misfolded protein fibrils (amyloid) in organs and tissues. The antibody's mechanism was designed to bind to SAP, a universal constituent of amyloid deposits, and promote their clearance by the immune system. Despite reaching clinical trials, the development of dezamizumab for amyloidosis was ultimately discontinued due to an unfavorable benefit-risk assessment, including insufficient efficacy in clearing amyloid from critical organs like the heart.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.