ABIN362193

antibody from antibodies-online

Targeting: MAP3K5 ASK1, MAPKKK5, MEKK5

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN362193

Provider

antibodies-online

Product name

anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (pSer83) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around phosphorylation site of pSer83 (G-S-S (p) -V-G) derived from Human ASK1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human

Host

Rabbit

Epitope

pSer83

Isotype

IgG

Vial size

50 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma.

Saha MN, Jiang H, Yang Y, Zhu X, Wang X, Schimmer AD, Qiu L, Chang H
PloS one 2012;7(1):e30215

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Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines.

Mabuchi S, Ohmichi M, Kimura A, Nishio Y, Arimoto-Ishida E, Yada-Hashimoto N, Tasaka K, Murata Y
Endocrinology 2004 Jan;145(1):49-58

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AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance.

Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, Cheng JQ
The Journal of biological chemistry 2003 Jun 27;278(26):23432-40

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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.

Kim AH, Khursigara G, Sun X, Franke TF, Chao MV
Molecular and cellular biology 2001 Feb;21(3):893-901