ABIN116930

antibody from antibodies-online

Targeting: MAP3K5 ASK1, MAPKKK5, MEKK5

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN116930

Provider

antibodies-online

Product name

anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 76-87), (pSer83) antibody

Antibody type

Polyclonal

Description

Multi-step process.

Reactivity

Human

Host

Rabbit

Epitope

AA 76-87, pSer83

Vial size

0.2 mg

Storage

Store the antibody (in aliquots) at -20°C.

Handling

Dilute only prior to immediate use . Avoid cycles of freezing and thawing.

References

Submitted references

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H
The EMBO journal 2001 Nov 1;20(21):6028-36

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ASK1-signaling promotes c-Myc protein stability during apoptosis.

Noguchi K, Kokubu A, Kitanaka C, Ichijo H, Kuchino Y
Biochemical and biophysical research communications 2001 Mar;281(5):1313-20

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ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.

Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H
EMBO reports 2001 Mar;2(3):222-8

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The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1.

Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS, Kiyokawa H
Molecular and cellular biology 2001 Jul;21(14):4818-28

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Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1.

Matsuzawa A, Ichijo H
Journal of biochemistry 2001 Jul;130(1):1-8

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Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.

Sayama K, Hanakawa Y, Shirakata Y, Yamasaki K, Sawada Y, Sun L, Yamanishi K, Ichijo H, Hashimoto K
The Journal of biological chemistry 2001 Jan 12;276(2):999-1004

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Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1.

Cho SG, Lee YH, Park HS, Ryoo K, Kang KW, Park J, Eom SJ, Kim MJ, Chang TS, Choi SY, Shim J, Kim Y, Dong MS, Lee MJ, Kim SG, Ichijo H, Choi EJ
The Journal of biological chemistry 2001 Apr 20;276(16):12749-55

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HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.

Geleziunas R, Xu W, Takeda K, Ichijo H, Greene WC
Nature 2001 Apr 12;410(6830):834-8

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ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.

Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H
The Journal of biological chemistry 2000 Oct 20;275(42):32747-52

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Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

Liu H, Nishitoh H, Ichijo H, Kyriakis JM
Molecular and cellular biology 2000 Mar;20(6):2198-208

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Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells.

Takeda K, Hatai T, Hamazaki TS, Nishitoh H, Saitoh M, Ichijo H
The Journal of biological chemistry 2000 Mar 31;275(13):9805-13

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Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons.

Kanamoto T, Mota M, Takeda K, Rubin LL, Miyazono K, Ichijo H, Bazenet CE
Molecular and cellular biology 2000 Jan;20(1):196-204

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Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.

Hatai T, Matsuzawa A, Inoshita S, Mochida Y, Kuroda T, Sakamaki K, Kuida K, Yonehara S, Ichijo H, Takeda K
The Journal of biological chemistry 2000 Aug 25;275(34):26576-81

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Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies.

Yasuda S, Inoue K, Hirabayashi M, Higashiyama H, Yamamoto Y, Fuyuhiro H, Komure O, Tanaka F, Sobue G, Tsuchiya K, Hamada K, Sasaki H, Takeda K, Ichijo H, Kakizuka A
Genes to cells : devoted to molecular & cellular mechanisms 1999 Dec;4(12):743-56