Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations [0]
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- Product number
- ABIN116930 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 76-87), (pSer83) antibody
- Antibody type
- Polyclonal
- Description
- Multi-step process.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 76-87, pSer83
- Vial size
- 0.2 mg
- Storage
- Store the antibody (in aliquots) at -20°C.
- Handling
- Dilute only prior to immediate use . Avoid cycles of freezing and thawing.
Submitted references Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.
ASK1-signaling promotes c-Myc protein stability during apoptosis.
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.
The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1.
Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1.
Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.
Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1.
HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.
ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.
Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells.
Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons.
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.
Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies.
Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H
The EMBO journal 2001 Nov 1;20(21):6028-36
The EMBO journal 2001 Nov 1;20(21):6028-36
ASK1-signaling promotes c-Myc protein stability during apoptosis.
Noguchi K, Kokubu A, Kitanaka C, Ichijo H, Kuchino Y
Biochemical and biophysical research communications 2001 Mar;281(5):1313-20
Biochemical and biophysical research communications 2001 Mar;281(5):1313-20
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.
Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H
EMBO reports 2001 Mar;2(3):222-8
EMBO reports 2001 Mar;2(3):222-8
The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1.
Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS, Kiyokawa H
Molecular and cellular biology 2001 Jul;21(14):4818-28
Molecular and cellular biology 2001 Jul;21(14):4818-28
Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1.
Matsuzawa A, Ichijo H
Journal of biochemistry 2001 Jul;130(1):1-8
Journal of biochemistry 2001 Jul;130(1):1-8
Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.
Sayama K, Hanakawa Y, Shirakata Y, Yamasaki K, Sawada Y, Sun L, Yamanishi K, Ichijo H, Hashimoto K
The Journal of biological chemistry 2001 Jan 12;276(2):999-1004
The Journal of biological chemistry 2001 Jan 12;276(2):999-1004
Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1.
Cho SG, Lee YH, Park HS, Ryoo K, Kang KW, Park J, Eom SJ, Kim MJ, Chang TS, Choi SY, Shim J, Kim Y, Dong MS, Lee MJ, Kim SG, Ichijo H, Choi EJ
The Journal of biological chemistry 2001 Apr 20;276(16):12749-55
The Journal of biological chemistry 2001 Apr 20;276(16):12749-55
HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.
Geleziunas R, Xu W, Takeda K, Ichijo H, Greene WC
Nature 2001 Apr 12;410(6830):834-8
Nature 2001 Apr 12;410(6830):834-8
ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.
Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H
The Journal of biological chemistry 2000 Oct 20;275(42):32747-52
The Journal of biological chemistry 2000 Oct 20;275(42):32747-52
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.
Liu H, Nishitoh H, Ichijo H, Kyriakis JM
Molecular and cellular biology 2000 Mar;20(6):2198-208
Molecular and cellular biology 2000 Mar;20(6):2198-208
Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells.
Takeda K, Hatai T, Hamazaki TS, Nishitoh H, Saitoh M, Ichijo H
The Journal of biological chemistry 2000 Mar 31;275(13):9805-13
The Journal of biological chemistry 2000 Mar 31;275(13):9805-13
Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons.
Kanamoto T, Mota M, Takeda K, Rubin LL, Miyazono K, Ichijo H, Bazenet CE
Molecular and cellular biology 2000 Jan;20(1):196-204
Molecular and cellular biology 2000 Jan;20(1):196-204
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.
Hatai T, Matsuzawa A, Inoshita S, Mochida Y, Kuroda T, Sakamaki K, Kuida K, Yonehara S, Ichijo H, Takeda K
The Journal of biological chemistry 2000 Aug 25;275(34):26576-81
The Journal of biological chemistry 2000 Aug 25;275(34):26576-81
Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies.
Yasuda S, Inoue K, Hirabayashi M, Higashiyama H, Yamamoto Y, Fuyuhiro H, Komure O, Tanaka F, Sobue G, Tsuchiya K, Hamada K, Sasaki H, Takeda K, Ichijo H, Kakizuka A
Genes to cells : devoted to molecular & cellular mechanisms 1999 Dec;4(12):743-56
Genes to cells : devoted to molecular & cellular mechanisms 1999 Dec;4(12):743-56
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