orb1825144

antibody from Biorbyt

Targeting: KRT14 EBS3, EBS4

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb1825144

Provider

Biorbyt

Product name

Cytokeratin 14 Antibody / CK14 / KRT14

Antibody type

Recombinant

Description

Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia.Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas.Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

rKRT14/7290

Vial size

100 ug

Storage

Aliquot the CK14 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.