orb386027

antibody from Biorbyt

Targeting: KRT15 CK15, K15, K1CO

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb386027

Provider

Biorbyt

Product name

KRT15 Antibody / Cytokeratin 15

Antibody type

Monoclonal

Description

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Reactivity

Human, Rat

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

LHK15

Vial size

20 ug

Storage

Store the Keratin 15 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).