15100-1-AP

antibody from Proteintech Group

Targeting: TGM2 TGC

Provider product page for 15100-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [44]
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Validations
Western blot [1]

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Product number: 15100-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15100-1-AP, RRID:AB_2202885
Product name: TGM2 antibody
Antibody type: Polyclonal
Description: KD/KO validated TGM2 antibody (Cat. #15100-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TGM2 protein structure - 15100-1-AP shown in red.

Submitted references TGM2-mediated serotonylation in tumor endothelial cells promotes angiogenesis and tumor growth in colorectal cancer.

Ling T, Zhang W, Cai H, Kien TT, Yan T, Wang J, Chen J
Cancer letters 2026 May 1;645:218396

TMEM176A drives anti-apoptotic signaling through TGM2-mediated ERK activation in gastric cancer.

Zhang Y, Wang Q, He D, Wei Y, Liu Y, Tang F, Li Y
International immunopharmacology 2026 Jan 1;168(Pt 1):115798

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6-GAS6 Axis.

Liu X, Du Z, Wang L, Xie Z, Meng Z, Zheng Y, Wang H, He Y, Xue D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(24):e20739

UHRF1-mediated DNA 5-mC modification drives super-enhancer redistribution and impedes osteogenesis via TGM2-regulated autophagic flux in senile osteoporosis.

Pang P, Chen J, Li Q, Su Z, Lin J, Zeng Y, Zhang W, Xiao Z, Chen Z, Liu Z, Lin Y, Zheng G, Yu W, Xie Z
Journal of advanced research 2026 Apr 17;

Gastrodin reduces myocardial ischemia/reperfusion injury via transgelin2/CNPase-mediated apoptosis regulation.

Li C, Rao P, Liu X, Yang L, Jiang Y, Yin G, Li S, Yang P, Sun L
Frontiers in pharmacology 2025;16:1604408

A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer.

Yu Y, Gao X, Zhao H, Sun J, Wang M, Xiong X, Li J, Huang C, Zhang H, Jiang G, Xiao X
Cancer research 2025 Jun 16;85(12):2288-2301

Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis.

Chen J, Li M, Mao J, Wang X, Guo B, Chen X, Kalvakolanu DV, Hong J, Yang M, Liu J, Luo Q, Yang J, Sun X, Tian Y, Zhang L
Biochemical pharmacology 2025 Jul;237:116926

NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression.

Xu W, Liu J, Liu Q, Xu J, Zhou L, Liang Z, Huang H, Huang B, Xiao GG, Guo J
Cell reports 2025 Feb 25;44(2):115226

Transglutaminase-2 Promotes Microglial Synaptic Phagocytosis and Ameliorates Epileptic Seizures by Inhibiting ABCA1 Ubiquitination.

Zhou Z, Wang X, Yang J, Qin J, Feng B, Qin Q, Tian J, Luo Z, Yang X, Huang H, Xu X, Li J, Xu Z, Yu C, Zhang H
CNS neuroscience & therapeutics 2025 Dec;31(12):e70725

TGM2-P2RX7 loop promotes gemcitabine resistance in pancreatic cancer by modulating glutamine metabolism and mitophagy.

Ye K, Zhou S, Gong X, Zhu Z, Xiao M, Liang S
Cell death discovery 2025 Dec 30;12(1):2

Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice.

Matsuoka M, Uchibe K, Tang N, Tian H, Suzuki A, Oichi T, Usami Y, Alferiev I, Otsuru S, Abzug JM, Herzenberg JE, Pacifici M, Enomoto-Iwamoto M, Chorny M, Iwamoto M
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2025 Apr 21;40(4):535-547

The upregulation of TGM2 is associated with poor prognosis and the shaping of the inflammatory tumor microenvironment in lung squamous cell carcinoma.

Chang W, Gao W, Liu D, Luo B, Li H, Zhong L, Chen Y
American journal of cancer research 2024;14(6):2823-2838

A guide to selecting high-performing antibodies for Protein-glutamine gamma-glutamyltransferase 2 (TGM2) for use in western blot, immunoprecipitation and immunofluorescence.

Ayoubi R, Fotouhi M, Alende C, González Bolívar S, Southern K, Laflamme C, Neuro/SGC/EDDU collaborative group, ABIF consortium
F1000Research 2024;13:481

TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.

Zhang M, Li L, Zhang W, Li M, Yan G, Tang C
Cellular signalling 2024 Sep;121:111296

Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer.

Ling T, Dai Z, Wang H, Kien TT, Cui R, Yu T, Chen J
Cancer letters 2024 Sep 28;600:217150

Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis.

Ninomiya Y, Matsuda S, Suzuki S, Hirata-Tsuchiya S, Ueda T, Nakashima F, Yasuda K, Shimada S, Memida T, Yoshimoto T, Yamada S, Ouhara K, Mizuno N
BMC oral health 2024 Nov 21;24(1):1422

Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice.

Matsuoka M, Uchibe K, Tang N, Tian H, Suzuki A, Oichi T, Usami Y, Alferiev I, Otsuru S, Abzug JM, Herzenberg JE, Pacifici M, Enomoto-Iwamoto M, Chorny M, Iwamoto M
bioRxiv : the preprint server for biology 2024 Nov 11;

New genes helped acorn barnacles adapt to a sessile lifestyle.

Han Z, Wang Z, Rittschof D, Huang Z, Chen L, Hao H, Yao S, Su P, Huang M, Zhang YY, Ke C, Feng D
Nature genetics 2024 May;56(5):970-981

Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.

Lei Y, Xu J, Xiao M, Wu D, Xu H, Yang J, Mao X, Pan H, Yu X, Shi S
British journal of cancer 2024 May;130(9):1505-1516

GK921, a transglutaminase inhibitor, strengthens the antitumor effect of cisplatin on pancreatic cancer cells by inhibiting epithelial-to-mesenchymal transition.

Li M, Wang X, Chen X, Hong J, Du Y, Song D
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166925

mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.

Ali Y, Gomez-Sanchez CE, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez EP
Endocrinology 2024 Feb 20;165(4)

RSL3 sensitizes glioma cells to ionizing radiation by suppressing TGM2-dependent DNA damage repair and epithelial-mesenchymal transition.

Wang X, Shi W, Li M, Xin Y, Jiang X
Redox biology 2024 Dec;78:103438

A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells.

González-Moro I, Rojas-Márquez H, Sebastian-delaCruz M, Mentxaka-Salgado J, Olazagoitia-Garmendia A, Mendoza LM, Lluch A, Fantuzzi F, Lambert C, Ares Blanco J, Marselli L, Marchetti P, Cnop M, Delgado E, Fernández-Real JM, Ortega FJ, Castellanos-Rubio A, Santin I
Frontiers in endocrinology 2023;14:1101934

Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer.

Zhang S, Yao HF, Li H, Su T, Jiang SH, Wang H, Zhang ZG, Dong FY, Yang Q, Yang XM
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1473-1492

Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells.

Li X, Ma Y, Wu J, Ni M, Chen A, Zhou Y, Dai W, Chen Z, Jiang R, Ling Y, Yao Q, Chen W
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2023 Mar;67:100930

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857

Damaged collagen detected by collagen hybridizing peptide as efficient diagnosis marker for early hepatic fibrosis.

Tao P, Liu J, Li Y, Zhang T, Wang F, Chang L, Li C, Ge X, Zuo T, Lu S, Ruan Y, Yang Z, Xu P
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194928

Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.

Li Y, Sun H, Liu X, Hu Z, Jiang H, Guo H, Long X
International immunopharmacology 2023 Jan;114:109486

Peroxiredoxins and Hypoxia-Inducible Factor-1α in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients.

Köse FA, Pabuccuoglu A, Karakoyun M, Aydogdu S
Current issues in molecular biology 2023 Feb 20;45(2):1779-1793

Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease.

Gruper Y, Wolff ASB, Glanz L, Spoutil F, Marthinussen MC, Osickova A, Herzig Y, Goldfarb Y, Aranaz-Novaliches G, Dobeš J, Kadouri N, Ben-Nun O, Binyamin A, Lavi B, Givony T, Khalaila R, Gome T, Wald T, Mrazkova B, Sochen C, Besnard M, Ben-Dor S, Feldmesser E, Orlova EM, Hegedűs C, Lampé I, Papp T, Felszeghy S, Sedlacek R, Davidovich E, Tal N, Shouval DS, Shamir R, Guillonneau C, Szondy Z, Lundin KEA, Osicka R, Prochazka J, Husebye ES, Abramson J
Nature 2023 Dec;624(7992):653-662

4,4'-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in macrophages.

Lin CC, Law BF, Hettick JM
Xenobiotica; the fate of foreign compounds in biological systems 2023 Dec;53(12):653-669

An immunogenic cell death-related signature predicts prognosis and immunotherapy response in stomach adenocarcinoma.

Liu Z, Sun L, Peng X, Liu S, Zhu Z, Huang C
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1564-1583

Elevated tissue transglutaminase levels in aqueous humor of congenital cataractous eyes with long axial length.

Yang T, Zhou X, Li H, Fan F, Yang J, Lin X, Liu X, Luo Y
Heliyon 2023 Aug;9(8):e18709

Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer.

Hu X, Ma Z, Xu B, Li S, Yao Z, Liang B, Wang J, Liao W, Lin L, Wang C, Zheng S, Wu Q, Huang Q, Yu L, Wang F, Shi M
Cancer communications (London, England) 2023 Aug;43(8):909-937

TGM2 positively regulates myoblast differentiation via enhancing the mTOR signaling.

Wang D, Zhao D, Li Y, Dai T, Liu F, Yan C
Biochimica et biophysica acta. Molecular cell research 2022 Mar;1869(3):119173

6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.

Sokouti H, Mohajeri D, Nourazar MA
Physiological research 2022 Aug 31;71(4):551-560

Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF-κB Signaling.

Hou Y, Xiao X, Yu W, Qi S
Journal of immunology research 2021;2021:4754454

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.

Ye D, Xu H, Xia H, Zhang C, Tang Q, Bi F
Journal of experimental & clinical cancer research : CR 2021 May 18;40(1):173

Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.

Mitachi K, Ariake K, Shima H, Sato S, Miura T, Maeda S, Ishida M, Mizuma M, Ohtsuka H, Kamei T, Igarashi K, Unno M
Scientific reports 2021 Mar 22;11(1):6541

TGFβ-1 Induced Cross-Linking of the Extracellular Matrix of Primary Human Dermal Fibroblasts.

Semkova ME, Hsuan JJ
International journal of molecular sciences 2021 Jan 20;22(3)

Immune subtyping for pancreatic cancer with implication in clinical outcomes and improving immunotherapy.

Liu J, Liu Q, Zhang X, Cui M, Li T, Zhang Y, Liao Q
Cancer cell international 2021 Feb 26;21(1):137

AFF1 inhibits adipogenic differentiation via targeting TGM2 transcription.

Chen Y, Wang Y, Lin W, Sheng R, Wu Y, Xu R, Zhou C, Yuan Q
Cell proliferation 2020 Jun;53(6):e12831

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R, Zhang N
Nature communications 2020 Jun 22;11(1):3162

Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.

Wang J, Xu H, Cheng X, Yang J, Yan Z, Ma H, Zhao Y, Ommati MM, Manthari RK, Wang J
Food & function 2020 Jan 29;11(1):1155-1164

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TGM2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TGM2. This antibody recognizes human, mouse, rat antigen. The TGM2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 15100-1-AP.pdf

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