Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Immunohistochemistry [4]
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- Product number
- NBP2-47926-0.1mg - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Transglutaminase 2/TGM2 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
- Reactivity
- Human, Mouse, Rat, Rabbit, Simian
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Transglutaminase 2/TGM2 Antibody (SPM358) - Azide and BSA Free [NBP2-47926] - Human Uterus stained with Transglutaminase II Monoclonal Antibody (TGM2/419)
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Transglutaminase 2/TGM2 Antibody (SPM358) - Azide and BSA Free [NBP2-47926] - Human Placenta stained with Transglutaminase II Monoclonal Antibody (TGM2/419)
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Transglutaminase 2/TGM2 Antibody (SPM358) - Azide and BSA Free [NBP2-47926] - Human Tonsil stained with Transglutaminase II Monoclonal Antibody (TGM2/419)
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Transglutaminase 2/TGM2 Antibody (SPM358) - Azide and BSA Free [NBP2-47926] - Human Leiomyosarcoma stained with Transglutaminase II Monoclonal Antibody (TGM2/419)