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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [125]
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- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Other assay [5]
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- Product number
- MA5-12739 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- TGM2 Monoclonal Antibody (CUB 7402)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MA5-12739 targets Transglutaminase II in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Guinea Pig, Human, and Rabbit samples.
- Antibody clone number
- CUB 7402
- Concentration
- 0.2 mg/mL
Submitted references An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers.
Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells.
Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma.
3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations.
Integrated Molecular Characterization of Uterine Carcinosarcoma.
Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease.
Protein cross-linking by chlorinated polyamines and transglutamylation stabilizes neutrophil extracellular traps.
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Transglutaminase 2--a novel inhibitor of adipogenesis.
Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1.
Intestinal-mucosa anti-transglutaminase antibody assays to test for genetic gluten intolerance.
Transglutaminase 2 and phospholipase A₂ interactions in the inflammatory response in human Thp-1 monocytes.
The kiwi fruit peptide kissper displays anti-inflammatory and anti-oxidant effects in in-vitro and ex-vivo human intestinal models.
TGM2: a cell surface marker in esophageal adenocarcinomas.
Increased expression of transglutaminase 2 drives glycolytic metabolism in renal carcinoma cells.
Lack of transglutaminase 2 diminished T-cell responses in mice.
Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2.
Sampling of proximal and distal duodenal biopsies in the diagnosis and monitoring of celiac disease.
Transglutaminase 2 is essential for adherence of Porphyromonas gingivalis to host cells.
Exercise, vascular stiffness, and tissue transglutaminase.
The role of TG2 in regulating S100A4-mediated mammary tumour cell migration.
Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA.
Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma.
A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis.
Gliadin does not induce mucosal inflammation or basophil activation in patients with nonceliac gluten sensitivity.
Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity.
Transglutaminase-2 induces N-cadherin expression in TGF-β1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation.
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.
Anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase by modulating cytosolic Ca2+ homeostasis.
Divergent results induced by different types of septic shock in transglutaminase 2 knockout mice.
Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.
Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1.
Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease.
Immunological effects of transglutaminase-treated gluten in coeliac disease.
Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells.
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Type 1 diabetes is associated with enterovirus infection in gut mucosa.
Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis.
Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities.
Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.
Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins.
Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis.
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.
Expression of tissue transglutaminase on primary olfactory ensheathing cells cultures exposed to stress conditions.
Persistently positive gliadin antibodies without transglutaminase antibodies in the elderly: gluten intolerance beyond coeliac disease.
Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination.
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.
Early developing celiac disease in children with cerebral palsy.
Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.
Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.
Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease.
Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa.
Anti transglutaminase antibodies cause ataxia in mice.
Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cells.
Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5.
I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway.
Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells.
Tissue transglutaminase expression in celiac mucosa: an immunohistochemical study.
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide.
The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis.
Fibroblastic reticular cell infection by hemorrhagic fever viruses.
Quantitative and rapid analysis of transglutaminase activity using protein arrays in mammalian cells.
Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments.
Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition.
Maternal celiac disease autoantibodies bind directly to syncytiotrophoblast and inhibit placental tissue transglutaminase activity.
Positive auto-regulation of MYCN in human neuroblastoma.
Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.
SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation.
Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase.
Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.
The monoclonal antibody 6B9 recognizes CD44 and not cell surface transglutaminase 2.
Increased tissue transglutaminase expression in human atherosclerotic coronary arteries.
Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling.
Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation.
Effect of acetylcholine precursors on proliferation and differentiation of astroglial cells in primary cultures.
Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1.
Mutagenesis of the catalytic triad of tissue transglutaminase abrogates coeliac disease serum IgA autoantibody binding.
Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease.
Tissue array-based expression of transglutaminase-2 in human breast and ovarian cancer.
In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes.
Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions.
Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivation.
SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix.
Transglutaminase activity regulates osteoblast differentiation and matrix mineralization in MC3T3-E1 osteoblast cultures.
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation.
Mammalian transglutaminases: a family portrait.
Distinct pH modulation for dual function of Galphah (transglutaminase II).
Characterizing monoclonal antibody epitopes by filtered gene fragment phage display.
Characterization of purified rat testicular transglutaminase and age-dependent changes of the enzyme activities.
Nuclear factor-kappab activation is associated with glutamate-evoked tissue transglutaminase up-regulation in primary astrocyte cultures.
Expression of apoptosis-related proteins in rat with induced colitis.
Excitotoxin-induced changes in transglutaminase during differentiation of cerebellar granule cells.
Protective role of tissue transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells.
Protective role of tissue transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells.
Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia.
Tissue transglutaminase is a multifunctional BH3-only protein.
Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia.
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.
Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes.
Glutamate-induced increases in transglutaminase activity in primary cultures of astroglial cells.
Glutamate-induced increases in transglutaminase activity in primary cultures of astroglial cells.
In patients with dermatitis herpetiformis distribution of transglutaminase in cutaneous tissue does not differ from controls.
In patients with dermatitis herpetiformis distribution of transglutaminase in cutaneous tissue does not differ from controls.
Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa.
NMDA-evoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells.
NMDA-evoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells.
Bone-specific antibodies in sera from patients with celiac disease: characterization and implications in osteoporosis.
Bone-specific antibodies in sera from patients with celiac disease: characterization and implications in osteoporosis.
Analysis of tissue transglutaminase function in the migration of Swiss 3T3 fibroblasts: the active-state conformation of the enzyme does not affect cell motility but is important for its secretion.
Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress.
Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress.
Up-regulation of tissue-type transglutaminase after traumatic brain injury.
Up-regulation of tissue-type transglutaminase after traumatic brain injury.
Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1.
Tissue transglutaminase facilitates the polymerization of insulin-like growth factor-binding protein-1 (IGFBP-1) and leads to loss of IGFBP-1's ability to inhibit insulin-like growth factor-I-stimulated protein synthesis.
Gene disruption of tissue transglutaminase.
Implication of tissue transglutaminase and desmoplakin in cell adhesion mechanism in human epidermis.
Implication of tissue transglutaminase and desmoplakin in cell adhesion mechanism in human epidermis.
Alpha 1B-adrenoceptor interacts with multiple sites of transglutaminase II: characteristics of the interaction in binding and activation.
Nüchel J, Tauber M, Nolte JL, Mörgelin M, Türk C, Eckes B, Demetriades C, Plomann M
Molecular cell 2021 Aug 19;81(16):3275-3293.e12
Molecular cell 2021 Aug 19;81(16):3275-3293.e12
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers.
Cho SY, Oh Y, Jeong EM, Park S, Lee D, Wang X, Zeng Q, Qin H, Hu F, Gong H, Liu X, Zhang G, Na D, Lee J, Chae J, Suh YS, Kong SH, Lee HJ, Kim JI, Park H, Zhang C, Yang HK, Lee C
Experimental & molecular medicine 2020 May;52(5):854-864
Experimental & molecular medicine 2020 May;52(5):854-864
Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells.
Trus I, Berube N, Jiang P, Rak J, Gerdts V, Karniychuk U
Viruses 2020 May 25;12(5)
Viruses 2020 May 25;12(5)
Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma.
Lee SH, Kang JH, Ha JS, Lee JS, Oh SJ, Choi HJ, Song J, Kim SY
International journal of molecular sciences 2020 Jul 17;21(14)
International journal of molecular sciences 2020 Jul 17;21(14)
3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations.
Court M, Malier M, Millet A
Biomaterials 2019 Jul;208:98-109
Biomaterials 2019 Jul;208:98-109
Integrated Molecular Characterization of Uterine Carcinosarcoma.
Cherniack AD, Shen H, Walter V, Stewart C, Murray BA, Bowlby R, Hu X, Ling S, Soslow RA, Broaddus RR, Zuna RE, Robertson G, Laird PW, Kucherlapati R, Mills GB, Cancer Genome Atlas Research Network, Weinstein JN, Zhang J, Akbani R, Levine DA
Cancer cell 2017 Mar 13;31(3):411-423
Cancer cell 2017 Mar 13;31(3):411-423
Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Hill SM, Nesser NK, Johnson-Camacho K, Jeffress M, Johnson A, Boniface C, Spencer SE, Lu Y, Heiser LM, Lawrence Y, Pande NT, Korkola JE, Gray JW, Mills GB, Mukherjee S, Spellman PT
Cell systems 2017 Jan 25;4(1):73-83.e10
Cell systems 2017 Jan 25;4(1):73-83.e10
Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease.
Di Niro R, Snir O, Kaukinen K, Yaari G, Lundin KE, Gupta NT, Kleinstein SH, Cols M, Cerutti A, Mäki M, Shlomchik MJ, Sollid LM
Mucosal immunology 2016 Jan;9(1):254-64
Mucosal immunology 2016 Jan;9(1):254-64
Protein cross-linking by chlorinated polyamines and transglutamylation stabilizes neutrophil extracellular traps.
Csomós K, Kristóf E, Jakob B, Csomós I, Kovács G, Rotem O, Hodrea J, Bagoly Z, Muszbek L, Balajthy Z, Csősz É, Fésüs L
Cell death & disease 2016 Aug 11;7(8):e2332
Cell death & disease 2016 Aug 11;7(8):e2332
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Altuntas S, Rossin F, Marsella C, D'Eletto M, Diaz-Hidalgo L, Farrace MG, Campanella M, Antonioli M, Fimia GM, Piacentini M
Oncotarget 2015 Dec 29;6(42):44941-54
Oncotarget 2015 Dec 29;6(42):44941-54
Transglutaminase 2--a novel inhibitor of adipogenesis.
Myneni VD, Melino G, Kaartinen MT
Cell death & disease 2015 Aug 27;6(8):e1868
Cell death & disease 2015 Aug 27;6(8):e1868
Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1.
Lee DY, Chang GD
Redox biology 2014;2:196-205
Redox biology 2014;2:196-205
Intestinal-mucosa anti-transglutaminase antibody assays to test for genetic gluten intolerance.
Quaglia S, De Leo L, Ziberna F, Vatta S, Villanacci V, Granzotto M, Petix V, Martelossi S, Di Leo G, Torelli L, Not T
Cellular & molecular immunology 2014 Nov;11(6):617-20
Cellular & molecular immunology 2014 Nov;11(6):617-20
Transglutaminase 2 and phospholipase A₂ interactions in the inflammatory response in human Thp-1 monocytes.
Currò M, Ferlazzo N, Risitano R, Condello S, Vecchio M, Caccamo D, Ientile R
Amino acids 2014 Mar;46(3):759-66
Amino acids 2014 Mar;46(3):759-66
The kiwi fruit peptide kissper displays anti-inflammatory and anti-oxidant effects in in-vitro and ex-vivo human intestinal models.
Ciacci C, Russo I, Bucci C, Iovino P, Pellegrini L, Giangrieco I, Tamburrini M, Ciardiello MA
Clinical and experimental immunology 2014 Mar;175(3):476-84
Clinical and experimental immunology 2014 Mar;175(3):476-84
TGM2: a cell surface marker in esophageal adenocarcinomas.
Leicht DT, Kausar T, Wang Z, Ferrer-Torres D, Wang TD, Thomas DG, Lin J, Chang AC, Lin L, Beer DG
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2014 Jun;9(6):872-81
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2014 Jun;9(6):872-81
Increased expression of transglutaminase 2 drives glycolytic metabolism in renal carcinoma cells.
Ku BM, Lee CH, Lee SH, Kim SY
Amino acids 2014 Jun;46(6):1527-36
Amino acids 2014 Jun;46(6):1527-36
Lack of transglutaminase 2 diminished T-cell responses in mice.
Kim JH, Hong JM, Jeong EM, Lee WJ, Kim HR, Kang JS, Kim IG, Hwang YI
Immunology 2014 Jul;142(3):506-16
Immunology 2014 Jul;142(3):506-16
Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2.
Nadalutti CA, Korponay-Szabo IR, Kaukinen K, Griffin M, Mäki M, Lindfors K
Cellular and molecular life sciences : CMLS 2014 Apr;71(7):1315-26
Cellular and molecular life sciences : CMLS 2014 Apr;71(7):1315-26
Sampling of proximal and distal duodenal biopsies in the diagnosis and monitoring of celiac disease.
Caruso R, Marafini I, Del Vecchio Blanco G, Fina D, Paoluzi OA, Colantoni A, Sedda S, Pallone F, Monteleone G
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2014 Apr;46(4):323-9
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2014 Apr;46(4):323-9
Transglutaminase 2 is essential for adherence of Porphyromonas gingivalis to host cells.
Boisvert H, Lorand L, Duncan MJ
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 8;111(14):5355-60
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 8;111(14):5355-60
Exercise, vascular stiffness, and tissue transglutaminase.
Steppan J, Sikka G, Jandu S, Barodka V, Halushka MK, Flavahan NA, Belkin AM, Nyhan D, Butlin M, Avolio A, Berkowitz DE, Santhanam L
Journal of the American Heart Association 2014 Apr 10;3(2):e000599
Journal of the American Heart Association 2014 Apr 10;3(2):e000599
The role of TG2 in regulating S100A4-mediated mammary tumour cell migration.
Wang Z, Griffin M
PloS one 2013;8(3):e57017
PloS one 2013;8(3):e57017
Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA.
Antonella Nadalutti C, Korponay-Szabo IR, Kaukinen K, Wang Z, Griffin M, Mäki M, Lindfors K
PloS one 2013;8(10):e77277
PloS one 2013;8(10):e77277
Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma.
Ku BM, Kim DS, Kim KH, Yoo BC, Kim SH, Gong YD, Kim SY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Sep;27(9):3487-95
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Sep;27(9):3487-95
A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis.
Wang Z, Perez M, Caja S, Melino G, Johnson TS, Lindfors K, Griffin M
Cell death & disease 2013 Sep 19;4:e808
Cell death & disease 2013 Sep 19;4:e808
Gliadin does not induce mucosal inflammation or basophil activation in patients with nonceliac gluten sensitivity.
Bucci C, Zingone F, Russo I, Morra I, Tortora R, Pogna N, Scalia G, Iovino P, Ciacci C
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013 Oct;11(10):1294-1299.e1
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013 Oct;11(10):1294-1299.e1
Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity.
Kanchan K, Ergülen E, Király R, Simon-Vecsei Z, Fuxreiter M, Fésüs L
The Biochemical journal 2013 Nov 1;455(3):261-72
The Biochemical journal 2013 Nov 1;455(3):261-72
Transglutaminase-2 induces N-cadherin expression in TGF-β1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation.
Park MK, You HJ, Lee HJ, Kang JH, Oh SH, Kim SY, Lee CH
European journal of cancer (Oxford, England : 1990) 2013 May;49(7):1692-705
European journal of cancer (Oxford, England : 1990) 2013 May;49(7):1692-705
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.
Iversen R, Di Niro R, Stamnaes J, Lundin KE, Wilson PC, Sollid LM
Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 15;190(12):5981-91
Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 15;190(12):5981-91
Anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase by modulating cytosolic Ca2+ homeostasis.
Caputo I, Lepretti M, Secondo A, Martucciello S, Paolella G, Sblattero D, Barone MV, Esposito C
Amino acids 2013 Jan;44(1):251-60
Amino acids 2013 Jan;44(1):251-60
Divergent results induced by different types of septic shock in transglutaminase 2 knockout mice.
Yoo H, Ahn ER, Kim SJ, Lee SH, Oh SH, Kim SY
Amino acids 2013 Jan;44(1):189-97
Amino acids 2013 Jan;44(1):189-97
Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.
Russo L, Marsella C, Nardo G, Massignan T, Alessio M, Piermarini E, La Rosa S, Finzi G, Bonetto V, Bertuzzi F, Maechler P, Massa O
Acta diabetologica 2013 Feb;50(1):61-72
Acta diabetologica 2013 Feb;50(1):61-72
Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1.
D'Argenio G, Mazzone G, Ribecco MT, Lembo V, Vitaglione P, Guarino M, Morisco F, Napolitano M, Fogliano V, Caporaso N
Clinical nutrition (Edinburgh, Scotland) 2013 Apr;32(2):252-8
Clinical nutrition (Edinburgh, Scotland) 2013 Apr;32(2):252-8
Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease.
Byrne G, Freeley M, Feighery C, Whelan A, Long A
Clinical immunology (Orlando, Fla.) 2013 Apr;147(1):1-8
Clinical immunology (Orlando, Fla.) 2013 Apr;147(1):1-8
Immunological effects of transglutaminase-treated gluten in coeliac disease.
Elli L, Roncoroni L, Hils M, Pasternack R, Barisani D, Terrani C, Vaira V, Ferrero S, Bardella MT
Human immunology 2012 Oct;73(10):992-7
Human immunology 2012 Oct;73(10):992-7
Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells.
Zemskov EA, Mikhailenko I, Smith EP, Belkin AM
Journal of cellular physiology 2012 May;227(5):2089-96
Journal of cellular physiology 2012 May;227(5):2089-96
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Ai L, Skehan RR, Saydi J, Lin T, Brown KD
The Journal of biological chemistry 2012 May 25;287(22):18330-41
The Journal of biological chemistry 2012 May 25;287(22):18330-41
Type 1 diabetes is associated with enterovirus infection in gut mucosa.
Oikarinen M, Tauriainen S, Oikarinen S, Honkanen T, Collin P, Rantala I, Mäki M, Kaukinen K, Hyöty H
Diabetes 2012 Mar;61(3):687-91
Diabetes 2012 Mar;61(3):687-91
Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis.
Kojima S, Kuo TF, Tatsukawa H
Journal of gastroenterology and hepatology 2012 Mar;27 Suppl 2:52-7
Journal of gastroenterology and hepatology 2012 Mar;27 Suppl 2:52-7
Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities.
Jung HJ, Chen Z, Wang M, Fayad L, Romaguera J, Kwak LW, McCarty N
Blood 2012 Mar 15;119(11):2568-78
Blood 2012 Mar 15;119(11):2568-78
Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.
D'Argenio G, Mazzone G, Tuccillo C, Ribecco MT, Graziani G, Gravina AG, Caserta S, Guido S, Fogliano V, Caporaso N, Romano M
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012 Jul;44(7):555-62
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012 Jul;44(7):555-62
Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins.
D'Eletto M, Farrace MG, Rossin F, Strappazzon F, Giacomo GD, Cecconi F, Melino G, Sepe S, Moreno S, Fimia GM, Falasca L, Nardacci R, Piacentini M
Cell death and differentiation 2012 Jul;19(7):1228-38
Cell death and differentiation 2012 Jul;19(7):1228-38
Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis.
Lauzier A, Charbonneau M, Paquette M, Harper K, Dubois CM
Arthritis research & therapy 2012 Jul 4;14(4):R159
Arthritis research & therapy 2012 Jul 4;14(4):R159
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
Wilhelmus MM, de Jager M, Rozemuller AJ, Brevé J, Bol JG, Eckert RL, Drukarch B
The Journal of pathology 2012 Jan;226(1):132-42
The Journal of pathology 2012 Jan;226(1):132-42
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.
Kumar A, Xu J, Sung B, Kumar S, Yu D, Aggarwal BB, Mehta K
Breast cancer research : BCR 2012 Jan 6;14(1):R4
Breast cancer research : BCR 2012 Jan 6;14(1):R4
Expression of tissue transglutaminase on primary olfactory ensheathing cells cultures exposed to stress conditions.
Campisi A, Spatuzza M, Russo A, Raciti G, Vanella A, Stanzani S, Pellitteri R
Neuroscience research 2012 Apr;72(4):289-95
Neuroscience research 2012 Apr;72(4):289-95
Persistently positive gliadin antibodies without transglutaminase antibodies in the elderly: gluten intolerance beyond coeliac disease.
Ruuskanen A, Luostarinen L, Collin P, Krekelä I, Patrikainen H, Tillonen J, Laurila K, Haimila K, Partanen J, Mäki M, Valve R, Kaukinen K
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2011 Oct;43(10):772-8
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2011 Oct;43(10):772-8
Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination.
Van Strien ME, Baron W, Bakker EN, Bauer J, Bol JG, Brevé JJ, Binnekade R, Van Der Laarse WJ, Drukarch B, Van Dam AM
Glia 2011 Nov;59(11):1622-34
Glia 2011 Nov;59(11):1622-34
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
Wilhelmus MM, Verhaar R, Andringa G, Bol JG, Cras P, Shan L, Hoozemans JJ, Drukarch B
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):130-9
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):130-9
Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.
Tatsukawa H, Sano T, Fukaya Y, Ishibashi N, Watanabe M, Okuno M, Moriwaki H, Kojima S
Molecular cancer 2011 Jan 9;10:4
Molecular cancer 2011 Jan 9;10:4
Early developing celiac disease in children with cerebral palsy.
Stenberg R, Kaukinen K, Bengtsson M, Lindberg E, Dahle C
Journal of pediatric gastroenterology and nutrition 2011 Dec;53(6):674-8
Journal of pediatric gastroenterology and nutrition 2011 Dec;53(6):674-8
Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.
Zemskov EA, Mikhailenko I, Hsia RC, Zaritskaya L, Belkin AM
PloS one 2011 Apr 27;6(4):e19414
PloS one 2011 Apr 27;6(4):e19414
Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.
Chiang NY, Hsiao CC, Huang YS, Chen HY, Hsieh IJ, Chang GW, Lin HH
The Journal of biological chemistry 2011 Apr 22;286(16):14215-25
The Journal of biological chemistry 2011 Apr 22;286(16):14215-25
Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease.
Koskinen O, Lindfors K, Collin P, Peräaho M, Laurila K, Woolley N, Partanen J, Mäki M, Kaukinen K
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010 Oct;42(10):692-7
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010 Oct;42(10):692-7
Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa.
Luciani A, Villella VR, Vasaturo A, Giardino I, Pettoello-Mantovani M, Guido S, Cexus ON, Peake N, Londei M, Quaratino S, Maiuri L
Gut 2010 Mar;59(3):311-9
Gut 2010 Mar;59(3):311-9
Anti transglutaminase antibodies cause ataxia in mice.
Boscolo S, Lorenzon A, Sblattero D, Florian F, Stebel M, Marzari R, Not T, Aeschlimann D, Ventura A, Hadjivassiliou M, Tongiorgi E
PloS one 2010 Mar 15;5(3):e9698
PloS one 2010 Mar 15;5(3):e9698
Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cells.
Prunotto M, Compagnone A, Bruschi M, Candiano G, Colombatto S, Bandino A, Petretto A, Moll S, Bochaton-Piallat ML, Gabbiani G, Dimuccio V, Parola M, Citti L, Ghiggeri G
Laboratory investigation; a journal of technical methods and pathology 2010 Jun;90(6):929-39
Laboratory investigation; a journal of technical methods and pathology 2010 Jun;90(6):929-39
Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5.
Frese-Schaper M, Schardt JA, Sakai T, Carboni GL, Schmid RA, Frese S
FEBS letters 2010 Jul 2;584(13):2867-71
FEBS letters 2010 Jul 2;584(13):2867-71
I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway.
Kim DS, Han BG, Park KS, Lee BI, Kim SY, Bae CD
Biochemical and biophysical research communications 2010 Aug 20;399(2):300-6
Biochemical and biophysical research communications 2010 Aug 20;399(2):300-6
Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells.
Faye C, Inforzato A, Bignon M, Hartmann DJ, Muller L, Ballut L, Olsen BR, Day AJ, Ricard-Blum S
The Biochemical journal 2010 Apr 14;427(3):467-75
The Biochemical journal 2010 Apr 14;427(3):467-75
Tissue transglutaminase expression in celiac mucosa: an immunohistochemical study.
Gorgun J, Portyanko A, Marakhouski Y, Cherstvoy E
Virchows Archiv : an international journal of pathology 2009 Oct;455(4):363-73
Virchows Archiv : an international journal of pathology 2009 Oct;455(4):363-73
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Wilhelmus MM, Grunberg SC, Bol JG, van Dam AM, Hoozemans JJ, Rozemuller AJ, Drukarch B
Brain pathology (Zurich, Switzerland) 2009 Oct;19(4):612-22
Brain pathology (Zurich, Switzerland) 2009 Oct;19(4):612-22
Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide.
Telci D, Collighan RJ, Basaga H, Griffin M
The Journal of biological chemistry 2009 Oct 23;284(43):29547-58
The Journal of biological chemistry 2009 Oct 23;284(43):29547-58
The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis.
Malorni W, Farrace MG, Matarrese P, Tinari A, Ciarlo L, Mousavi-Shafaei P, D'Eletto M, Di Giacomo G, Melino G, Palmieri L, Rodolfo C, Piacentini M
Cell death and differentiation 2009 Nov;16(11):1480-92
Cell death and differentiation 2009 Nov;16(11):1480-92
Fibroblastic reticular cell infection by hemorrhagic fever viruses.
Steele KE, Anderson AO, Mohamadzadeh M
Immunotherapy 2009 Mar;1(2):187-97
Immunotherapy 2009 Mar;1(2):187-97
Quantitative and rapid analysis of transglutaminase activity using protein arrays in mammalian cells.
Kwon MH, Jung JW, Jung SH, Park JY, Kim YM, Ha KS
Molecules and cells 2009 Mar 31;27(3):337-43
Molecules and cells 2009 Mar 31;27(3):337-43
Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments.
Del Duca S, Serafini-Fracassini D, Bonner P, Cresti M, Cai G
The Biochemical journal 2009 Mar 15;418(3):651-64
The Biochemical journal 2009 Mar 15;418(3):651-64
Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition.
Kim DS, Park KS, Jeong KC, Lee BI, Lee CH, Kim SY
Cancer letters 2009 Jan 18;273(2):243-9
Cancer letters 2009 Jan 18;273(2):243-9
Maternal celiac disease autoantibodies bind directly to syncytiotrophoblast and inhibit placental tissue transglutaminase activity.
Anjum N, Baker PN, Robinson NJ, Aplin JD
Reproductive biology and endocrinology : RB&E 2009 Feb 19;7:16
Reproductive biology and endocrinology : RB&E 2009 Feb 19;7:16
Positive auto-regulation of MYCN in human neuroblastoma.
Suenaga Y, Kaneko Y, Matsumoto D, Hossain MS, Ozaki T, Nakagawara A
Biochemical and biophysical research communications 2009 Dec 4;390(1):21-6
Biochemical and biophysical research communications 2009 Dec 4;390(1):21-6
Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.
Huebner JL, Johnson KA, Kraus VB, Terkeltaub RA
Osteoarthritis and cartilage 2009 Aug;17(8):1056-64
Osteoarthritis and cartilage 2009 Aug;17(8):1056-64
SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation.
Luciani A, Villella VR, Vasaturo A, Giardino I, Raia V, Pettoello-Mantovani M, D'Apolito M, Guido S, Leal T, Quaratino S, Maiuri L
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 15;183(4):2775-84
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 15;183(4):2775-84
Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase.
Hadjivassiliou M, Aeschlimann P, Strigun A, Sanders DS, Woodroofe N, Aeschlimann D
Annals of neurology 2008 Sep;64(3):332-43
Annals of neurology 2008 Sep;64(3):332-43
Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.
Lai TS, Liu Y, Tucker T, Daniel KR, Sane DC, Toone E, Burke JR, Strittmatter WJ, Greenberg CS
Chemistry & biology 2008 Sep 22;15(9):969-78
Chemistry & biology 2008 Sep 22;15(9):969-78
The monoclonal antibody 6B9 recognizes CD44 and not cell surface transglutaminase 2.
Stamnaes J, Fleckenstein B, Lund-Johansen F, Sollid LM
Scandinavian journal of immunology 2008 Nov;68(5):534-42
Scandinavian journal of immunology 2008 Nov;68(5):534-42
Increased tissue transglutaminase expression in human atherosclerotic coronary arteries.
Cho BR, Kim MK, Suh DH, Hahn JH, Lee BG, Choi YC, Kwon TJ, Kim SY, Kim DJ
Coronary artery disease 2008 Nov;19(7):459-68
Coronary artery disease 2008 Nov;19(7):459-68
Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling.
Telci D, Wang Z, Li X, Verderio EA, Humphries MJ, Baccarini M, Basaga H, Griffin M
The Journal of biological chemistry 2008 Jul 25;283(30):20937-47
The Journal of biological chemistry 2008 Jul 25;283(30):20937-47
Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation.
Li HY, Shen JT, Chang SP, Hsu WL, Sung YJ
Placenta 2008 Jan;29(1):20-9
Placenta 2008 Jan;29(1):20-9
Effect of acetylcholine precursors on proliferation and differentiation of astroglial cells in primary cultures.
Bramanti V, Campisi A, Tomassoni D, Li Volti G, Caccamo D, Cannavò G, Currò M, Raciti G, Napoli M, Ientile R, Vanella A, Amenta F, Avola R
Neurochemical research 2008 Dec;33(12):2601-8
Neurochemical research 2008 Dec;33(12):2601-8
Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1.
Zemskov EA, Mikhailenko I, Strickland DK, Belkin AM
Journal of cell science 2007 Sep 15;120(Pt 18):3188-99
Journal of cell science 2007 Sep 15;120(Pt 18):3188-99
Mutagenesis of the catalytic triad of tissue transglutaminase abrogates coeliac disease serum IgA autoantibody binding.
Byrne G, Ryan F, Jackson J, Feighery C, Kelly J
Gut 2007 Mar;56(3):336-41
Gut 2007 Mar;56(3):336-41
Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease.
Barone MV, Caputo I, Ribecco MT, Maglio M, Marzari R, Sblattero D, Troncone R, Auricchio S, Esposito C
Gastroenterology 2007 Apr;132(4):1245-53
Gastroenterology 2007 Apr;132(4):1245-53
Tissue array-based expression of transglutaminase-2 in human breast and ovarian cancer.
Singer CF, Hudelist G, Walter I, Rueckliniger E, Czerwenka K, Kubista E, Huber AV
Clinical & experimental metastasis 2006;23(1):33-9
Clinical & experimental metastasis 2006;23(1):33-9
In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes.
Zanoni G, Navone R, Lunardi C, Tridente G, Bason C, Sivori S, Beri R, Dolcino M, Valletta E, Corrocher R, Puccetti A
PLoS medicine 2006 Sep;3(9):e358
PLoS medicine 2006 Sep;3(9):e358
Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions.
Balajthy Z, Csomós K, Vámosi G, Szántó A, Lanotte M, Fésüs L
Blood 2006 Sep 15;108(6):2045-54
Blood 2006 Sep 15;108(6):2045-54
Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivation.
Kim DS, Park SS, Nam BH, Kim IH, Kim SY
Cancer research 2006 Nov 15;66(22):10936-43
Cancer research 2006 Nov 15;66(22):10936-43
SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix.
Chlenski A, Liu S, Guerrero LJ, Yang Q, Tian Y, Salwen HR, Zage P, Cohn SL
International journal of cancer 2006 Jan 15;118(2):310-6
International journal of cancer 2006 Jan 15;118(2):310-6
Transglutaminase activity regulates osteoblast differentiation and matrix mineralization in MC3T3-E1 osteoblast cultures.
Al-Jallad HF, Nakano Y, Chen JL, McMillan E, Lefebvre C, Kaartinen MT
Matrix biology : journal of the International Society for Matrix Biology 2006 Apr;25(3):135-48
Matrix biology : journal of the International Society for Matrix Biology 2006 Apr;25(3):135-48
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation.
Strnad P, Siegel M, Toivola DM, Choi K, Kosek JC, Khosla C, Omary MB
FEBS letters 2006 Apr 17;580(9):2351--2357
FEBS letters 2006 Apr 17;580(9):2351--2357
Mammalian transglutaminases: a family portrait.
Mehta K
Progress in experimental tumor research 2005;38:1-18
Progress in experimental tumor research 2005;38:1-18
Distinct pH modulation for dual function of Galphah (transglutaminase II).
Chae KY, Kim JH, Park WJ, Kim YG, Yun HY, Kwon NS, Im MJ, Baek KJ
Journal of biochemistry 2005 Mar;137(3):407-13
Journal of biochemistry 2005 Mar;137(3):407-13
Characterizing monoclonal antibody epitopes by filtered gene fragment phage display.
Di Niro R, Ferrara F, Not T, Bradbury AR, Chirdo F, Marzari R, Sblattero D
The Biochemical journal 2005 Jun 15;388(Pt 3):889-94
The Biochemical journal 2005 Jun 15;388(Pt 3):889-94
Characterization of purified rat testicular transglutaminase and age-dependent changes of the enzyme activities.
Wu YW, Lai WF, Tsai YH
The international journal of biochemistry & cell biology 2005 Feb;37(2):386-96
The international journal of biochemistry & cell biology 2005 Feb;37(2):386-96
Nuclear factor-kappab activation is associated with glutamate-evoked tissue transglutaminase up-regulation in primary astrocyte cultures.
Caccamo D, Campisi A, Currò M, Aguennouz M, Li Volti G, Avola R, Ientile R
Journal of neuroscience research 2005 Dec 15;82(6):858-65
Journal of neuroscience research 2005 Dec 15;82(6):858-65
Expression of apoptosis-related proteins in rat with induced colitis.
D'Argenio G, Farrace MG, Cosenza V, De Ritis F, Della Valle N, Manguso F, Piacentini M
International journal of colorectal disease 2004 Sep;19(5):451-60
International journal of colorectal disease 2004 Sep;19(5):451-60
Excitotoxin-induced changes in transglutaminase during differentiation of cerebellar granule cells.
Caccamo D, Currò M, Cusumano G, Crisafulli G, Ientile R
Amino acids 2004 Mar;26(2):197-201
Amino acids 2004 Mar;26(2):197-201
Protective role of tissue transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells.
Kweon SM, Lee ZW, Yi SJ, Kim YM, Han JA, Paik SG, Ha SS
Journal of biochemistry and molecular biology 2004 Mar 31;37(2):185-91
Journal of biochemistry and molecular biology 2004 Mar 31;37(2):185-91
Protective role of tissue transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells.
Kweon SM, Lee ZW, Yi SJ, Kim YM, Han JA, Paik SG, Ha SS
Journal of biochemistry and molecular biology 2004 Mar 31;37(2):185-91
Journal of biochemistry and molecular biology 2004 Mar 31;37(2):185-91
Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia.
Ientile R, Caccamo D, Marciano MC, Currò M, Mannucci C, Campisi A, Calapai G
Neuroscience letters 2004 Jun 10;363(2):173-7
Neuroscience letters 2004 Jun 10;363(2):173-7
Tissue transglutaminase is a multifunctional BH3-only protein.
Rodolfo C, Mormone E, Matarrese P, Ciccosanti F, Farrace MG, Garofano E, Piredda L, Fimia GM, Malorni W, Piacentini M
The Journal of biological chemistry 2004 Dec 24;279(52):54783-92
The Journal of biological chemistry 2004 Dec 24;279(52):54783-92
Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia.
Lee J, Kim YS, Choi DH, Bang MS, Han TR, Joh TH, Kim SY
The Journal of biological chemistry 2004 Dec 17;279(51):53725-35
The Journal of biological chemistry 2004 Dec 17;279(51):53725-35
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.
Suh MD, Park CH, Kim SS, Kil MO, Lee GH, Johnson GV, Chun W
Archives of pharmacal research 2004 Aug;27(8):850-6
Archives of pharmacal research 2004 Aug;27(8):850-6
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.
Suh MD, Park CH, Kim SS, Kil MO, Lee GH, Johnson GV, Chun W
Archives of pharmacal research 2004 Aug;27(8):850-6
Archives of pharmacal research 2004 Aug;27(8):850-6
Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes.
Ladd PA, Du L, Capdevila JH, Mernaugh R, Keeney DS
The Journal of biological chemistry 2003 Sep 12;278(37):35184-92
The Journal of biological chemistry 2003 Sep 12;278(37):35184-92
Glutamate-induced increases in transglutaminase activity in primary cultures of astroglial cells.
Campisi A, Caccamo D, Raciti G, Cannavò G, Macaione V, Currò M, Macaione S, Vanella A, Ientile R
Brain research 2003 Jul 18;978(1-2):24-30
Brain research 2003 Jul 18;978(1-2):24-30
Glutamate-induced increases in transglutaminase activity in primary cultures of astroglial cells.
Campisi A, Caccamo D, Raciti G, Cannavò G, Macaione V, Currò M, Macaione S, Vanella A, Ientile R
Brain research 2003 Jul 18;978(1-2):24-30
Brain research 2003 Jul 18;978(1-2):24-30
In patients with dermatitis herpetiformis distribution of transglutaminase in cutaneous tissue does not differ from controls.
Biagi F, Bassi E, Ardigó M, Vignini MA, Caravaggi M, Borroni G, Corazza GR
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2003 Jan;35(1):41-5
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2003 Jan;35(1):41-5
In patients with dermatitis herpetiformis distribution of transglutaminase in cutaneous tissue does not differ from controls.
Biagi F, Bassi E, Ardigó M, Vignini MA, Caravaggi M, Borroni G, Corazza GR
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2003 Jan;35(1):41-5
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2003 Jan;35(1):41-5
Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa.
Ciccocioppo R, Di Sabatino A, Ara C, Biagi F, Perilli M, Amicosante G, Cifone MG, Corazza GR
Clinical and experimental immunology 2003 Dec;134(3):516-24
Clinical and experimental immunology 2003 Dec;134(3):516-24
NMDA-evoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells.
Ientile R, Caccamo D, Macaione V, Torre V, Macaione S
Neuroscience 2002;115(3):723-9
Neuroscience 2002;115(3):723-9
NMDA-evoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells.
Ientile R, Caccamo D, Macaione V, Torre V, Macaione S
Neuroscience 2002;115(3):723-9
Neuroscience 2002;115(3):723-9
Bone-specific antibodies in sera from patients with celiac disease: characterization and implications in osteoporosis.
Sugai E, Cherñavsky A, Pedreira S, Smecuol E, Vazquez H, Niveloni S, Mazure R, Mauriro E, Rabinovich GA, Bai JC
Journal of clinical immunology 2002 Nov;22(6):353-62
Journal of clinical immunology 2002 Nov;22(6):353-62
Bone-specific antibodies in sera from patients with celiac disease: characterization and implications in osteoporosis.
Sugai E, Cherñavsky A, Pedreira S, Smecuol E, Vazquez H, Niveloni S, Mazure R, Mauriro E, Rabinovich GA, Bai JC
Journal of clinical immunology 2002 Nov;22(6):353-62
Journal of clinical immunology 2002 Nov;22(6):353-62
Analysis of tissue transglutaminase function in the migration of Swiss 3T3 fibroblasts: the active-state conformation of the enzyme does not affect cell motility but is important for its secretion.
Balklava Z, Verderio E, Collighan R, Gross S, Adams J, Griffin M
The Journal of biological chemistry 2002 May 10;277(19):16567-75
The Journal of biological chemistry 2002 May 10;277(19):16567-75
Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress.
Piacentini M, Farrace MG, Piredda L, Matarrese P, Ciccosanti F, Falasca L, Rodolfo C, Giammarioli AM, Verderio E, Griffin M, Malorni W
Journal of neurochemistry 2002 Jun;81(5):1061-72
Journal of neurochemistry 2002 Jun;81(5):1061-72
Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress.
Piacentini M, Farrace MG, Piredda L, Matarrese P, Ciccosanti F, Falasca L, Rodolfo C, Giammarioli AM, Verderio E, Griffin M, Malorni W
Journal of neurochemistry 2002 Jun;81(5):1061-72
Journal of neurochemistry 2002 Jun;81(5):1061-72
Up-regulation of tissue-type transglutaminase after traumatic brain injury.
Tolentino PJ, DeFord SM, Notterpek L, Glenn CC, Pike BR, Wang KK, Hayes RL
Journal of neurochemistry 2002 Feb;80(4):579-88
Journal of neurochemistry 2002 Feb;80(4):579-88
Up-regulation of tissue-type transglutaminase after traumatic brain injury.
Tolentino PJ, DeFord SM, Notterpek L, Glenn CC, Pike BR, Wang KK, Hayes RL
Journal of neurochemistry 2002 Feb;80(4):579-88
Journal of neurochemistry 2002 Feb;80(4):579-88
Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1.
Kang SK, Kim DK, Damron DS, Baek KJ, Im MJ
Biochemical and biophysical research communications 2002 Apr 26;293(1):383-90
Biochemical and biophysical research communications 2002 Apr 26;293(1):383-90
Tissue transglutaminase facilitates the polymerization of insulin-like growth factor-binding protein-1 (IGFBP-1) and leads to loss of IGFBP-1's ability to inhibit insulin-like growth factor-I-stimulated protein synthesis.
Sakai K, Busby WH Jr, Clarke JB, Clemmons DR
The Journal of biological chemistry 2001 Mar 23;276(12):8740-5
The Journal of biological chemistry 2001 Mar 23;276(12):8740-5
Gene disruption of tissue transglutaminase.
De Laurenzi V, Melino G
Molecular and cellular biology 2001 Jan;21(1):148-55
Molecular and cellular biology 2001 Jan;21(1):148-55
Implication of tissue transglutaminase and desmoplakin in cell adhesion mechanism in human epidermis.
Esposito C, Lombardi ML, Ruocco V, Cozzolino A, Mariniello L, Porta R
Molecular and cellular biochemistry 2000 Mar;206(1-2):57-65
Molecular and cellular biochemistry 2000 Mar;206(1-2):57-65
Implication of tissue transglutaminase and desmoplakin in cell adhesion mechanism in human epidermis.
Esposito C, Lombardi ML, Ruocco V, Cozzolino A, Mariniello L, Porta R
Molecular and cellular biochemistry 2000 Mar;206(1-2):57-65
Molecular and cellular biochemistry 2000 Mar;206(1-2):57-65
Alpha 1B-adrenoceptor interacts with multiple sites of transglutaminase II: characteristics of the interaction in binding and activation.
Feng JF, Gray CD, Im MJ
Biochemistry 1999 Feb 16;38(7):2224-32
Biochemistry 1999 Feb 16;38(7):2224-32
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of Transglutaminase II using Transglutaminase II Monoclonal Antibody (Product # MA5-12739) on HUVEC Cells.
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Knockout of TGM2 was achieved by CRISPR-Cas9 genome editing using LentiArray™ Lentiviral sgRNA (Product # A32042, Assay ID CRISPR979226_LV) and LentiArray Cas9 Lentivirus (Product # A32064). Western blot analysis of TGM2 was performed by loading 30 µg of HeLa Wild type (Lane 1), HeLa Cas9 (Lane 2) and HeLa TGM2 KO (Lane 3) whole cell extracts. The samples were electrophoresed using NuPAGE™ Novex™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with Anti-TGM2 Monoclonal Antibody (CUB 7402) (Product # MA5-12739, 0.25 µg dilution) and Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:5,000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005). Loss of signal upon CRISPR mediated knockout (KO) using the LentiArray™ CRISPR product line confirms that antibody is specific to TGM2.
Supportive validation
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- Invitrogen Antibodies (provider)
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- Formalin-fixed, paraffin-embedded human breast carcinoma stained with Transglutaminase II antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane and cytoplasmic staining of tumor and endothelial cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
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- Immunoprecipitation of Transglutaminase II using Transglutaminase II Monoclonal Antibody (Product # MA5-12739) on denatured Human HUVEC Cells.
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- Invitrogen Antibodies (provider)
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- Experimental details
- Immunoprecipitation of Transglutaminase II using Transglutaminase II Monoclonal Antibody (Product # MA5-12739) on Native Human MCF-7 Cells.
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- Invitrogen Antibodies (provider)
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- Figure 6 The GRASP55-dependent surfactome (A) Experimental outline of the SILAC-based GRASP55-dependent surfactome assay in WI-26 cells (details in text). (B) CC GO term analysis reveals enrichment of cell-junction-related terms among the GRASP55-dependent surfactome proteins. Cell plot labeled as in Figure 4 B. (C) Volcano plot showing all proteins identified in the GRASP55-dependent surfactome (gray dots). Proteins used in (B) are shown in blue. Proteins within this subset that belong to the CC GO term ""cell junction"" are shown in blue with black outline. (D) BP GO term analysis reveals enrichment of cell-motility-related terms among the GRASP55-dependent surfactome proteins. Cell plot labeled as in Figure 4 B. (E) Volcano plot showing proteins as in (C), but with outlined blue dots corresponding to the BP GO term ""cell motility."" (F) MF GO term analysis reveals enrichment of cell-adhesion-molecule-binding-related terms among the GRASP55-dependent surfactome proteins. Cell plot labeled as in Figure 4 B. (G) Volcano plot showing proteins as in (C), but with outlined blue dots corresponding to the MF GO term ""cell adhesion molecule binding."" (H) Percentage of proteins in the GRASP55-dependent surfactome that contain or lack a signal peptide. (I) TGM2 levels at the cell surface tested by surface protein biotinylation assays and immunoblotting in WT and GRASP55 KO WI-26 cells. Intracellular TGM2, GRASP55, and actin are used as controls. See also Tables S6 and S7 .
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- Figure 3 Morphology of glioblastoma stem cells ( a : GSC 528; b : GSC 157) in vitro; phase-contrast microscopy. ( c ) Positive TGM2 and negative SOX2 staining in GSC 528. ( d ) Negative TGM2 and positive SOX2 staining in GSC 157. Morphology of GSC tumors ( e: GSC 528; f : GSC 157) in in ovo cultures by bright-field microscopy. ( g ) Vascularization of a GSC tumor. ( h ) Intact chorioallantoic membrane in a control egg. ( i ) The volume of tumors formed at sampling (day 19 of embryonic development (ED); Mann-Whitney test). Scale bars are 0.1 ( a - d ) and 1 mm ( e - h ). Implantation efficiency of GSC cell cultures (GSC 528: n = 27, GSC 157: n = 26) on chicken embryo CAM (GSC 528: 96%, GSC 157: 88%) and egg viability at ED 19 (GSC 528: 92%, GSC 157: 93%) were comparable in both GSC models.
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- Figure 4 Hematoxylin and eosine staining in glioblastoma stem cells (GSC 528 ( a ) and GSC 157 ( b ) tumors at day 19 of embryonic development. CE: chorionic epithelium, AE: allantoic epithelium, M: intermediate vascularized mesenchyme, BV: blood vessel, and T: tumor. TGM2 ( c : GSC 528; d : GSC 157) and SOX2 ( e : GSC 528; f : GSC 157) protein expression in tumor cells; TGM2-positive staining is in red ( c ). Scale bars are 1 ( a , b ) and 0.1 mm ( c - f ).
