PAB16972

antibody from Abnova Corporation

Targeting: GAB1 DFNB26

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

PAB16972

Provider

Abnova Corporation

Proper citation

Abnova Corporation Cat#PAB16972, RRID:AB_10616189

Product name

GAB1 (phospho Y659) polyclonal antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of GAB1.

Storage

Store at 4°C for three months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.

References

Submitted references

Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules.

Hoffmann KM, Tapia JA, Jensen RT
Cellular signalling 2006 Jul;18(7):942-54

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A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation.

Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P
The Journal of biological chemistry 2005 Feb 18;280(7):5350-60

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Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.

Cunnick JM, Mei L, Doupnik CA, Wu J
The Journal of biological chemistry 2001 Jun 29;276(26):24380-7

Immunohistochemistry

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma tissue using GAB1 (phospho Tyr659) polyclonal antibody (Cat # PAB16972).

Validation comment

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)