Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-8085 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-Grb2-associated binder 1 Antibody
- Antibody type
- Polyclonal
- Description
- GAB1 (GRB2-associated-binding protein 1) belongs to the scaffolding adaptor protein family. GAB1 has an N-terminal pleckstrin homology domain, as well as multiple tyrosine-based motifs and proline-rich sequences, which are potential binding sites for various Src homology 2 (SH2) domains and Src homology 3 domains, respectively. It is required for fibroblast cell survival and maintaining cardiac function. It is expressed in myocardial tissue in acyanotic and cyanotic children with congenital heart defects (26090437). GAB1 is an important docking protein responsible for intracellular signaling assembly and transduction. It is involved in proliferation and apoptosis in human chondrosarcoma (CS). It plays a role in FGFR1 signaling and involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant Grb2-a
ssociated binder 1 protein (amino a
cids 110-320) was used as the immun
ogen for this antibody.- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of Grb2-associated binder 1. Anti-Grb2-associated binder 1 antibody (11-8085) was used at 4 µg/ml on (1) A431 and (2) K562 lysates.