11-8085-25

antibody from ABEOMICS Inc.
Targeting: GAB1 DFNB26
Provider product page for 11-8085-25

Antibody data

Product number
11-8085-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Grb2-associated binder 1 Antibody
Antibody type
Polyclonal
Description
GAB1 (GRB2-associated-binding protein 1) belongs to the scaffolding adaptor protein family. GAB1 has an N-terminal pleckstrin homology domain, as well as multiple tyrosine-based motifs and proline-rich sequences, which are potential binding sites for various Src homology 2 (SH2) domains and Src homology 3 domains, respectively. It is required for fibroblast cell survival and maintaining cardiac function. It is expressed in myocardial tissue in acyanotic and cyanotic children with congenital heart defects (26090437). GAB1 is an important docking protein responsible for intracellular signaling assembly and transduction. It is involved in proliferation and apoptosis in human chondrosarcoma (CS). It plays a role in FGFR1 signaling and involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant Grb2-a
ssociated binder 1 protein (amino a
cids 110-320) was used as the immun
ogen for this antibody.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
GAB1 protein structure - 11-8085-25 shown in red.