16195-1-AP

antibody from Proteintech Group

Targeting: CLDN4 CPE-R, CPETR, CPETR1, hCPE-R, WBSCR8

Provider product page for 16195-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [44]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 16195-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16195-1-AP, RRID:AB_2082969
Product name: Claudin 4-specific antibody
Antibody type: Polyclonal
Description: Claudin 4-specific antibody (Cat. #16195-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CLDN4 protein structure - 16195-1-AP shown in red.

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Saccharomyces boulardii alleviates allergic asthma by restoring gut microbiota and metabolic homeostasis via up-regulation of METTL3 in an m6A-dependent manner.

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Immunology letters 2024 Jun;267:106853

Angiotensin-converting enzyme inhibitory peptide IVGFPAYGH protects against liver injury in mice fed a high‑sodium diet by inhibiting the RAS and remodeling gut microbial communities.

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International journal of biological macromolecules 2024 Jan;256(Pt 1):128265

S-amlodipine induces liver inflammation and dysfunction through the alteration of intestinal microbiome in a rat model.

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Gut microbes 2024 Jan-Dec;16(1):2316923

Effect of chronic noise exposure on glucose and lipid metabolism in mice via modulating gut microbiota and regulating CREB/CRTC2 and SREBP1/SCD pathway.

Wu S, Du W, Wu Z, Wen F, Zhong X, Huang X, Gu H, Wang J
Ecotoxicology and environmental safety 2024 Jan 15;270:115887

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mSystems 2024 Feb 20;9(2):e0125523

Lithium chloride promotes mesenchymal-epithelial transition in murine cutaneous wound healing via inhibiting CXCL9 and IGF2.

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Experimental dermatology 2024 Apr;33(4):e15078

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Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes.

Yang J, Yang X, Wu G, Huang F, Shi X, Wei W, Zhang Y, Zhang H, Cheng L, Yu L, Shang J, Lv Y, Wang X, Zhai R, Li P, Cui B, Fang Y, Deng X, Tang S, Wang L, Yuan Q, Zhao L, Zhang F, Zhang C, Yuan H
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American journal of physiology. Lung cellular and molecular physiology 2023 Oct 1;325(4):L447-L459

Rat tight junction proteins are disrupted after subchronic exposure to okadaic acid.

Huang L, Liu B, Yu XW, Pan GQ, Xu JY, Yan D, Wang YL, Guo QN
Environmental science and pollution research international 2023 May;30(22):62201-62212

Bisphenol P exposure in C57BL/6 mice caused gut microbiota dysbiosis and induced intestinal barrier disruption via LPS/TLR4/NF-κB signaling pathway.

Ma N, Ma D, Liu X, Zhao L, Ma L, Ma D, Dong S
Environment international 2023 May;175:107949

TWEAK Signaling-Induced ID1 Expression Drives Malignant Transformation of Hepatic Progenitor Cells During Hepatocarcinogenesis.

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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(18):e2300350

Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosis.

Liang J, Huang G, Liu X, Liu N, Taghavifar F, Dai K, Yao C, Deng N, Wang Y, Chen P, Hogaboam C, Stripp BR, Parks WC, Noble PW, Jiang D
eLife 2023 Jun 14;12

The microbial metabolite Urolithin A reduces C. difficile toxin expression and repairs toxin-induced epithelial damage.

Ghosh S, Erickson D, Chua MJ, Collins J, Jala VR
bioRxiv : the preprint server for biology 2023 Jul 24;

DHA-enriched phosphatidylserine alleviates high fat diet-induced jejunum injury in mice by modulating gut microbiota.

Tian S, Zhao Y, Qian L, Jiang S, Tang Y, Han T
Food & function 2023 Feb 6;14(3):1415-1429

Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3/caspase-1 signaling pathway.

Wu S, Wen F, Zhong X, Du W, Chen M, Wang J
Annals of medicine 2023 Dec;55(1):2216942

Loss of Pkd1 limits susceptibility to colitis and colorectal cancer.

Nikonova AS, Deneka AY, Silva FN, Pirestani S, Tricarico R, Kiseleva AA, Zhou Y, Nicolas E, Flieder DB, Grivennikov SI, Golemis EA
Oncogenesis 2023 Aug 5;12(1):40

D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway.

Huang J, Wang B, Tao S, Hu Y, Wang N, Zhang Q, Wang C, Chen C, Gao B, Cheng X, Li Y
Frontiers in immunology 2022;13:928312

Porphyromonas gingivalis secretion leads to dysplasia of normal esophageal epithelial cells via the Sonic hedgehog pathway.

Jia X, Liu J, He Y, Huang X
Frontiers in cellular and infection microbiology 2022;12:982636

CLDN4 promotes growth of acute myeloid leukemia cells via regulating AKT and ERK1/2 signaling.

Hao S, Yang C, Song P, Shi H, Zou Y, Chen M, Wu X, Yin Y, Yu Z, Zhu W, Li M
Biochemical and biophysical research communications 2022 Sep 3;619:137-143

DHA-enriched phosphatidylcholine from Clupea harengus roes regulates the gut-liver axis to ameliorate high-fat diet-induced non-alcoholic fatty liver disease.

Qian L, Tian S, Jiang S, Tang Y, Han T
Food & function 2022 Nov 14;13(22):11555-11567

Effects of Enzamin, a Microbial Product, on Alterations of Intestinal Microbiota Induced by a High-Fat Diet.

Yasuzawa T, Nishi R, Ishitani S, Matsuo O, Ueshima S
Nutrients 2022 Nov 10;14(22)

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis.

Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P
bioRxiv : the preprint server for biology 2022 Jul 18;

A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling.

Yang Q, Liu J, Wang Y, Zhao W, Wang W, Cui J, Yang J, Yue Y, Zhang S, Chu M, Lyu Q, Ma L, Tang Y, Hu Y, Miao K, Zhao H, Tian J, An L
The Journal of biological chemistry 2022 Jan;298(1):101456

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis.

Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P
EBioMedicine 2022 Aug;82:104185

Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis.

Luo Y, Zhang Y, Han X, Yuan Y, Zhou Y, Gao Y, Yu H, Zhang J, Shi Y, Duan Y, Zhao X, Yan S, Hao H, Dai C, Zhao S, Shi J, Li W, Zhang S, Xu W, Fang N, Gong Y, Li Y
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Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo.

Xiang Y, Cai M, Li X, Bao X, Cai D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8257495

Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity.

Jing Y, Ma R, Chu Y, Dou M, Wang M, Li X, Zhu L
Journal of chemical neuroanatomy 2021 Nov;117:102004

Targeting PVT1 Exon 9 Re-Expresses Claudin 4 Protein and Inhibits Migration by Claudin-Low Triple Negative Breast Cancer Cells.

Levine F, Ogunwobi OO
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Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland.

Matsuoka S, Suzuki H, Kato C, Kamikawa-Tokai M, Kamikawa A, Okamatsu-Ogura Y, Kimura K
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2021 Jun;69(6):373-388

Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.

Zhang X, Li F, Zhou Y, Mao F, Lin Y, Shen S, Li Y, Zhang S, Sun Q
Cell death & disease 2021 Jun 18;12(7):627

Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.

Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115

Kaempferol attenuates diquat-induced oxidative damage and apoptosis in intestinal porcine epithelial cells.

Jin Y, Zhai Z, Jia H, Lai J, Si X, Wu Z
Food & function 2021 Aug 2;12(15):6889-6899

ROS Plays a Role in the Neonatal Rat Intestinal Barrier Damages Induced by Hyperoxia.

Liu DY, Lou WJ, Zhang DY, Sun SY
BioMed research international 2020;2020:8819195

Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.

Wu J, Lai X, Cui G, Chen Q, Liu J, Kang Y, Zhang Y, Feng X, Hu C, Shao L
Journal of hazardous materials 2020 Nov 15;399:122809

Targeting claudin-4 enhances chemosensitivity in breast cancer.

Luo Y, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R, Mori S, Goto K, Nishiguchi Y, Mori T, Kawahara I, Kondoh M, Kuniyasu H
Cancer science 2020 May;111(5):1840-1850

Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikrein‑related peptidase 4 and tight junction proteins in ameloblasts.

Gao J, Li X, Gao L, Chen H, Baras BH, Liu X, Liu H, Rana A, Gao M, Ruan J
International journal of molecular medicine 2020 Jul;46(1):179-190

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.

Kobayashi Y, Tata A, Konkimalla A, Katsura H, Lee RF, Ou J, Banovich NE, Kropski JA, Tata PR
Nature cell biology 2020 Aug;22(8):934-946

The chromatin remodeling protein BRM regulates the transcription of tight junction proteins: Implication in breast cancer metastasis.

Yang Y, Liu L, Fang M, Bai H, Xu Y
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 May;1862(5):547-556

Endotoxemia alters tight junction gene and protein expression in the kidney.

Eadon MT, Hack BK, Xu C, Ko B, Toback FG, Cunningham PN
American journal of physiology. Renal physiology 2012 Sep 15;303(6):F821-30

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse small intestine tissue were subjected to SDS PAGE followed by western blot with 16195-1-AP(CLDN4-specific antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Claudin 4-specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Claudin 4-specific. This antibody recognizes human,mouse,rat antigen. The Claudin 4-specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 16195-1-AP.pdf

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