Antibody data
- Antibody Data
- Antigen structure
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- Product number
- RB-02-0035-200 - Provider product page
- Provider
- RayBiotech, Inc.
- Proper citation
- RayBiotech Cat#RB-02-0035-200, RRID:AB_11219613
- Product name
- Rabbit anti-Bim
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide derived from human Tau.
- Description
- Bim/Bod is a pro-apoptotic protein belonging to the BH3-only group of Bcl-2 family members, including Bad, Bid, Bik, Hrk and Noxa, which contain a BH3 domain but lack other conserved BH1 or BH2 domains. Bim induces apoptosis by binding to and antagonizing anti-apoptotic members of the Bcl-2 family. Interactions have been observed with Bcl-2, Bcl-xL, Mcl-1, Bcl-w, Bfl-1 and BHRF-1. Bim functions in regulating apoptosis associated with thymocyte negative selection and following growth factor withdrawal, during which Bim expression is elevated. Three major isoforms of Bim are generated by alternative splicing: BimEL, BimL and BimS. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells derived from the immunized mouse. The IgM fraction of cell culture supernatant was purified by affinity chromatography.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Biotin
- Antigen sequence
This antibody was produced from a h
ybridoma resulting from the fusion
of a mouse myeloma with B cells der
ived from the immunized mouse. The
IgM fraction of cell culture supern
atant was purified by affinity chro
matography.- Isotype
- IgG
- Vial size
- 200 µg
- Handling
- Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1x PBS to a final concentration of 1 mg/ml.
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